LOCUS       NM_009665               3206 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus S-adenosylmethionine decarboxylase 1 (Amd1), mRNA.
ACCESSION   NM_009665
VERSION     NM_009665.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Bian,X., Shi,D., Xing,K., Zhou,H., Lu,L., Yu,D. and Wu,W.
  TITLE     AMD1 upregulates hepatocellular carcinoma cells stemness by FTO
            mediated mRNA demethylation
  JOURNAL   Clin Transl Med 11 (3), e352 (2021)
   PUBMED   33783988
  REMARK    GeneRIF: AMD1 upregulates hepatocellular carcinoma cells stemness
            by FTO mediated mRNA demethylation.
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Sari,I.N., Yang,Y.G., Wijaya,Y.T., Jun,N., Lee,S., Kim,K.S.,
            Bajaj,J., Oehler,V.G., Kim,S.H., Choi,S.Y., Park,S.H., Kim,D.W.,
            Reya,T., Han,J. and Kwon,H.Y.
  TITLE     AMD1 is required for the maintenance of leukemic stem cells and
            promotes chronic myeloid leukemic growth
  JOURNAL   Oncogene 40 (3), 603-617 (2021)
   PUBMED   33203990
  REMARK    GeneRIF: AMD1 is required for the maintenance of leukemic stem
            cells and promotes chronic myeloid leukemic growth.
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Fenelon,J.C. and Murphy,B.D.
  TITLE     Inhibition of polyamine synthesis causes entry of the mouse
            blastocyst into embryonic diapause
  JOURNAL   Biol Reprod 97 (1), 119-132 (2017)
   PUBMED   28637295
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Zhang,D., Zhao,T., Ang,H.S., Chong,P., Saiki,R., Igarashi,K.,
            Yang,H. and Vardy,L.A.
  TITLE     AMD1 is essential for ESC self-renewal and is translationally
            down-regulated on differentiation to neural precursor cells
  JOURNAL   Genes Dev 26 (5), 461-473 (2012)
   PUBMED   22391449
  REMARK    GeneRIF: Amd1 is a major regulator of embryonic stem cell
            self-renewal and that its essential role lies in its regulation of
            Myc levels within the cell
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Raney,A., Law,G.L., Mize,G.J. and Morris,D.R.
  TITLE     Regulated translation termination at the upstream open reading
            frame in s-adenosylmethionine decarboxylase mRNA
  JOURNAL   J Biol Chem 277 (8), 5988-5994 (2002)
   PUBMED   11741992
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Raney,A., Baron,A.C., Mize,G.J., Law,G.L. and Morris,D.R.
  TITLE     In vitro translation of the upstream open reading frame in the
            mammalian mRNA encoding S-adenosylmethionine decarboxylase
  JOURNAL   J Biol Chem 275 (32), 24444-24450 (2000)
   PUBMED   10829027
REFERENCE   7  (bases 1 to 3206)
  AUTHORS   Nishimura,K., Kashiwagi,K., Matsuda,Y., Janne,O.A. and Igarashi,K.
  TITLE     Gene structure and chromosomal localization of mouse
            S-adenosylmethionine decarboxylase
  JOURNAL   Gene 238 (2), 343-350 (1999)
   PUBMED   10570962
REFERENCE   8  (bases 1 to 3206)
  AUTHORS   Waris,T., Ihalainen,R., Keranen,M.R. and Pajunen,A.
  TITLE     Molecular cloning of the mouse S-adenosylmethionine decarboxylase
            cDNA: specific protein binding to the conserved region of the mRNA
            5'-untranslated region
  JOURNAL   Biochem Biophys Res Commun 189 (1), 424-429 (1992)
   PUBMED   1449493
REFERENCE   9  (bases 1 to 3206)
  AUTHORS   Suorsa,A., Hietala,O. and Pajunen,A.
  TITLE     Developmental expression of ornithine and S-adenosylmethionine
            decarboxylases in mouse brain
  JOURNAL   Biochem Biophys Res Commun 184 (2), 1114-1118 (1992)
   PUBMED   1374235
REFERENCE   10 (bases 1 to 3206)
  AUTHORS   Janne,O.A., Crozat,A., Palvimo,J. and Eisenberg,L.M.
  TITLE     Androgen-regulation of ornithine decarboxylase and
            S-adenosylmethionine decarboxylase genes
  JOURNAL   J Steroid Biochem Mol Biol 40 (1-3), 307-315 (1991)
   PUBMED   1958536
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142273.3 and AK146840.1.
            
            On Mar 19, 2011 this sequence version replaced NM_009665.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011110.1, AK146840.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 10829027
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC142273.3         21685-21686         c
            3-3198              AK146840.1         2-3197
            3199-3206           AC142273.3         6956-6963           c
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 21.85 cM"
     gene            1..3206
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /note="S-adenosylmethionine decarboxylase 1"
                     /db_xref="GeneID:11702"
                     /db_xref="MGI:MGI:88004"
     exon            1..440
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14..34
                     /regulatory_class="uORF"
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10829027]"
                     /note="this uORF is predicted to encode a 6 aa peptide
                     (PMID:10829027)"
     CDS             331..1335
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /EC_number="4.1.1.50"
                     /note="adoMetDC 1"
                     /codon_start=1
                     /product="S-adenosylmethionine decarboxylase proenzyme 1"
                     /protein_id="NP_033795.1"
                     /db_xref="CCDS:CCDS48544.1"
                     /db_xref="GeneID:11702"
                     /db_xref="MGI:MGI:88004"
                     /translation="MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLL
                     KDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYS
                     GFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLY
                     TLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVI
                     DATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFK
                     PGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
                     "
     exon            441..527
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..654
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..757
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..800
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1038
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1194
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..3206
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3173..3178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="Amd1"
                     /gene_synonym="AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1"
                     /note="major polyA site"
ORIGIN      
        1 tcgcttacac agtatggccg gcgacattag ctagcgctcg ctcaactctc ctaacgggaa
       61 agcagcggac tacaagagac tgaactgtat ctgcctctat ttccaacaga ctcacgttca
      121 actttcgctc acgaaaatag ccgggaaaat tttattagtc ctttttttaa aaaaaagtta
      181 atataaaatt atagcaaaaa aaaaaaaaaa aggaacctga actttagtaa cacagctgga
      241 acaatccgca gcggcggcag gagcggcggg agaagagatt taatttagtt gattttctgt
      301 ggttgttggt tgttcgctag tctcacggtg atggaagctg cacatttttt cgaagggacg
      361 gagaaactgc tggaggtctg gttttccaga cagcagtccg acgcaagcca gggatctggg
      421 gatcttcgta ccatcccaag atctgaatgg gatgtccttt tgaaggatgt gcagtgctca
      481 atcataagtg tgacaaagac tgacaagcag gaagcttatg tactcagtga gagtagcatg
      541 tttgtctcca agagacgttt cattttgaag acatgtggta ccaccctctt actgaaagca
      601 ctggttcccc tgttgaagct tgctagggat tacagtgggt ttgactcaat tcaaagcttc
      661 ttttattctc gtaagaattt catgaagcct tctcaccaag ggtacccaca ccggaatttc
      721 caggaagaaa tcgagtttct taatgcaatt ttcccaaatg gagcagcata ttgtatggga
      781 cgcatgaatt ctgactgctg gtacttgtat actttggatt tcccagagag ccgagtaatc
      841 agtcagccag atcaaacact ggaaattctg atgagtgagc ttgacccagc agttatggac
      901 cagttctaca tgaaagatgg tgttactgca aaggatgtca ctcgtgagag tggaattcgt
      961 gacctgatac caggttctgt cattgatgcc acactgttca atccttgtgg ctactcgatg
     1021 aatggaatga aatcggatgg aacatattgg actattcaca tcactccaga accagaattt
     1081 tcttatgtta gctttgaaac aaacctaagt cagacctcct atgacgacct gatcaggaaa
     1141 gttgtggaag tcttcaagcc aggaaaattt gtgaccacct tgtttgttaa tcagagttct
     1201 aaatgtcgca cagtgctttc ttcgccccag aagattgacg gctttaaacg tcttgattgc
     1261 cagagtgcta tgttcaacga ttacaatttt gtttttacca gttttgctaa gaaacagcaa
     1321 caacagcaga gttgattagg aaaaatgaag aagaaaaaac gcaaaaagag aagacacaca
     1381 ggaggtggtg gctgctttct agatgctgat cctgagggcc atgctgacca tgaccaccac
     1441 ctcgtagttg cagaaagccc taggtgtaat gatagtgcaa tcattttgaa gtgtatgcat
     1501 tattatatca aggagttagg tatcttgcat gaatgctctc ttctgtgttt aggtgttcta
     1561 tgccactctt gctgtggaac tgaagtgcat gtagaaaaga cctttgactg tatgaatctt
     1621 tacgacactt gtgaaaatga tacaatttgg tttatgcaca gtgtaatatt tctgcaggca
     1681 tcatccaaaa ttccccacag acaaggcttt cgtccccatt agatgcggcc tcagctgaca
     1741 tctgtgactg ttctattaaa ttgctgccag agtttttaca tccaggcacc tccactttct
     1801 agggcatatt ctctactaat gttactcaaa accaatttct acttcataca ggtgttttat
     1861 gcaatggcaa ttaaagtttt tcttccacaa gttgagtctt tgtaagaaaa tgactccagt
     1921 tgcttgtttt atgttctgct gttttaataa ttgctcctgc atttagagtc ctatagtttt
     1981 tccaccacct ttgatgaagc aatacactgt tacactgtgg gcttatatta taattttaca
     2041 ccccaggtga gagtttggag atggtccctt gcttaatttt ttttcctaag acataagaat
     2101 gtggtctctt tattggcatg aacttctgtg gaagataaat gacaaaactg aatgtatcaa
     2161 atgaaaagaa ctcacagtct ccagggcgat gagcaaggag aacccattaa agaaaactcc
     2221 atggaaatga taggctgtgc agtgcacctt aattagcgtt aatggagtgc ctactatgcc
     2281 ctcactaatt tactaagtga taggaatgtc cactatgtca aagcagaaat gtagtcctag
     2341 cattctgacc tcagtaagtg ctgccgttgc caccaggttt tatttactaa aggagatttt
     2401 gattcgaagg agaatctggt ttctacttgt cctaccgtca gctggtctct ggtcttcctt
     2461 tcaccgtggc cttcagatga tcagatgaat gactgaccag agggaggagg cctctccagg
     2521 ttactcagcc agatagtgaa tgtatgaatg gatggaacgg cgcaatattc tgaatctatt
     2581 taatggcact agaaataatg ggcgttgaag agtcggcatg ttggtgggac ttaaacagaa
     2641 aagagcaaac tggactaaac tccctattta ttgcccttct gttttcttgg tagtttctgg
     2701 actgatgcag tgatgttttg ttccttccgt atttataacg aaacactttt ttagcgtttc
     2761 taaacagagt ctacttggtt tgagatcaag tggttggaac actgtctgga ctctttctac
     2821 acggtgttga ttgaaggctt ctttggggaa gctttcggtc agctttatct gtctgattct
     2881 gtaatgagca cagcacctat tttgaattgc tatttggagg gccagtgctt atttaagctg
     2941 gattttgtaa cccagtagat tttggcttga ggtctgattt ccccgtctta aattaagaat
     3001 cctaatgttg agaattgcat aggtttgtgt ggaacaaagc ctagaacaac tgtaggtaaa
     3061 ctagtgatct agtctaatta caggtgggga agttttggtg ccataatttc tctttgttgg
     3121 tgttggactt ttaatcagct gaaatgtatt tctgtaccac aatgtaagct tcaataaaag
     3181 tttgcttaat tgtctagtaa cattga
//
