LOCUS       NP_031472                511 aa            linear   ROD 06-NOV-2024
DEFINITION  alpha-amylase 1 precursor [Mus musculus].
ACCESSION   NP_031472
VERSION     NP_031472.2
DBSOURCE    REFSEQ: accession NM_007446.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 511)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Smolik,O., Lebron-Mora,L.,
            Abaffy,P., Benesova,S., Zucha,D., Valihrach,L., Berkova,Z.,
            Saudek,F. and Pavlinkova,G.
  TITLE     NEUROD1 reinforces endocrine cell fate acquisition in pancreatic
            development
  JOURNAL   Nat Commun 14 (1), 5554 (2023)
   PUBMED   37689751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 511)
  AUTHORS   Cyge,B., Voronina,V., Hoque,M., Kim,E.N., Hall,J.,
            Bailey-Lundberg,J.M., Pazour,G.J., Crawford,H.C., Moon,R.T.,
            Li,F.Q. and Takemaru,K.I.
  TITLE     Loss of the ciliary protein Chibby1 in mice leads to exocrine
            pancreatic degeneration and pancreatitis
  JOURNAL   Sci Rep 11 (1), 17220 (2021)
   PUBMED   34446743
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 511)
  AUTHORS   Culp,D.J., Robinson,B. and Cash,M.N.
  TITLE     Murine Salivary Amylase Protects Against Streptococcus
            mutans-Induced Caries
  JOURNAL   Front Physiol 12, 699104 (2021)
   PUBMED   34276419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 511)
  AUTHORS   Usher,C.L., Handsaker,R.E., Esko,T., Tuke,M.A., Weedon,M.N.,
            Hastie,A.R., Cao,H., Moon,J.E., Kashin,S., Fuchsberger,C.,
            Metspalu,A., Pato,C.N., Pato,M.T., McCarthy,M.I., Boehnke,M.,
            Altshuler,D.M., Frayling,T.M., Hirschhorn,J.N. and McCarroll,S.A.
  TITLE     Structural forms of the human amylase locus and their relationships
            to SNPs, haplotypes and obesity
  JOURNAL   Nat Genet 47 (8), 921-925 (2015)
   PUBMED   26098870
  REMARK    GeneRIF: Data indicate that the amylase 1 (AMY1) copy number in an
            individual's genome is generally even and partially correlates with
            nearby single nucleotide polymorphism (SNPs), which do not
            associate with body mass index (BMI).
REFERENCE   5  (residues 1 to 511)
  AUTHORS   Viljakainen,H., Andersson-Assarsson,J.C., Armenio,M., Pekkinen,M.,
            Pettersson,M., Valta,H., Lipsanen-Nyman,M., Makitie,O. and
            Lindstrand,A.
  TITLE     Low Copy Number of the AMY1 Locus Is Associated with Early-Onset
            Female Obesity in Finland
  JOURNAL   PLoS One 10 (7), e0131883 (2015)
   PUBMED   26132294
  REMARK    GeneRIF: our findings suggest that AMY1 copy number differences
            play a role in childhood-onset obesity but the effect differs
            between males and females.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 511)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   7  (residues 1 to 511)
  AUTHORS   Hjorth,J.P.
  TITLE     Genetic variation in mouse salivary amylase rate of synthesis
  JOURNAL   Biochem Genet 17 (7-8), 665-682 (1979)
   PUBMED   94264
REFERENCE   8  (residues 1 to 511)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   9  (residues 1 to 511)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of hydroxyacid oxidase isozymes in the mouse: localisation
            of Hao-2 on linkage group XVI
  JOURNAL   Heredity (Edinb) 41 (3), 403-406 (1978)
   PUBMED   284003
REFERENCE   10 (residues 1 to 511)
  AUTHORS   Taylor,B.A.
  TITLE     Linkage of the cadmium resistance locus to loci on mouse chromosome
            12
  JOURNAL   J Hered 67 (6), 389-390 (1976)
   PUBMED   1021597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            V00719.1, V00717.1, CK791844.1, J00356.1, BB462169.1 and
            AA616210.1.
            
            On Nov 16, 2007 this sequence version replaced NP_031472.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V00719.1, AK029642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 49.35 cM"
     Protein         1..511
                     /product="alpha-amylase 1 precursor"
                     /EC_number="3.2.1.1"
                     /note="alpha-amylase 1; 1,4-alpha-D-glucan
                     glucanohydrolase 1; salivary and hepatic alpha-amylase;
                     alpha-amylase amy1a"
                     /calculated_mol_wt=55873
     sig_peptide     1..15
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1789
     mat_peptide     16..511
                     /product="alpha-amylase 1"
                     /calculated_mol_wt=55873
     Site            16
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000269|Ref.8; propagated from
                     UniProtKB/Swiss-Prot (P00687.2)"
     Region          25..416
                     /region_name="AmyAc_bac_euk_AmyA"
                     /note="Alpha amylase catalytic domain found in bacterial
                     and eukaryotic Alpha amylases (also called
                     1,4-alpha-D-glucan-4-glucanohydrolase); cd11317"
                     /db_xref="CDD:200456"
     Site            order(73..74,77..78,113,116,177..180,210,212..213,
                     215..216,248,250,255,314..315,320)
                     /site_type="active"
                     /db_xref="CDD:200456"
     Site            order(115,182)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:200456"
     Site            order(212,248,315)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:200456"
     Site            315
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P04746; propagated from
                     UniProtKB/Swiss-Prot (P00687.2)"
     Region          422..510
                     /region_name="Aamy_C"
                     /note="Aamy_C domain; smart00632"
                     /db_xref="CDD:214749"
     CDS             1..511
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /coded_by="NM_007446.2:205..1740"
                     /db_xref="CCDS:CCDS17776.1"
                     /db_xref="GeneID:11722"
                     /db_xref="MGI:MGI:88019"
ORIGIN      
        1 mkfflllsli gfcwaqydph tqygrtaivh lfewrwvdia kecerylapn gfagvqvspp
       61 nenivvhsps rpwweryqpi sykicsrsgn edefrdmvnr cnnvgvriyv davinhmcgv
      121 gaqagqsstc gsyfnpnnrd fpgvpysgfd fndgkcrtas ggienyqdaa qvrdcrlsgl
      181 ldlalekdyv rtkvadymnh lidigvagfr ldaskhmwpg dikaildklh nlntkwfsqg
      241 srpfifqevi dlggeavssn eyfgngrvte fkygaklgkv mrkwdgekms ylknwgegwg
      301 lmpsdralvf vdnhdnqrgh gaggasiltf wdarlykmav gfmlahpygf trvmssyywp
      361 rnfqngkdvn dwvgppnnng ktkevsinpd stcgndwice hrwrqirnmv afrnvvngqp
      421 fanwwdndsn qvafgrgnkg fivfnnddwa lsetlqtglp agtycdvisg dkvdgnctgi
      481 kvyvgndgka hfsisnsaed pfiaihaesk i
//
