LOCUS       NM_001289546            3247 bp    mRNA    linear   ROD 04-OCT-2023
DEFINITION  Mus musculus amphiphysin (Amph), transcript variant 2, mRNA.
ACCESSION   NM_001289546 XM_006516644
VERSION     NM_001289546.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Wu J, Moriwaki K, Asuka T, Nakai R, Kanda S, Taniguchi M, Sugiyama
            T, Yoshimura SI, Kunii M, Nagasawa T, Hosen N, Miyoshi E and Harada
            A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Cattaneo P, Hayes MGB, Baumgarten N, Hecker D, Peruzzo S, Aslan GS,
            Kunderfranco P, Larcher V, Zhang L, Contu R, Fonseca G, Spinozzi S,
            Chen J, Condorelli G, Dimmeler S, Schulz MH, Heinz S,
            Guimaraes-Camboa N and Evans SM.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J,
            Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K and Zhang Z.
  TITLE     Amphiphysin I cleavage by asparagine endopeptidase leads to tau
            hyperphosphorylation and synaptic dysfunction
  JOURNAL   Elife 10, e65301 (2021)
   PUBMED   34018922
  REMARK    GeneRIF: Amphiphysin I cleavage by asparagine endopeptidase leads
            to tau hyperphosphorylation and synaptic dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, Matlik K,
            Olfat S, Montano-Rodriguez AR, Huh SH, Costantini F, Andressoo JO
            and Kuure S.
  TITLE     Postnatal prolongation of mammalian nephrogenesis by excess fetal
            GDNF
  JOURNAL   Development 148 (10) (2021)
   PUBMED   34032268
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Prokic I, Cowling BS, Kutchukian C, Kretz C, Tasfaout H, Gache V,
            Hergueux J, Wendling O, Ferry A, Toussaint A, Gavriilidis C,
            Nattarayan V, Koch C, Laine J, Combe R, Tiret L, Jacquemond V,
            Pilot-Storck F and Laporte J.
  TITLE     Differential physiological roles for BIN1 isoforms in skeletal
            muscle development, function and regeneration
  JOURNAL   Dis Model Mech 13 (11) (2020)
   PUBMED   32994313
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Modregger J, Schmidt AA, Ritter B, Huttner WB and Plomann M.
  TITLE     Characterization of Endophilin B1b, a brain-specific
            membrane-associated lysophosphatidic acid acyl transferase with
            properties distinct from endophilin A1
  JOURNAL   J Biol Chem 278 (6), 4160-4167 (2003)
   PUBMED   12456676
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E,
            Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O and De
            Camilli P.
  TITLE     Decreased synaptic vesicle recycling efficiency and cognitive
            deficits in amphiphysin 1 knockout mice
  JOURNAL   Neuron 33 (5), 789-804 (2002)
   PUBMED   11879655
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Douglas KR and Camper SA.
  TITLE     Partial transcriptome of the developing pituitary gland
  JOURNAL   Genomics 70 (3), 335-346 (2000)
   PUBMED   11161784
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   Rattner A, Hsieh JC, Smallwood PM, Gilbert DJ, Copeland NG, Jenkins
            NA and Nathans J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Jenkins NA, Gilbert DJ, Yamamoto R, Kilimann MW and Copeland NG.
  TITLE     Amphiphysin (Amph) maps to the proximal region of mouse chromosome
            13
  JOURNAL   Genomics 28 (2), 363-365 (1995)
   PUBMED   8530056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132168.1, BC054718.1 and BE949100.1.
            
            [WARNING] On Dec 15, 2023 this sequence was replaced by
            NM_001289546.2.
            
            On Jan 23, 2014 this sequence version replaced XM_006516644.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, which results in a
            longer protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132168.1, SRR1660821.13440.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AK132168.1         2-201
            201-1156            BC054718.1         181-1136
            1157-3224           AK132168.1         1158-3225
            3225-3247           BE949100.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.89 cM"
     gene            1..3247
                     /gene="Amph"
                     /note="amphiphysin"
                     /db_xref="GeneID:218038"
                     /db_xref="MGI:MGI:103574"
     exon            1..151
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2155
                     /gene="Amph"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="amphiphysin isoform 2"
                     /protein_id="NP_001276475.1"
                     /db_xref="CCDS:CCDS79165.1"
                     /db_xref="GeneID:218038"
                     /db_xref="MGI:MGI:103574"
                     /translation="MADIKTGIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQ
                     NFKRQEAEGTRLQRELRGYLAAIKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKC
                     DVLWEDFHQKLVDGSLLTLDTYLGQFPDIKNRIAKRSRKLVDYDSARHHLEALQSSKR
                     KDESRISKAEEEFQKAQKVFEEFNVDLQEELPSLWSSRVGFYVNTFKNVSSLEAKFHK
                     EIAVLCHKLYEVMTKLGDQHADKAFSIQGAPSDSGPLRIAKTPSPPEEPSPLPSPTAS
                     PNHTLAPASPAPVRPRSPSQTRKGPPVPPLPKVTPTKELKQENIINFFEDNFVPEINV
                     TTPSQNEVLEVKKEETLLDLDFDPFKPDVAPAGSAAATHSPMSQTLPWDLWTTSTDLV
                     QPASGGSFNDFTQAQDTSLFTMQTDQNMVGGLAETEQALPTEPQAEEPPATAAAPTAG
                     LDLGLEMEEPKEEAVIPPATDTGETVETAVPTEGAPVEEAEAEKAALPAGEGGSPEGA
                     KIDGESTELAISESPQPVEPEAGAPQVIPSVVIEPASNHEGEGEHQETATGTEPREAA
                     EDVAAQGSAGEKQEVATEPTPLDSQATLPASAGAVDASLSAGDATQELPPGFLYKVET
                     LHDFEAANSDELNLQRGDVVLVVPSDSEADQDAGWLVGVKESDWLQYRDLATYKGLFP
                     ENFTRRLE"
     exon            152..232
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            233..287
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            288..382
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            383..478
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            479..586
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            587..672
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            673..748
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            749..831
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            832..970
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1099
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1216
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1240
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1264
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1297
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1354
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1477
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1684
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1945
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2047
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..3231
                     /gene="Amph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccttctct tcctgggctc ctcggtgccg ccgccggctc gctgcgcgct ctgctcttcc
       61 agctctgcgg accgcagcag ccatggccga catcaagacg ggcatcttcg ccaaaaacgt
      121 gcaaaagcgc ctcaaccgcg cgcaggaaaa ggtcctccag aagctgggga aggctgacga
      181 gacaaaagat gaacagtttg aagaatatgt ccagaacttc aaacggcagg aggcagaggg
      241 taccagactt cagcgagaac tccggggata tttagcagca atcaaaggta tgcaggaggc
      301 ctcaatgaag ctcactgaat ctctacatga agtctacgag ccagactggt atggacggga
      361 agatgtaaag atggttggtg agaagtgtga tgtgctgtgg gaagacttcc atcaaaagct
      421 agtggatggc tccttgctga cactggacac ctacctgggc cagtttcctg acataaagaa
      481 tcgcatcgct aagcgcagca ggaagcttgt ggattatgat agtgctcgcc atcacctgga
      541 ggctctgcag agttccaaac ggaaagatga gagtcggatc tctaaggcag aagaggagtt
      601 tcagaaagca cagaaagtgt ttgaagagtt caatgttgac ttacaagaag agttgccgtc
      661 attgtggtca agtcgagttg gcttttacgt caatactttc aaaaatgtct ccagccttga
      721 ggccaagttt cataaggaaa tcgcagtgct ttgccacaag ctctatgaag tgatgacgaa
      781 actcggtgat cagcatgctg acaaggcctt cagcattcaa ggagctccca gtgactcggg
      841 tcctcttcgc attgcaaaga caccatcacc tccagaggag ccttctcccc tgcccagccc
      901 cacggctagt cccaaccaca cattagcacc tgcatctcct gccccagtgc gacccagatc
      961 accttcacag acaaggaaag ggcctcctgt cccacctctg cctaaagtca ccccaacaaa
     1021 ggaactgaaa caggagaaca tcatcaattt ctttgaggac aactttgtac cagaaatcaa
     1081 tgtgacaaca ccttcccaga acgaagtctt ggaggtgaag aaggaagaga ctttgctgga
     1141 tttggacttt gaccctttca agcccgatgt ggctccggca ggttctgctg cagcgaccca
     1201 ctctcccatg tctcagacat tgccctggga cttatggacg acaagcactg atttggtaca
     1261 accagcttct gggggttcat ttaatgattt cacccaggcc caggacactt cattattcac
     1321 catgcagaca gatcagaata tggtaggtgg cttggctgaa actgagcagg ctctacctac
     1381 agagccccaa gccgaagagc ctcctgccac tgctgctgca cctactgctg ggctggacct
     1441 tgggctagag atggaggagc caaaggagga ggctgtgatc cctcccgcaa ctgatactgg
     1501 cgagactgtg gaaactgcag tgccaactga gggtgccccg gtggaggaag cagaggcaga
     1561 gaaggcagcc ctccctgctg gagaaggagg aagtccagag ggagccaaaa ttgacgggga
     1621 aagcacggag cttgcaatca gtgagagccc tcaaccagtg gagcccgaag cgggtgctcc
     1681 tcaggtcatc ccttctgttg tcattgagcc agcctccaac catgaaggag aaggagaaca
     1741 ccaagaaact gctacgggta ctgaaccgag ggaggccgct gaggatgtgg ctgcccaggg
     1801 ctcagcgggt gagaagcagg aagtggctac agagcccacg cctctggatt ctcaggcaac
     1861 tctgcctgca tctgcaggtg ctgtggatgc ctcgctgtct gcaggggatg ccactcagga
     1921 actgcctcct ggctttctct acaaggtgga aaccctgcat gatttcgagg cagcgaactc
     1981 tgatgaactt aacctacaaa ggggtgacgt ggtactcgtg gtgccttcag actcagaagc
     2041 cgaccaggat gcaggctggt tggtgggggt gaaggagtca gactggcttc agtacagaga
     2101 cctggccacg tacaaaggcc tctttccaga gaacttcacg cggcgcctgg agtagggctg
     2161 cagatgctgc aaatgggtca cgtgactggg ttcttaacca ttcacggaat gcagaggcgt
     2221 tcacttttgc tactacactc ttcatgattg acagactggt gccagatgag gcttgggaag
     2281 acggatcaat agagcatgta tgcaaaaact atacgaagag gggaaagagc aaattaagga
     2341 aagagtcctt actctgtttc ctgcgttcat agcggtctgt ttgtgctttg tctaacagtg
     2401 aacactggta cttgattctc ctcccaccaa gtctaaagta gccttctcca gaccagactt
     2461 tgacttcttt gcatcaagtg tgtggtgtcg agtggttgcc ctgcagatgt gatgagttat
     2521 cctgtagtga gacatcatct tactcccttg cccgaattgt gagctcctgc tctcttgccc
     2581 tttcaagttt actgcgttta aaactgaaca gctgcaaacg ttcttaacgg tcttctccaa
     2641 tcacctctat atacacatgt acggacacac agtcgcacaa gctagtccca tgcctgctgg
     2701 acctatgtgt atgcagatgg ctacatatac atagctgatc ccttcccttt ccactgtagc
     2761 tcttctcctc taagtgtcat tgatacacgc attgctctta tttgtcggca ttacagctgc
     2821 agttttgcct tggggcaaaa ccattcatcc cattgccaaa acagttgaca gtgtctgtgt
     2881 gtgttgtgtg cagttttcag gatgatataa cagatagcgc gtccacgctg ctgccccttt
     2941 ggaaagagca gggcctggtt atgtagctgc ccagctgctc agtccagata aatacatgga
     3001 ctagcaacta tgcagtcatc attcctgcct ttacgtgatt ggctggacga gggggcaaaa
     3061 gaacctattt ataaaagctc ctatatactt ccacgttcta tttatgcaac tcatcttcac
     3121 agatcattct aaaatgaacg aggtgatgta tgctgtatca gaaaccatct gtaacagttg
     3181 tgttctcagt gctgtgtcat tccaaataaa cctttggtaa tctccaagtt aaaaaaaaaa
     3241 aaaaaaa
//
