LOCUS       NM_001033303            2342 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adenosine monophosphate deaminase 1 (Ampd1), mRNA.
ACCESSION   NM_001033303 XM_131103 XM_899199 XM_899217 XM_911404 XM_921986
            XM_921992
VERSION     NM_001033303.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Andres-Hernando,A., Cicerchi,C., Garcia,G.E., Orlicky,D.J.,
            Stenvinkel,P., Johnson,R.J. and Lanaspa,M.A.
  TITLE     Phosphate depletion in insulin-insensitive skeletal muscle drives
            AMPD activation and sarcopenia in chronic kidney disease
  JOURNAL   iScience 26 (4), 106355 (2023)
   PUBMED   36994079
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Nemkov,T., Sun,K., Reisz,J.A., Song,A., Yoshida,T., Dunham,A.,
            Wither,M.J., Francis,R.O., Roach,R.C., Dzieciatkowska,M.,
            Rogers,S.C., Doctor,A., Kriebardis,A., Antonelou,M.,
            Papassideri,I., Young,C.T., Thomas,T.A., Hansen,K.C.,
            Spitalnik,S.L., Xia,Y., Zimring,J.C., Hod,E.A. and D'Alessandro,A.
  TITLE     Hypoxia modulates the purine salvage pathway and decreases red
            blood cell and supernatant levels of hypoxanthine during
            refrigerated storage
  JOURNAL   Haematologica 103 (2), 361-372 (2018)
   PUBMED   29079593
REFERENCE   4  (bases 1 to 2342)
  AUTHORS   Pan,Y., Zhang,L., Liu,Q., Li,Y., Guo,H., Peng,Y., Peng,H., Tang,B.,
            Hu,Z., Zhao,J., Xia,K. and Li,J.D.
  TITLE     Insertion of a knockout-first cassette in Ampd1 gene leads to
            neonatal death by disruption of neighboring genes expression
  JOURNAL   Sci Rep 6, 35970 (2016)
   PUBMED   27775065
  REMARK    GeneRIF: AMPD1 is an adenosine monophosphate deaminase that
            catalyzes the deamination of AMP to IMP. An elevated AMP level and
            almost complete lack of IMP was detected in the skeletal muscle of
            E18.5 Ampd1(tm1a/tm1a) mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2342)
  AUTHORS   Cheng,J., Morisaki,H., Sugimoto,N., Dohi,A., Shintani,T.,
            Kimura,E., Toyama,K., Ikawa,M., Okabe,M., Higuchi,I., Matsuo,S.,
            Kawai,Y., Hisatome,I., Sugama,T., Holmes,E.W. and Morisaki,T.
  TITLE     Effect of isolated AMP deaminase deficiency on skeletal muscle
            function
  JOURNAL   Mol Genet Metab Rep 1, 51-59 (2014)
   PUBMED   27896074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2342)
  AUTHORS   Shao,H., Pandey,A., O'Shea,K.S., Seldin,M. and Dixit,V.M.
  TITLE     Characterization of B61, the ligand for the Eck receptor
            protein-tyrosine kinase
  JOURNAL   J Biol Chem 270 (10), 5636-5641 (1995)
   PUBMED   7890684
REFERENCE   7  (bases 1 to 2342)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   8  (bases 1 to 2342)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   9  (bases 1 to 2342)
  AUTHORS   Kingsmore,S.F., Moseley,W.S., Watson,M.L., Sabina,R.L., Holmes,E.W.
            and Seldin,M.F.
  TITLE     Long-range restriction site mapping of a syntenic segment conserved
            between human chromosome 1 and mouse chromosome 3
  JOURNAL   Genomics 7 (1), 75-83 (1990)
   PUBMED   1970802
REFERENCE   10 (bases 1 to 2342)
  AUTHORS   Moseley,W.S., Morisaki,T., Sabina,R.L., Holmes,E.W. and Seldin,M.F.
  TITLE     Ampd-2 maps to distal mouse chromosome 3 in linkage with Ampd-1
  JOURNAL   Genomics 6 (3), 572-574 (1990)
   PUBMED   2328996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163297.4 and AC150894.4.
            
            On Sep 15, 2006 this sequence version replaced NM_001033303.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC163297.4         190377-190480
            105-116             AC163297.4         191770-191781
            117-291             AC150894.4         133333-133507       c
            292-457             AC150894.4         131419-131584       c
            458-623             AC150894.4         127064-127229       c
            624-843             AC150894.4         124000-124219       c
            844-973             AC150894.4         122362-122491       c
            974-1168            AC150894.4         121198-121392       c
            1169-1300           AC150894.4         120788-120919       c
            1301-1464           AC150894.4         120072-120235       c
            1465-1591           AC150894.4         118010-118136       c
            1592-1755           AC150894.4         117659-117822       c
            1756-1876           AC150894.4         116774-116894       c
            1877-2050           AC150894.4         113693-113866       c
            2051-2161           AC150894.4         113400-113510       c
            2162-2342           AC150894.4         112816-112996       c
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..2342
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /note="adenosine monophosphate deaminase 1"
                     /db_xref="GeneID:229665"
                     /db_xref="MGI:MGI:88015"
     exon            1..104
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..116
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..291
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..457
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..623
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..843
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..973
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1168
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1300
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1464
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1591
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1755
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1876
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2050
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2161
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2342
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2320..2325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /note="hexamer: AATAAA"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /note="hexamer: AGTAAA"
     polyA_site      2339
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /note="major polyA site"
     polyA_site      2342
                     /gene="Ampd1"
                     /gene_synonym="Ampd-1"
                     /note="major polyA site"
ORIGIN      
        1 atttcagaga gtcattccgc catccccaca gtctctctcc ttcctctgct gtgctatcct
       61 agaatcaagg atcccagcca caatgcctct attcaaacta acaggtcaag gaaaacaaat
      121 tgatgatgca atgcgtagct ttgctgaaaa agtgtttgcc tctgaagtca aagatgaggg
      181 aggtcggcac gagatctccc ccttcgacgt ggatgagatc tgcccaattt cccttcatga
      241 gatgcaggcc cacatattcc acatggagaa cctgtccatg gatggcagga gaaaaaggcg
      301 tttccaagga cggaagactg ttaatttgtc cattccacaa agtgaaacat cttctaccaa
      361 actgtcccac atcgaagaat ttatttcttc atccccaacc tacgagagtg tgcctgactt
      421 ccagagggtg cagatcactg gagactatgc ctcgggggta accgttgaag actttgaggt
      481 ggtttgtaaa ggtctctatc gggcattgtg tatacgagag aaatacatgc agaagtcatt
      541 ccagaggttc cccaagaccc cctccaagta cttgaggaac attgatggcg aagccttggt
      601 aggaaacgag agcttctacc cagtatttac ccctcctccg aagaagggtg aagacccctt
      661 tcgcacagag gaccttcctg caaacctggg ctatcacctc aagatgaaag ctggtgtgat
      721 ttacatctac cctgatgaag cggcagccaa cagagatgag cccaagccct acccttaccc
      781 aaatctggat gacttcctgg atgacatgaa ttttttgctt gctctaattg cacaagggcc
      841 tgttaagact tatgctcacc gccgcctgaa gttcctctcc tccaagttcc aggtccatca
      901 gatgctcaac gagatggatg agctgaagga gctgaagaac aacccccacc gggactttta
      961 taactgcagg aaggtggata ctcacatcca tgcagctgcc tgcatgaacc agaagcacct
     1021 gctgcgcttc attaagaaat cttaccatat tgacgccgac agggtggtct acagcactaa
     1081 agagaagagc ctgactctga aggaactttt cgctaagttg aatatgcatc cctatgacct
     1141 gactgttgac tctctggatg ttcatgctgg acgccagacg ttccaacgtt ttgataagtt
     1201 caatgacaaa tacaatcccg tgggtgcaag tgagcttcgg gacctctacc taaaaacaga
     1261 caactacatt aatggggagt attttgccac tatcatcaag gaggtgggtg cagacctggt
     1321 ggaggccaag tatcagcatg cagagcctcg cttatccatc tacggtcgca gtccagatga
     1381 gtggaacaaa ctctcctctt ggtttgtctg caatcgcatc tattgcccca acatgacgtg
     1441 gatgatccag gtccccagga tctatgatgt gttccgatcc aagaatttcc tgccacactt
     1501 cggaaagatg ctggagaata ttttccttcc agtgtttgag gccaccatca acccccaagc
     1561 tcacccagac ctcagtgtct tcctcaagca catcactggc tttgacagtg tggatgatga
     1621 atccaaacac agtggtcaca tgttttcctc caagagtccc aaacccgagg agtggacaat
     1681 ggaaaacaac ccgtcttata cttactatgc ctactacatg tatgcaaaca tcacggtgct
     1741 caacagcctg agaaaggaac gaggcatgaa tacatttctg tttcgtcccc actgtgggga
     1801 ggctggggct ctcactcacc tcatgacagc cttcatgata gcagacaata tttctcatgg
     1861 actgaattta aagaagagtc ctgtgctaca gtacttgttt ttcctagccc agattcccat
     1921 cgccatgtca ccgctgagta acaacagtct gttcctcgaa tatgcaaaga atcctttctt
     1981 agatttcctc cagaaaggcc tgatgatctc actgtcgacc gatgacccga tgcagttcca
     2041 cttcaccaag gagcccctga tggaagaata cgccatcgct gcgcaagtct tcaagctgag
     2101 cacgtgtgac atgtgtgagg tggcaaggaa cagtgtcctg cagtgtggga tttctcatga
     2161 ggaaaaagca aagtttctgg gcaacaatta ccttgaggaa ggccctgttg gaaatgacat
     2221 ccggaggaca aatgtcgctc agattcgcat ggcctatcgt tatgaaactt ggtgttatga
     2281 actcaattta attgctgagg gtcttaaagc aacagaatga ataaagtaaa tagactaaat
     2341 aa
//
