LOCUS       NM_027793               1022 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus amelotin (Amtn), mRNA.
ACCESSION   NM_027793 XM_284166 XM_904684
VERSION     NM_027793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1022)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1022)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   3  (bases 1 to 1022)
  AUTHORS   Saito,K., Michon,F., Yamada,A., Inuzuka,H., Yamaguchi,S.,
            Fukumoto,E., Yoshizaki,K., Nakamura,T., Arakaki,M., Chiba,Y.,
            Ishikawa,M., Okano,H., Thesleff,I. and Fukumoto,S.
  TITLE     Sox21 Regulates Anapc10 Expression and Determines the Fate of
            Ectodermal Organ
  JOURNAL   iScience 23 (7), 101329 (2020)
   PUBMED   32674056
REFERENCE   4  (bases 1 to 1022)
  AUTHORS   Noda,K., Yamazaki,M., Iwai,Y., Matsui,S., Kato,A., Takai,H.,
            Nakayama,Y. and Ogata,Y.
  TITLE     IL-1beta and TNF-alpha regulate mouse amelotin gene transcription
            in gingival epithelial cells
  JOURNAL   J Oral Sci 60 (3), 388-398 (2018)
   PUBMED   30158339
  REMARK    GeneRIF: IL-1beta and TNF-alpha increase AMTN gene transcription
            via the C/EBP1, C/EBP2 and YY1 elements in the mouse AMTN gene
            promoter.
REFERENCE   5  (bases 1 to 1022)
  AUTHORS   Tian,Z., Lv,X., Zhang,M., Wang,X., Chen,Y., Tang,P., Xu,P.,
            Zhang,L., Wu,B. and Zhang,L.
  TITLE     Deletion of epithelial cell-specific Cdc42 leads to enamel
            hypermaturation in a conditional knockout mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (8), 2623-2632 (2018)
   PUBMED   29684584
REFERENCE   6  (bases 1 to 1022)
  AUTHORS   Jheon,A.H., Mostowfi,P., Snead,M.L., Ihrie,R.A., Sone,E.,
            Pramparo,T., Attardi,L.D. and Klein,O.D.
  TITLE     PERP regulates enamel formation via effects on cell-cell adhesion
            and gene expression
  JOURNAL   J Cell Sci 124 (Pt 5), 745-754 (2011)
   PUBMED   21285247
REFERENCE   7  (bases 1 to 1022)
  AUTHORS   Sun,Y., Zhang,J.J., Han,T.T., Li,D.L., Cao,X.M., Li,W.X. and
            Gao,Y.G.
  TITLE     [Preparation and characterization of anti-Amelotin polyclonal
            antibody]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 (4), 328-331 (2009)
   PUBMED   19351503
  REMARK    GeneRIF: Data show that the anti-Amelotin antibody from the rabbit
            with high titer and specificity had been prepared with the purified
            recombinant Amelotin as immunogen, which is helpful for further
            research into the detection and function of Amelotin.
REFERENCE   8  (bases 1 to 1022)
  AUTHORS   Moffatt,P., Smith,C.E., St-Arnaud,R., Simmons,D., Wright,J.T. and
            Nanci,A.
  TITLE     Cloning of rat amelotin and localization of the protein to the
            basal lamina of maturation stage ameloblasts and junctional
            epithelium
  JOURNAL   Biochem J 399 (1), 37-46 (2006)
   PUBMED   16787391
REFERENCE   9  (bases 1 to 1022)
  AUTHORS   Iwasaki,K., Bajenova,E., Somogyi-Ganss,E., Miller,M., Nguyen,V.,
            Nourkeyhani,H., Gao,Y., Wendel,M. and Ganss,B.
  TITLE     Amelotin--a Novel Secreted, Ameloblast-specific Protein
  JOURNAL   J Dent Res 84 (12), 1127-1132 (2005)
   PUBMED   16304441
REFERENCE   10 (bases 1 to 1022)
  AUTHORS   Letterio,J.J.
  TITLE     Disruption of the TGF-beta pathway and modeling human cancer in
            mice
  JOURNAL   Mutat Res 576 (1-2), 120-131 (2005)
   PUBMED   15935406
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017352.1, AC121585.3 and AV294366.1.
            
            On or before Jul 23, 2009 this sequence version replaced
            XM_904684.2, XM_284166.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017352.1, BY717166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK017352.1         1-17
            18-18               AC121585.3         38467-38467
            19-869              AK017352.1         19-869
            870-870             AV294366.1         46-46
            871-1022            AK017352.1         871-1022
FEATURES             Location/Qualifiers
     source          1..1022
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1022
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /note="amelotin"
                     /db_xref="GeneID:71421"
                     /db_xref="MGI:MGI:1918671"
     exon            1..76
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            77..145
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..733
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /codon_start=1
                     /product="amelotin precursor"
                     /protein_id="NP_082069.1"
                     /db_xref="CCDS:CCDS51538.1"
                     /db_xref="GeneID:71421"
                     /db_xref="MGI:MGI:1918671"
                     /translation="MKTMILLLCLLGSAQSLPKQLNPASGVPATKPTPGQVTPLPQQQ
                     PNQVFPSISLIPLTQLLTLGSDLPLFNPAAGPHGAHTLPFTLGPLNGQQQLQPQMLPI
                     IVAQLGAQGALLSSEELPLASQIFTGLLIHPLFPGAIPPSGQAGTKPDVQNGVLPTRQ
                     AGAKAVNQGTTPGHVTTPGVTDDDDYEMSTPAGLRRATHTTEGTTIDPPNRTQ"
     exon            146..232
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            233..298
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            299..385
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            386..421
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..448
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            449..722
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1022
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1020
                     /gene="Amtn"
                     /gene_synonym="5430427O21Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaaagataaa ttttgcaccg agtaaagtgg agaagtcatc tggatttcga atatcatttt
       61 gcctggtagc agaaaggtag caaatcgaaa catgaagacc atgattctac tgctttgtct
      121 tctaggatca gcccagtcat taccaaagca gcttaaccct gcttcgggag ttcctgcaac
      181 aaaaccgact ccaggtcagg tgaccccact acctcaacag caaccaaatc aggtttttcc
      241 ttccataagt ctcataccat taacacagct gctcactctg gggtcagacc tgccgttgtt
      301 caaccctgct gctgggcccc acggcgcaca tactctcccg ttcaccctgg gaccactgaa
      361 tggacagcaa cagctgcaac cgcagatgtt acccattatt gtggcacaac ttggagctca
      421 gggtgctctc ctaagctcag aggaactgcc gttagcctcc caaatcttca caggcctcct
      481 tatccacccc ttgttccctg gagccattcc tccctctggt caggcaggca ctaaaccaga
      541 tgtgcagaat ggagtccttc ctacaagaca ggcaggagcg aaagctgtca accagggaac
      601 cactccgggc catgtcacaa ctcctggtgt cacagatgat gatgactatg agatgagcac
      661 ccctgcaggc ctgcgaaggg ccacacacac cacggaggga accaccatag atccaccaaa
      721 tagaactcag taagctgttt cagatctcct cagctaaacc gcatcacagt tggaggttcc
      781 atgtgagcca tccccattca tcacatgatg gaaaagacag agaccagtgg aaggtcttgg
      841 gaggtataaa gtctttaaat ttacctgaaa ttttttcttg aaatttcaag agagatattg
      901 aatgaagaga attccaagtt caaaaaaatc attaaagaaa tcaatttgtc tttgaaatac
      961 tttagtatgc cacttcagac agacctggaa aatgtgtgta ttaaaatata ttttgaaaac
     1021 tg
//
