LOCUS       NM_011787               3711 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus autocrine motility factor receptor (Amfr), transcript
            variant 1, mRNA.
ACCESSION   NM_011787 XM_911140
VERSION     NM_011787.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Li,C., Wu,Y., Chen,K., Chen,R., Xu,S., Yang,B., Lian,Z., Wang,X.,
            Wang,K., Xie,H., Zheng,S., Liu,Z., Wang,D. and Xu,X.
  TITLE     Gp78 deficiency in hepatocytes alleviates hepatic
            ischemia-reperfusion injury via suppressing ACSL4-mediated
            ferroptosis
  JOURNAL   Cell Death Dis 14 (12), 810 (2023)
   PUBMED   38065978
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Liu,S., Zhang,Z., Wang,Y., Zhang,Y., Min,J., Li,X. and Liu,S.
  TITLE     The chemokine CCL1 facilitates pulmonary fibrosis by promoting
            macrophage migration and M2 polarization
  JOURNAL   Int Immunopharmacol 120, 110343 (2023)
   PUBMED   37220693
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Sun,L., Zhang,H., Zhang,H., Lou,X., Wang,Z., Wu,Y., Yang,X.,
            Chen,D., Guo,B., Zhang,A. and Qian,F.
  TITLE     Staphylococcal virulence factor HlgB targets the
            endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote
            pneumonia
  JOURNAL   Nat Microbiol 8 (1), 107-120 (2023)
   PUBMED   36593296
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Zhang,H., Wei,R., Yang,X., Xu,L., Jiang,H., Li,M., Jiang,H.,
            Zhang,H., Chen,Z., Qian,F. and Sun,L.
  TITLE     AMFR drives allergic asthma development by promoting alveolar
            macrophage-derived GM-CSF production
  JOURNAL   J Exp Med 219 (5) (2022)
   PUBMED   35333296
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Li,G., Zhao,G., Zhou,X., Schindelin,H. and Lennarz,W.J.
  TITLE     The AAA ATPase p97 links peptide N-glycanase to the endoplasmic
            reticulum-associated E3 ligase autocrine motility factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 103 (22), 8348-8353 (2006)
   PUBMED   16709668
  REMARK    GeneRIF: cytoplasmic protein mouse p97(mp97) participates in the
            formation of a ternary complex containing mouse autocrine motility
            factor receptor (mAMFR), mp97, and peptide N-glycanase
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3711)
  AUTHORS   Onishi,Y., Tsukada,K., Yokota,J. and Raz,A.
  TITLE     Overexpression of autocrine motility factor receptor (AMFR) in
            NIH3T3 fibroblasts induces cell transformation
  JOURNAL   Clin Exp Metastasis 20 (1), 51-58 (2003)
   PUBMED   12650607
REFERENCE   9  (bases 1 to 3711)
  AUTHORS   Park,H., Suzuki,T. and Lennarz,W.J.
  TITLE     Identification of proteins that interact with mammalian
            peptide:N-glycanase and implicate this hydrolase in the
            proteasome-dependent pathway for protein degradation
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11163-11168 (2001)
   PUBMED   11562482
REFERENCE   10 (bases 1 to 3711)
  AUTHORS   Shimizu,K., Tani,M., Watanabe,H., Nagamachi,Y., Niinaka,Y.,
            Shiroishi,T., Ohwada,S., Raz,A. and Yokota,J.
  TITLE     The autocrine motility factor receptor gene encodes a novel type of
            seven transmembrane protein
  JOURNAL   FEBS Lett 456 (2), 295-300 (1999)
   PUBMED   10456327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138118.4.
            
            On Nov 17, 2022 this sequence version replaced NM_011787.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040338.1, AK170716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               AC138118.4         65046-65500
            456-548             AC138118.4         72494-72586
            549-713             AC138118.4         77250-77414
            714-866             AC138118.4         78469-78621
            867-907             AC138118.4         89960-90000
            908-1040            AC138118.4         90213-90345
            1041-1174           AC138118.4         92247-92380
            1175-1285           AC138118.4         92775-92885
            1286-1476           AC138118.4         94217-94407
            1477-1580           AC138118.4         97298-97401
            1581-1715           AC138118.4         101551-101685
            1716-1799           AC138118.4         102900-102983
            1800-1984           AC138118.4         103476-103660
            1985-3711           AC138118.4         104405-106131
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 45.96 cM"
     gene            1..3711
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /note="autocrine motility factor receptor"
                     /db_xref="GeneID:23802"
                     /db_xref="MGI:MGI:1345634"
     exon            1..455
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..2132
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /EC_number="2.3.2.36"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase AMFR; AMF receptor; RING-type E3
                     ubiquitin transferase AMFR"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase AMFR isoform 1"
                     /protein_id="NP_035917.2"
                     /db_xref="CCDS:CCDS22533.1"
                     /db_xref="GeneID:23802"
                     /db_xref="MGI:MGI:1345634"
                     /translation="MPLLFLERFPWPSLRTYTGLSGLALLGTIVSAYRALSQPEDGSG
                     EPEPLTAPLQPEARLTAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIV
                     FGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQL
                     CKDRFEYLSFSPTTPMSSHGRVLSLLIAMLLSCCGLAVVCCVTGYTHGMHTLAFMAAE
                     SLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELALLSLDLMHHIHML
                     LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNN
                     DDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRAREDHQG
                     ENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASN
                     SQLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNILEGRIQVPFPTQRSDSLRP
                     ALNSPVERPSPDLEEGEASVQTERVPLDLSPRLEETLDFSEVELEPIEVEDFEARGSR
                     FSKSADERQRMLVQRKDDLLQQARKRFLNKSSEDDGASERLLPSEGTSSDPVTLRRRM
                     LAAAAERRLQRQRTT"
     exon            456..548
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            549..713
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            714..866
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            867..907
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1040
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1174
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1285
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1476
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1580
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1715
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1799
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1984
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..3711
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3355..3360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /note="hexamer: AATAAA"
     polyA_site      3383
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /note="major polyA site"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /note="hexamer: AATAAA"
     polyA_site      3497
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /note="major polyA site"
     regulatory      3690..3695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amfr"
                     /gene_synonym="gp78"
                     /note="hexamer: AATAAA"
     polyA_site      3711
                     /gene="Amfr"
                     /gene_synonym="gp78"
ORIGIN      
        1 gaggctcttc cgcgccggca ggggcagcag cgggagcggc gcggggcgga gcggcgcgag
       61 cagctaggag cggcccggct cggcccggcg cagcggcggc ggcagcggca gcggcagcga
      121 cgccagagcc cgtgggcgcc tttcgcaagg ccgccgcagg cgcctggccg cagcgcggga
      181 agcctcgggg gccggagccc gtcgctgccg ccatgccgct gctcttcctc gagcgcttcc
      241 cgtggcccag cctccgcacc tacacgggcc tcagcggcct ggccttgctg ggcaccatcg
      301 tcagcgccta ccgcgccctc agtcagccgg aggacggctc gggtgagccg gagccgctaa
      361 cggccccact gcagcccgag gcgcgcctga ccgccggcgg cccccgggcc cgcgacgtgg
      421 cccagtacct gctgtcggac agcctgttcg tgtgggttct ggtgaatact gcttgctgtg
      481 ttttgatgtt ggtggctaag cttatccagt gtattgtgtt cggccctctt cgagtgagtg
      541 aaagacagca tctcaaagac aagttttgga attttatttt ctacaagttc attttcattt
      601 ttggagtgct gaatgtccag actgtggagg aagtggtgat gtggtgcctc tggtttgctg
      661 gacttgtctt cctgcatctg atggttcagc tctgcaaaga cagatttgaa tacctttcct
      721 tttctcccac cactccaatg agcagccatg ggagagtcct gtccctgctg attgctatgc
      781 tgctctcctg ctgtggactg gcagtcgtct gctgtgtcac aggctacaca catggcatgc
      841 acaccttggc tttcatggct gcagagtctc ttcttgtgac cgtgagaaca gctcatgtga
      901 ttttaagata tgtaattcac ctctgggacc tcaaccacga agggacgtgg gaaggaaagg
      961 gaacctatgt gtattacacc gactttgtca tggagctcgc tctcctgtcc ctggacctca
     1021 tgcaccacat ccacatgctg ttatttggca acatctggtt atctatggct agcttggtca
     1081 tctttatgca acttcgttac ctgttccatg aggtacagcg tcgaatccgt cgacacaaga
     1141 attatttgcg agtggtagga aacatggaag ccaggtttgc tgttgcaact ccagaggaac
     1201 tagctgtcaa taatgatgac tgtgcaatct gctgggactc catgcaggct gcaaggaaac
     1261 tgccctgtgg acatcttttt cacaactcct gccttcgttc ttggctagaa caagacacct
     1321 cttgtccaac atgcagaatg tctcttaata ttgctgatgg cagtcgtgcc agggaagacc
     1381 atcaaggaga gaacctggac gagaacttgg ttcctgtagc agctgccgaa ggcaggcctc
     1441 gcttgaacca gcacaatcac ttcttccact tcgatgggtc ccggattgca agctggctgc
     1501 caagtttttc agttgaagtg atgcacacta ccaacattct tggcatcacg caggcaagca
     1561 actctcagct aaatgccatg gctcatcaga ttcaggagat gttccctcag gtcccgtacc
     1621 accttgtgct ccaggacctc cagatgacac gctccgtgga gataacaaca gataacatct
     1681 tagaaggacg gattcaagta cctttcccca cgcagcggtc ggatagcctg aggcctgcac
     1741 tgaacagccc agtggagagg cccagccctg acctggagga gggagaagct tctgtccaga
     1801 cggagcgtgt accactggac ctcagtcctc gcctagagga gaccttggac ttcagtgagg
     1861 tagaactaga gcctattgag gtggaagact ttgaggcccg tggaagccgc ttctccaagt
     1921 ctgctgatga gagacagcgc atgttagttc agcgcaagga tgacctcctg cagcaggctc
     1981 gaaagcggtt cttaaacaaa agttctgaag atgatggggc ctcagagaga ctcctccctt
     2041 ctgaaggcac atcctctgac cccgtgaccc tgcgccgaag gatgctggca gccgctgctg
     2101 agcggagact tcagaggcaa cggacaacct agtgcttcct caccttcctc agcctcctgc
     2161 ccagctctac ctaccggaag aggcctgtcc cagttctgcc tgctgtgtgg agacctgcga
     2221 ctgcattgct gctgcataaa gcatgtggtc tttagtgtgt ggacagctga caaatttaat
     2281 cctttgtaat actttctttg tgacatttct cttcccctta gaaacattgc acattttaac
     2341 tctaggcatg gcctcttctg gtgttgactg gacttgttgg gagtagggga cgagcaaaaa
     2401 gaagtgggca ctggggcgct cgcctgcctg cagcagctag tttgaatttc tgttttgata
     2461 taaaccacag cagatgttga gtattttagc accacagctg gaaggaagca cggatcttgg
     2521 ggagggtgca taacagcagt cagaaggtgc gcagcaggag cctgaccacc actatggcaa
     2581 agtagcctac gattaaatgc tgtgcttagg gaggaggcca gtcccacagg cgcctggacc
     2641 tctagaccag caggacatgg tgtagaaaga actggtttgg tacctggagt agaaagagga
     2701 agctcagggc tgcagaatga ggaggccctt ttctgccctt aacattcagg accaatctga
     2761 gcccagtccc cagctggctt cacttccgtc actctggtgc tctcgcatca cagaagcttg
     2821 cccccatggc tgccgcctct tcctttcctt tggttatgac tttaattcct tggtcaaccc
     2881 aattaggcta tgctaaacat atgggtttga tccttggaaa aaggcatggg gcctgcccag
     2941 caagggcagg ggtgtttgga ggacactgct gaagaaacac ctttcgtatc tttgtccctg
     3001 gagcccttga gttccctgct tttgttcctg tgggtctcat taaacggaaa cagaggatgt
     3061 tgaataatcc acatgcctca agcagactcg gtcccagatc ggctcaaatt ctccacgtat
     3121 ttaaggattt gaaacatgca atcataggat acatagtttt atgtcccatt ggattaaggt
     3181 tttttttttt taatgtttca aaacatagtt ttatggtagt ccttttggga aaaatccagt
     3241 attatctaaa attattggca aagttaaatg tattttacat acctggaagt ttttagactg
     3301 ttgataagta actgagaaag gataacaggc gcctaggtga agataattta tttcaataaa
     3361 tctttcaaaa gccttacctt gaactgctgt tagttaaatt cctgtgggtt tttgttttgt
     3421 tttactttgt tttgctgaga gcgtagcaat ttgtttttat tgtaaagcaa caataataaa
     3481 aaggaaaatc tcttgtagtg tggtgtgggg gcagtggagt cccacgctgc tctgtgtgtg
     3541 ccgtttgggt tggggtttat aatgctgttc aactgggagg ggcgtggttt ataatgctgt
     3601 tcaactggga gggcgtggtc gctcctgtgt tttacttgga ggaggaagca ctgagcttgt
     3661 ctttgacacc tttccaggct gcacatgaaa ataaagggga agctaagtcc a
//
