LOCUS       NM_001110505            1688 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus amylase 1, salivary (Amy1), transcript variant 2,
            mRNA.
ACCESSION   NM_001110505
VERSION     NM_001110505.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1688)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Smolik,O., Lebron-Mora,L.,
            Abaffy,P., Benesova,S., Zucha,D., Valihrach,L., Berkova,Z.,
            Saudek,F. and Pavlinkova,G.
  TITLE     NEUROD1 reinforces endocrine cell fate acquisition in pancreatic
            development
  JOURNAL   Nat Commun 14 (1), 5554 (2023)
   PUBMED   37689751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1688)
  AUTHORS   Cyge,B., Voronina,V., Hoque,M., Kim,E.N., Hall,J.,
            Bailey-Lundberg,J.M., Pazour,G.J., Crawford,H.C., Moon,R.T.,
            Li,F.Q. and Takemaru,K.I.
  TITLE     Loss of the ciliary protein Chibby1 in mice leads to exocrine
            pancreatic degeneration and pancreatitis
  JOURNAL   Sci Rep 11 (1), 17220 (2021)
   PUBMED   34446743
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1688)
  AUTHORS   Culp,D.J., Robinson,B. and Cash,M.N.
  TITLE     Murine Salivary Amylase Protects Against Streptococcus
            mutans-Induced Caries
  JOURNAL   Front Physiol 12, 699104 (2021)
   PUBMED   34276419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1688)
  AUTHORS   Usher,C.L., Handsaker,R.E., Esko,T., Tuke,M.A., Weedon,M.N.,
            Hastie,A.R., Cao,H., Moon,J.E., Kashin,S., Fuchsberger,C.,
            Metspalu,A., Pato,C.N., Pato,M.T., McCarthy,M.I., Boehnke,M.,
            Altshuler,D.M., Frayling,T.M., Hirschhorn,J.N. and McCarroll,S.A.
  TITLE     Structural forms of the human amylase locus and their relationships
            to SNPs, haplotypes and obesity
  JOURNAL   Nat Genet 47 (8), 921-925 (2015)
   PUBMED   26098870
  REMARK    GeneRIF: Data indicate that the amylase 1 (AMY1) copy number in an
            individual's genome is generally even and partially correlates with
            nearby single nucleotide polymorphism (SNPs), which do not
            associate with body mass index (BMI).
REFERENCE   5  (bases 1 to 1688)
  AUTHORS   Viljakainen,H., Andersson-Assarsson,J.C., Armenio,M., Pekkinen,M.,
            Pettersson,M., Valta,H., Lipsanen-Nyman,M., Makitie,O. and
            Lindstrand,A.
  TITLE     Low Copy Number of the AMY1 Locus Is Associated with Early-Onset
            Female Obesity in Finland
  JOURNAL   PLoS One 10 (7), e0131883 (2015)
   PUBMED   26132294
  REMARK    GeneRIF: our findings suggest that AMY1 copy number differences
            play a role in childhood-onset obesity but the effect differs
            between males and females.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1688)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   7  (bases 1 to 1688)
  AUTHORS   Hjorth,J.P.
  TITLE     Genetic variation in mouse salivary amylase rate of synthesis
  JOURNAL   Biochem Genet 17 (7-8), 665-682 (1979)
   PUBMED   94264
REFERENCE   8  (bases 1 to 1688)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   9  (bases 1 to 1688)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of hydroxyacid oxidase isozymes in the mouse: localisation
            of Hao-2 on linkage group XVI
  JOURNAL   Heredity (Edinb) 41 (3), 403-406 (1978)
   PUBMED   284003
REFERENCE   10 (bases 1 to 1688)
  AUTHORS   Taylor,B.A.
  TITLE     Linkage of the cadmium resistance locus to loci on mouse chromosome
            12
  JOURNAL   J Hered 67 (6), 389-390 (1976)
   PUBMED   1021597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            V00720.1, V00717.1, CK791844.1, J00356.1, BB462169.1 and
            AA616210.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009121.1, V00717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                V00720.1           1-60
            61-179              V00717.1           59-177
            180-643             CK791844.1         222-685
            644-780             V00720.1           644-780
            781-1415            J00356.1           734-1368
            1416-1493           BB462169.1         65-142
            1494-1688           AA616210.1         388-582
FEATURES             Location/Qualifiers
     source          1..1688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 49.35 cM"
     gene            1..1688
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /note="amylase 1, salivary"
                     /db_xref="GeneID:11722"
                     /db_xref="MGI:MGI:88019"
     exon            1..50
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            51..263
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1631
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /EC_number="3.2.1.1"
                     /note="alpha-amylase 1; 1,4-alpha-D-glucan
                     glucanohydrolase 1; salivary and hepatic alpha-amylase;
                     alpha-amylase amy1a"
                     /codon_start=1
                     /product="alpha-amylase 1 precursor"
                     /protein_id="NP_001103975.1"
                     /db_xref="CCDS:CCDS17776.1"
                     /db_xref="GeneID:11722"
                     /db_xref="MGI:MGI:88019"
                     /translation="MKFFLLLSLIGFCWAQYDPHTQYGRTAIVHLFEWRWVDIAKECE
                     RYLAPNGFAGVQVSPPNENIVVHSPSRPWWERYQPISYKICSRSGNEDEFRDMVNRCN
                     NVGVRIYVDAVINHMCGVGAQAGQSSTCGSYFNPNNRDFPGVPYSGFDFNDGKCRTAS
                     GGIENYQDAAQVRDCRLSGLLDLALEKDYVRTKVADYMNHLIDIGVAGFRLDASKHMW
                     PGDIKAILDKLHNLNTKWFSQGSRPFIFQEVIDLGGEAVSSNEYFGNGRVTEFKYGAK
                     LGKVMRKWDGEKMSYLKNWGEGWGLMPSDRALVFVDNHDNQRGHGAGGASILTFWDAR
                     LYKMAVGFMLAHPYGFTRVMSSYYWPRNFQNGKDVNDWVGPPNNNGKTKEVSINPDST
                     CGNDWICEHRWRQIRNMVAFRNVVNGQPFANWWDNDSNQVAFGRGNKGFIVFNNDDWA
                     LSETLQTGLPAGTYCDVISGDKVDGNCTGIKVYVGNDGKAHFSISNSAEDPFIAIHAE
                     SKI"
     exon            264..410
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            411..608
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..839
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            840..973
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1096
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1196
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1315
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1441
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1663
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1639..1644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1663
                     /gene="Amy1"
                     /gene_synonym="Amy-1; Amy1a; C030014B17Rik"
                     /note="major polyA site"
ORIGIN      
        1 attctcaacg taaatcagaa gattccaact gcagtggaag gcagcacatg aaataaatta
       61 cttgttagaa agaatactgc caacagcata gcaaaatgaa attcttcctg ctgctttccc
      121 tcattggatt ctgctgggcc caatatgacc cacatactca atatggacga actgctattg
      181 tccacctgtt tgagtggcgc tgggttgata ttgctaagga atgtgagaga tacttagctc
      241 ctaatggatt tgcaggtgtg caggtctctc cacccaatga aaacatcgta gtccacagcc
      301 cttcaagacc atggtgggaa agatatcaac caattagcta caaaatatgt tccaggtctg
      361 gaaatgaaga tgaattcagg gacatggtga acaggtgcaa caatgttggt gtccgtattt
      421 atgtggatgc tgtcattaac cacatgtgtg gagtgggggc tcaagctgga caaagcagta
      481 catgtggaag ttatttcaac ccaaataaca gggactttcc tggagttccc tattctggtt
      541 ttgactttaa tgatggaaaa tgtagaactg caagtggagg tatcgagaac taccaagatg
      601 ctgctcaggt cagagattgt cgtctgtctg gccttctgga tcttgcactt gagaaagatt
      661 atgttcgaac caaggtggct gactatatga accatctcat tgacattggc gtagcagggt
      721 tcagacttga tgcttctaag cacatgtggc ctggagacat aaaggcaatt ttggacaaac
      781 tgcataatct caatacaaaa tggttctccc aaggaagcag acctttcatt ttccaagagg
      841 tgattgatct gggtggtgag gcagtgtcaa gtaatgagta ttttggaaat ggccgtgtga
      901 cagaattcaa atatggagca aaattgggca aagttatgcg caagtgggat ggagaaaaga
      961 tgtcctactt aaagaactgg ggagaaggtt ggggtttgat gccttctgac agagcccttg
     1021 tgtttgtgga caaccatgac aatcagcgag gacatggtgc tgggggagca tccatcttga
     1081 cattctggga tgctagactc tataaaatgg ctgttggctt tatgttggct catccttatg
     1141 gtttcacacg ggtgatgtca agttactatt ggccaagaaa tttccagaat ggaaaagatg
     1201 tcaatgactg ggttggacca ccaaataaca atggaaaaac caaagaagtg agcattaacc
     1261 cagacagcac ttgtggcaat gactggatct gtgaacatcg atggcgtcaa ataaggaaca
     1321 tggttgcctt cagaaatgtc gtcaatggtc agccttttgc aaactggtgg gataatgaca
     1381 gcaaccaggt agcttttggc agaggaaaca aaggattcat tgtctttaac aatgatgact
     1441 gggctttgtc agaaacttta cagactggtc ttcctgctgg cacatactgt gatgtcattt
     1501 ctggagataa agtcgatggc aattgcactg gaataaaagt ctatgttggc aatgatggca
     1561 aagctcactt ttctattagt aactctgccg aagacccatt tattgcaatc catgcagagt
     1621 caaaaatata aaatttaaaa taaacacata ttgagagcat caaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaa
//
