LOCUS       NM_144547               1947 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2),
            transcript variant 1, mRNA.
ACCESSION   NM_144547
VERSION     NM_144547.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1947)
  AUTHORS   Smith,E.R., Ye,D., Luo,S., Xu,I.R.L. and Xu,X.X.
  TITLE     AMH regulates a mosaic population of AMHR2-positive cells in the
            ovarian surface epithelium
  JOURNAL   J Biol Chem 300 (11), 107897 (2024)
   PUBMED   39424141
REFERENCE   2  (bases 1 to 1947)
  AUTHORS   Granados-Aparici,S., Yang,Q. and Clarke,H.J.
  TITLE     SMAD4 promotes somatic-germline contact during murine oocyte growth
  JOURNAL   Elife 13, 91798 (2024)
   PUBMED   38819913
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1947)
  AUTHORS   Douglas,J.C., Sekulovski,N., Arreola,M.R., Oh,Y., Hayashi,K. and
            MacLean,J.A. 2nd.
  TITLE     Normal Ovarian Function in Subfertile Mouse with Amhr2-Cre-Driven
            Ablation of Insr and Igf1r
  JOURNAL   Genes (Basel) 15 (5), 616 (2024)
   PUBMED   38790245
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1947)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1947)
  AUTHORS   Tscherner,A.K., McClatchie,T., Kaboba,G., Boison,D. and Baltz,J.M.
  TITLE     Oocyte-Specific Deletion of Slc6a9 Encoding the GLYT1 Glycine
            Transporter Eliminates Glycine Transport in Mouse Preimplantation
            Embryos and Their Ability to Counter Hypertonic Stress
  JOURNAL   Cells 12 (20), 2500 (2023)
   PUBMED   37887344
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1947)
  AUTHORS   Kunieda,T., Ojika,I. and Katoh,H.
  TITLE     The gene encoding anti-mullerian hormone type 2 receptor maps to
            mouse chromosome 15
  JOURNAL   Mamm Genome 9 (3), 259 (1998)
   PUBMED   9501316
REFERENCE   7  (bases 1 to 1947)
  AUTHORS   Mishina,Y., Tizard,R., Deng,J.M., Pathak,B.G., Copeland,N.G.,
            Jenkins,N.A., Cate,R.L. and Behringer,R.R.
  TITLE     Sequence, genomic organization, and chromosomal location of the
            mouse Mullerian-inhibiting substance type II receptor gene
  JOURNAL   Biochem Biophys Res Commun 237 (3), 741-746 (1997)
   PUBMED   9299437
REFERENCE   8  (bases 1 to 1947)
  AUTHORS   Chen,J.Y., Chang,C.Y., Chen,J.C., Shen,S.C. and Wu,J.L.
  TITLE     Production of biologically active recombinant tilapia insulin-like
            growth factor-II polypeptides in Escherichia coli cells and
            characterization of the genomic structure of the coding region
  JOURNAL   DNA Cell Biol 16 (7), 883-892 (1997)
   PUBMED   9260931
REFERENCE   9  (bases 1 to 1947)
  AUTHORS   Mishina,Y., Rey,R., Finegold,M.J., Matzuk,M.M., Josso,N., Cate,R.L.
            and Behringer,R.R.
  TITLE     Genetic analysis of the Mullerian-inhibiting substance signal
            transduction pathway in mammalian sexual differentiation
  JOURNAL   Genes Dev 10 (20), 2577-2587 (1996)
   PUBMED   8895659
REFERENCE   10 (bases 1 to 1947)
  AUTHORS   Visser,J.A., McLuskey,A., van Beers,T., Weghuis,D.O., van
            Kessel,A.G., Grootegoed,J.A. and Themmen,A.P.
  TITLE     Structure and chromosomal localization of the human anti-mullerian
            hormone type II receptor gene
  JOURNAL   Biochem Biophys Res Commun 215 (3), 1029-1036 (1995)
   PUBMED   7488027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868995.1, BC119571.1, CJ194934.1 and BB052908.1.
            
            On Sep 28, 2009 this sequence version replaced NM_144547.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503863.1, BC119571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB868995.1         2-48
            48-69               BB868995.1         50-71
            70-1868             BC119571.1         1-1799
            1869-1870           CJ194934.1         402-403
            1871-1947           BB052908.1         213-289
FEATURES             Location/Qualifiers
     source          1..1947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.58 cM"
     gene            1..1947
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /note="anti-Mullerian hormone type 2 receptor"
                     /db_xref="GeneID:110542"
                     /db_xref="MGI:MGI:105062"
     exon            1..156
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1814
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /EC_number="2.7.11.30"
                     /note="anti-Muellerian hormone type-2 receptor; AMH type
                     II receptor; anti-Muellerian hormone type II receptor; MIS
                     type II receptor; anti-Mullerian hormone type 2 receptor
                     delta 9/10; anti-Mullerian hormone type 2 receptor delta
                     2"
                     /codon_start=1
                     /product="anti-Muellerian hormone type-2 receptor
                     precursor"
                     /protein_id="NP_653130.2"
                     /db_xref="CCDS:CCDS27882.1"
                     /db_xref="GeneID:110542"
                     /db_xref="MGI:MGI:105062"
                     /translation="MLGTLGLWTLLPAAAQVSPNRRTCVFFEAPGVRGSTKTLGEMVD
                     AGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCRDSDEPGCESLHCDPVPRAHPNP
                     SSTLFTCSCGTDFCNANYSHLPPSGNQGAPGPQEPQATPGGPVWMALLLLGMFLVLLL
                     SSIILALLQRKACRVQGGSDPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRL
                     QGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQGGPGPLPSGPLLVLE
                     LYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQN
                     VLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTL
                     DLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELW
                     ALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPH
                     GASSFPESPQGCPENCLSAPASAVFPCRPQQSSCLLSVQQGPGSRSPDPVGDTVQVYV
                     NE"
     exon            157..339
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            340..531
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            532..603
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            604..716
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            717..947
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1062
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1235
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1383
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1520
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1947
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /note="hexamer: AATAAA"
     polyA_site      1939
                     /gene="Amhr2"
                     /gene_synonym="C14; Misiir; Misrii; Mrii"
                     /note="major polyA site"
ORIGIN      
        1 gaaggcttgg aagccccaca gtgccctgta tttgtaggaa gccttggctg aggtagctgt
       61 gctggttttt gctggtttat gctgtccagc tggcatcctt ttgcaggatg ctggggacac
      121 tggggctttg gacactgctt cctgcggcag cacaagtatc cccaaacagg aggacctgtg
      181 tgttctttga ggctcctgga gtgcggggaa gcacaaagac actgggggaa atggtagatg
      241 caggaccagg cccccccaag ggtatccgct gcctctacag ccattgctgc tttgggatct
      301 ggaatcttac ccatggccgg gcacaagtgg agatgcaagg atgccgagac agtgatgagc
      361 caggctgtga gtccctccac tgtgacccag tccccagagc ccacccgaac cccagctcca
      421 cactcttcac gtgttcctgt ggcactgact tctgcaatgc caattacagc catctgcctc
      481 cttcgggaaa ccaaggggct cctggccccc aggagcccca ggctacccca ggtgggcccg
      541 tctggatggc actgctgctc ctgggaatgt ttctcgtgtt gttgctgagt agcatcatct
      601 tggccctgct acaacgaaag gcctgcagag tgcaaggtgg gtcagaccca gagcccggct
      661 caggcggaga ctgcagtgag gaactgccag agctggccga gctgcgtttc tcccaggtaa
      721 tccaggaagg aggtcatgca gtcgtctggg ccgggaggct tcagggtgag atggtagcca
      781 tcaaggcctt ccccccaagg gctgtggccc agttccgagc tgagagggct gtgtaccagc
      841 tgctaggcct acagcatgac catatcgttc gctttatcac tgctggccag ggaggccctg
      901 gccctctgcc ctctgggcct ttgctggtac tggaactgta ccctaagggc tccttatgcc
      961 actacttgac tcagtacacg agcgactggg gaagttcctt gaggatggct ctgtccctgg
     1021 cagagggctt ggcttttctc cacgaggagc gttggcagga tggccagtac aaaccaggta
     1081 tcgcccaccg agacctgagc agccagaatg tgctcattcg ggaagatagg tcatgcgcca
     1141 tcggggacct gggccttgcc ttggtactcc ctggtcttgc tcagccccct gccttggccc
     1201 ctactcaacc ccgaggcccc gctgccattt tggaggctgg cacccagcgg tacatggctc
     1261 cagagctctt ggacaagact ctagacttgc aggactgggg tacagctctc cagagagcgg
     1321 atgtttactc tctggcgcta ctactgtggg agatcctgag ccgctgttcc gatttgaggc
     1381 ctgaccacag accaccacct ttccaattgg cttatgaggc agaactgggc agcaatccca
     1441 gtgcctgtga gctctgggcc ctggcagtgg aggagaggaa gcgccccaac atcccatcca
     1501 cttggagctg ctctgccaca gaccctcggg ggctgaggga gctcctggaa gattgctggg
     1561 acgcagaccc agaagcacgg ctgacagctg agtgtgtgca gcagcgcctg gcagccctgg
     1621 cttaccctca cggggcgtcc tctttcccag agagtccaca gggctgccca gagaactgcc
     1681 tttcagctcc cgcctctgcc gttttcccct gtcggcctca gcagagttct tgtctcctca
     1741 gtgttcagca aggccctggc tctaggagtc ccgatcctgt aggcgacact gttcaggtgt
     1801 atgtaaatga gtagcttgtt tgaactctct gtacaggccg acatgcgtgt ggccgacatg
     1861 cctactgctg tcattctctg tgggtttcta acccatgggg tagatatgct caggaaagag
     1921 aataaataag gttcccgcac actcttc
//
