LOCUS       NM_001081978             828 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus amelogenin, X-linked (Amelx), transcript variant 1,
            mRNA.
ACCESSION   NM_001081978
VERSION     NM_001081978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 828)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   2  (bases 1 to 828)
  AUTHORS   Pagella,P., Lai,C.F., Pirenne,L., Cantu,C., Schwab,M.E. and
            Mitsiadis,T.A.
  TITLE     An unexpected role of neurite outgrowth inhibitor A as regulator of
            tooth enamel formation
  JOURNAL   Int J Oral Sci 16 (1), 60 (2024)
   PUBMED   39426966
  REMARK    Erratum:[Int J Oral Sci. 2024 Nov 8;16(1):64. doi:
            10.1038/s41368-024-00330-y.. PMID: 39511159]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 828)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   5  (bases 1 to 828)
  AUTHORS   Nag,P., Inubushi,T., Sasaki,J.I., Murotani,T., Kusano,S.,
            Nakanishi,Y., Shiraishi,Y., Kurosaka,H., Imazato,S., Yamaguchi,Y.
            and Yamashiro,T.
  TITLE     Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in
            Mouse
  JOURNAL   J Dent Res 102 (10), 1162-1171 (2023)
   PUBMED   37449307
REFERENCE   6  (bases 1 to 828)
  AUTHORS   Blecher,S.R.
  TITLE     Amelogenin genes and sexual dimorphism of teeth in humans and mice
  JOURNAL   Am J Hum Genet 51 (6), 1451-1452 (1992)
   PUBMED   1463023
REFERENCE   7  (bases 1 to 828)
  AUTHORS   Lau,E.C., Simmer,J.P., Bringas,P. Jr., Hsu,D.D., Hu,C.C.,
            Zeichner-David,M., Thiemann,F., Snead,M.L., Slavkin,H.C. and
            Fincham,A.G.
  TITLE     Alternative splicing of the mouse amelogenin primary RNA transcript
            contributes to amelogenin heterogeneity
  JOURNAL   Biochem Biophys Res Commun 188 (3), 1253-1260 (1992)
   PUBMED   1445358
REFERENCE   8  (bases 1 to 828)
  AUTHORS   Chen,L.S., Couwenhoven,R.I., Hsu,D., Luo,W. and Snead,M.L.
  TITLE     Maintenance of amelogenin gene expression by transformed epithelial
            cells of mouse enamel organ
  JOURNAL   Arch Oral Biol 37 (10), 771-778 (1992)
   PUBMED   1444889
REFERENCE   9  (bases 1 to 828)
  AUTHORS   Bailey,D.M., Affara,N.A. and Ferguson-Smith,M.A.
  TITLE     The X-Y homologous gene amelogenin maps to the short arms of both
            the X and Y chromosomes and is highly conserved in primates
  JOURNAL   Genomics 14 (1), 203-205 (1992)
   PUBMED   1427830
REFERENCE   10 (bases 1 to 828)
  AUTHORS   Chapman,V.M., Keitz,B.T., Disteche,C.M., Lau,E.C. and Snead,M.L.
  TITLE     Linkage of amelogenin (Amel) to the distal portion of the mouse X
            chromosome
  JOURNAL   Genomics 10 (1), 23-28 (1991)
   PUBMED   1675194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029358.1 and BC059090.1.
            
            On Dec 28, 2007 this sequence version replaced NM_001081978.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059090.1, CB590451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK029358.1         5-34
            31-828              BC059090.1         1-798
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.95 cM"
     gene            1..828
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /note="amelogenin, X-linked"
                     /db_xref="GeneID:11704"
                     /db_xref="MGI:MGI:88005"
     exon            1..56
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
     exon            57..122
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..728
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; enamel matrix protein; leucine-rich amelogenin
                     peptide; amelogenin X chromosome"
                     /codon_start=1
                     /product="amelogenin, X isoform isoform 1 precursor"
                     /protein_id="NP_001075447.1"
                     /db_xref="CCDS:CCDS41213.1"
                     /db_xref="GeneID:11704"
                     /db_xref="MGI:MGI:88005"
                     /translation="MGTWILFACLLGAAFAMPLPPHPGSPGYINLSYEVLTPLKWYQS
                     MIRQPYPSYGYEPMGGWLHHQIIPVLSQQHPPSHTLQPHHHLPVVPAQQPVAPQQPMM
                     PVPGHHSMTPTQHHQPNIPPSAQQPFQQPFQPQAIPPQSHQPMQPQSPLHPMQPLAPQ
                     PPLPPLFSMQPLSPILPELPLEAWPATDKTKREEVAFSPMKWYQGMTRHPLNMESTTE
                     K"
     exon            123..170
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
     exon            171..215
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
     exon            216..653
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
     exon            654..698
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
     exon            699..811
                     /gene="Amelx"
                     /gene_synonym="ALGN; Amel; Amg; AMGL; AMGX; LRAP; Rgsc888"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcggatcaa gcatccctga gcttcagaca gaaactcact gagcatacac tcaaagaacc
       61 atcaagaaat ggggacctgg attttgtttg cctgcctcct gggagcagct tttgctatgc
      121 ccctaccacc tcatcctgga agccctggtt atatcaactt aagctatgag gtgcttaccc
      181 ctttgaagtg gtaccagagc atgataaggc agccgtatcc ttcctatggt tacgaaccca
      241 tgggtggatg gctgcaccac caaatcatcc ctgtgctgtc tcaacagcat cccccgagtc
      301 acacccttca gcctcatcac caccttcccg tggtgccagc tcaacagccc gtggcccccc
      361 agcaaccaat gatgccagtt cctggccacc actccatgac tccaacccaa caccatcagc
      421 caaacatccc tccatccgcc cagcagccct tccagcagcc cttccagccc caggccattc
      481 caccccagtc tcatcagccc atgcagcccc agtcacctct gcatcccatg cagcccctgg
      541 caccacagcc acctctgcct ccactgttct ccatgcagcc cctgtccccc attcttcctg
      601 agctgcctct ggaagcttgg ccagcgacag acaagaccaa gcgggaagaa gtggcgtttt
      661 ctcctatgaa gtggtaccag ggcatgacaa ggcatccgct taacatggaa agcacaacag
      721 aaaaatgatt ccaaccactc tcctaccttc ccagaacata atggcatgta gtagtgttca
      781 atattgcctt aataaaattc tcatcggctt aaaaaaaaaa aaaaaaaa
//
