LOCUS       NM_001160152            3723 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Mus musculus amylase 2a2 (Amy2a2), mRNA.
ACCESSION   NM_001160152 XM_001480963
VERSION     NM_001160152.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Sugino,H.
  TITLE     Comparative genomic analysis of the mouse and rat amylase multigene
            family
  JOURNAL   FEBS Lett 581 (3), 355-360 (2007)
   PUBMED   17223109
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Hagenbuchle,O., Schibler,U., Petrucco,S., Van Tuyle,G.C. and
            Wellauer,P.K.
  TITLE     Expression of mouse Amy-2a alpha-amylase genes is regulated by
            strong pancreas-specific promoters
  JOURNAL   J Mol Biol 185 (2), 285-293 (1985)
   PUBMED   3877171
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Pittet,A.C. and Schibler,U.
  TITLE     Mouse alpha-amylase loci, Amy-1a and Amy-2a, are closely linked
  JOURNAL   J Mol Biol 182 (3), 359-365 (1985)
   PUBMED   2989529
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Bodary,S., Grossi,G., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     Members of the Amy-2 alpha-amylase gene family of mouse strain CE/J
            contain duplicated 5' termini
  JOURNAL   J Mol Biol 182 (1), 1-10 (1985)
   PUBMED   2987507
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Hagenbuchle,O., Wellauer,P.K., Cribbs,D.L. and Schibler,U.
  TITLE     Termination of transcription in the mouse alpha-amylase gene Amy-2a
            occurs at multiple sites downstream of the polyadenylation site
  JOURNAL   Cell 38 (3), 737-744 (1984)
   PUBMED   6091898
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Schibler,U., Pittet,A.C., Young,R.A., Hagenbuchle,O., Tosi,M.,
            Gellman,S. and Wellauer,P.K.
  TITLE     The mouse alpha-amylase multigene family. Sequence organization of
            members expressed in the pancreas, salivary gland and liver
  JOURNAL   J Mol Biol 155 (3), 247-266 (1982)
   PUBMED   6176715
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Hagenbuchle,O., Bovey,R. and Young,R.A.
  TITLE     Tissue-specific expression of mouse-alpha-amylase genes: nucleotide
            sequence of isoenzyme mRNAs from pancreas and salivary gland
  JOURNAL   Cell 21 (1), 179-187 (1980)
   PUBMED   6157477
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC161580.12.
            
            On May 13, 2009 this sequence version replaced XM_001480963.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.158292.1,
                                           SRR5189682.68874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC161580.12        202802-203124       c
            324-470             AC161580.12        202325-202471       c
            471-659             AC161580.12        201060-201248       c
            660-890             AC161580.12        200097-200327       c
            891-1024            AC161580.12        198297-198430       c
            1025-1147           AC161580.12        197497-197619       c
            1148-1247           AC161580.12        197305-197404       c
            1248-1366           AC161580.12        196024-196142       c
            1367-1492           AC161580.12        195790-195915       c
            1493-3723           AC161580.12        191515-193745       c
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 49.35 cM"
     gene            1..3723
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /note="amylase 2a2"
                     /db_xref="GeneID:100043688"
                     /db_xref="MGI:MGI:3711220"
     exon            1..323
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1682
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /EC_number="3.2.1.1"
                     /note="amylase 2a2, pancreatic; Pancreatic alpha-amylase;
                     1,4-alpha-D-glucan glucanohydrolase"
                     /codon_start=1
                     /product="amylase 2a2 precursor"
                     /protein_id="NP_001153624.1"
                     /db_xref="CCDS:CCDS51056.1"
                     /db_xref="GeneID:100043688"
                     /db_xref="MGI:MGI:3711220"
                     /translation="MKFVLLLSLIGFCWAQYDPHTSDGRTAIVHLFEWRWVDIAKECE
                     RYLAPKGFGGVQVSPPNENVVVHNPSRPWWERYQPISYKICTRSGNEDEFRDMVTRCN
                     NVGVRIYVDAVINHMCGAGNPAGTSSTCGSYLNPNNREFPAVPYSAWDFNDNKCNGEI
                     DNYNDAYQVRNCRLTGLLDLALEKDYVRTKVADYMNHLIDIGVAGFRLDAAKHMWPGD
                     IKAVLDKLHNLNTKWFSQGSRPFIFQEVIDLGGEAIKGSEYFGNGRVTEFKYGAKLGT
                     VIRKWNGEKMSYLKNWGEGWGLVPSDRALVFVDNHDNQRGHGAGGSSILTFWDARMYK
                     MAVGFMLAHPYGFTRVMSSYRWNRNFQNGKDQNDWIGPPNNNGVTKEVTINADTTCGN
                     DWVCEHRWRQIRNMVAFRNVVNGQPFSNWWDNNSNQVAFSRGNRGFIVFNNDDWALSA
                     TLQTGLPAGTYCDVISGDKVDGNCTGLRVNVGSDGKAHFSISNSAEDPFIAIHADSKL
                     "
     exon            324..470
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            471..659
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            660..890
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1024
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1147
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1247
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1366
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1492
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..3723
                     /gene="Amy2a2"
                     /gene_synonym="Amy2; Amy2a; mAmy2-5; PA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccttcagc tgtgcacatc attgctacta atctctttcg aatgatagac tgtaccttaa
       61 atatttactc atgagcattt actttggaaa atgtactttt tgtagaaata taaataggcg
      121 ctagagagaa agaacactga caacttcaaa gcaaaatgaa gttcgttctg ctgctttccc
      181 tcattgggtt ctgctgggct caatatgacc cacatacttc agatgggagg actgctattg
      241 tccacctgtt cgagtggcgc tgggttgata ttgccaagga atgtgagcga tacttagctc
      301 ctaagggatt tggaggggtg caggtctctc cacccaatga aaacgttgta gttcataacc
      361 catcaagacc ttggtgggaa agataccaac caatcagcta taaaatctgc acaaggtctg
      421 gaaatgaaga tgaattcaga gacatggtga caaggtgcaa caatgttggt gtccgtattt
      481 atgtggatgc tgtcattaac cacatgtgtg gcgcaggcaa tcctgcagga acaagcagta
      541 cctgtggaag ttacctcaat ccaaataaca gggaattccc agcagttcca tactctgctt
      601 gggactttaa cgataataaa tgtaatggag aaattgataa ctacaatgat gcttatcagg
      661 tcagaaattg tcgtctgact ggccttctgg atcttgcact tgagaaagat tatgttcgta
      721 ccaaggtggc tgactatatg aaccatctca ttgacattgg agtagcaggg ttcagacttg
      781 atgctgctaa gcacatgtgg cctggagaca taaaggcagt tttggacaaa ctgcataatc
      841 tcaatacaaa atggttctcc caaggaagca gacctttcat tttccaagag gtcattgatc
      901 tgggtggtga ggcaattaaa ggtagtgagt actttggaaa tggccgtgtg acagaattca
      961 agtatggtgc aaaacttggc acagttatcc gcaagtggaa tggcgagaag atgtcctatt
     1021 taaagaactg gggagaaggt tggggtttgg tgccttctga cagagccctt gtgtttgtgg
     1081 acaaccatga taatcagcga ggacatggtg ctggaggatc atccatcctg acattctggg
     1141 atgctagaat gtataaaatg gctgtcggat ttatgttggc tcatccttat ggattcacaa
     1201 gagtaatgtc aagttaccgt tggaatagaa atttccagaa tggaaaagat cagaatgact
     1261 ggattggacc acccaataac aatggagtaa caaaagaagt gaccattaat gcagacacta
     1321 cttgtggcaa tgactgggtc tgtgaacaca gatggcgtca aatcaggaac atggttgcct
     1381 tcaggaatgt ggtcaatggt cagccttttt caaactggtg ggataataac agcaaccaag
     1441 tagcttttag cagaggaaac agaggattca ttgtctttaa caatgatgac tgggctttgt
     1501 cagccacttt acagactggt cttcctgctg gcacatactg tgatgtcatc tctggagata
     1561 aggtcgatgg caattgcact ggacttagag tgaatgttgg cagtgatggc aaagctcact
     1621 tttccattag taactctgct gaggacccat ttattgcaat ccatgctgac tcaaaattgt
     1681 aagaatctat attaaagaga tttggattaa gcatcaattg catgtgtttc tttttcatat
     1741 gctctgtact atatttttat ttctattttg tttctttatt tttatgtttc catgtgtgct
     1801 ttgtcttctg agccctggag tgtatgtagg atgtttgaac aaccctgtgc tgtggcataa
     1861 cctctctaca ttttcccatg agctgtgctg atcaaactaa atccatgagg cttccctgga
     1921 actcactttt atctgctatt ctatgttgtt atctcatatg ccctttaatt cttgcagttt
     1981 atttccttgt agtaaaaacc atagacaact gtcttaatta gggtttctat tcctgcacaa
     2041 acatcatgac caagaagcaa gttgggaagg aaagggttta ttcagcttaa acttctatac
     2101 tgctgttcat caccaaggaa gtcaggactg gaactcaagc aggtcaggaa gcaggagctg
     2161 atgcaaggcc atggagtgat gttctttact ggcttgtctc ctctggcttg ctcagcctgt
     2221 tctcttatag aaccaagact atcagctcag agatggcacc acccacaaag gaacctccct
     2281 gcttgatcac taattgagaa aatgcattgc agctggatct catggaggca tttccccaat
     2341 tgaatctctt ttctctgaga taactccagc ctgtgtcaag ttgacacaaa actagccagt
     2401 acaacaataa acttgaatag gcaaatatct taaaactcac ataaaatcat ctgataacaa
     2461 catcctaaat atcctaagca ttagcagaat gtctaaatgt ttttttctaa taaattctca
     2521 aatatcttaa tagtgttctg gcaaatattt tgctttacta ttactataaa ttctttcatg
     2581 tagccgtttt aaagtatgaa aatttatttt caataaattt cattgacaat ctaattactc
     2641 attaaacatg cttttggcta cttggaaaat ccatcattga ataatttctt ctcatgactg
     2701 ttttcttcaa gttcctttca taattaattt ttccaggaaa gaagtttcct cattccacaa
     2761 tacccacctg tttctttttt ggtgttctgt tatgcatggc ctgtggttct tgtgatcggg
     2821 gagacccttg ttcagtagaa tgtctctgct ggcgatttgg cggcttgtgt gaccgctgat
     2881 gtttagggta ctggggtttt aggaactggc ataaccttgg attctggata agtcattgtc
     2941 tctggtagag caaagagctt ctgccagagt tgtggtatgg gacatggaga tgagtgaagg
     3001 ggccactgtt ggggaaagtt ccacaggctc tgaggaaatg ttggtggtct gcctcagggc
     3061 ctgacctgat agagcagggt gattctgctg gagctatggg tcaagatatg gagacctgga
     3121 aggcatgcac ttgtacctgc tgtgctatgt tgctggctca tctgtacttt gatttttaaa
     3181 gtttatttat tttttaccaa tagccttaaa caatgaactt gaataggtag acatgatgaa
     3241 ttgcacatgt aatcattaga taacttcatc ccaaatttac tatgcattag gagaaaatct
     3301 aaattttttt tcgaagaaaa taatcagaac tttggatggc ttcccaagaa atatcttttt
     3361 accattaata tgatttcctt catgttcccc tatatatttt atgaaaaagt gtttcaatat
     3421 aaattcactc acttattaaa catgctttgg ttactttaaa tctcatcatt gctcaatttc
     3481 ctctggtggc cattttttaa aaaaaattgt cttataaata gttatttcaa gaaaaaaata
     3541 tcttttttta attccacaat actaacaata ctgacagcac atattgtaac ctatcttgtt
     3601 actcagttaa tggcattctt tgtttggtgt acagaagcat tttagtgtca tgaattcctg
     3661 ttcttattgt atgagaaatt gcaatcacat tcagtaaagc cttccttttg caaatgagtt
     3721 taa
//
