LOCUS       NM_177275               2549 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adhesion molecule with Ig like domain 3 (Amigo3),
            mRNA.
ACCESSION   NM_177275
VERSION     NM_177275.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Raja,R., Dumontier,E., Phen,A. and Cloutier,J.F.
  TITLE     Insertion of a neomycin selection cassette in the Amigo1 locus
            alters gene expression in the olfactory epithelium leading to
            region-specific defects in olfactory receptor neuron development
  JOURNAL   Genesis 62 (2), e23594 (2024)
   PUBMED   38590146
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137678.11, AB167510.1 and AI413948.1.
            
            On Jun 2, 2007 this sequence version replaced NM_177275.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK088051.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC137678.11        65686-65737
            53-1540             AB167510.1         1-1488
            1541-1541           AC137678.11        67226-67226
            1542-2478           AB167510.1         1490-2426
            2479-2549           AI413948.1         1-71                c
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..2549
                     /gene="Amigo3"
                     /gene_synonym="ali3; E430002N15Rik; mKIAA1851"
                     /note="adhesion molecule with Ig like domain 3"
                     /db_xref="GeneID:320844"
                     /db_xref="MGI:MGI:2444854"
     exon            1..2543
                     /gene="Amigo3"
                     /gene_synonym="ali3; E430002N15Rik; mKIAA1851"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1748
                     /gene="Amigo3"
                     /gene_synonym="ali3; E430002N15Rik; mKIAA1851"
                     /EC_number="2.7.7.13"
                     /note="amphoterin induced gene and ORF 3;
                     amphoterin-induced protein 3; alivin 3; AMIGO-3"
                     /codon_start=1
                     /product="amphoterin-induced protein 3 precursor"
                     /protein_id="NP_796249.1"
                     /db_xref="CCDS:CCDS23516.1"
                     /db_xref="GeneID:320844"
                     /db_xref="MGI:MGI:2444854"
                     /translation="MAWLVLSGILLCMLGAGLGTSDLEDVLPPAPHNCPDICICAADV
                     LSCAGRGLQDLPVALPTTAAELDLSHNALKRLHPGWLAPLSRLRALHLGYNKLEVLGH
                     GAFTNASGLRTLDLSSNMLRMLHTHDLDGLEELEKLLLFNNSLMHLDLDAFQGLRMLS
                     HLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSNWLKHISIPELAALPTYLKNRLYLHN
                     NPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLVFKVSESRVRFFEHSRVFKNCSVA
                     AAPGLELPEEQLHAQVGQSLRLFCNTSVPATRVAWVSPKNELLVAPASQDGSIAVLAD
                     GSLAIGRVQEQHAGVFVCLASGPRLHHNQTLEYNVSVQKARPEPETFNTGFTTLLGCI
                     VGLVLVLLYLFAPPCRGCCHCCQRACRNRCWPRASSPLQELSAQSSMLSTTPPDAPSR
                     KASVHKHVVFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLVMS
                     "
     regulatory      2521..2526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amigo3"
                     /gene_synonym="ali3; E430002N15Rik; mKIAA1851"
                     /note="hexamer: AATAAA"
     polyA_site      2543
                     /gene="Amigo3"
                     /gene_synonym="ali3; E430002N15Rik; mKIAA1851"
                     /note="major polyA site"
ORIGIN      
        1 agaaagctct tggagaagct agaagaaggg ctgcgggccc cacctcacaa cccagaccag
       61 aagagcagga gaagccggct gggcaggggg agccagcgtt gtgcctctcg agccatgggc
      121 catagggaac cacaatccgc aagcctgtgc agaagtaggt gagtcttgga gctgttgacc
      181 tgcactgagc tgtccccata tcttccctgg tagtcactgg catggcctgg ctagtgctat
      241 caggtatact actatgcatg ttgggtgctg gattgggcac ttcagacttg gaggatgttc
      301 tgcctcctgc tccccacaac tgccccgata tatgcatctg tgctgccgat gtgttgagct
      361 gtgcgggccg tgggttacag gacttgccgg tagcactgcc taccactgct gcagaactcg
      421 atttgagcca caacgcactc aaacgcctgc acccggggtg gttagcgccc ctctcccggc
      481 tgcgtgcctt gcacctaggc tataataagc tggaagtcct gggccatggt gcgttcacca
      541 atgccagtgg cctgaggaca cttgacctgt cctctaatat gttaaggatg ctccataccc
      601 atgacctgga tggcctggag gagctggaga agttacttct gttcaataac agcctgatgc
      661 acttggacct ggatgccttc cagggcctgc gcatgcttag ccacctctat ctcagctgca
      721 acgagctctc ctctttctct ttcaaccact tgcacggtct ggggttaacc cgcctgcgga
      781 ctctggacct ctcctccaac tggctgaaac atatctccat ccctgagttg gctgcactgc
      841 caacttatct caagaacagg ctctacctgc acaacaaccc gctgccctgt gactgcagcc
      901 tctaccacct gctccggcgc tggcaccagc ggggcctgag tgccctgcat gattttgaac
      961 gcgagtacac atgcttggtc tttaaggtgt cagagtcccg agtgcgcttt tttgagcaca
     1021 gccgggtctt caagaactgc tctgtggctg cagctccagg cttagagctg cctgaagagc
     1081 agctgcacgc gcaggtgggc cagtccctga ggctcttctg caacaccagt gtgcctgcca
     1141 ctcgggtggc ctgggtctcc ccgaagaatg agctgcttgt ggcgccagcc tctcaggatg
     1201 gtagcatcgc tgtgttggct gatggcagct tagccatagg cagggtgcaa gagcagcacg
     1261 caggcgtctt tgtgtgcctg gccagtgggc cccgcctgca ccacaaccag acacttgagt
     1321 acaatgtgag tgtgcaaaag gctcgccccg agccagagac tttcaacaca ggctttacca
     1381 ccctgctggg ctgtattgtg ggcctggtgc tggtgttgct ctacttgttt gcaccaccct
     1441 gtcgtggctg ctgtcactgc tgtcagcggg cctgccgcaa ccgttgctgg ccccgggcat
     1501 ccagtccact ccaggagctg agcgcacagt cctccatgct tagcactacg ccaccagatg
     1561 cacccagccg caaggccagt gtccacaagc atgtggtctt cctggagccg ggcaagaagg
     1621 gcctcaatgg ccgtgtgcag ctcgcagtag ctgaagactt cgatctgtgc aaccccatgg
     1681 gcttgcaact caaggctggc tctgaatcag ccagttccac gggctcagag ggtctcgtga
     1741 tgagctagac tgcctgagat ctcctgctgc ttgccctgct tgctgctgca gtctaaagaa
     1801 ctgacctgct ggtggggcgt gctgtgcctg gtcccacaac tgcatgtgag ccttgatcct
     1861 actgtaacag ttctaacact agctcaggac aaggtctcag actactagag cctgcttccc
     1921 ctaggaccac agagtgacca aatgtcccat taacattaca gactaagcca atctgataaa
     1981 agccctggca tcagagtctg gggaccaccc ccaggagtta atgcagatgt cagggtgtgg
     2041 tatagaagag tcaagcatac cacacttccc ctccctgccc ggagggaact ggcagctcag
     2101 aagatccagc ttccactctg agatggaagg aggaaatgag ccttccctgt actgaaagag
     2161 gacccagtct gctgccaccc agcctcctga aagctttgca actcctgtgg agtctggtgg
     2221 gcatacacac ctacaggacc ctcctacaga gtagccctgc tgtcttcagc tacaggcaga
     2281 cccaatccct aaggctcaca acccagcagg aaaaagcata gataggtgac taacctggga
     2341 ctcttgtctt tggagagcag gaggcctctc aagagctggc actcatctca acctaatggc
     2401 taaacagagc cctcagggca tgcgccctgc acacccactg gggtgggtgt ggaagacggt
     2461 cagtgcctgc ccaatgatga gctggcagca ctgtgctgtc tgactgctat gacattttgt
     2521 aataaaagtg gtacatgatc atcaaaaaa
//
