LOCUS       NM_007446               1797 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus amylase 1, salivary (Amy1), transcript variant 1,
            mRNA.
ACCESSION   NM_007446
VERSION     NM_007446.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Smolik,O., Lebron-Mora,L.,
            Abaffy,P., Benesova,S., Zucha,D., Valihrach,L., Berkova,Z.,
            Saudek,F. and Pavlinkova,G.
  TITLE     NEUROD1 reinforces endocrine cell fate acquisition in pancreatic
            development
  JOURNAL   Nat Commun 14 (1), 5554 (2023)
   PUBMED   37689751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Cyge,B., Voronina,V., Hoque,M., Kim,E.N., Hall,J.,
            Bailey-Lundberg,J.M., Pazour,G.J., Crawford,H.C., Moon,R.T.,
            Li,F.Q. and Takemaru,K.I.
  TITLE     Loss of the ciliary protein Chibby1 in mice leads to exocrine
            pancreatic degeneration and pancreatitis
  JOURNAL   Sci Rep 11 (1), 17220 (2021)
   PUBMED   34446743
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1797)
  AUTHORS   Culp,D.J., Robinson,B. and Cash,M.N.
  TITLE     Murine Salivary Amylase Protects Against Streptococcus
            mutans-Induced Caries
  JOURNAL   Front Physiol 12, 699104 (2021)
   PUBMED   34276419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1797)
  AUTHORS   Usher,C.L., Handsaker,R.E., Esko,T., Tuke,M.A., Weedon,M.N.,
            Hastie,A.R., Cao,H., Moon,J.E., Kashin,S., Fuchsberger,C.,
            Metspalu,A., Pato,C.N., Pato,M.T., McCarthy,M.I., Boehnke,M.,
            Altshuler,D.M., Frayling,T.M., Hirschhorn,J.N. and McCarroll,S.A.
  TITLE     Structural forms of the human amylase locus and their relationships
            to SNPs, haplotypes and obesity
  JOURNAL   Nat Genet 47 (8), 921-925 (2015)
   PUBMED   26098870
  REMARK    GeneRIF: Data indicate that the amylase 1 (AMY1) copy number in an
            individual's genome is generally even and partially correlates with
            nearby single nucleotide polymorphism (SNPs), which do not
            associate with body mass index (BMI).
REFERENCE   5  (bases 1 to 1797)
  AUTHORS   Viljakainen,H., Andersson-Assarsson,J.C., Armenio,M., Pekkinen,M.,
            Pettersson,M., Valta,H., Lipsanen-Nyman,M., Makitie,O. and
            Lindstrand,A.
  TITLE     Low Copy Number of the AMY1 Locus Is Associated with Early-Onset
            Female Obesity in Finland
  JOURNAL   PLoS One 10 (7), e0131883 (2015)
   PUBMED   26132294
  REMARK    GeneRIF: our findings suggest that AMY1 copy number differences
            play a role in childhood-onset obesity but the effect differs
            between males and females.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1797)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   7  (bases 1 to 1797)
  AUTHORS   Hjorth,J.P.
  TITLE     Genetic variation in mouse salivary amylase rate of synthesis
  JOURNAL   Biochem Genet 17 (7-8), 665-682 (1979)
   PUBMED   94264
REFERENCE   8  (bases 1 to 1797)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   9  (bases 1 to 1797)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of hydroxyacid oxidase isozymes in the mouse: localisation
            of Hao-2 on linkage group XVI
  JOURNAL   Heredity (Edinb) 41 (3), 403-406 (1978)
   PUBMED   284003
REFERENCE   10 (bases 1 to 1797)
  AUTHORS   Taylor,B.A.
  TITLE     Linkage of the cadmium resistance locus to loci on mouse chromosome
            12
  JOURNAL   J Hered 67 (6), 389-390 (1976)
   PUBMED   1021597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            V00719.1, V00717.1, CK791844.1, J00356.1, BB462169.1 and
            AA616210.1.
            
            On Nov 16, 2007 this sequence version replaced NM_007446.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V00719.1, AK029642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               V00719.1           1-169
            170-288             V00717.1           59-177
            289-752             CK791844.1         222-685
            753-889             V00719.1           753-889
            890-1524            J00356.1           734-1368
            1525-1602           BB462169.1         65-142
            1603-1797           AA616210.1         388-582
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 49.35 cM"
     gene            1..1797
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /note="amylase 1, salivary"
                     /db_xref="GeneID:11722"
                     /db_xref="MGI:MGI:88019"
     exon            1..159
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            160..372
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1740
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /EC_number="3.2.1.1"
                     /note="alpha-amylase 1; 1,4-alpha-D-glucan
                     glucanohydrolase 1; salivary and hepatic alpha-amylase;
                     alpha-amylase amy1a"
                     /codon_start=1
                     /product="alpha-amylase 1 precursor"
                     /protein_id="NP_031472.2"
                     /db_xref="CCDS:CCDS17776.1"
                     /db_xref="GeneID:11722"
                     /db_xref="MGI:MGI:88019"
                     /translation="MKFFLLLSLIGFCWAQYDPHTQYGRTAIVHLFEWRWVDIAKECE
                     RYLAPNGFAGVQVSPPNENIVVHSPSRPWWERYQPISYKICSRSGNEDEFRDMVNRCN
                     NVGVRIYVDAVINHMCGVGAQAGQSSTCGSYFNPNNRDFPGVPYSGFDFNDGKCRTAS
                     GGIENYQDAAQVRDCRLSGLLDLALEKDYVRTKVADYMNHLIDIGVAGFRLDASKHMW
                     PGDIKAILDKLHNLNTKWFSQGSRPFIFQEVIDLGGEAVSSNEYFGNGRVTEFKYGAK
                     LGKVMRKWDGEKMSYLKNWGEGWGLMPSDRALVFVDNHDNQRGHGAGGASILTFWDAR
                     LYKMAVGFMLAHPYGFTRVMSSYYWPRNFQNGKDVNDWVGPPNNNGKTKEVSINPDST
                     CGNDWICEHRWRQIRNMVAFRNVVNGQPFANWWDNDSNQVAFGRGNKGFIVFNNDDWA
                     LSETLQTGLPAGTYCDVISGDKVDGNCTGIKVYVGNDGKAHFSISNSAEDPFIAIHAE
                     SKI"
     exon            373..519
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..717
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            718..948
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1082
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1205
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1305
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1424
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1550
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1772
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1772
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccatcatagg tcactgtgga gctcagatca cagtgctgac agaatccata tttggagaat
       61 tacataaggt ttgaaagaga ggatagtgaa aggatacgaa ttcctaaaaa cgtttaatct
      121 ggccttttgt ttgaacgaaa gagaaattga aaccaaatga aataaattac ttgttagaaa
      181 gaatactgcc aacagcatag caaaatgaaa ttcttcctgc tgctttccct cattggattc
      241 tgctgggccc aatatgaccc acatactcaa tatggacgaa ctgctattgt ccacctgttt
      301 gagtggcgct gggttgatat tgctaaggaa tgtgagagat acttagctcc taatggattt
      361 gcaggtgtgc aggtctctcc acccaatgaa aacatcgtag tccacagccc ttcaagacca
      421 tggtgggaaa gatatcaacc aattagctac aaaatatgtt ccaggtctgg aaatgaagat
      481 gaattcaggg acatggtgaa caggtgcaac aatgttggtg tccgtattta tgtggatgct
      541 gtcattaacc acatgtgtgg agtgggggct caagctggac aaagcagtac atgtggaagt
      601 tatttcaacc caaataacag ggactttcct ggagttccct attctggttt tgactttaat
      661 gatggaaaat gtagaactgc aagtggaggt atcgagaact accaagatgc tgctcaggtc
      721 agagattgtc gtctgtctgg ccttctggat cttgcacttg agaaagatta tgttcgaacc
      781 aaggtggctg actatatgaa ccatctcatt gacattggcg tagcagggtt cagacttgat
      841 gcttctaagc acatgtggcc tggagacata aaggcaattt tggacaaact gcataatctc
      901 aatacaaaat ggttctccca aggaagcaga cctttcattt tccaagaggt gattgatctg
      961 ggtggtgagg cagtgtcaag taatgagtat tttggaaatg gccgtgtgac agaattcaaa
     1021 tatggagcaa aattgggcaa agttatgcgc aagtgggatg gagaaaagat gtcctactta
     1081 aagaactggg gagaaggttg gggtttgatg ccttctgaca gagcccttgt gtttgtggac
     1141 aaccatgaca atcagcgagg acatggtgct gggggagcat ccatcttgac attctgggat
     1201 gctagactct ataaaatggc tgttggcttt atgttggctc atccttatgg tttcacacgg
     1261 gtgatgtcaa gttactattg gccaagaaat ttccagaatg gaaaagatgt caatgactgg
     1321 gttggaccac caaataacaa tggaaaaacc aaagaagtga gcattaaccc agacagcact
     1381 tgtggcaatg actggatctg tgaacatcga tggcgtcaaa taaggaacat ggttgccttc
     1441 agaaatgtcg tcaatggtca gccttttgca aactggtggg ataatgacag caaccaggta
     1501 gcttttggca gaggaaacaa aggattcatt gtctttaaca atgatgactg ggctttgtca
     1561 gaaactttac agactggtct tcctgctggc acatactgtg atgtcatttc tggagataaa
     1621 gtcgatggca attgcactgg aataaaagtc tatgttggca atgatggcaa agctcacttt
     1681 tctattagta actctgccga agacccattt attgcaatcc atgcagagtc aaaaatataa
     1741 aatttaaaat aaacacatat tgagagcatc aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
