LOCUS       NM_007445               1704 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus anti-Mullerian hormone (Amh), mRNA.
ACCESSION   NM_007445
VERSION     NM_007445.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1704)
  AUTHORS   Smith,E.R., Ye,D., Luo,S., Xu,I.R.L. and Xu,X.X.
  TITLE     AMH regulates a mosaic population of AMHR2-positive cells in the
            ovarian surface epithelium
  JOURNAL   J Biol Chem 300 (11), 107897 (2024)
   PUBMED   39424141
REFERENCE   2  (bases 1 to 1704)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 1704)
  AUTHORS   Hurtado,A., Mota-Gomez,I., Lao,M., Real,F.M., Jedamzick,J.,
            Burgos,M., Lupianez,D.G., Jimenez,R. and Barrionuevo,F.J.
  TITLE     Complete male-to-female sex reversal in XY mice lacking the
            miR-17~92 cluster
  JOURNAL   Nat Commun 15 (1), 3809 (2024)
   PUBMED   38714644
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1704)
  AUTHORS   Lecot-Connan,T., Boumerdassi,Y., Magnin,F., Binart,N.,
            Kamenicky,P., Sonigo,C. and Beau,I.
  TITLE     Anti-Mullerian hormone induces autophagy to preserve the primordial
            follicle pool in mice
  JOURNAL   FASEB J 38 (5), e23506 (2024)
   PUBMED   38411466
  REMARK    GeneRIF: Anti-Mullerian hormone induces autophagy to preserve the
            primordial follicle pool in mice.
REFERENCE   5  (bases 1 to 1704)
  AUTHORS   Ming,Z., Bagheri-Fam,S., Frost,E.R., Ryan,J.M. and Harley,V.R.
  TITLE     A role for TRPC3 in mammalian testis development
  JOURNAL   Front Cell Dev Biol 12, 1337714 (2024)
   PUBMED   38425503
  REMARK    Erratum:[Front Cell Dev Biol. 2024 Oct 15;12:1484634. doi:
            10.3389/fcell.2024.1484634.. PMID: 39474354]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1704)
  AUTHORS   Behringer,R.R., Finegold,M.J. and Cate,R.L.
  TITLE     Mullerian-inhibiting substance function during mammalian sexual
            development
  JOURNAL   Cell 79 (3), 415-425 (1994)
   PUBMED   7954809
REFERENCE   7  (bases 1 to 1704)
  AUTHORS   Munsterberg,A. and Lovell-Badge,R.
  TITLE     Expression of the mouse anti-mullerian hormone gene suggests a role
            in both male and female sexual differentiation
  JOURNAL   Development 113 (2), 613-624 (1991)
   PUBMED   1782869
REFERENCE   8  (bases 1 to 1704)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   9  (bases 1 to 1704)
  AUTHORS   Knebelmann,B., Boussin,L., Guerrier,D., Legeai,L., Kahn,A.,
            Josso,N. and Picard,J.Y.
  TITLE     Anti-Mullerian hormone Bruxelles: a nonsense mutation associated
            with the persistent Mullerian duct syndrome
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3767-3771 (1991)
   PUBMED   2023927
REFERENCE   10 (bases 1 to 1704)
  AUTHORS   Behringer,R.R., Cate,R.L., Froelick,G.J., Palmiter,R.D. and
            Brinster,R.L.
  TITLE     Abnormal sexual development in transgenic mice chronically
            expressing mullerian inhibiting substance
  JOURNAL   Nature 345 (6271), 167-170 (1990)
   PUBMED   2336108
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC166937.2.
            
            On Feb 22, 2019 this sequence version replaced NM_007445.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate N- and C-terminal cleavage
            products that homodimerize and associate to form a biologically
            active noncovalent complex. This complex binds to the
            anti-Mullerian hormone receptor type 2 and causes the regression of
            Mullerian ducts in the male embryo that would otherwise
            differentiate into the uterus and fallopian tubes. This protein
            also plays a role in Leydig cell differentiation and function and
            follicular development in adult females. Homozygous knockout male
            mice develop female reproductive organs and are often sterile,
            while homozygous knockout female mice exhibit premature depletion
            of primordial follicles. [provided by RefSeq, Jul 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY911505.1, BC150477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AC166937.2         79058-79468         c
            412-554             AC166937.2         78542-78684         c
            555-663             AC166937.2         78256-78364         c
            664-823             AC166937.2         78009-78168         c
            824-1704            AC166937.2         77029-77909         c
FEATURES             Location/Qualifiers
     source          1..1704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1704
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /note="anti-Mullerian hormone"
                     /db_xref="GeneID:11705"
                     /db_xref="MGI:MGI:88006"
     exon            1..411
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1673
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /note="muellerian-inhibiting factor; anti-Muellerian
                     hormone; muellerian-inhibiting substance; Mullerian
                     inhibiting substance"
                     /codon_start=1
                     /product="muellerian-inhibiting factor precursor"
                     /protein_id="NP_031471.2"
                     /db_xref="CCDS:CCDS24033.1"
                     /db_xref="GeneID:11705"
                     /db_xref="MGI:MGI:88006"
                     /translation="MQGPHLSPLVLLLATMGAVLQPEAVENLATNTRGLIFLEDELWP
                     PSSPPEPLCLVTVRGEGNTSRASLRVVGGLNSYEYAFLEAVQESRWGPQDLATFGVCS
                     TDSQATLPALQRLGAWLGETGEQQLLVLHLAEVIWEPELLLKFQEPPPGGASRWEQAL
                     LVLYPGPGPQVTVTGTGLRGTQNLCPTRDTRYLVLTVDFPAGAWSGSGLILTLQPSRE
                     GATLSIDQLQAFLFGSDSRCFTRMTPTLVVLPPAEPSPQPAHGQLDTMPFPQPGLSLE
                     PEALPHSADPFLETLTRLVRALRGPLTQASNTQLALDPGALASFPQGLVNLSDPAALG
                     RLLDWEEPLLLLLSPAAATEREPMPLHGPASAPWAAGLQRRVAVELQAAASELRDLPG
                     LPPTAPPLLARLLALCPNDSRSSGDPLRALLLLKALQGLRAEWHGREGRGRTGRSAGT
                     GTDGPCALRELSVDLRAERSVLIPETYQANNCQGACAWPQSDRNPRYGNHVVLLLKMQ
                     ARGAALGRLPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCR"
     exon            412..554
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     exon            555..663
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     exon            664..823
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1704
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaccaccat gcaggggcca cacctctctc cactggtact gctgctagcg actatggggg
       61 ctgtgttaca gcctgaggcg gttgaaaacc tggccaccaa taccaggggc ctcatcttcc
      121 ttgaagatga gctctggccc cccagcagcc cccctgaacc tttgtgcctg gtgacagtga
      181 gaggagaggg gaacacaagc agagcttccc tgagggtggt ggggggtctg aacagctatg
      241 agtatgcctt cctggaggct gtccaggagt ctcgctgggg accccaagac ctggccacct
      301 tcggagtctg cagcactgac tcccaggcta ccctgcctgc cctgcagcgc cttggggcct
      361 ggctagggga gactggagaa cagcagttgc tagtcctaca tctggctgaa gtgatatggg
      421 agcccgagct cttgctgaag ttccaagagc ctccacctgg gggagccagc cgctgggagc
      481 aggccctgtt agtgctatac cctggaccag gcccccaggt cacagtcaca gggactggac
      541 tgcggggcac acagaacctc tgccctactc gggacacccg ctatttggtg ctaaccgtgg
      601 acttcccagc gggggcctgg agcggctcgg gcctcatctt aacccttcaa ccaagcagag
      661 aaggtgccac cctgagcatc gatcagctgc aagcctttct atttggctct gattcccgct
      721 gtttcacgcg gatgactccc accctggtgg tgctgccacc cgccgagccg tcaccgcagc
      781 cagcacacgg ccagctggac accatgcctt tcccgcagcc tggactgtcc ctggagcctg
      841 aggccctgcc acacagcgcc gaccccttcc tagagaccct cactcgcttg gttcgtgctc
      901 tgcggggacc tctgacccag gcttcgaaca cgcaactggc cctggaccct ggtgcgctgg
      961 ccagcttccc acagggcctg gtcaacctgt cagaccccgc agcactggga cgcctgctcg
     1021 actgggagga acccctatta ctgctgctgt cacccgctgc ggccacggag agggaaccta
     1081 tgccgctgca cggccccgct tctgctccct gggcagcggg cctgcaacgc agggtggcag
     1141 tggagctgca ggcggcagcc tcagagctgc gggacctccc gggtctgcca cccacagctc
     1201 ccccgctgct ggcgcgcctg ctagcgctgt gtcccaacga ctcccgcagc tccggggacc
     1261 cgctgcgcgc gctgctgctg ctaaaggcgc tgcagggctt acgtgccgag tggcatgggc
     1321 gggaagggcg tgggagaacg gggcgcagcg cggggacagg gacagacggg ccttgcgcgc
     1381 tgcgcgagct gagtgtagat ctgcgcgcgg agcgttcagt gctcatcccg gagacctacc
     1441 aagccaacaa ctgccaaggc gcctgcgcgt ggccgcagtc tgaccgtaat ccgcgctacg
     1501 ggaaccacgt ggtgctgctg ctaaaaatgc aggctcgcgg ggctgccctg ggccgcctgc
     1561 cctgctgcgt gcccactgcc tacgcgggca agctgctcat cagcctgtcc gaggagcgca
     1621 tcagcgcgca ccacgtgccc aacatggtag ccaccgagtg cggctgccgg tgacgcccgc
     1681 cctcctcctc ccctcccccc cccc
//
