LOCUS       NM_028779               3694 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus adenosine monophosphate deaminase 2 (Ampd2),
            transcript variant 2, mRNA.
ACCESSION   NM_028779
VERSION     NM_028779.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Andres-Hernando,A., Orlicky,D.J., Kuwabara,M., Fini,M.A.,
            Tolan,D.R., Johnson,R.J. and Lanaspa,M.A.
  TITLE     Activation of AMPD2 drives metabolic dysregulation and liver
            disease in mice with hereditary fructose intolerance
  JOURNAL   Commun Biol 7 (1), 849 (2024)
   PUBMED   38992061
  REMARK    GeneRIF: Activation of AMPD2 drives metabolic dysregulation and
            liver disease in mice with hereditary fructose intolerance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Yang,H., Wang,Q., Xi,Y., Yu,W., Xie,D., Morisaki,H., Morisaki,T.
            and Cheng,J.
  TITLE     AMPD2 plays important roles in regulating hepatic glucose and lipid
            metabolism
  JOURNAL   Mol Cell Endocrinol 577, 112039 (2023)
   PUBMED   37567359
  REMARK    GeneRIF: AMPD2 plays important roles in regulating hepatic glucose
            and lipid metabolism.
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Andres-Hernando,A., Cicerchi,C., Kuwabara,M., Orlicky,D.J.,
            Sanchez-Lozada,L.G., Nakagawa,T., Johnson,R.J. and Lanaspa,M.A.
  TITLE     Umami-induced obesity and metabolic syndrome is mediated by
            nucleotide degradation and uric acid generation
  JOURNAL   Nat Metab 3 (9), 1189-1201 (2021)
   PUBMED   34552272
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Nemkov,T., Sun,K., Reisz,J.A., Song,A., Yoshida,T., Dunham,A.,
            Wither,M.J., Francis,R.O., Roach,R.C., Dzieciatkowska,M.,
            Rogers,S.C., Doctor,A., Kriebardis,A., Antonelou,M.,
            Papassideri,I., Young,C.T., Thomas,T.A., Hansen,K.C.,
            Spitalnik,S.L., Xia,Y., Zimring,J.C., Hod,E.A. and D'Alessandro,A.
  TITLE     Hypoxia modulates the purine salvage pathway and decreases red
            blood cell and supernatant levels of hypoxanthine during
            refrigerated storage
  JOURNAL   Haematologica 103 (2), 361-372 (2018)
   PUBMED   29079593
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3694)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3694)
  AUTHORS   Taketo,M.M., Araki,Y., Matsunaga,A., Yokoi,A., Tsuchida,J.,
            Nishina,Y., Nozaki,M., Tanaka,H., Koga,M., Uchida,K., Matsumiya,K.,
            Okuyama,A., Rochelle,J.M., Nishimune,Y., Matsui,M. and Seldin,M.F.
  TITLE     Mapping of eight testis-specific genes to mouse chromosomes
  JOURNAL   Genomics 46 (1), 138-142 (1997)
   PUBMED   9403069
REFERENCE   10 (bases 1 to 3694)
  AUTHORS   Moseley,W.S., Morisaki,T., Sabina,R.L., Holmes,E.W. and Seldin,M.F.
  TITLE     Ampd-2 maps to distal mouse chromosome 3 in linkage with Ampd-1
  JOURNAL   Genomics 6 (3), 572-574 (1990)
   PUBMED   2328996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK389537.1, BC049119.1 and AL671854.14.
            
            On Jan 25, 2014 this sequence version replaced NM_028779.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence and uses an alternate in-frame splice junction at
            the 3' end of an exon compared to variant 1. The resulting isoform
            (b) has a shorter and distinct N-terminus and lacks an alternate
            internal segment compared to isoform a. Variants 2 and 3 both
            encode the same isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049119.1, SRR9219382.226705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CK389537.1         1-39
            40-3113             BC049119.1         1-3074
            3114-3114           AL671854.14        18013-18013         c
            3115-3694           BC049119.1         3076-3655
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..3694
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /note="adenosine monophosphate deaminase 2"
                     /db_xref="GeneID:109674"
                     /db_xref="MGI:MGI:88016"
     exon            1..449
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..2836
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /EC_number="3.5.4.6"
                     /note="isoform b is encoded by transcript variant 2;
                     adenosine monophosphate deaminase 2 (isoform L); AMP
                     deaminase 2"
                     /codon_start=1
                     /product="AMP deaminase 2 isoform b"
                     /protein_id="NP_083055.1"
                     /db_xref="CCDS:CCDS17749.1"
                     /db_xref="GeneID:109674"
                     /db_xref="MGI:MGI:88016"
                     /translation="MASEARSGLGASPLQSARSLPGNAPCLKHFPLDLRTSMDGKCKE
                     IAEELFSRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQ
                     DFLKTDSDSDLQLYKEQGEGQGDRGLWERDVVLEREFQRVIISGEEKCGVPFTDLLDA
                     AKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQSPDTPVSADAPVH
                     PPALEQHPYEHCEPSAMPGDLGLGLRMVRGVVHVYTRRDPDEHCPEVELPYPDLQEFV
                     ADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRK
                     VDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSV
                     DTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNKISGKYFAHIIKEVMADLE
                     ESKYQNAELRLSIYGRSRDEWDKLARWAVNHKVHSPNVRWLVQVPRLFDVYRTKGQLA
                     NFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPE
                     AWVEEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLA
                     ENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLS
                     TDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNY
                     TKEGPEGNDIRRTNVPDIRVGYRYETLCQELALITQAVQSEMLETIPEEVGIVMSPGP
                     "
     exon            450..580
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            581..711
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            712..780
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            781..892
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1079
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1221
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1311
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1441
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1636
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1768
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1932
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2059
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2223
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2344
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2518
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2629
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..3689
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /note="hexamer: AATAAA"
     polyA_site      3689
                     /gene="Ampd2"
                     /gene_synonym="1200014F01Rik; Ampd-2; m4521Dajl"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggcct ggggtacgcg agattggcgc gcagcccgga aggtttcggc ggggtcgcac
       61 ctgttgcgtg actcccccgt agcccggcca caggagccgg atccctaatt gattcccaga
      121 aagtggtgaa agaaccctag gcgaattccg ggtccggttt tctggggagc acgtggcctg
      181 tttcctcttg agtgcaggct tggggtcgcg actccggggt ctcctgaggt cagtctggcc
      241 gctgaagtcg gcgggagtcc gccccccggc cagctggcca ttttgaaaac cttgccttcc
      301 ttcccgcttc tcagtgcggg tgcaggggcc agtggcgcga cttcgccccg gtgggggccc
      361 tctcccctct tcagcccggc tccctcgctg tgcagacttt cgtaggctgc cttcctggtc
      421 cacgcgggac ttgggcagca tggcctcaga agctcgaagc ggtctggggg cctctccgct
      481 acagtctgcc cgatccctgc caggcaacgc cccttgcctc aagcacttcc cgcttgacct
      541 gcgcacgtct atggatggca aatgcaagga gatcgctgag gagttgttca gccgctcact
      601 ggctgagagt gagcttcgta gcgcccctta tgagttccca gaggaaagcc ccatcgagca
      661 gctagaagaa cggaggcagc ggctggagcg ccagatcagc caggatgtca agctggagcc
      721 agatattctt cttcgagcca agcaagattt cctgaagaca gacagcgact cagacttaca
      781 gctgtacaag gagcaaggag agggacaggg tgacaggggt ctttgggaac gtgatgtggt
      841 attggaacgg gaatttcagc gggtcatcat ctctggggag gagaagtgtg gggtgccatt
      901 cacagacctc ttagacgcag ccaaaagtgt ggttcgggca cttttcatcc gggagaagta
      961 catggcccta tcactgcaga gcttctgtcc caccacccgc cgttacctgc agcagctggc
     1021 tgagaagccc ctggagactc gaacttatga gcagagtcct gatacccctg tatctgctga
     1081 tgccccagtg catccccctg cactggagca gcacccgtat gagcactgtg agccaagcgc
     1141 catgcctggg gacctgggct tgggtctgcg catggtgcgt ggtgtggtgc acgtctacac
     1201 ccgcagggac cctgatgagc actgtccgga ggtggagctt ccataccctg acctacagga
     1261 atttgtagct gacgtcaatg tgctgatggc cctgatcatc aatggtccca taaagtcatt
     1321 ctgctaccgc cggctgcagt acctgagctc caaattccag atgcacgttt tgctcaatga
     1381 gatgaaggag ctcgctgctc agaagaaagt gccacaccgg gacttctaca atatccgtaa
     1441 ggtggacaca cacatccacg cctcgtcctg catgaaccag aaacatctac tgcgcttcat
     1501 caagcgggcc atgaagcggc acctggagga gattgtgcat gtggaacagg gccgcgagca
     1561 gacgctgaga gaagtcttcg agagcatgaa cctcactgcc tacgacttaa gtgtggacac
     1621 gctggatgtg catgcggaca ggaatacctt tcatcgattt gacaaattca atgccaaata
     1681 caaccctatt ggggagtctg ttctccgaga gatcttcatt aaaaccgaca acaagatttc
     1741 tgggaagtac tttgctcaca tcatcaagga ggtgatggca gacttggagg agagcaaata
     1801 ccagaatgca gagctccggc tgtccatcta cgggcgttcg agggatgagt gggacaagct
     1861 ggcacgctgg gcagtgaacc acaaagtgca ctctcccaat gtccgctggc tggtgcaggt
     1921 gccccgcctc ttcgatgtgt accgcaccaa gggccagctg gccaacttcc aagagatgct
     1981 ggagaacatc tttctgcccc tgtttgaggc tactgtgcac cctgccagcc acccggagct
     2041 gcacctcttt ctggagcacg tggatggttt tgatagcgtg gatgatgagt ccaagccaga
     2101 gaaccacgtc ttcaacctgg agagtcccct cccagaagct tgggtggagg aggacaaccc
     2161 tccctatgcc tactacctgt actacacctt cgctaacatg gctatgttga accatctgcg
     2221 caggcagaga ggtttccaca cgttcgtgct gaggccgcac tgtggggagg ccgggcccat
     2281 ccaccacctg gtatcagcct tcatgctggc cgagaacatc tcccacgggc tgctcctgcg
     2341 caaggccccc gtcctgcagt acctgtatta cctggctcag atcggcatcg ccatgtcccc
     2401 gctcagcaac aacagcctgt tcctcagcta ccaccggaac cctctccctg agtacttgtc
     2461 ccgtggcctc atggtctcgc tgtccacaga tgatcccttg cagttccact tcaccaagga
     2521 gcccctgatg gaggagtaca gcatcgccac ccaggtgtgg aagctcagct cctgcgatat
     2581 gtgcgagctg gcccgtaaca gcgtgctcat gagtggcttc tctcacaagg tgaaaagcca
     2641 ctggctggga cccaactata ccaaggaggg ccctgagggc aatgatatcc gccgtaccaa
     2701 cgtgccagac atccgagtgg gctaccgcta tgagacgcta tgccaggagc tggcacttat
     2761 cacacaggcc gtccaaagtg agatgctgga gaccatccca gaggaagtgg gcattgtcat
     2821 gagcccaggg ccttagtgca cctggtctgt gcagtgctcg tcccatctca gcgacttgac
     2881 tgtgaccgtg attagacccc tcccacctga tgtggtctct gcatgtctcc gtgctatgtt
     2941 tctgtcctgc atgtcttcga ccatgtcttg cctctgggcc acctcagtga aagcaagtcc
     3001 aggaatctgc ttcattattg tctcggctca ggtggtacct ggtggctgag atttaagagt
     3061 tggccctgct cgtgacccat ctcagaattg tcagaagtct ggctgtccta tggtatcctc
     3121 agtgtccaca ggggcttggg atggttgtgt agggctggcc ccttgagcac cgggaaccca
     3181 ggctttggtt agagttcaag ttgagtttcc ctcttgttta tgtggctgtg ggacaggagg
     3241 ggctcgttat ctctctgctg tggcactggc tgctcagcct ctgaagttcc agctggtctg
     3301 cgctgggcag agcaggactt aggctcactc acggccctgg aggcctggcc tgaggggctg
     3361 gcccactgtc cctgctgagt cactgcccat cagccccgtt cctccccagc ccacgtgttc
     3421 ctttgttacc agcccccttg tatccctgtg ggagggggca gctgccctga cctgtctcag
     3481 ttggaggcta ttgcagttgg agggtgctgg aactgttact agctctggag gtggcacctt
     3541 ctttgggggt ttccaggtct ttgaccagac ccagttccca gccagcctct tgtgttatgt
     3601 tctagaccga ggcctttgct atgaagaaca gtgtttcata tgacccattt tttcctagtg
     3661 catgagaaat aaaaagatta tttaattaaa aaaa
//
