LOCUS       NM_019484               1273 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Aly/REF export factor 2 (Alyref2), mRNA.
ACCESSION   NM_019484 NM_177071
VERSION     NM_019484.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Tunnicliffe,R.B., Hautbergue,G.M., Wilson,S.A., Kalra,P. and
            Golovanov,A.P.
  TITLE     Competitive and cooperative interactions mediate RNA transfer from
            herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF
  JOURNAL   PLoS Pathog 10 (2), e1003907 (2014)
   PUBMED   24550725
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Hammock,E.A., Eagleson,K.L., Barlow,S., Earls,L.R., Miller,D.M. 3rd
            and Levitt,P.
  TITLE     Homologs of genes expressed in Caenorhabditis elegans GABAergic
            neurons are also found in the developing mouse forebrain
  JOURNAL   Neural Dev 5, 32 (2010)
   PUBMED   21122108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Hautbergue,G.M., Hung,M.L., Golovanov,A.P., Lian,L.Y. and
            Wilson,S.A.
  TITLE     Mutually exclusive interactions drive handover of mRNA from export
            adaptors to TAP
  JOURNAL   Proc Natl Acad Sci U S A 105 (13), 5154-5159 (2008)
   PUBMED   18364396
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Golovanov,A.P., Hautbergue,G.M., Tintaru,A.M., Lian,L.Y. and
            Wilson,S.A.
  TITLE     The solution structure of REF2-I reveals interdomain interactions
            and regions involved in binding mRNA export factors and RNA
  JOURNAL   RNA 12 (11), 1933-1948 (2006)
   PUBMED   17000901
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   Stutz,F., Bachi,A., Doerks,T., Braun,I.C., Seraphin,B., Wilm,M.,
            Bork,P. and Izaurralde,E.
  TITLE     REF, an evolutionary conserved family of hnRNP-like proteins,
            interacts with TAP/Mex67p and participates in mRNA nuclear export
  JOURNAL   RNA 6 (4), 638-650 (2000)
   PUBMED   10786854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048243.1 and AA189877.1.
            
            On May 23, 2007 this sequence version replaced NM_019484.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK048243.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-777               AK048243.1         2-778
            778-1069            AA189877.1         218-509
            1070-1273           AK048243.1         1070-1273
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.48 cM"
     gene            1..1273
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="Aly/REF export factor 2"
                     /db_xref="GeneID:56009"
                     /db_xref="MGI:MGI:1913144"
     exon            1..1273
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..836
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="RNA and export factor binding protein 2-I; RNA and
                     export factor-binding protein 2"
                     /codon_start=1
                     /product="aly/REF export factor 2"
                     /protein_id="NP_062357.3"
                     /db_xref="CCDS:CCDS15497.1"
                     /db_xref="GeneID:56009"
                     /db_xref="MGI:MGI:1913144"
                     /translation="MADKMDMSLDDIIKLNRNQRRVNRGGGPRRNRPAIARGGRNRPA
                     PYSRPKPLPDKWQHDLFDSGCGGGEGVETGAKLLVSNLDFGVSDADIQELFAEFGTLK
                     KAAVDYDRSGRSLGTADVHFERRADALKAMKQYKGVPLDGRPMDIQLVTSQIDPQRRP
                     AQSGNRGGMTRSRGSGGFGGRGSQGRGRGTGRNSKQQQLSAEELDAQLDAYNARRDTS
                     "
     regulatory      1113..1118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="hexamer: AATAAA"
     regulatory      1118..1123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="hexamer: AATAGA"
     polyA_site      1133
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="hexamer: ATTAAA"
     polyA_site      1145
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="major polyA site"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
                     /note="hexamer: AAGAAA"
     polyA_site      1168
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
     polyA_site      1175
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
     polyA_site      1272
                     /gene="Alyref2"
                     /gene_synonym="C130042O11Rik; REF2; Refbp2"
ORIGIN      
        1 agagcgaaag ccagattcac aagcgcacag acttccaatt tccaagtgtg attttggtgc
       61 gcttgtgatt ccagcaccgg tcggagaggc ggagtcaagg cgggggaatc attgaatttg
      121 agtactttct ggtctgcacc gcgagggccg ggccagtcag gcccggatcc gcgcccgcca
      181 tggccgacaa gatggacatg tctttggacg acatcattaa gctgaaccgt aaccagcgcc
      241 gggtgaatcg aggcggcggg cctaggagga accggcccgc catcgcccgc ggcggcagga
      301 accggccggc accgtacagt agaccgaaac cacttccgga caagtggcag cacgacctat
      361 tcgacagcgg ctgcgggggt ggggaaggcg tggagaccgg tgccaagctg ctcgtgtcaa
      421 acctggactt cggggtgtca gatgctgaca ttcaggaact ctttgctgaa tttggaacgt
      481 tgaaaaaagc cgctgtggac tacgatcgct ctggacgaag tttagggacg gcggatgtac
      541 actttgaacg gagggcagat gccctgaagg ctatgaagca gtacaagggc gtccctttgg
      601 atggccgccc tatggacatc cagcttgtca cgtcacagat cgatccacag cgaagacctg
      661 cacaaagcgg aaacagaggc ggcatgacaa ggagccgtgg ctctggaggc tttggtggcc
      721 gcggcagcca gggaaggggt agaggcactg gcaggaactc aaagcagcag cagctttctg
      781 cagaggagtt ggacgcacag ctggatgctt acaatgcaag gagggacacc agctaaacaa
      841 ccgaacaaat ccgcacaaga accgggaccc agacgcctcg tctgtgatgc cttagaggga
      901 gggtaggcaa ctggactgtg cagacaatgg tgaatttggt tttttgtttc tttttacttc
      961 ctgttttaaa ataggatcta aaaactcatg taaagttttt tttttttttt ttttttaaat
     1021 tctgaaacag acctgttttg tactgagtta ttttttggga taagttttcc tgggtgctgt
     1081 tgtggagaag gtggcatttt cacctttgtc ataataaaat agaaatgtgt gtagaactgg
     1141 aaaaattaaa aaagaaaaag aaaaattaca aattacaata tgacttttat ggacagaaca
     1201 catgactgac tagcatgcat gaagaagtgg gtttcattct cagctccatc atgtaagaat
     1261 aaaacaagaa ttg
//
