LOCUS       NM_007443               1284 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus alpha 1 microglobulin/bikunin precursor (Ambp), mRNA.
ACCESSION   NM_007443
VERSION     NM_007443.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Kristiansson,A., Bergwik,J., Alattar,A.G., Flygare,J., Gram,M.,
            Hansson,S.R., Olsson,M.L., Storry,J.R., Allhorn,M. and Akerstrom,B.
  TITLE     Human radical scavenger alpha1-microglobulin protects against
            hemolysis in vitro and alpha1-microglobulin knockout mice exhibit a
            macrocytic anemia phenotype
  JOURNAL   Free Radic Biol Med 162, 149-159 (2021)
   PUBMED   32092412
  REMARK    GeneRIF: Human radical scavenger alpha1-microglobulin protects
            against hemolysis in vitro and alpha1-microglobulin knockout mice
            exhibit a macrocytic anemia phenotype.
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Bergwik,J., Kristiansson,A., Welinder,C., Goransson,O.,
            Hansson,S.R., Gram,M., Erlandsson,L. and Akerstrom,B.
  TITLE     Knockout of the radical scavenger alpha1-microglobulin in mice
            results in defective bikunin synthesis, endoplasmic reticulum
            stress and increased body weight
  JOURNAL   Free Radic Biol Med 162, 160-170 (2021)
   PUBMED   32092411
  REMARK    GeneRIF: Knockout of the radical scavenger alpha1-microglobulin in
            mice results in defective bikunin synthesis, endoplasmic reticulum
            stress and increased body weight.
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Kristiansson,A., Gram,M., Flygare,J., Hansson,S.R., Akerstrom,B.
            and Storry,J.R.
  TITLE     The Role of alpha1-Microglobulin (A1M) in Erythropoiesis and
            Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic
            Conditions
  JOURNAL   Int J Mol Sci 21 (19), 7234 (2020)
   PUBMED   33008134
  REMARK    GeneRIF: The Role of alpha1-Microglobulin (A1M) in Erythropoiesis
            and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic
            Conditions.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Pilz,A., Fountain,J., Peters,J. and Abbott,C.
  TITLE     Linkage mapping of the Aldo-2, Pax-5, Ambp, and D4h9S3E loci on
            mouse chromosome 4 in the region of homology with human chromosome
            9
  JOURNAL   Genomics 18 (3), 705-708 (1993)
   PUBMED   7508415
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Salier,J.P., Chan,P., Raguenez,G., Zwingman,T. and Erickson,R.P.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Chan,P. and Salier,J.P.
  TITLE     Mouse alpha-1-microglobulin/bikunin precursor: cDNA analysis, gene
            evolution and physical assignment of the gene next to the
            orosomucoid locus
  JOURNAL   Biochim Biophys Acta 1174 (2), 195-200 (1993)
   PUBMED   7689339
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Salier,J.P., Simon,D., Rouet,P., Raguenez,G., Muscatelli,F.,
            Gebhard,W., Guenet,J.L. and Mattei,M.G.
  TITLE     Homologous chromosomal locations of the four genes for
            inter-alpha-inhibitor and pre-alpha-inhibitor family in human and
            mouse: assignment of the ancestral gene for the lipocalin
            superfamily
  JOURNAL   Genomics 14 (1), 83-88 (1992)
   PUBMED   1385302
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Salier,J.P., Verga,V., Doly,J., Diarra-Mehrpour,M. and
            Erickson,R.P.
  TITLE     The genes for the inter-alpha-inhibitor family share a homologous
            organization in human and mouse
  JOURNAL   Mamm Genome 2 (4), 233-239 (1992)
   PUBMED   1371941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL691496.13, AK004907.1 and
            BU758284.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_007443.5.
            
            On Oct 9, 2015 this sequence version replaced NM_007443.3.
            
            Summary: This gene encodes a fusion protein that undergoes
            proteolytic processing to generate two mature proteins:
            alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein
            of the lipocalin superfamily of proteins that bind to hydrophobic
            molecules, whereas bikunin belongs to the superfamily of
            Kunitz-type protease inhibitors. The transgenic mice specifically
            lacking bikunin, but not A1m, exhibit female infertility and an
            increased sensitivity to lung metastasis. [provided by RefSeq, Oct
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021660.1, D28812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AL691496.13        27809-27852         c
            45-254              AK004907.1         16-225
            255-255             AL691496.13        26383-26383         c
            256-670             AK004907.1         227-641
            671-671             AL691496.13        22428-22428         c
            672-1250            AK004907.1         643-1221
            1251-1284           BU758284.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..1284
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /note="alpha 1 microglobulin/bikunin precursor"
                     /db_xref="GeneID:11699"
                     /db_xref="MGI:MGI:88002"
     exon            1..231
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1167
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /note="protein AMBP; ulinastatin; Urinary Trypsin
                     Inhibitor"
                     /codon_start=1
                     /product="protein AMBP preproprotein"
                     /protein_id="NP_031469.1"
                     /db_xref="CCDS:CCDS18248.1"
                     /db_xref="GeneID:11699"
                     /db_xref="MGI:MGI:88002"
                     /translation="MQGLRTLFLLLTACLASRADPASTLPDIQVQENFSESRIYGKWY
                     NLAVGSTCPWLSRIKDKMSVSTLVLQEGATETEISMTSTRWRRGVCEEITGAYQKTDI
                     DGKFLYHKSKWNITLESYVVHTNYDEYAIFLTKKSSHHHGLTITAKLYGREPQLRDSL
                     LQEFKDVALNVGISENSIIFMPDRGECVPGDREVEPTSIARARRAVLPQESEGSGTEP
                     LITGTLKKEDSCQLNYSEGPCLGMQERYYYNGASMACETFQYGGCLGNGNNFISEKDC
                     LQTCRTIAACNLPIVQGPCRAFIKLWAFDAAQGKCIQFHYGGCKGNGNKFYSEKECKE
                     YCGVPGDGYEELIRS"
     exon            232..374
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            375..451
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            452..568
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            569..670
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            671..717
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            718..799
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            800..967
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1141
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1267
                     /gene="Ambp"
                     /gene_synonym="ASPI; HI-30; Intin4; Itil; UTI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatttgcct ccggatcctt ccccagcctc agtttgtagc tgccactgcc ggggaagtaa
       61 tccctgctcc cacactgagc tgtgagagag acatcaaaga ccaaagacca cagagccatg
      121 cagggtctca ggaccctgtt cctgctgctg actgcctgcc tcgcttcgag ggctgaccct
      181 gcgtcaacac tgccagatat ccaggttcag gagaacttca gtgagtcccg gatctatgga
      241 aaatggtaca acctggcggt gggatccacc tgcccgtggc tgagccgcat taaggacaag
      301 atgagcgtga gcacgctggt gctgcaggag ggggcgacag aaacagagat cagcatgacc
      361 agtactcgat ggcggagagg tgtctgtgag gagatcactg gggcgtacca gaagacggac
      421 atcgatggaa agttcctcta ccacaaatcc aaatggaaca taaccttgga atcctatgtg
      481 gtccacacca actatgacga atatgccatt ttccttacca agaagtccag ccaccaccac
      541 gggctcacca tcactgccaa gctctatggt cgggagccac agctgaggga cagccttctg
      601 caggagttca aggatgtggc cctgaatgtg ggcatctctg agaactccat catttttatg
      661 cctgacagag gggaatgtgt ccctggggat cgggaggtgg agcccacatc aattgccaga
      721 gcccggcggg cagtgctgcc ccaagagagt gaggggtcag ggactgagcc actaataact
      781 gggaccctca agaaagaaga ctcctgccag ctcaattact cagaaggccc ctgcctaggg
      841 atgcaagaga ggtattacta caacggcgct tccatggcct gcgagacctt tcaatatggg
      901 ggttgcctag gcaacggcaa caacttcatc tctgagaagg actgtctgca gacatgtcgg
      961 accatagcgg cctgcaatct ccccatagtc caaggcccct gccgagcctt cataaagctc
     1021 tgggcatttg atgcagcaca agggaagtgc atccaattcc actacggggg ctgcaaaggc
     1081 aacggcaaca aattctactc tgagaaggaa tgcaaagagt actgtggagt ccctggtgat
     1141 gggtacgagg aactaatacg cagttgaagg tgccagtctg caagccagag ggtagccact
     1201 gtttgtcaca gcgcagtcca gcttagatga tctggaccca aataaaacaa gttgtcactt
     1261 cctagcaaaa aaaaaaaaaa aaaa
//
