LOCUS       NM_027908               2421 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus amidohydrolase domain containing 1 (Amdhd1), mRNA.
ACCESSION   NM_027908 XM_125854 XM_990660
VERSION     NM_027908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856590.1, AK005066.1 and AK090143.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_990660.1, XM_125854.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090143.1, AK005066.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BB856590.1         2-50
            50-2054             AK005066.1         6-2010
            2055-2421           AK090143.1         2047-2413
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.54 cM"
     gene            1..2421
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /note="amidohydrolase domain containing 1"
                     /db_xref="GeneID:71761"
                     /db_xref="MGI:MGI:1919011"
     exon            1..200
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1344
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /EC_number="3.5.2.7"
                     /note="amidohydrolase domain-containing protein 1"
                     /codon_start=1
                     /product="probable imidazolonepropionase"
                     /protein_id="NP_082184.1"
                     /db_xref="CCDS:CCDS48671.1"
                     /db_xref="GeneID:71761"
                     /db_xref="MGI:MGI:1919011"
                     /translation="MTSSHRLLLENAQQVVLVCARGERFLTGSALRSLAVLEGASVVV
                     GTDGLIKAVGPAAVIQKQFSGETFEERIDCSGKCVLPGLVDAHTHPVWAGERVHEFAM
                     KLAGATYMDIHQAGGGINFTVEHTRQASEEELFCSFQQRLQCMMRAGTTLVECKSGYG
                     LNLETELKMLRVIERARRELHLSLSATYCGAHSVPKGKTAVEAADDIISHHLPRLKEL
                     SRNGDLHVDNIDVFCEKGVFDLDTTRRILEGGKKMGLQINFHGDELHPMKAAELGAEL
                     GAQAISHLEEVSDEGIAAMAAARCSAVLLPTTAYMLRLKQPRARKMLDEGVIVALGSD
                     FNPNAYCFSMPMVMHLACVNMRMSMPEALAAATINAAYALGKSHTHGSLEVGKQGDAI
                     IINASRWEHLIYQFGGHHELIDYVITKGKVIYKK"
     exon            201..307
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            308..372
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            373..650
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            651..876
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1001
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1095
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1256
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..2421
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2057
                     /gene="Amdhd1"
                     /gene_synonym="1300019J08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcccgggagc cacagctcgc aggctctcct gtcctccgca gcccgccagc ggctagagcg
       61 acaatgacga gcagccaccg cctcctgctg gagaacgcac agcaagtggt gctggtgtgt
      121 gcccgcggcg agcgcttcct gaccgggtct gcgctgcgca gcctggcggt gctggagggc
      181 gccagcgtgg tggtgggcac tgacgggctt ataaaagctg ttggccctgc tgctgttatc
      241 caaaaacagt tttccggaga aacttttgaa gaaagaattg attgctctgg gaaatgcgtc
      301 ttgccaggtt tggtggacgc acacacacat ccggtgtggg cgggtgaaag agtccacgag
      361 tttgcaatga agttggcagg ggccacgtac atggacattc accaggctgg aggagggatc
      421 aacttcacgg tggagcacac ccgccaggcc tcggaggagg aactgttctg ctccttccag
      481 cagcggctgc agtgcatgat gagggctggc accacgctgg tggagtgcaa gagcggatat
      541 ggcctcaacc tggagacaga gctcaagatg ctgcgcgtaa tcgagcgcgc caggcgggag
      601 ctgcacctca gcctctcagc cacttactgc ggagctcact cagtacccaa agggaaaact
      661 gcagtggaag ctgctgatga catcatcagt caccacctgc caaggctgaa ggaactcagc
      721 agaaatgggg acctgcatgt tgacaacata gatgtgttct gtgagaaggg tgtctttgat
      781 ctggatacca ccagaaggat tctggaaggt ggaaaaaaga tgggcttaca gatcaacttc
      841 catggggatg aactccaccc gatgaaggct gccgagcttg gggccgaact gggagcacag
      901 gctatcagcc acctggagga agtcagcgac gaaggcattg ctgccatggc tgcggctcgg
      961 tgttctgctg tcctcctgcc caccacagcc tacatgctga ggctgaagca gcctcgagcc
     1021 aggaagatgt tagacgaggg tgtcatagtt gctctgggca gcgatttcaa ccccaacgcg
     1081 tactgctttt ccatgccgat ggtcatgcac ctggcctgtg tgaacatgag aatgtccatg
     1141 ccggaggcct tggccgctgc caccatcaac gcggcttatg cgctgggaaa atctcacacc
     1201 cacggatctt tggaagttgg caagcagggg gacgccatca tcatcaatgc atccagatgg
     1261 gaacatttga tttaccagtt tggaggccat catgaattaa ttgattatgt tataactaaa
     1321 ggaaaagtca tctacaagaa gtgatatctt tgaaccaata agatgcctca gtgcgataag
     1381 tctcttgtca ccaaaccctg agttcgatcc tggagctcat gagggtggga ggagagaatg
     1441 tctaagagtt accctctgac ctccacgtac tcacctgcta tgtaccagac ccctcctcac
     1501 ctccacataa atcaatgtaa taagataaaa aatatttttt aaaaaatgac agctcttcaa
     1561 ggaaagattt gatgctttgt atcaaataac gccatgtaag ttaaagccct tccgtggctt
     1621 acagaacggt gtcacttaag cctaaccaga tgtcagggtt ttactattca ccggaaaccc
     1681 caagggatgg acctgtttga agtgaacatg tatggctatc tggaagtgta aataggtaaa
     1741 cctgggatga aatgtagagt tgtttttcaa agactggctg cagacattct gagatgaata
     1801 tgctatgaat gtgaattgaa tatatgagat gaatttcaga tagctcagaa attcccttgt
     1861 gggagaaaca accttggctt gagagatctg ttttgtttct gcaaatgtta tgccccagtg
     1921 agaccaaggg taccatttcc taagaagcag gcagagtctt tgctccccac ggtttgtctg
     1981 gggacaaacg tggggggcag agatggcctc ccatttttaa catcgtatca gcccttgtaa
     2041 taaagcttta ccacagagtt caagacctga tatcttgcac agatatggaa actctcctcc
     2101 acagacacgc tttagtcaat gacaatgagg ttgtgttaaa acagaaatct ttacgttaat
     2161 ttttttttcg tatcacaaag tcatgggttt tatagttctc cataaatatt tgctgttatt
     2221 accattgttg cctgacaacc ccggacatgg atcagttgtt ttgtctaggg agtttttgga
     2281 aatgttcaaa gaacggatca caaaattatc tgcagagtga atgactattt aggcaaactt
     2341 gtatttctaa agccacaccc ccttgaaaac ttgtaaacta tttcagtgaa atttgcaatg
     2401 ctaatacaaa ttagtgacgc c
//
