LOCUS       NM_146137               5514 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus adhesion molecule with Ig like domain 1 (Amigo1),
            transcript variant 1, mRNA.
ACCESSION   NM_146137
VERSION     NM_146137.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5514)
  AUTHORS   Raja,R., Dumontier,E., Phen,A. and Cloutier,J.F.
  TITLE     Insertion of a neomycin selection cassette in the Amigo1 locus
            alters gene expression in the olfactory epithelium leading to
            region-specific defects in olfactory receptor neuron development
  JOURNAL   Genesis 62 (2), e23594 (2024)
   PUBMED   38590146
REFERENCE   2  (bases 1 to 5514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5514)
  AUTHORS   Soto,F., Shen,N. and Kerschensteiner,D.
  TITLE     AMIGO1 Promotes Axon Growth and Territory Matching in the Retina
  JOURNAL   J Neurosci 42 (13), 2678-2689 (2022)
   PUBMED   35169021
REFERENCE   4  (bases 1 to 5514)
  AUTHORS   Zhao,X., Rouhiainen,A., Li,Z., Guo,S. and Rauvala,H.
  TITLE     Regulation of Neurogenesis in Mouse Brain by HMGB1
  JOURNAL   Cells 9 (7), 1714 (2020)
   PUBMED   32708917
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5514)
  AUTHORS   Li,L., Ruan,X., Wen,C., Chen,P., Liu,W., Zhu,L., Xiang,P.,
            Zhang,X., Wei,Q., Hou,L., Yin,B., Yuan,J., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     The COMPASS Family Protein ASH2L Mediates Corticogenesis via
            Transcriptional Regulation of Wnt Signaling
  JOURNAL   Cell Rep 28 (3), 698-711 (2019)
   PUBMED   31315048
REFERENCE   6  (bases 1 to 5514)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   7  (bases 1 to 5514)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 5514)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
REFERENCE   9  (bases 1 to 5514)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
REFERENCE   10 (bases 1 to 5514)
  AUTHORS   Ramamoorthy,S., Leibach,F.H., Mahesh,V.B., Han,H., Yang-Feng,T.,
            Blakely,R.D. and Ganapathy,V.
  TITLE     Functional characterization and chromosomal localization of a
            cloned taurine transporter from human placenta
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 893-900 (1994)
   PUBMED   8010975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671854.14.
            
            On Aug 26, 2022 this sequence version replaced NM_146137.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173118.1, BC010598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AL671854.14        129737-130054
            319-5514            AL671854.14        130467-135662
FEATURES             Location/Qualifiers
     source          1..5514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.86 cM"
     gene            1..5514
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /note="adhesion molecule with Ig like domain 1"
                     /db_xref="GeneID:229715"
                     /db_xref="MGI:MGI:2653612"
     exon            1..318
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /inference="alignment:Splign:2.1.0"
     exon            319..5514
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1893
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; amphoterin-induced protein 1; alivin 2;
                     amphoterin induced gene and ORF (Amigo); AMIGO-1"
                     /codon_start=1
                     /product="amphoterin-induced protein 1 isoform a
                     precursor"
                     /protein_id="NP_666249.2"
                     /db_xref="CCDS:CCDS17753.1"
                     /db_xref="GeneID:229715"
                     /db_xref="MGI:MGI:2653612"
                     /translation="MQPQRDLRGLWLLLLSVFLLLFEVARAGRSVVSCPANCLCASNI
                     LSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFIS
                     SEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQL
                     QKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYL
                     HNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCMHSKKLHNIFSLDFFNCSEYKES
                     AWEAHLGDTLTIRCDTKQQGMTKVWVSPSNEQVLSQGSNGSVSVRNGDLFFKKVQVED
                     GGVYTCYAMGETFNETLSVELKVYNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYL
                     TPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQ
                     GQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV"
     regulatory      4975..4980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /note="hexamer: ATTAAA"
     polyA_site      5007
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /note="major polyA site"
     regulatory      5490..5495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /note="hexamer: CATAAA"
     polyA_site      5514
                     /gene="Amigo1"
                     /gene_synonym="ali2; Amigo"
                     /note="major polyA site"
ORIGIN      
        1 gctcgctgcc cccacgctgc tccctcggct gggatcgcgg cgtctcccgc tcgccgcact
       61 gcttctcgcc tggcccgtgg ctccggaggc ggcagtcgtg ccaggtgggc tcgggtggac
      121 gggcgcggcg gtccgggcgc ggcggcggcg cgggtggaca gcgcggaacc cagcaagttc
      181 ctcgcaggcg atgtcgccgg gcgcgggccc ctacgtacgc tgggcgctgt gacaggccgg
      241 ccggggaggc gcggacgggg gaggccgcga cggagctcct ggactggcca tgggctgaga
      301 cgcatcctcg ccgagcagcc tgtagtgaaa gtgacccttc catactccac cagaacatgc
      361 cggggtgact ccctcccaga tcctgtggcc ttcctcgctc ttcccagtga cactatgcaa
      421 ccccagcgtg acctgcgagg cctctggctc ctgctgctct ccgtgttcct gcttctcttt
      481 gaggtagcca gggccggccg atctgtggtt agttgtcccg ccaactgcct gtgcgccagc
      541 aacatcctca gctgctccaa gcagcagctg cccaatgtgc cccaatcttt gcccagctac
      601 acagcactgc tggacctcag ccacaacaac ttgagcaggc tgcgggccga gtggaccccc
      661 acccggctga ccaacctgca ctccctgctg ctgagccaca accacctgaa cttcatctcc
      721 tccgaggcct tcgtccccgt acccaacctt aggtacttgg acctctcctc caaccatctt
      781 cacacgctgg atgagttcct gttcagcgac ctgcaggcgc tggaagtgct gttgctctac
      841 aataaccaca ttgtggtggt ggaccggaat gcctttgagg acatggccca gctgcagaaa
      901 ctctacttaa gccagaatca gatctctcgc tttcctgtgg aactgatcaa ggatgggaac
      961 aaattaccca aactgatgct cttggatctg tcctccaaca agctgaagaa gttgcccctg
     1021 actgacctgc agaaattgcc agcctgggtc aagaatgggc tatacctgca taacaacccc
     1081 ttggagtgcg actgcaagct ctaccagctc ttttcgcact ggcagtaccg gcagctgagc
     1141 tctgtgatgg acttccagga ggacctgtac tgcatgcact ccaagaagct gcacaacatc
     1201 ttcagcctgg atttcttcaa ttgcagcgag tacaaggaaa gtgcctggga ggctcacctg
     1261 ggagacacct tgaccatcag gtgtgacacc aaacagcaag gcatgaccaa agtgtgggtg
     1321 tccccaagca atgaacaggt gctaagtcag gggtccaatg gctcggtgag cgtgaggaat
     1381 ggcgaccttt tttttaaaaa ggtgcaggtc gaggatgggg gtgtgtatac ctgttacgcc
     1441 atgggggaga ctttcaacga gacactgtct gtggagttga aagtgtataa cttcaccttg
     1501 cacggacacc atgacaccct caacacagcc tacactaccc tggtgggctg tatcctcagt
     1561 gtggttctgg tcctcatata cttgtacctc accccttgcc gctgctggtg tcggggtgtg
     1621 gagaaacctt ccagccacca aggagatagc ctcagctctt ctatgctcag taccacaccc
     1681 aaccacgacc ctatggctgg tggggacaaa gatgatggtt ttgaccggcg ggtggccttc
     1741 ctggaacctg ctggacccgg gcagggtcaa aatggcaaac tcaagccagg caacactctg
     1801 ccggtgcccg aagctacagg caagggccaa cggaggatgt ccgatccaga gtcggtcagc
     1861 tcggtctttt ctgatacacc cattgtggtg tgagcagcgt aggctgatgg ggaggttctg
     1921 ccccaggaga ggtacccctg agggatatga cagggtggaa gagagggctg gatgcccaag
     1981 ggagtgggtt cctcctgacc accagggaat cggtcacagg cgccggagga ggcaagaccc
     2041 cagtgagggt gtggatgctg cgagtttcac ctatggatat cctcaggcag atgccacacc
     2101 cctacccaaa gccttggcta ttctcagtgt gggggagggg gacaggaacg aggaaagggc
     2161 ggaggggagg agcaaattcc ctaaactttt ttgaggtcat ccctagctcc ttaagagaaa
     2221 accatttgaa aaacaatgtt ttttttttct gtctctgccc acccacacct gtgaggttgt
     2281 gtgtgtttgg gggagcctcc acaggagcca tgctgggaag ctgcagtgtc ttctctggtc
     2341 gggaagtcac attgatagct agagaactgg aaacctttgg gaaatgagtc aggaaaaggc
     2401 tgagacctgg atcaataaca ctccctaaag ctgctgggag acttctcact agagccgtct
     2461 tctttccctg ggagtcctga gtgggtggat ctctgcagga gcctggcctc tcgactgtta
     2521 gttatggcag caatgtagga cactgtgtct gtgccttgtc ctggggcagg tggcacagat
     2581 gggtacagaa tgaattaata ggtccctgtc atagcataca acttgtagat agggcataaa
     2641 ttccaggtag gctaattccc tggctggggg aaagctttaa ttagtatttg acttccagtg
     2701 tctgtctgtc aggacaagag tcagggatac tgaggaaaga gcattgtgat ggctgccacc
     2761 actgtggcac aagggctgcc acacttgcta gaagaatggg gaaaccagcc tctttgatgt
     2821 agcagccagc cagacctacc tgattttcca tgtatgccat cccttctgtc aaccttctaa
     2881 tcagctcagg tggggttctg taccttctat agaaggctgc tctgcaaagg agaagtcgga
     2941 aaagcccagt cctgctctgt tagaataggt ctggagatac acaggacctc acatttatct
     3001 tctctgtgct aacaaggctg cctcactcct gcagagtgtg ggggttttgt catctgaagg
     3061 gttggaacct agtggtctct gtcccagaat ggcgatacag agtgtggctt agagttctgt
     3121 gctcccccac cagactggaa ggcaggtagt cttgttacag aggcagaagg ggcactacac
     3181 tttgaaaagt cagtcggaca tcagggcagt tgtagctgtc agagcagagg cacttaaaaa
     3241 caaacccagc cttagcttcc atccaggctc gcaaaatgtt ttgggtacag atatgactgt
     3301 gccctgcatc ctgtgagcat actgcaggcc ccagaggcag ctgttctgag ctttggaaga
     3361 ggggtgggca gggcagaggc gaatgtgttc ccgtgttggt cttttccggt gtcttttctt
     3421 tcccttgttt cctgtggttg gaagtcatcc aggtcctcca gtttcctgac ctgcttttgg
     3481 gattcttaag gggtgttgtt tacctatggg tgagggctgc ctagtgttag gagggcctgt
     3541 caggctgctt ataaggactg gggaagagaa acgaaagtaa acattgtccc gtctgctcct
     3601 gggatctcaa ggctgctgtc catcctttat tagtaaccta gttttgtcaa gagagaggtg
     3661 cagcgattcc ccttaagtag ttgcatgctc ataggtatgc atgctcatag gtatgcatgc
     3721 acgccagcac cttgacctcc accaggacag tgagtctgcg gccctctctg atgccaccat
     3781 ttctagaacg gcctccaccc ccagcgcaca acttctcaca cacagttttc ttgcactgca
     3841 ggagagacag tgaccatgcc aggctcctca aatgcacaat ctcttgtact tttaatttct
     3901 gaacatcctg aacttttttg cccatatctc catggagctg aaccactttt ctgcagatgt
     3961 ggagttaggg ggaccacacg ctggagcctt tgggagaagg ggggtgaggt actagctagt
     4021 tcatcagact cctctgaaac cctcctaaaa acctacattc ttgtaagaca gggggctagg
     4081 gccagagtaa tgaggactcc aaaggatcct ggcagaggct aagcagctct gagttgttct
     4141 tcctgtgtcc taatagacaa gggttggaga ggaaccagtt gtattccaaa gacttctggg
     4201 gactttgtca ccagaggttg aagaaccaga cctccaccct caaactcctc agggaatgag
     4261 aaaatctttt aggtggcaga atcctctcct gacaccatcg cgggctgtga gactctttaa
     4321 aatggaggtc aaatgaagtt tgccttctgg agcattctag ctgagctccc aaggaccagg
     4381 agggtcattt tctttttaag tcctgctcca cagcctaact ctccctacta catccactaa
     4441 cttggacccc agttcaagac acctgcagga catgtctgga tgctccacca aaaaccattt
     4501 aactgattgg tctcaccttg atttcagttc ttataaccca atggtagctt tgtccttgta
     4561 ggtgtaggtg gggtgtatgt gtgtatccat attccgcata tatgatccca ttagaccttg
     4621 ggaagaaaac agccacgtgt agatataaga aaggatagcc ttcacctcat ctgtacccat
     4681 aaactgtatc acccagaaag gaaaagcagg attctctgga gacaggatgt gacagggctc
     4741 tacggtttgt gtaattatct gtgatttttt tctttgctgt tatctatggg gcccctgaaa
     4801 gaggccagga aagggtagac ctgtctgagg agaacaaagc caattttcca ggtttatgtt
     4861 tgttcttgcc ttgtaattct tttttttttt tctgtgtcta ggactcttcc ccccactgtg
     4921 tacaccaggc tggcaaacct cagagcccat gggctctata actagacaat gaccattaaa
     4981 cctggcttga gtctctgctc tggcacagtt tgtggttggt ttatttacct tagcatatgg
     5041 gtgggttccg tatactgaaa aagggtgtga catcatcaaa ttagcagaga gtctcttcta
     5101 agtgttgtta tctgcatcat ctaggaaact aagtataaaa tctgaatcat ccaggcatta
     5161 agattagaga agagaatggc aaactttttc tctcaagcca gacagtaaat attttgggcc
     5221 gtagaggatt caccatctat tagacctcca ctgcactgcc atagcaggca aacatccaca
     5281 gacagtgtac agatgaatca ccatggttct gtcccagtat agcagtctgt ttgcgggagg
     5341 gaaatgccca aggcagagcg ttttataagg gagaagaggt ttacgtagct tacagttttg
     5401 gaggatggaa gttgaagatc cggttgttca tgtcatgagg gccatggtgt gtgtcattac
     5461 aataatggga ggaaatgcag aagggatcac ataaagagat agggtgaaag acaa
//
