LOCUS       NM_001372441            3886 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus adenosine monophosphate deaminase 3 (Ampd3),
            transcript variant 4, mRNA.
ACCESSION   NM_001372441 XM_006507221
VERSION     NM_001372441.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3886)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3886)
  AUTHORS   Chen,C., Xie,T., Zhang,Y., Wang,Y., Yu,F., Lin,L., Zhang,W.,
            Brown,B.C., Zhang,X., Kellems,R.E., D'Alessandro,A. and Xia,Y.
  TITLE     Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia
            Sensor and Energy Regulator Combating CKD in a Mouse Model
  JOURNAL   J Am Soc Nephrol 34 (10), 1647-1671 (2023)
   PUBMED   37725437
  REMARK    GeneRIF: Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic
            Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.
REFERENCE   3  (bases 1 to 3886)
  AUTHORS   Zhan,X., Zhong,X., Choi,J.H., Su,L., Wang,J., Nair-Gill,E.,
            Anderton,P., Li,X., Tang,M., Russell,J., Ludwig,S., Gallagher,T.
            and Beutler,B.
  TITLE     Adenosine monophosphate deaminase 3 null mutation causes reduction
            of naive T cells in mouse peripheral blood
  JOURNAL   Blood Adv 4 (15), 3594-3605 (2020)
   PUBMED   32761233
  REMARK    GeneRIF: Adenosine monophosphate deaminase 3 null mutation causes
            reduction of naive T cells in mouse peripheral blood.
REFERENCE   4  (bases 1 to 3886)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3886)
  AUTHORS   Marjonen,H., Toivonen,M., Lahti,L. and Kaminen-Ahola,N.
  TITLE     Early prenatal alcohol exposure alters imprinted gene expression in
            placenta and embryo in a mouse model
  JOURNAL   PLoS One 13 (5), e0197461 (2018)
   PUBMED   29763474
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3886)
  AUTHORS   Lee,S., Wang,Y., Kim,S.O. and Han,J.
  TITLE     AMPD3 is involved in anthrax LeTx-induced macrophage cell death
  JOURNAL   Protein Cell 2 (7), 564-572 (2011)
   PUBMED   21822801
REFERENCE   7  (bases 1 to 3886)
  AUTHORS   Li,P., Ogino,K., Hoshikawa,Y., Morisaki,H., Cheng,J., Toyama,K.,
            Morisaki,T., Hashimoto,K., Ninomiya,H., Tomikura-Shimoyama,Y.,
            Igawa,O., Shigemasa,C. and Hisatome,I.
  TITLE     Remote reperfusion lung injury is associated with AMP deaminase 3
            activation and attenuated by inosine monophosphate
  JOURNAL   Circ J 71 (4), 591-596 (2007)
   PUBMED   17384464
  REMARK    GeneRIF: Along with the activation of AMPD3,
            ischemia-reperfusion-induced lung inflammation is associated with
            increased MPO activity and TNF-alpha level.
REFERENCE   8  (bases 1 to 3886)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   9  (bases 1 to 3886)
  AUTHORS   Sermsuvitayawong,K., Wang,X., Nagabukuro,A., Matsuda,Y.,
            Morisaki,H., Toyama,K., Mukai,T. and Morisaki,T.
  TITLE     Genomic organization of Ampd3, heart-type AMPD gene, located in
            mouse chromosome 7
  JOURNAL   Mamm Genome 8 (10), 767-769 (1997)
   PUBMED   9321472
REFERENCE   10 (bases 1 to 3886)
  AUTHORS   Wang,X., Morisaki,H., Sermsuvitayawong,K., Mineo,I., Toyama,K.,
            Ogasawara,N., Mukai,T. and Morisaki,T.
  TITLE     Cloning and expression of cDNA encoding heart-type isoform of AMP
            deaminase
  JOURNAL   Gene 188 (2), 285-290 (1997)
   PUBMED   9133604
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122844.4.
            
            On Sep 9, 2022 this sequence version replaced NM_001372441.1.
            
            Summary: This gene encodes a member of the adenosine and AMP
            deaminases family. The encoded protein is an AMP deaminase involved
            in nucleotide and energy metabolism in erythrocytes. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1344390.1,
                                           SRR13422601.1602514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC122844.4         119635-119729
            96-321              AC122844.4         128596-128821
            322-526             AC122844.4         139407-139611
            527-686             AC122844.4         141985-142144
            687-906             AC122844.4         144437-144656
            907-1036            AC122844.4         146476-146605
            1037-1231           AC122844.4         151440-151634
            1232-1363           AC122844.4         153229-153360
            1364-1527           AC122844.4         153878-154041
            1528-1654           AC122844.4         154524-154650
            1655-1818           AC122844.4         155622-155785
            1819-1939           AC122844.4         156761-156881
            1940-2113           AC122844.4         158577-158750
            2114-2224           AC122844.4         160593-160703
            2225-3886           AC122844.4         161531-163192
FEATURES             Location/Qualifiers
     source          1..3886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.85 cM"
     gene            1..3886
                     /gene="Ampd3"
                     /note="adenosine monophosphate deaminase 3"
                     /db_xref="GeneID:11717"
                     /db_xref="MGI:MGI:1096344"
     exon            1..95
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2401
                     /gene="Ampd3"
                     /EC_number="3.5.4.6"
                     /note="isoform 3 is encoded by transcript variant 4;
                     heart-type AMPD; AMP deaminase H-type; AMP deaminase 3"
                     /codon_start=1
                     /product="AMP deaminase 3 isoform 3"
                     /protein_id="NP_001359370.1"
                     /db_xref="CCDS:CCDS90309.1"
                     /db_xref="GeneID:11717"
                     /db_xref="MGI:MGI:1096344"
                     /translation="MALPSESAEMPRQFPKLNMSDLDEHVRLLAEKVFAKVLREEDSK
                     DVMSLFTVPEDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSLSLQMPTQ
                     QDWKGPPTASPAMSPATPLVPGATSKPGPAPYAMPEYQRVTISGDYCAGITVEDYEQA
                     AKSLAKALMIREKYARLAYHRFPRTTAQYLAHQGESVPLEEGLPDFHPPPLPQEDPYC
                     LDDAPPNLGYLVRMHGGVLFVYDNQTMLERQEPHSLPYPDLETYIVDMSHILALITDG
                     PTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQ
                     KHLLRFIKHTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFH
                     RFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSEPRLSI
                     YGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPL
                     FKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYY
                     LYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSP
                     VLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEA
                     LMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKT
                     NVAQIRMAFRYETLCNELSFLSDAMKSEEITALTK"
     exon            96..321
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..526
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..686
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..906
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1036
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1231
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1363
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1527
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1654
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1818
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1939
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2113
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2224
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..3886
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3864..3869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ampd3"
                     /note="hexamer: AATAAA"
     polyA_site      3886
                     /gene="Ampd3"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgctgc tgccgctgcc ctgtgcgccc tgcccggcgc ggcacctgcg ctccagcccg
       61 gcagccggcc cccatggccc tgccctccga atccgccgag atgccgcgcc agttccccaa
      121 gttgaacatg tccgatttgg acgaacatgt ccggctgttg gcggagaagg tgtttgctaa
      181 ggtgctccga gaagaggaca gcaaagatgt catgtccctg tttactgtcc ccgaggactg
      241 tcccatcgga cagaaggaag ccaaggagag ggagctacag aaggagcttg cagagcagaa
      301 gtctgtggag acagcaaaaa gaaagaagag tttcaagatg atccggtcgc agtctttgtc
      361 cctgcagatg ccaacacaac aagactggaa aggtcctcca actgccagtc ctgccatgtc
      421 tcctgcaacc cctctggttc ccggagctac ttctaagcct gggccagcac cctatgctat
      481 gcctgagtat cagcgggtca ccatcagtgg agattactgt gcagggatca ctgtggaaga
      541 ctatgagcag gctgccaaga gcctggccaa ggccctgatg atccgggaga agtatgcacg
      601 gcttgcctac caccgcttcc cacggaccac agcccagtac ctggctcatc agggggaaag
      661 tgtgcctttg gaagagggtc tcccagactt ccaccctccc ccactgcccc aggaagaccc
      721 ttattgcctg gatgatgcac cccccaacct gggctacctg gttcgcatgc acggaggtgt
      781 tctctttgtg tatgacaatc agacgatgtt ggaacgccag gagccccaca gcctgcccta
      841 ccctgacctg gagacctaca ttgtggacat gagccatatt ctggcactca tcactgatgg
      901 ccccacgaaa acctattgtc accggcgact gaactttctg gaatccaagt ttagccttca
      961 tgagatgtta aatgaaatgt cagagttcaa ggaattgaag agtaaccccc acagagactt
     1021 ttataatgtg agaaaggtag acacacacat tcatgcagcg gcctgcatga atcagaagca
     1081 cctgctgcgt ttcatcaagc acacgtacca gacagagccc gacagaactg tggcggagaa
     1141 gctaggtcgg aagatcaccc tgcggcaggt gtttgacagc ctgcacatgg acccctacga
     1201 cctcacggtg gactcgctgg atgttcatgc aggccgccag acatttcacc gcttcgacaa
     1261 gttcaactcc aagtacaacc ccgtgggggc cagcgagctc cgggacctgt atctgaaaac
     1321 tgagaactac ctcgggggag aatactttgc tcgcatggtc aaggaagtgg cccgggagct
     1381 agaggacagc aagtaccaat actcagaacc ccggctctcc atctatggtc gcagtcccaa
     1441 ggagtggtct agcctggccc gctggttcat ccagcacaag gtctactcac ccaacatgcg
     1501 ctggatcatc caggtgcccc gcatctatga tatatttagg tcaaagaaac tactgccaaa
     1561 ctttgggaag atgctggaga acatcttcct gcccctgttc aaagctacca tcaaccccca
     1621 agatcatcgg gagcttcacc tcttccttaa atacgtgact gggtttgaca gtgtggatga
     1681 cgaatccaag cacagtgacc acatgttctc agacaagagt cccagcccag acctctggac
     1741 cagcgagcag aacccgccct atagttacta cctgtactac atgtatgcca acatcatggt
     1801 gctgaacaac ctccgcaggg aacgaggcct gagcacgttc ctcttccggc ctcactgtgg
     1861 ggaggccggc tccatcactc acctagtgtc tgccttcctg acggcagaca acatttccca
     1921 cgggctgctg cttaagaaga gccctgtttt gcagtacctc tactaccttg ctcagatccc
     1981 tattgccatg tctcctctca gcaacaacag cctgtttctg gaatattcca agaaccccct
     2041 ccgggaattc ctgcacaagg gactacatgt ctctctctct accgatgacc ccatgcagtt
     2101 tcactacaca aaggaagcgc tcatggagga gtacgccatt gcggcacaag tgtggaagct
     2161 gagtacctgc gacctgtgtg agatcgccag gaacagtgtg ctgcagagtg gcctctcaca
     2221 tcaggagaag cagaagtttc tgggtcagaa ttattacaag gaaggaccag agggcaatga
     2281 cattcgaaag acaaatgttg cacagatccg gatggcattc cgctacgaga ccctgtgtaa
     2341 tgagctcagc tttctgtccg atgccatgaa gtccgaggag atcacagccc tgaccaaata
     2401 ggcccagcgg tccacacaca cttcactatt tggtttaatg tcaggtctgc tgggggtaat
     2461 ggtggccaag atctcaaact agggcttccg tctgtgatga ggacgcctct gaagaaatct
     2521 caagctccca attttggttg cactttacga acatgctcac ttcgttagca tttctgagcc
     2581 agaggctggc tccctcccgt ggggatctgg gagctggcac tgtgtacacc tgtccctgac
     2641 tgtccacgtc tcccgtgatt gccagtgcta atatggctgg ggctgagact ttgcaaggcc
     2701 taatgccaaa ggacacaagg cctgtgtggt gtctgccaca ctcagcaggc cctgtagtgg
     2761 ttctcatttt ggcatctggc tggctgcctg ccttaaaccc ccaccaaagc tccttttcat
     2821 aaaggggcta ccttgagaga aaatacaaac gctctcctgt tgatgatttg tgcattttaa
     2881 aaaatgagtt tctttccctc ttagcacccc tccttcctgt ctggttagga agcccaatgc
     2941 accctctgag gtcatcactt ctgttctatg ttattatcta ggactcaacg agtcatctca
     3001 aaccatattc tgtgaatcca tctcatggtc cactcctggg ctgcggaagg tacaaggcga
     3061 ggttatgggg ctgctcttca ctttttgttt ttaaatgaag acctctgaaa agcacagggc
     3121 ctctgctcct tctggctctg atgtcctgtg actgtagtgt caccacctcc cctgggagtc
     3181 agaccaggga ctcctcaggg agtgaaatgt gcttcaggac acacaggact cgagccaagc
     3241 tcctgatcca gtcacacccc acccccgact cccctgcctc ctcctactgt tttaggcttc
     3301 acatatttta aatgtttgaa aaagagtcac taacaaagtg gattttattt taaagcagat
     3361 ttcttcagaa gctatcatgg tcccagggac taggtagaat ttttaagtct aacgtgaact
     3421 ttagctttat cagacatttt tgttactagt gcctagaaca tagtaggtgc tcaataaata
     3481 cacatggagt aattgaatga ctttctcttt tggcatctgt atgtgcagaa tactcaacaa
     3541 tgttcaaaga ccttcttaac tattcagaag gcaggaagtc ctacaccata gttagatgaa
     3601 cctaactgta cctggaagtt gcccatttaa ctaattattc tgtcctgtga ctgtcatcct
     3661 tccagttgtt gtgtagcgta tggaaccatg tcatcctttt actaggcaaa tacacatact
     3721 atctcacata gatgattatg aaactgaatg aaaacctgtc atgcgggatt atttttgaaa
     3781 agcctccatt tgtatacatt tgcccaaaca tagcaactat tgtacagttt ttcattgtat
     3841 caaatacttt tttaaagact acaaataaag tctattagga ctgtga
//
