LOCUS       NM_001164602            2839 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adhesion molecule with Ig like domain 2 (Amigo2),
            transcript variant 3, mRNA.
ACCESSION   NM_001164602
VERSION     NM_001164602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2839)
  AUTHORS   Raja,R., Dumontier,E., Phen,A. and Cloutier,J.F.
  TITLE     Insertion of a neomycin selection cassette in the Amigo1 locus
            alters gene expression in the olfactory epithelium leading to
            region-specific defects in olfactory receptor neuron development
  JOURNAL   Genesis 62 (2), e23594 (2024)
   PUBMED   38590146
REFERENCE   2  (bases 1 to 2839)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2839)
  AUTHORS   Company,V., Murcia-Ramon,R., Andreu-Cervera,A., Aracil-Pastor,P.,
            Almagro-Garcia,F., Martinez,S., Echevarria,D. and Puelles,E.
  TITLE     Adhesion molecule Amigo2 is involved in the fasciculation process
            of the fasciculus retroflexus
  JOURNAL   Dev Dyn 251 (11), 1834-1847 (2022)
   PUBMED   35727300
  REMARK    GeneRIF: Adhesion molecule Amigo2 is involved in the fasciculation
            process of the fasciculus retroflexus.
REFERENCE   4  (bases 1 to 2839)
  AUTHORS   Soto,F., Shen,N. and Kerschensteiner,D.
  TITLE     AMIGO1 Promotes Axon Growth and Territory Matching in the Retina
  JOURNAL   J Neurosci 42 (13), 2678-2689 (2022)
   PUBMED   35169021
REFERENCE   5  (bases 1 to 2839)
  AUTHORS   Williams Avram,S.K., Lee,H.J., Fastman,J., Cymerblit-Sabba,A.,
            Smith,A., Vincent,M., Song,J., Granovetter,M.C., Lee,S.H.,
            Cilz,N.I., Stackmann,M., Chaturvedi,R. and Young,W.S.
  TITLE     NMDA Receptor in Vasopressin 1b Neurons Is Not Required for
            Short-Term Social Memory, Object Memory or Aggression
  JOURNAL   Front Behav Neurosci 13, 218 (2019)
   PUBMED   31787886
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2839)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   7  (bases 1 to 2839)
  AUTHORS   Laeremans,A., Nys,J., Luyten,W., D'Hooge,R., Paulussen,M. and
            Arckens,L.
  TITLE     AMIGO2 mRNA expression in hippocampal CA2 and CA3a
  JOURNAL   Brain Struct Funct 218 (1), 123-130 (2013)
   PUBMED   22314660
  REMARK    GeneRIF: Report AMIGO2 mRNA expression in CA2/Ca3a hippocampal
            region of mouse brain.
REFERENCE   8  (bases 1 to 2839)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   9  (bases 1 to 2839)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
  REMARK    GeneRIF: Expression of ali1 promotes depolarization-dependent
            survival of cerebellar granule neurons. Mouse ali1 mapped to a
            chromosome 15 locus syntenic to candidate loci for familial
            Alzheimer's disease type 5 and Parkinson's disease 8 on human
            chromosome 12.
REFERENCE   10 (bases 1 to 2839)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102914.9 and CK623441.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.195066.1,
                                           SRR1660811.48814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC102914.9         57344-57394         c
            52-686              CK623441.1         1-635
            687-2839            AC102914.9         54181-56333         c
FEATURES             Location/Qualifiers
     source          1..2839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 52.91 cM"
     gene            1..2839
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /note="adhesion molecule with Ig like domain 2"
                     /db_xref="GeneID:105827"
                     /db_xref="MGI:MGI:2145995"
     exon            1..315
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..2839
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1933
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /note="amphoterin induced gene and ORF 2;
                     amphoterin-induced protein 2; alivin 1"
                     /codon_start=1
                     /product="amphoterin-induced protein 2 precursor"
                     /protein_id="NP_001158074.1"
                     /db_xref="CCDS:CCDS27780.1"
                     /db_xref="GeneID:105827"
                     /db_xref="MGI:MGI:2145995"
                     /translation="MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSASGMCPTAC
                     ICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLILRHN
                     NITSISTGSFSTTPNLKCLDLSSNRLKSVKSATFQELKALEVLLLYNNHISYLDPAAF
                     GGLSHLQKLYLSGNFLTQFPMDLYTGRFKLADLTFLDVSYNRIPSIPMHHINLVPGRQ
                     LRGIYLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDSRHSHQLQLLQE
                     SFLNCSYSVINGSFHALGFIHEAQVGERAIVHCDSKTGNGNTDFIWVGPDNRLLEPDK
                     DMGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHAH
                     EAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKAKRQKNTLSQSSAHSSILSPGPTG
                     DASADDRKAGKRVVFLEPLKDTAAGQNGKVKLFPSETVIAEGILKSTRAKSDSDSVNS
                     VFSDTPFVAST"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2611
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /note="major polyA site"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /note="hexamer: AATACA"
     polyA_site      2793
                     /gene="Amigo2"
                     /gene_synonym="Ali1; AMIGO-2"
                     /note="major polyA site"
ORIGIN      
        1 gcacgggata aaaggcgggc ggcgggcgcg ggagcccggg ccctgcagcc tgcgagcgcc
       61 accggcgggc cggcttcccc cgccgcccac cccgctcccg gcgcggccga gctccggcgg
      121 tacctgcagc cgagcgagag agccggggag cccgcgccgc tgcctcgaaa ctcgccaaag
      181 ttgagaggct gccgcccacc gggagctgga gggaaggtgc gagcgcgcgg ggcgcaaacc
      241 ggcaggcgga cgcgcggacc ttccgagcgc accgccgtcg gcggcctctc cgagccgctg
      301 cggcttccca gcgctattgg tgggagactg agctgatgag aagcgactgg caagagactc
      361 agaggcgacc ataatgtcgt taaggttcca cacactgccc accctgccta gagctgtcaa
      421 accgggttgc agagagctgc tgtgtctgtt ggtgatcgca gtgatggtga gccccagcgc
      481 ctcaggaatg tgccccactg cttgcatctg tgccaccgac attgtcagct gcaccaacaa
      541 aaacctatct aaggtgcccg ggaacctttt cagactgatt aaaagactgg atctgagcta
      601 taacagaatc ggactgttgg atgccgactg gatcccggtg tcgtttgtca agctgagcac
      661 cttaattctt cgccacaaca acatcaccag catctccacg ggcagtttct ccacaacccc
      721 aaatttaaag tgtctggact tatcatccaa taggctgaag tcggtaaaga gtgccacatt
      781 ccaagagctg aaggctctgg aagtactgct gctgtacaac aaccacattt cctatctgga
      841 ccccgcagcg ttcggggggc tttcccactt gcagaaactc tatctgagtg ggaactttct
      901 cacacagttc cctatggatt tgtatactgg gaggttcaag ctggctgatc tgacattttt
      961 agatgtttcc tataatcgaa tcccttccat accgatgcac catataaact tagtgccggg
     1021 gagacagctg agaggcatct accttcacgg gaacccattt gtatgtgact gttctctgta
     1081 ctcgttgctg atcttttggt accgtaggca ctttagctcc gtgatggatt ttaagaatga
     1141 ctatacctgt cgcctgtggt ctgactccag gcactcccac cagctgcagc tgctccagga
     1201 gagctttctg aactgttctt acagcgttat caacggctcc ttccacgcac ttggctttat
     1261 ccacgaggct caggttgggg agagggcgat cgtccactgt gacagcaaga ctggcaatgg
     1321 aaatactgat ttcatctggg tcggtcccga taacaggctg ctggagccag ataaagacat
     1381 ggggaacttt cgtgtgtttt acaacggaag tctggtcata gagaaccctg gctttgagga
     1441 cgccggggta tattcttgta tcgcaatgaa caggcagcgg ctgttaaacg agacggtgga
     1501 tatcatgatc aacgtgagca atttcaccat aaacagatcc cacgcccacg aggcgtttaa
     1561 cacggccttt accaccctgg ctgcctgcgt ggccagtata gttctagtgc tactgtatct
     1621 gtacctgacg ccgtgcccat gcaaatgcaa agccaagaga cagaaaaaca cgctgagcca
     1681 aagcagtgcc cactcgtcca ttctcagtcc tggccccact ggcgatgcct ctgctgacga
     1741 tcggaaggca ggtaaaagag tcgtgtttct ggagcccctg aaggacacgg cggccggaca
     1801 gaatggcaaa gtcaagcttt tccccagtga gaccgttata gccgagggca tcttaaagtc
     1861 caccagggca aagtctgact cagactcagt caattccgtg ttctcagaca caccctttgt
     1921 ggcatccact tagctgggtg cctgtgttcg tctggtgtcg tgatttaaag tctccctgct
     1981 ttaactttgg tccgaagaat taatagcagg acggggtgaa aaccctattt tgtcttttga
     2041 gatgaaacca aatggtgtct ttttaagatg gttgctagga agtgaggcag agcacactgg
     2101 ttgcttcttg gactgggtca ggagacggtt gagtttgaga gttttgagta acagcatctt
     2161 agccttcagc atcgccgagg atttcaaagc tgccttgaag gcagtaggac cagccattat
     2221 ctctttattt ggttatcttg aaggaaaaat ggagctatgt gttagcattc tttaaaaata
     2281 gactcttttt gacttactag aaccaaagtt gagctgagct tttttttttc ttttaaagaa
     2341 aaacattagt ggcttctttc ccttttaaaa gatatagaag gaagaattgg ctatttataa
     2401 agcataaagt tagcatagag gtttttcagc caaaatcatc atttcagacc agaatgacaa
     2461 acttataaca tccacagggt tctgccacat cccatgtagt gcaaagggac atttagctgt
     2521 ttagctgtct tctccgtcct cgctgtcctg aataccctgg tacaaaagat ctcgctgaaa
     2581 cattaaagat gtcattattt gttgcaaaga atatgtgtca gtaccgaaat gtctgagtaa
     2641 ctccctaaac cttcatcgta gcagactcac ggctgtccgt ctgcttgtgt atctgtagaa
     2701 ccttaagtta tgtgaatggc tgagtagacc ctaatgtgct gtgtttcagg catttaaatc
     2761 catgcaaata catacacgtg ctctgtgact ttatgcttga gttgcctatt taccgatgca
     2821 acctgaaatg ttgaacgtg
//
