LOCUS       NM_007442               5203 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus aristaless-like homeobox 4 (Alx4), mRNA.
ACCESSION   NM_007442
VERSION     NM_007442.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5203)
  AUTHORS   Lan,Y., Wu,Z., Liu,H. and Jiang,R.
  TITLE     Lineage-specific requirements of Alx4 function in craniofacial and
            hair development
  JOURNAL   Dev Dyn 253 (10), 940-948 (2024)
   PUBMED   38481039
REFERENCE   2  (bases 1 to 5203)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   3  (bases 1 to 5203)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5203)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5203)
  AUTHORS   Nguyen,T.T., Mitchell,J.M., Kiel,M.D., Kenny,C.P., Li,H.,
            Jones,K.L., Cornell,R.A., Williams,T.J., Nichols,J.T. and Van
            Otterloo,E.
  TITLE     TFAP2 paralogs regulate midfacial development in part through a
            conserved ALX genetic pathway
  JOURNAL   Development 151 (1) (2024)
   PUBMED   38063857
REFERENCE   6  (bases 1 to 5203)
  AUTHORS   Maas,R., Elfering,S., Glaser,T. and Jepeal,L.
  TITLE     Deficient outgrowth of the ureteric bud underlies the renal
            agenesis phenotype in mice manifesting the limb deformity (ld)
            mutation
  JOURNAL   Dev Dyn 199 (3), 214-228 (1994)
   PUBMED   7517224
REFERENCE   7  (bases 1 to 5203)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
REFERENCE   8  (bases 1 to 5203)
  AUTHORS   Forsthoefel,P.F. and Williams,M.L.
  TITLE     The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone
            and in combination with normal nucleic acid precursors on
            development of mice in lines selected for low and high expression
            of Strong's luxoid gene
  JOURNAL   Teratology 11 (1), 1-13 (1975)
   PUBMED   124471
REFERENCE   9  (bases 1 to 5203)
  AUTHORS   Forsthoefel,P.F. and Shenk,T.E.
  TITLE     Linkage relationships of Strong's luxoid gene in the mouse
  JOURNAL   J Hered 61 (2), 64-66 (1970)
   PUBMED   5480943
REFERENCE   10 (bases 1 to 5203)
  AUTHORS   Forsthoefel,P.F.
  TITLE     Responses to selection for plus and minus modifiers of some effects
            of Strong's luxoid gene on the mouse skeleton
  JOURNAL   Teratology 1 (3), 339-351 (1968)
   PUBMED   5759552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732493.17.
            
            On Apr 7, 2010 this sequence version replaced NM_007442.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.2802810.1, AB221573.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AL732493.17        35396-36050
            656-966             AL732493.17        61317-61627
            967-1095            AL732493.17        68258-68386
            1096-5203           AL732493.17        70194-74301
FEATURES             Location/Qualifiers
     source          1..5203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.62 cM"
     gene            1..5203
                     /gene="Alx4"
                     /gene_synonym="lst"
                     /note="aristaless-like homeobox 4"
                     /db_xref="GeneID:11695"
                     /db_xref="MGI:MGI:108359"
     exon            1..655
                     /gene="Alx4"
                     /gene_synonym="lst"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1425
                     /gene="Alx4"
                     /gene_synonym="lst"
                     /note="ALX-4; Strong's luxoid; aristaless 4;
                     Aristaless-like 4"
                     /codon_start=1
                     /product="homeobox protein aristaless-like 4"
                     /protein_id="NP_031468.1"
                     /db_xref="CCDS:CCDS16455.1"
                     /db_xref="GeneID:11695"
                     /db_xref="MGI:MGI:108359"
                     /translation="MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRGFPGGDKFG
                     TTFLSAGAKGQGFGDAKSRARYGAGQQDLAAPLESSSGARGSFNKFQPQPPTPQPPPA
                     PPAPPAHLYLQRGACKTPPDGSLKLQEGSGGHNAALQVPCYAKESNLGEPELPPDSEP
                     VGMDNSYLSVKETGAKGPQDRASAEIPSPLEKTDSESNKGKKRRNRTTFTSYQLEELE
                     KVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTA
                     YELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSV
                     SDFLSVSGAGSHVGQTHMGSLFGAAGISPGLNGYEMNGEPDRKTSSIAALRMKAKEHS
                     AAISWAT"
     exon            656..966
                     /gene="Alx4"
                     /gene_synonym="lst"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1095
                     /gene="Alx4"
                     /gene_synonym="lst"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..5203
                     /gene="Alx4"
                     /gene_synonym="lst"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagaaaag gagagaaagg aagagagaga gagagagaga gagagagaga gagagagaga
       61 gacagagaga gagagacaga gagagagaga gagagagaga gagagagcag gcccggtgca
      121 gagcactgcc accgcctctt tgcctcccca actcctagcc aaggcgcgcg gtggcgtcct
      181 cgcgccctcg ccggcgcccc cgcccgtcgc ccgcgcaggc caggcatgaa cgctgagact
      241 tgcgtctctt actgcgagtc cccggccgct gccatggacg cctactacag cccggtgtcg
      301 cagagccggg aaggttcgtc gccttttagg ggattcccag gaggcgacaa gttcggtaca
      361 acttttctgt cggccggggc caaaggacag ggattcgggg acgccaagag ccgggcccgc
      421 tacggcgcgg ggcagcagga cctggcggca ccgctggaga gcagctccgg ggcgcgggga
      481 tcctttaaca agttccagcc gcagccgccc accccacagc cgccgcccgc tccacccgcg
      541 ccgcctgcgc atctctactt gcagaggggc gcctgcaaaa cgcccccgga cggtagcctc
      601 aagctccagg agggcagcgg cggccacaac gcggccttgc aggtcccctg ctacgccaaa
      661 gagagcaacc tgggtgagcc agagttgcct cctgactctg aacccgtggg catggacaac
      721 agctacctca gtgtgaagga gacaggggcc aaggggcccc aggaccgggc cagcgctgaa
      781 ataccaagcc ccctggaaaa gaccgattct gagagtaaca aaggcaagaa gcggcggaac
      841 cgaaccacct tcactagcta ccagctggaa gagctggaga aagtcttcca gaagacacac
      901 taccctgatg tgtatgcacg ggagcagctg gctatgagga ccgacctcac cgaggcccgt
      961 gtgcaggttt ggttccagaa ccggagggcc aagtggcgaa agagggagcg ctttgggcag
     1021 atgcagcagg tccggaccca cttctccacg gcctatgagt tgcccctcct cacccgggct
     1081 gagaactacg cccagattca gaacccatcc tggattggca acaatggggc tgcctcgcca
     1141 gtgccagcct gtgtggtccc ctgtgacccg gtaccagcct gtatgtcccc tcacgctcac
     1201 cctcctggct ccggggccag cagcgtctcc gacttcttga gtgtctctgg agctggcagt
     1261 cacgtgggcc agacacacat gggcagcctg tttggagcag ctggcatcag tccgggcctc
     1321 aatggctacg agatgaacgg cgagccagac cgcaagacct caagcatcgc tgccttgcgc
     1381 atgaaggcca aggagcacag tgcagccatc tcttgggcca catgacagaa cccctcctgc
     1441 aactcctgat gtcatccccc tccctggggc cctggccatg tccctgcttt ccaggccccc
     1501 agcttcccac ttgactctcc tcttaggaac ccggcctggc ccaggggcct ggccctcagc
     1561 actttcagcc accccaagtc tgaggcccca gggactgctg ggagggagga ggtgatggta
     1621 ggctcttgtc cctccctggc tctgaggtca tgacccctgc tccctgccaa aggcagtgga
     1681 gagaggcagg cggctctgtg cgtacctttg catcatgtaa gctgaggccc tgtctttctt
     1741 cgtgttcttc caccccttcc gtttgacttg agtcaaagtc aggccccctt ccagatctac
     1801 cagcttcaac agttcagcct tgcctaacct tcctttctcc tgtggggtat cctggtcgct
     1861 gggcctgtgg ctgtgtgtct tagaaccaag cttccgtgca gggtcagctc ccgatcctct
     1921 ttgctccttg aaaacataga accccacttt ccgtatcgaa ggcatctggt catccactca
     1981 tcccatgagc cctgtgactg tagcttcact gtcccctgtg atggatgtgc ctggaagatg
     2041 tgggagatga gaggaggggt cagagctgaa aggactctgc tgctgtccac ccataagccc
     2101 catggggacg tgggccagcc tttgctcctg caggtggtat tggttgacac tgtgaaggtg
     2161 atgtgccagg tgtgaaggga ggcaagaaca taggtttttt ttttttctcc cattattacc
     2221 accacacatg gacactggga gccagagaag ctctcagaat gatggccatg gggatgatcc
     2281 agcgggctga acctggtgtc ttctgtggcg gagaggtcct ttggtctgca ctggcgcctc
     2341 ctcagggcac ctctgggagg agttgagata tttatcctct ccctcctggt cactcactgg
     2401 ggctggctgg gctggaagaa ttcacacctt ggaagacata agctagagca cagggctgcc
     2461 tgtggctgaa ggaatcaggg gcggaggaca cgtgaccagc tcagcagcct cctggtggcc
     2521 tttctatgct cagactaacc atgtccaccc accaccccac cacagcatct catctgttga
     2581 agctttccgt gcagggtagg tggagactgg tgcccctcta ggctaaaagg agaaccgctt
     2641 ttcagttatc ctacacactc tcttagagat cctatcctta cttctccccc aggggccatg
     2701 atctctgcct cagctggcct caggaaaggc tcccatcaga ccccaccagg tccactctcc
     2761 atggcgggaa gtcctcctga agccagtcca ctatctgaag gaaggggctc cctgtctacc
     2821 tgacttgacc tggagctagg aactaggact tgaagtggcc ccggccctca cctgagcaca
     2881 gaaccaccct tgaggtaggt ccctcaagca ggtggccttt tccccaggag acactcttgc
     2941 cttttctacc ttctgccttg actattgtcc atcaggtggg cttggctcac taggcccaag
     3001 gttcagctct ccgaatggcc tctcaagttg ggctgaggac gaggacccct gccttggatc
     3061 tgacctaggt ctcagtgggt aagagggaag catgacttcc tgctgtgtgc cctcatctgc
     3121 tctggaatgc agacagactg aaccctccat agaatgcaga ctctgggatg ggtctgccac
     3181 tcctagcaag agtcagacct cttcagaaac tttagttctc gaaaagatct tagggacaca
     3241 aagaaggtct tgggtactga attcaggggt cctggtggct tggctttaat gcttcagatc
     3301 tttggggaat ctgggtctgt cttacaagtt ctccagaact aactcacttc ctcagaatct
     3361 atcaagagaa ggaaggactt aaggccagaa gcaacacctt ggggtccttc tttcacggct
     3421 gttatggcca gggaagggca tgtcggaaaa gaattccata cctagacaat cagtacagag
     3481 agtgagagcc agggcagctg gggaagaaaa gaggacagag ggcttttagt agattcttcc
     3541 ggaagggaga gacgtttaac tgctctgagt tttatttttg gccaagctag atgcaagtca
     3601 ggaaaattcc aacccagaag cttcagaatg gcaagaatat atagaaatac ccctttgttt
     3661 ccagcatagc caagagttgg catgctttcc accgtccctc cagatgaagc cgtttctacc
     3721 gaggctgttc tggaggtgcc ttggcctcag ttgattcctg gggcagctgg agatgtcctg
     3781 agctcccact gccccctccc cccaccatgt ctcagacctc ctcagcttcc cagtttgcgg
     3841 ttctgtcgtc tccagtgggt ctgtcttagc tcctcggatg ctaagcaagt aataaaacct
     3901 atcatggcaa cctggcttcc taaagagaca gagaggcaga tgaggagaga ggacttcctg
     3961 ccagcggtca ctgctcgatg aggaaactga ctgagctgag gccggccttg cctgacagca
     4021 cagcaagtgg ccacgcttag tcctgccagc ccggctgtgc cacagagagt ggttatgccc
     4081 agtccagccc atctatccag gagccccttc acagcacagg gccaaggtcc tggggcagac
     4141 aggcactctt ccaagttttt ctttgagttg tttcttcccc attttcagtt ctcacaacca
     4201 catctccacc tttgaggaac aggatgagtg gggatttagg caaagaggca cagctctggg
     4261 ttccccggca cacgctgcca ggctcatgtt ggacacagtt ccaatgcccc atgtccccca
     4321 gcagacagaa aggatcccat agaaaccacc tctcctttac tcagtcaatt gccctctggg
     4381 ccatccttga gcagaacatc gctagggact cagagaaacc cgaggttaaa ggtcaatagg
     4441 aatgaccctg actgtcagct acagagacga acagacccag cagagggaga gaggcaggca
     4501 atctgccacc ctcccccagg atgctaattc ataaccttac catttcaaac cggggcaggc
     4561 ttccatttct ttcccccaac cccactttgc tgcaaggatg ccatctctcc ccctccccct
     4621 ccttccttcc cccttcactt acacatagag ctaggcctgt atactactga ttttggagga
     4681 ctgttttcag tgtctaataa cctgtttggg tgtgcagtgg tcagaaagag agagagagag
     4741 agagagaagc tgatcgagag atggaacgtg aacctcaaat actggctgtt cttgtaagat
     4801 agtttaaccc tgtataaatg caacttttct cttagcttaa tggcctgggg tggaacattc
     4861 aaatatataa atatatatat taaaatacat taaaatttca gaaaaaatgt aaaaaaaaat
     4921 aattgaggtc tgttccataa agttttactg cctataccac catgtaacta cattatagca
     4981 aaatattaaa aaaagaaaca ttcttttctt ttaaagtaag ttattgcact tacatctttt
     5041 ggagagagga ggaatgtgag aagaagggag ctgaggagct gaggggctga ggtgggcaga
     5101 aggcaaggca gaggcagctg acactcccag cacccctttg tcgggtgcag ccaagactgt
     5161 ctgtttggtt gttgttgttt gcaataaact ccttcctcct ctc
//
