LOCUS       NM_019764               4191 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus angiomotin-like 2 (Amotl2), transcript variant 1,
            mRNA.
ACCESSION   NM_019764
VERSION     NM_019764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4191)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 4191)
  AUTHORS   Zhang,Y., Zhang,Y., Hutterer,E., Hultin,S., Bergman,O.,
            Kolbeinsdottir,S., Jin,H., Forteza,M.J., Ketelhuth,D.F.J., Roy,J.,
            Hedin,U., Enge,M., Matic,L., Eriksson,P. and Holmgren,L.
  TITLE     The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic
            inflammation and the formation of abdominal aortic aneurysms
  JOURNAL   Nat Cardiovasc Res 2 (7), 629-644 (2023)
   PUBMED   39195920
  REMARK    GeneRIF: The VE-cadherin/AmotL2 mechanosensory pathway suppresses
            aortic inflammation and the formation of abdominal aortic
            aneurysms.
REFERENCE   3  (bases 1 to 4191)
  AUTHORS   Fang,P., Deng,W.J., Fan,N., Shi,J., Shi,H.Y., Ou,L., Pan,J.L. and
            Yang,S.Y.
  TITLE     AMOTL2 restrains transforming growth factor-beta1-induced
            proliferation and extracellular matrix deposition of airway smooth
            muscle cells via the down-regulation of YAP1 activation
  JOURNAL   Environ Toxicol 36 (11), 2225-2235 (2021)
   PUBMED   34323359
  REMARK    GeneRIF: AMOTL2 restrains transforming growth factor-beta1-induced
            proliferation and extracellular matrix deposition of airway smooth
            muscle cells via the down-regulation of YAP1 activation.
REFERENCE   4  (bases 1 to 4191)
  AUTHORS   Nantie,L.B., Young,R.E., Paltzer,W.G., Zhang,Y., Johnson,R.L.,
            Verheyden,J.M. and Sun,X.
  TITLE     Lats1/2 inactivation reveals Hippo function in alveolar type I cell
            differentiation during lung transition to air breathing
  JOURNAL   Development 145 (21) (2018)
   PUBMED   30305289
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4191)
  AUTHORS   Hildebrand,S., Hultin,S., Subramani,A., Petropoulos,S., Zhang,Y.,
            Cao,X., Mpindi,J., Kalloniemi,O., Johansson,S., Majumdar,A.,
            Lanner,F. and Holmgren,L.
  TITLE     The E-cadherin/AmotL2 complex organizes actin filaments required
            for epithelial hexagonal packing and blastocyst hatching
  JOURNAL   Sci Rep 7 (1), 9540 (2017)
   PUBMED   28842668
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4191)
  AUTHORS   Sugihara-Mizuno,Y., Adachi,M., Kobayashi,Y., Hamazaki,Y.,
            Nishimura,M., Imai,T., Furuse,M. and Tsukita,S.
  TITLE     Molecular characterization of angiomotin/JEAP family proteins:
            interaction with MUPP1/Patj and their endogenous properties
  JOURNAL   Genes Cells 12 (4), 473-486 (2007)
   PUBMED   17397395
  REMARK    GeneRIF: Data show that MUPP1 interacts with angiomotin (Amot),
            JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP
            family proteins also interacted with Patj, a close relative of
            MUPP1.
REFERENCE   7  (bases 1 to 4191)
  AUTHORS   Patrie,K.M.
  TITLE     Identification and characterization of a novel tight
            junction-associated family of proteins that interacts with a WW
            domain of MAGI-1
  JOURNAL   Biochim Biophys Acta 1745 (1), 131-144 (2005)
   PUBMED   16019084
REFERENCE   8  (bases 1 to 4191)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 4191)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4191)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141348.1 and BB726257.1.
            
            On Dec 8, 2006 this sequence version replaced NM_019764.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141348.1, AK169419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4162              AK141348.1         1-4162
            4163-4191           BB726257.1         414-442
FEATURES             Location/Qualifiers
     source          1..4191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.71 cM"
     gene            1..4191
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /note="angiomotin-like 2"
                     /db_xref="GeneID:56332"
                     /db_xref="MGI:MGI:1929286"
     exon            1..99
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            100..895
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2480
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /note="Leman coiled-coil protein"
                     /codon_start=1
                     /product="angiomotin-like protein 2"
                     /protein_id="NP_062738.2"
                     /db_xref="CCDS:CCDS40745.1"
                     /db_xref="GeneID:56332"
                     /db_xref="MGI:MGI:1929286"
                     /translation="MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAG
                     AGGTGSPQASLEIGAPEDSQVLQQATRQEPQGQEHQGGETHLAENRLYRLCPQPSKGE
                     ELPTYEEAKAHSQYYAAQQAGSRPHVGDRDPRGGVSGGGRRQDEALRELRHGHVRSLS
                     ERLLQLSLERNGARVPSHMSSSHSFPQLARSQQGPQPRGPPAEGPEPRGPPPQYPHAV
                     MAQETAAVTDPRYRPRSSPHFQHAEVRILQAQVPPVFLQQQQYQYLPQPQEHSPPLHP
                     AALGHGPPSSFGPPAVEGPPSAQATLGSAHLAQMETVLRENARLQRDNERLQRELEST
                     SEKAGRIEKLENEIQRLSEAHESLMRTSSKREALEKTMRNKMDGEMRRLQDFNRDLRE
                     RLESANRHLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRH
                     AELLEQALGNAQSRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRT
                     RLEQELKALRAQQRQTGTLAGGGGSHGGSAELSALRLSEQLREKEEQILALEADMTKW
                     EQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLPGNHRHQEMES
                     RLKVLHAQILEKDAVIKVLQQRSRKDPGKATQGTLRPAKSVPSIFAAAVGTQGWQGLV
                     SSERQTDARPAGDRVPAEEPPATAPLPAHTKHGSRDGSTQTDGPADNTSACLASEPDG
                     LLGCNSSQRTPSLDSIAATRVQDLSDMVEILI"
     exon            896..1190
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1335
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1428
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1724
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..2035
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2244
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2421
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..4191
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4168..4173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /note="hexamer: AATAAA"
     polyA_site      4190
                     /gene="Amotl2"
                     /gene_synonym="Lccp; MASCOT; mKIAA0989"
                     /note="major polyA site"
ORIGIN      
        1 aagcagatca tcggcgccac cgactagtgc gcacctccgt tgctgactgt acctaagccg
       61 aaccgggtct gcgtgcgccg gcagccgcgg gccgcagcgg tgctctgaga ccaggtgcct
      121 gctggccatt gtctaggcag gtgtgtgcaa gccagagaag catgaggaca ctggaagact
      181 cctcagggac agtcctgcac cgtctcatcc aagagcagct gcgctacggc aacctgacag
      241 agactcgcac tctgctggct atccagcagc aggccctgcg gggtggggct ggagctgggg
      301 gcacggggag cccccaggct tccttggaga tcggagcacc cgaggacagt caggtgctgc
      361 agcaagccac caggcaggag ccccagggcc aggagcatca gggtggagag acccacctgg
      421 cagagaacag gctgtaccgg ctgtgcccac agcccagcaa aggagaagag ttgcccacct
      481 atgaggaggc caaagcccat tcgcagtact acgcagcgca gcaggcaggg tcccggccgc
      541 atgttgggga ccgggatcct agaggagggg tgtccggagg cggccggcga caggatgaag
      601 ctcttcgaga gctgaggcat ggccatgtgc gctccttgag tgaacggctt ctgcaactgt
      661 ccctggaaag aaacggtgct cgggtcccca gccacatgag ctcttcccac agcttccctc
      721 agctggcccg cagccagcag ggcccccaac cccgagggcc cccagctgag ggcccagagc
      781 cccgcgggcc accacctcag tacccacacg ctgtaatggc tcaggagact gcggctgtca
      841 ctgacccaag ataccgaccc cgaagcagcc cacacttcca gcatgccgaa gtcaggatcc
      901 tgcaggccca ggtaccaccg gtgttcctcc agcagcagca gtaccagtac ctgccacagc
      961 cccaggagca ctctccaccc ctccacccgg cagctctggg ccatggaccc ccaagctcct
     1021 ttggtccacc tgcagtggag ggaccaccca gtgcccaggc caccttgggc agtgcccacc
     1081 tggcccagat ggagactgta ctgagggaga atgccaggct gcagagggac aatgagcgat
     1141 tgcagagaga gctggagagc acttcagaga aggctggccg catagaaaag ctggaaaatg
     1201 aaatccagcg gctctctgag gcccacgaga gcctgatgag gacctcttcc aagcgtgagg
     1261 ccctggagaa gaccatgagg aacaagatgg acggtgagat gagacggttg caggacttca
     1321 accgagacct tagagagaga ttggaatcgg caaaccgcca cctggcaagc aagacccagg
     1381 aagcccaggc gggcagtcag gacatggtgg cgaaactgct tgcccagagc tatgagcagc
     1441 aacaggaaca ggagaagctg gagcgggaga tggcactgct gcgtggtgcc atcgaggacc
     1501 agcggcgaca tgctgaactg ctggagcagg ctctgggcaa tgcacaaagc cgtgccgccc
     1561 gggctgaaga ggagctacgc aaaaagcagg cctatgtgga gaaggtggag cggctgcagc
     1621 aggcactggg gcagttgcag gctgcctgtg aaaagcgaga gcagttggag ctgcgtctgc
     1681 gcacgcgcct ggagcaggaa ctcaaagcct tgcgtgcaca gcagaggcag acaggcaccc
     1741 tcgcaggtgg tggcggcagc catggtgggt ccgccgagct cagtgccctg cggctgtctg
     1801 aacagctgcg ggagaaggag gaacagatcc tggctctaga ggcggacatg accaagtggg
     1861 aacagaagta tttggaagaa cgggctatga ggcagttcgc catggacgcg gctgccactg
     1921 cggctgccca gcgcgatacc actctcatcc ggcactcccc ccagccctcg cccagcagca
     1981 gtttcaacga gggcctgctg ccaggcaacc acaggcacca ggagatggag agcagattga
     2041 aggtgctcca tgctcagatc ctagagaagg atgcggtgat caaggtcctt cagcagcgct
     2101 ccaggaaaga ccctggcaag gccacccagg gcaccctacg gcctgccaag tcggtgccgt
     2161 ccatcttcgc ggctgcagtg ggaactcagg gctggcaagg gctcgtatcc agtgagcggc
     2221 aaactgatgc acggccagcg ggagaccggg tcccagcaga ggagcctccg gccacagctc
     2281 ctctccctgc ccacaccaaa catggcagca gagacgggag cacccagacg gatggccctg
     2341 cagacaacac ctctgcctgc ttggcctcag aacccgatgg cctcctgggg tgcaacagta
     2401 gccagaggac accctctctg gactctatag ctgcaaccag agtccaggat ctgtcagaca
     2461 tggtagaaat actgatctga aggaaggagg cagtgccttg gggaccccga agcctggctc
     2521 cctcctggca ttccggcagt tgtcttcaaa tgctgtgcct cacatcctcc gaccagtgat
     2581 gccttggtgc atggggctca gagaggagca ccccagggga gctagctaga aaagcctgca
     2641 ccccctagaa gactgctttt tggcctatat ttctcctatg acaatgagga aggaaaagcc
     2701 agacatcacc tgcagccgga ggcctgttgc tggggcagaa aggagctgag ccccctccgt
     2761 cctgcctgaa ggaaacagcg gattctgacg cccaagaatg gctgggcacc agccgagcgg
     2821 tctgcaggga tcgttaggcc agctatggtg ttctgtggct aagcatggct ccagccaaca
     2881 ctatctgctc ttcagtccct gactgacttc ctcagatcac taagacttga atccttggga
     2941 ggtgggggac gatgggagtg tgagtctttc gggagccacc agcatgtccc cttggagtag
     3001 gttagaggtc acttgagagg ccccgcagag cagtgtgttt tgtatataat tctttttcct
     3061 tgggaacaga agactaagcg tgccggttca gagtctcctc cagggctgtg ctgcctgccc
     3121 ctgctgccac agttcttgaa acatgtgaca ggtctaccag atgttcctct gcctgcagtt
     3181 cctggctgtg gattttgata ctggttggct ttcctctgct ttttaaatcc ctgtgtttcg
     3241 tgcccatggg attcttatca ccagcctttg tgaatggctc cacagctcct atccctggga
     3301 catcctgtca gtttggttat aaactgagcc agatgtgatg agccaccaca agcggacatc
     3361 tgtcatgccc agcaccaggt tctctttgaa gaaactggag aagttgttct cataaatgta
     3421 ttcgttccca ccagcaggga ctgggagagg gagctatgtt gttaaaacga atcagtgaac
     3481 ttaaagaaaa gtcctcatta tggtgccccc accacagaat ggcaccctta gaggctggct
     3541 cctcaagttt tggtgcccca gccctgaagc agggccagct acttggaatt aggtgaacta
     3601 cccccacgtg gcagaccacc agcagcagtg actttgactt ctggtcttaa agcaaccccc
     3661 attcagctca aaaagcgatt ggtggatttc agatcttttg tgtttttctc ctctggttgt
     3721 tttgtttgtt tttctttcac tgtttgaagt tctgtctgtt gtttgttcca ttcccatagt
     3781 tctctctgca tttccttttt aaacatttgc atttgctggg caattgcgta tttttttaat
     3841 tccctttccc ctatgtaaag ctgagaaata catctggttc atgtacgttg tttacaaaga
     3901 taaaagtttt taaaaaaaaa ggagggggaa aagaaggcaa aaaaatattg tgaaaggaaa
     3961 aaaaaaacaa cttaatatat tttggattaa tatttggtat ttcttttaaa gtattttttt
     4021 tgtgctgtga acgttttctg ccaaagacca tgacgtgtgt ctgtgtgttt aagttatcat
     4081 gaatatttaa agtgtaaaca tggctgtttt gttacgccac tctgtaccag gattgctgct
     4141 gcattccgcc aggtatgaca gtattttaat aaaaaaagag cttataagga g
//
