LOCUS       NM_007441               1973 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus aristaless-like homeobox 3 (Alx3), mRNA.
ACCESSION   NM_007441 XM_910022
VERSION     NM_007441.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Mirasierra,M., Fernandez-Perez,A., Lizarbe,B., Keiran,N.,
            Ruiz-Canas,L., Casarejos,M.J., Cerdan,S., Vendrell,J.,
            Fernandez-Veledo,S. and Vallejo,M.
  TITLE     Alx3 deficiency disrupts energy homeostasis, alters body
            composition, and impairs hypothalamic regulation of food intake
  JOURNAL   Cell Mol Life Sci 81 (1), 343 (2024)
   PUBMED   39129011
  REMARK    GeneRIF: Alx3 deficiency disrupts energy homeostasis, alters body
            composition, and impairs hypothalamic regulation of food intake.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Nishino,T., Ranade,S.S., Pelonero,A., van Soldt,B.J., Ye,L.,
            Alexanian,M., Koback,F., Huang,Y., Sadagopan,N., Lam,A.,
            Zholudeva,L.V., Li,F., Padmanabhan,A., Thomas,R., van Bemmel,J.G.,
            Gifford,C.A., Costa,M.W. and Srivastava,D.
  TITLE     Single Cell Multimodal Analyses Reveal Epigenomic and
            Transcriptomic Basis for Birth Defects in Maternal Diabetes
  JOURNAL   Nat Cardiovasc Res 2 (12), 1190-1203 (2023)
   PUBMED   39183978
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Vallejo,M.
  TITLE     The aristaless-like homeobox protein Alx3 as an etiopathogenic
            factor for diabetes mellitus
  JOURNAL   Islets 3 (2), 66-68 (2011)
   PUBMED   21350340
  REMARK    GeneRIF: ALX3 could be considered as a candidate gene for the
            etiopathogenesis of diabetes or its complications during embryonic
            or fetal development is discussed
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Mirasierra,M., Fernandez-Perez,A., Diaz-Prieto,N. and Vallejo,M.
  TITLE     Alx3-deficient mice exhibit decreased insulin in beta cells,
            altered glucose homeostasis and increased apoptosis in pancreatic
            islets
  JOURNAL   Diabetologia 54 (2), 403-414 (2011)
   PUBMED   21104068
  REMARK    GeneRIF: ALX3 participates in the regulation of the expression of
            essential genes for the function of pancreatic islets, and its
            deficiency alters the regulation of glucose homeostasis in vivo.
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Lakhwani,S., Garcia-Sanz,P. and Vallejo,M.
  TITLE     Alx3-deficient mice exhibit folic acid-resistant craniofacial
            midline and neural tube closure defects
  JOURNAL   Dev Biol 344 (2), 869-880 (2010)
   PUBMED   20534379
  REMARK    GeneRIF: Alx3-deficient mice exhibit folic acid-resistant
            craniofacial midline and neural tube closure defects.
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Manley,N.R., Barrow,J.R., Zhang,T. and Capecchi,M.R.
  TITLE     Hoxb2 and hoxb4 act together to specify ventral body wall formation
  JOURNAL   Dev Biol 237 (1), 130-144 (2001)
   PUBMED   11518511
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Beverdam,A. and Meijlink,F.
  TITLE     Expression patterns of group-I aristaless-related genes during
            craniofacial and limb development
  JOURNAL   Mech Dev 107 (1-2), 163-167 (2001)
   PUBMED   11520673
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   ten Berge,D., Brouwer,A., Korving,J., Reijnen,M.J., van Raaij,E.J.,
            Verbeek,F., Gaffield,W. and Meijlink,F.
  TITLE     Prx1 and Prx2 are upstream regulators of sonic hedgehog and control
            cell proliferation during mandibular arch morphogenesis
  JOURNAL   Development 128 (15), 2929-2938 (2001)
   PUBMED   11532916
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Meijlink,F., Beverdam,A., Brouwer,A., Oosterveen,T.C. and
            Berge,D.T.
  TITLE     Vertebrate aristaless-related genes
  JOURNAL   Int J Dev Biol 43 (7), 651-663 (1999)
   PUBMED   10668975
  REMARK    Review article
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   ten Berge,D., Brouwer,A., el Bahi,S., Guenet,J.L., Robert,B. and
            Meijlink,F.
  TITLE     Mouse Alx3: an aristaless-like homeobox gene expressed during
            embryogenesis in ectomesenchyme and lateral plate mesoderm
  JOURNAL   Dev Biol 199 (1), 11-25 (1998)
   PUBMED   9676189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122902.4 and AK142019.1.
            
            On Apr 16, 2013 this sequence version replaced NM_007441.2.
            
            Summary: This gene belongs to Group 1 of aristaless-like genes,
            which are characterized by the presence of an aristaless domain and
            a conserved paired-like homeodomain. The encoded protein acts as a
            transcriptional regulator. The protein plays a role in the
            development of craniofacial and appendicular skeleton and may have
            a role in pancreatic function. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96109.1, AK142019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC122902.4         96159-96233
            76-1874             AK142019.1         2-1800
            1875-1973           AC122902.4         106905-107003
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..1973
                     /gene="Alx3"
                     /note="aristaless-like homeobox 3"
                     /db_xref="GeneID:11694"
                     /db_xref="MGI:MGI:1277097"
     exon            1..422
                     /gene="Alx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1177
                     /gene="Alx3"
                     /note="proline-rich transcription factor Alx3"
                     /codon_start=1
                     /product="homeobox protein aristaless-like 3"
                     /protein_id="NP_031467.1"
                     /db_xref="CCDS:CCDS17739.1"
                     /db_xref="GeneID:11694"
                     /db_xref="MGI:MGI:1277097"
                     /translation="MDPERCAPFSVGPAAGPYAAAGDEAPGPQGTPDAAPHLHPAPPR
                     GPRLSRFPACGPLEPYLPEPAKPPAKYLQDLGPGPVLNGGHFYEGSAEAEEKASKAAS
                     FPQLPVDCRGGPRDGPSNVQASPGPCLASLSVPLSPGLPDSMELAKTKSKKRRNRTTF
                     STFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQ
                     EGRNPFTTAYDISVLPRTDSHPQLQNSLWPSPGSGSPGGPCLMSPEGIPSPCMSPYSH
                     SHGNVAGFMGVPASPAAHPGIYSIHGFPPALGGHSFEPSPDGDYKSPSLVSLRMKPKE
                     PPGLLNWTT"
     exon            423..739
                     /gene="Alx3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..868
                     /gene="Alx3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1973
                     /gene="Alx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alx3"
                     /note="hexamer: AATAAA"
     polyA_site      1868
                     /gene="Alx3"
                     /note="major polyA site"
ORIGIN      
        1 cccctctcct gccccccacc ccccgcggcg cgcgccgctc ccgggggctc cgcgcccccg
       61 agcccaggtc cctccccctt ggctcacagg ccgcgcgggt tagcgggagc cccggagctc
      121 cggcggcctg tgagcccgag ccggcatgga ccccgagcgc tgcgcgcctt tctccgtggg
      181 gccggcggcc ggtccttacg cggccgcggg ggacgaggct ccgggtcccc aggggactcc
      241 cgatgctgcg cctcacctgc accccgcgcc accccgcggt ccgcgcctga gccgcttccc
      301 ggcctgtggg cccctggaac cctacctccc agagcccgcc aagccgcccg ccaagtacct
      361 gcaggacctc gggccaggcc cggtgctcaa cggcggccac ttctacgagg gctccgcgga
      421 agccgaggag aaggcctcca aagctgccag cttcccccag ctaccagtgg attgccgagg
      481 gggtcccagg gacggaccct ctaatgtgca agcttccccg ggcccctgcc tggccagcct
      541 gagcgtccct ctttccccgg gactccccga ctccatggag ttggccaaga ccaagagcaa
      601 gaagcgccgg aaccgcacaa ccttcagcac gttccagctg gaagagctgg agaaagtctt
      661 ccagaaaacc cactaccctg acgtgtatgc tcgggagcag ctggctttgc gaacagacct
      721 gactgaggcc agggtacagg tctggttcca gaaccgaaga gccaagtggc ggaagcgtga
      781 gcgttatggg aagatgcagg aggggcggaa ccccttcact acagcctatg acatctccgt
      841 actgcccaga actgacagcc atcctcagct gcagaactcc ctgtggccca gtccaggatc
      901 tggaagccca ggggggccct gtctcatgtc tccagagggc atcccctctc catgcatgtc
      961 cccatactcc cactcccatg gaaatgtggc tggcttcatg ggagtgccag cctcccctgc
     1021 agcccaccct ggcatctatt ccatccatgg cttccctcct gccctgggag ggcacagctt
     1081 tgagccttct ccggatggtg actacaagtc cccaagcctc gtttcactca ggatgaagcc
     1141 caaagagccc cctggcctgc tgaactggac cacgtgatgg gttacatggg cacagactga
     1201 gctgtccact tctcttcctg ctctgacctg ctcctagccc atctctacct ggacaccaaa
     1261 cagcaaaccc ttttacctcc ataacctggg tggttctgga agcttggaag aggagctggg
     1321 accctcagcc tcctgcaggg aacaggctac agggtcttat ttcttaaaat aggtggggct
     1381 gcctaggaga cagggacttc aaagcaggta ggactcctcc ttataaaatg gctcccctca
     1441 tttaaattgg gctggagaaa aggtgacaga tgccccctgt tttccaaaga ctgtttctaa
     1501 gtccagggag cccaggaaga tgggaggagg gtgcagacta aacagggagg cgctctctgt
     1561 ggttcttagg gctggcctca cttttgcctt cctaccacca gggggcggta cgctcagctc
     1621 ctgggactga caagatccca gacggtgaag gtcagctcaa taataggtgg gggggtctcc
     1681 tctgttccaa gcatccctca cttctgccct gtgctagtct acagagatac tataaagtca
     1741 ttttctccaa gtagggagaa gaaattccac caaacattaa atatttggat ttgctttcat
     1801 gggatcaggg atatgccatg aaaaccatat tggacatcga tcaaaataaa aaaaaaattt
     1861 tttttccagt ttctgagccc ctgatcccca gaccctgatt tttgtaaaga tacttttgtt
     1921 ttgttgtagt gtgctgctta gcatagtaat aaacacaata gtgtttttca ttc
//
