LOCUS       NM_001403389            6186 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus angiomotin (Amot), transcript variant 6, mRNA.
ACCESSION   NM_001403389
VERSION     NM_001403389.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6186)
  AUTHORS   Skory,R.M., Moverley,A.A., Ardestani,G., Alvarez,Y.,
            Domingo-Muelas,A., Pomp,O., Hernandez,B., Tetlak,P., Bissiere,S.,
            Stern,C.D., Sakkas,D. and Plachta,N.
  TITLE     The nuclear lamina couples mechanical forces to cell fate in the
            preimplantation embryo via actin organization
  JOURNAL   Nat Commun 14 (1), 3101 (2023)
   PUBMED   37248263
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6186)
  AUTHORS   Sallais,J., Park,C., Alahari,S., Porter,T., Liu,R., Kurt,M.,
            Farrell,A., Post,M. and Caniggia,I.
  TITLE     HIF1 inhibitor acriflavine rescues early-onset preeclampsia
            phenotype in mice lacking placental prolyl hydroxylase domain
            protein 2
  JOURNAL   JCI Insight 7 (23), e158908 (2022)
   PUBMED   36227697
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6186)
  AUTHORS   Royer,C., Sandham,E., Slee,E., Schneider,F., Lagerholm,C.B.,
            Godwin,J., Veits,N., Hathrell,H., Zhou,F., Leonavicius,K.,
            Garratt,J., Narendra,T., Vincent,A., Jones,C., Child,T., Coward,K.,
            Graham,C., Fritzsche,M., Lu,X. and Srinivas,S.
  TITLE     ASPP2 maintains the integrity of mechanically stressed
            pseudostratified epithelia during morphogenesis
  JOURNAL   Nat Commun 13 (1), 941 (2022)
   PUBMED   35177595
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6186)
  AUTHORS   Basak,T., Dey,A.K., Banerjee,R., Paul,S., Maiti,T.K. and Ain,R.
  TITLE     Sequestration of eIF4A by angiomotin: A novel mechanism to restrict
            global protein synthesis in trophoblast cells
  JOURNAL   Stem Cells 39 (2), 210-226 (2021)
   PUBMED   33237582
  REMARK    GeneRIF: Sequestration of eIF4A by angiomotin: A novel mechanism to
            restrict global protein synthesis in trophoblast cells.
REFERENCE   5  (bases 1 to 6186)
  AUTHORS   Lim,H.Y.G., Alvarez,Y.D., Gasnier,M., Wang,Y., Tetlak,P.,
            Bissiere,S., Wang,H., Biro,M. and Plachta,N.
  TITLE     Keratins are asymmetrically inherited fate determinants in the
            mammalian embryo
  JOURNAL   Nature 585 (7825), 404-409 (2020)
   PUBMED   32848249
REFERENCE   6  (bases 1 to 6186)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
REFERENCE   7  (bases 1 to 6186)
  AUTHORS   Hallonet,M., Kaestner,K.H., Martin-Parras,L., Sasaki,H., Betz,U.A.
            and Ang,S.L.
  TITLE     Maintenance of the specification of the anterior definitive
            endoderm and forebrain depends on the axial mesendoderm: a study
            using HNF3beta/Foxa2 conditional mutants
  JOURNAL   Dev Biol 243 (1), 20-33 (2002)
   PUBMED   11846474
REFERENCE   8  (bases 1 to 6186)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 6186)
  AUTHORS   Shimono,A. and Behringer,R.R.
  TITLE     Isolation of novel cDNAs by subtractions between the anterior
            mesendoderm of single mouse gastrula stage embryos
  JOURNAL   Dev Biol 209 (2), 369-380 (1999)
   PUBMED   10328927
REFERENCE   10 (bases 1 to 6186)
  AUTHORS   Kim,S.J., Shon,B.H., Kang,J.H., Hahm,K.S., Yoo,O.J., Park,Y.S. and
            Lee,K.K.
  TITLE     Cloning of novel trinucleotide-repeat (CAG) containing genes in
            mouse brain
  JOURNAL   Biochem Biophys Res Commun 240 (1), 239-243 (1997)
   PUBMED   9367917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807753.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.169714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AL807753.10        129867-129969       c
            104-557             AL807753.10        126180-126633       c
            558-702             AL807753.10        122370-122514       c
            703-795             AL807753.10        121895-121987       c
            796-941             AL807753.10        117593-117738       c
            942-1091            AL807753.10        107911-108060       c
            1092-1282           AL807753.10        106174-106364       c
            1283-1405           AL807753.10        99527-99649         c
            1406-1638           AL807753.10        98570-98802         c
            1639-2511           AL807753.10        96606-97478         c
            2512-6186           AL807753.10        92599-96273         c
FEATURES             Location/Qualifiers
     source          1..6186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 66.72 cM"
     gene            1..6186
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /note="angiomotin"
                     /db_xref="GeneID:27494"
                     /db_xref="MGI:MGI:108440"
     exon            1..103
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            104..557
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..2609
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /note="isoform 3 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="angiomotin isoform 3"
                     /protein_id="NP_001390318.1"
                     /db_xref="GeneID:27494"
                     /db_xref="MGI:MGI:108440"
                     /translation="MPRAQQSASYQPMPADPFAMVSRAQQMVEILSDENRNLRQELDG
                     CYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLR
                     DRLETANKQLAEKEYEGSEDTRKTISQLFAKHKENQREKEKLEAELATARSTNEDQRR
                     HIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLR
                     TRLERELESLRIQQRQGNSQPTNASEYNAAALMELLREKEERILALEADMTKWEQKYL
                     EENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDM
                     EGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSSMRPAKSLMSISNAGSGLLAHS
                     STLTGAPIMEEKRDDKSWKGSLGVLLGGDYRVEPVPSTPSPVPPSTPLLSAHSKTGSR
                     DCSTQTERGPESTKTAAVTPISAPMAGPVAAAAPAAAINATAATNTATAATNTTIMVA
                     AAPVAVAAVAAPAAAAATPSPANAAALAAAAAPATSVSAATSVSAANSISPAAPVAPA
                     AVVPPAAPVSPAAAVQIPAAASLTPATVSPTAATATAAVAAATTAAITAAAAAATTAI
                     QVAPATSAPVPSPASIPAPATAQASAPTPTQASTPAPTEPPSPVPTPTPALVQTEGPA
                     NPGASSGPRRLSTPNLMCNPDKPDAPAFHSSTLERKTPIQILGQEPDAEMVEYLI"
     exon            558..702
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            703..795
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            796..941
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1091
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1282
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1405
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1638
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..2511
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..6186
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6161..6166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /note="hexamer: AATAAA"
     polyA_site      6186
                     /gene="Amot"
                     /gene_synonym="CAG-2; D0Kist1; Sii6"
                     /note="major polyA site"
ORIGIN      
        1 agaacagagc tccctgtgcg attggaatgg ccggacttat tcacaagctg ctccacgatt
       61 cacattcgct gtcacagaac ctgggagggg cactatttcg gtgggcaaca caggacatct
      121 cctcgctgtc tttgtcagcc aggaactctc aacctcatag ccctacttct tccctgacag
      181 ctggggcttc cagcttgccc ttgctgcagt ctccgccgtc cactagattg cctcctggtc
      241 aacacctggt ctcgaaccaa ggtgaccact ctgctcacct gtcaaggcat cagcagcatc
      301 ttctttcgag tcagagtcat cagggggacc actaccgtca cgcccaggcc agcctgactt
      361 cagcgcagca gcagccagga gaagcctact cagctatgcc tcgggctcag cagtctgctt
      421 cttatcagcc catgccagct gacccttttg ctatggtctc tagagctcag cagatggttg
      481 agatcctgtc tgatgagaat cgcaacttgc ggcaggagtt ggatggatgc tatgagaagg
      541 tggcgagact gcagaaggtg gagacagaaa tccaacgggt ctcagaggct tatgagaact
      601 tggtgaagtc atcttccaaa agagaggctc tggagaaagc catgaggaac aagctggagg
      661 gcgagattag aaggatgcat gacttcaaca gagatctgag agaccgtcta gagactgcca
      721 acaagcagct ggcagagaag gagtacgagg ggtccgagga caccaggaag accatctcgc
      781 agctctttgc caaacataaa gaaaaccagc gggagaagga gaagctggaa gctgagctgg
      841 ctactgcccg ttctaccaat gaagaccaaa ggcgacacat tgaaatccga gaccaggcat
      901 tgagcaatgc ccaggcgaag gtggtgaagc tggaagaaga gctgaaaaag aagcaagtgt
      961 acgtagataa ggtggagaag atgcagcagg cccttgtgca gctccaggcc gcctgtgaga
     1021 agcgtgagca gctggagcac cggctccgga cacgtttgga gagggaactg gaatccctta
     1081 gaatccagca gcgccagggc aactcccagc ccactaatgc ttcagaatac aatgccgctg
     1141 cactgatgga gctcctccgg gagaaggaag agagaattct ggccctggaa gcagatatga
     1201 ccaagtggga gcaaaagtat ttggaagaga atgtgatgag acactttgct ctggatgctg
     1261 ctgcaactgt ggctgcacag agagacacaa cagtcattag ccactctcct aacaccagct
     1321 atgacacagc cttagaggcc cgcatccaga aggaagagga agaaatcctg atggccaaca
     1381 agcgttgctt ggacatggaa ggaaggatta agaccctcca tgcccagatt attgaaaagg
     1441 atgccatgat caaggtgctg cagcagcgct ccagaaagga gccgagtaaa acagagcaac
     1501 tctcatccat gcggccagca aagtctctga tgtccatttc caatgctgga tcaggcctcc
     1561 ttgcacactc ctctaccttg actggtgcgc ccattatgga ggagaagcgt gatgacaaga
     1621 gctggaaggg gagcctaggc gttcttctgg gaggagatta ccgtgttgag ccggtcccat
     1681 ccacaccgtc ccctgtgccc ccgtctactc cccttctctc agctcattcg aagacaggca
     1741 gtcgcgattg cagcacccaa actgaacgtg gaccggaatc gaccaaaacc gcagctgtca
     1801 ctcccatctc ggctccaatg gctggtccag ttgctgctgc tgcccctgct gctgccatca
     1861 atgcaactgc tgccaccaac actgccactg ctgccaccaa caccactatc atggtagctg
     1921 ctgctccagt tgctgttgct gctgttgctg ctccagctgc tgctgccgcc accccatctc
     1981 cagcaaacgc tgctgctctt gccgctgctg ccgctccagc tacttctgtc tctgcagcta
     2041 cttctgtctc tgcagctaat tctatctctc cagctgctcc tgtcgctcca gctgctgtag
     2101 tgcctccagc tgctcctgtc tctccagctg ctgctgttca gattccagct gctgcatctc
     2161 ttactcctgc tactgtttct ccaactgctg ccactgctac tgctgctgtt gctgcagcta
     2221 ctactgctgc tatcactgct gctgctgctg ctgccactac tgctattcag gttgctccag
     2281 ctacttcggc tccggttcca tctccagctt cgattccggc tccagcaacg gctcaggctt
     2341 ctgctccgac tccgactcag gcatcaactc cagctccgac tgaacctcct agtccagttc
     2401 caactccaac tccagctttg gttcaaactg agggtcctgc aaatccaggt gccagttccg
     2461 gaccacgccg cttgtctaca ccaaatctga tgtgcaaccc agataagcca gatgcccctg
     2521 ctttccactc cagcactctg gaaagaaaga cacccattca gatcctgggg caagagcctg
     2581 atgcagagat ggtggaatat ctcatctaaa cagcacaatc aagagctggc gttatcagca
     2641 agagttcttt ttaataattt ttccctttca tttgtttaat ctggggtgaa gatagggtgg
     2701 ggaggtgggg atgatttttc taaagggact ttttattgga ctctggtagt acataagtaa
     2761 taccatagaa acgaattcca atctattttg gaatacttag ggagtacctc aaaaagatag
     2821 gttaagcaga atgtgctcta aagcttactg ttgggctttg tacaactcat ggactattaa
     2881 ccagtagtga tgtccattga tgttttgaat acgcttcaag ttgttttaaa tttccctatt
     2941 tgaggtcatt tttcattgaa gaatacagta tgtgtagaag gcaggttgta acatggagtt
     3001 ccgaagtgga aattcaggga gagtttgagg acttgctact ttgtcgggtc tctacctaga
     3061 caacagccac agaaagctct gactttgggc ttgaggaaag aaagtgtttt aggagctatg
     3121 gaagctaaag aaaagttaga gaggattggg gtgaagaagg gtgctggaac caattttttc
     3181 tcccagttgc cagttatcct gccccctcat tgatggtatt tctctccatt tcaatggtgc
     3241 tttggaagtg gattcttttg gtttcctcct ggaggttgat acattcatat atatactgtg
     3301 gaataattta tgcatttgga taattaatat attgctttca gatggtagga aggtaaatga
     3361 acagtgatcc atgactgcct ctctcatagg ggattagatg ttagaggcct tgataaaagg
     3421 ctgcatgaga tgctgcatgc agacttttgt gatctgggta tagtcatgac catggctcag
     3481 tcaccttaaa ttagtcctgg tgactggcat agcctttccc cacccataat gcagattcgc
     3541 tggctgcttt gccaatattt gtttaccagt agtttgcaag ataaggaaac atcgttgttg
     3601 acaggttgaa tgtgttgaat ttctggcaaa tacttggaaa tatttctctt tttttttccc
     3661 aaatctttag catgtgcctt caaaggcata tgcaactgtc acctccaagg aaatcacata
     3721 agaaatccaa agtaccaggc tgcagtcatg atcaaggttg attgcagcaa tctcctcaac
     3781 tacctcttct cattaccagt gactccatct tggaatccct ttgggaagca gctaggaatg
     3841 tatatatggg cgggaccaac atggggcctt gccacagagc tgcctccaag gacacagaag
     3901 gtgtcagttg tcacaggtcc ttgtcctttg tctctgccct tcattgaggc aatagaacta
     3961 cagatagtac cattaagatg agttttcagg ggtctaggga agttaagggt gggagggtat
     4021 taggtaaggg agatagacgt ttagagatgt gttaagttag aaatcagatt gatgcaagtg
     4081 tatcctgtat tatgccatgg gctatagtga tggggaggaa ctttacttag caatgtagca
     4141 ttaagtttag tgatgaggaa tctgagagtt ggaaaagttc actgactttt tcaagatcac
     4201 acagcacatc tctctgttct gccaactaca tacccatttg gcaaatgatt ataaaaaaga
     4261 agactctgtt ttaaagaaag gacatcttca tagtctaggg cgtacctatg ttatgaaaat
     4321 attcttggtg tgaatagatt gattaggtgt ctgaattctt atcttgtctc tgctggagtg
     4381 ccttgtgtga gactggattt tttcctcatc ccatttaatc attgagctac atgaaatgca
     4441 cccataaaga aaagtcaacc catctgtttt tcactataaa atcgggtgtc ttgggtcatt
     4501 ttatgtattc ctctgtgagt ataagagtgc tatatttacc tgtattcttg tgtagttcct
     4561 aattaccttc caaaagattt atgtgtgtgt ttgtgtgtgt gtgtctgtct gtctgtctgt
     4621 ctgtctgtct gtctgtagat gagggaaggc aattcaacaa cttttaacta gtatcttttt
     4681 cacattttta atagcaaagt gatcatccaa tgtattggtc ctcagttaca gagtgaatga
     4741 caaatagaca attaaaagtg caaggaaata aaccccttca gacagtagaa gaatcaggca
     4801 gcaaacacca ggagagctac tttctgtcca agcaaatgaa tgaaaatcaa agaaacttca
     4861 tgtcctctca tgatgaaaac tcattgatag aatttgggct gactctggga gccattatta
     4921 taatcacata ctctaaagtg atagatgaaa tgaattcctc actgtggcaa ccatcgcttt
     4981 agagtcatgt gtttggggag aaaaggaagt ccttgctgaa gtatgaactt tccagaacct
     5041 ttgtgccctg tcacataaga ggcactcctt ctcttcagtt ttctgtccca ggaaatttgc
     5101 tagaaggaca ttgtgtgtct aagacatgga agaagactat attggtatag tctgtataga
     5161 ctccaccatt tgagaaaaat ttctaccaca taccagttaa aaaattcagt atatgggatg
     5221 aatctcgaat taaccttgcc ttcacagttg tgtggatgta acatttcagg ccttttcctg
     5281 gacttcccag aagaggaggg aatatttctt gtcttaactt ttactgtcta gttgtctatg
     5341 aggatcttat aattcatttt gttatcccca atgtcccatg tccagcaaaa tttcatttga
     5401 gggaactata cttgatacaa aactattaac attgttgagg aagtaattta acttcctttg
     5461 aaagtcatgt attgtgactg ttgtcttaat gaaggtttta atttcagtgt tgcttttgag
     5521 ctgcagggtg acggggcagt agaaacttga aacatctgcc atcatccatg gcaggaaaca
     5581 tagcaagatg ttctcttttt acttttgcac tgttgagtgg gtctaacaaa ctgatttccc
     5641 agctagtttt taaaatgaag aatctaaata atgtggcagc ttaaagtata gatgtatgtg
     5701 ctaacttgaa taaatgctca tgtctgttag ccatacagtc tgttatctta catcctcatt
     5761 catacatgga ttatgttact taagatatgt tccttcttac agaaaatatt ttcaaaggga
     5821 actattcact gtgggttcat tgtcactgat ttctgcctgc cacaatcttc agaaattctt
     5881 ctctcatgtg ccacccattg acagtaggac aagggttgga aatacatttt cttctggtgg
     5941 taagggtggg tgacaagacg ttttcaaatc cttctggcct cctttgcgat cgatggcatg
     6001 tgtttaataa gatggctaga tgggactggc agattgttca agaagaatta cttttggctt
     6061 aatgtacatg gtcttgtagt gattgtgatc ctattctgta atcaagagag ttagatcaaa
     6121 taaagttaag caggttaaat ccactttgtg cctatctttc aataaagtta gccattttaa
     6181 aatgca
//
