LOCUS       NM_007433               2113 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus alkaline phosphatase, placental-like 2 (Alppl2), mRNA.
ACCESSION   NM_007433
VERSION     NM_007433.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Arno,B., Galli,F., Roostalu,U., Aldeiri,B.M., Miyake,T.,
            Albertini,A., Bragg,L., Prehar,S., McDermott,J.C., Cartwright,E.J.
            and Cossu,G.
  TITLE     TNAP limits TGF-beta-dependent cardiac and skeletal muscle fibrosis
            by inactivating the SMAD2/3 transcription factors
  JOURNAL   J Cell Sci 132 (15) (2019)
   PUBMED   31289197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2113)
  AUTHORS   Yu,C., Ji,S.Y., Dang,Y.J., Sha,Q.Q., Yuan,Y.F., Zhou,J.J.,
            Yan,L.Y., Qiao,J., Tang,F. and Fan,H.Y.
  TITLE     Oocyte-expressed yes-associated protein is a key activator of the
            early zygotic genome in mouse
  JOURNAL   Cell Res 26 (3), 275-287 (2016)
   PUBMED   26902285
REFERENCE   3  (bases 1 to 2113)
  AUTHORS   Foster,B.L., Nagatomo,K.J., Nociti,F.H. Jr., Fong,H., Dunn,D.,
            Tran,A.B., Wang,W., Narisawa,S., Millan,J.L. and Somerman,M.J.
  TITLE     Central role of pyrophosphate in acellular cementum formation
  JOURNAL   PLoS One 7 (6), e38393 (2012)
   PUBMED   22675556
REFERENCE   4  (bases 1 to 2113)
  AUTHORS   Sambasivan,R., Gayraud-Morel,B., Dumas,G., Cimper,C., Paisant,S.,
            Kelly,R.G. and Tajbakhsh,S.
  TITLE     Distinct regulatory cascades govern extraocular and pharyngeal arch
            muscle progenitor cell fates
  JOURNAL   Dev Cell 16 (6), 810-821 (2009)
   PUBMED   19531352
  REMARK    Erratum:[Dev Cell. 2009 Jul;17(1):150. Kelly, Robert [corrected to
            Kelly, Robert G]]
REFERENCE   5  (bases 1 to 2113)
  AUTHORS   Narisawa,S., Hoylaerts,M.F., Doctor,K.S., Fukuda,M.N., Alpers,D.H.
            and Millan,J.L.
  TITLE     A novel phosphatase upregulated in Akp3 knockout mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 293 (5), G1068-G1077 (2007)
   PUBMED   17901166
REFERENCE   6  (bases 1 to 2113)
  AUTHORS   Wang,D., Ikeda,Y., Parker,K.L. and Enders,G.C.
  TITLE     Germ cell nuclear antigen (GCNA1) expression does not require a
            gonadal environment or steroidogenic factor 1: examination of GCNA1
            in ectopic germ cells and in Ftz-F1 null mice
  JOURNAL   Mol Reprod Dev 48 (2), 154-158 (1997)
   PUBMED   9291464
REFERENCE   7  (bases 1 to 2113)
  AUTHORS   Narisawa,S., Frohlander,N. and Millan,J.L.
  TITLE     Inactivation of two mouse alkaline phosphatase genes and
            establishment of a model of infantile hypophosphatasia
  JOURNAL   Dev Dyn 208 (3), 432-446 (1997)
   PUBMED   9056646
REFERENCE   8  (bases 1 to 2113)
  AUTHORS   Miyake,T., Cameron,A.M. and Hall,B.K.
  TITLE     Stage-specific expression patterns of alkaline phosphatase during
            development of the first arch skeleton in inbred C57BL/6 mouse
            embryos
  JOURNAL   J Anat 190 (Pt 2) (Pt 2), 239-260 (1997)
   PUBMED   9061447
REFERENCE   9  (bases 1 to 2113)
  AUTHORS   Manes,T., Glade,K., Ziomek,C.A. and Millan,J.L.
  TITLE     Genomic structure and comparison of mouse tissue-specific alkaline
            phosphatase genes
  JOURNAL   Genomics 8 (3), 541-554 (1990)
   PUBMED   2286375
REFERENCE   10 (bases 1 to 2113)
  AUTHORS   Hahnel,A.C., Rappolee,D.A., Millan,J.L., Manes,T., Ziomek,C.A.,
            Theodosiou,N.G., Werb,Z., Pedersen,R.A. and Schultz,G.A.
  TITLE     Two alkaline phosphatase genes are expressed during early
            development in the mouse embryo
  JOURNAL   Development 110 (2), 555-564 (1990)
   PUBMED   2133555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN717647.1, BC052874.1, AK145571.1 and BB727113.1.
            
            On Jan 26, 2007 this sequence version replaced NM_007433.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052874.1, AY054302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CN717647.1         379-395
            18-691              BC052874.1         13-686
            692-2080            AK145571.1         601-1989
            2081-2104           BC052874.1         2076-2099
            2105-2108           AK145571.1         2015-2018
            2109-2109           BC052874.1         2104-2104
            2110-2111           BB727113.1         421-422
            2112-2113           BC052874.1         2107-2108
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.05 cM"
     gene            1..2113
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /note="alkaline phosphatase, placental-like 2"
                     /db_xref="GeneID:11650"
                     /db_xref="MGI:MGI:108009"
     exon            1..229
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1755
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /EC_number="3.1.3.1"
                     /note="embryonic-type alkaline phosphatase; embryonic
                     alkaline phosphatase; alkaline phosphatase 5; alkaline
                     phosphatase, germ cell type"
                     /codon_start=1
                     /product="alkaline phosphatase, germ cell type precursor"
                     /protein_id="NP_031459.3"
                     /db_xref="CCDS:CCDS15126.1"
                     /db_xref="GeneID:11650"
                     /db_xref="MGI:MGI:108009"
                     /translation="MWGACLLLLGLSLQVCPSVIPVEEENPAFWNRKAAEALDAAKKL
                     KPIQTSAKNLVILMGDGMGVSTVTATRILKGQQQGHLGPETQLAMDRFPHMALSKTYN
                     TDKQIPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTWGNEVVSVMHRAKKAGKS
                     VGVVTTTSVQHASPAGTYAHTVNRGWYSDAQMPASALQDGCKDISTQLISNMDIDVIL
                     GGGRKFMFPKGTPDQEYPTDTKQAGTRLDGRNLVQEWLAKHQGARYVWNRSELIQASL
                     NRSVTHLMGLFEPNDMKYEIHRDPAQDPSLAEMTEVAVRMLSRNPKGFYLFVEGGRID
                     HGHHETVAYRALTEAVMFDSAVDKADKLTSEQDTMILVTADHSHVFSFGGYTQRGASI
                     FGLAPFKAEDGKSFTSILYGNGPGYKLHNGARADVTEEESSNPTYQQQAAVPLSSETH
                     SGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAACLEPYTDCGLASPAGQSSAVSPGY
                     MSTLLCLLAGKMLMLMAAAEP"
     exon            230..346
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            347..462
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            463..637
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            638..810
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            811..945
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1018
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1153
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1345
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1462
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..2113
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /note="hexamer: AATAAA"
     polyA_site      2113
                     /gene="Alppl2"
                     /gene_synonym="Akp5; Alpg; D1Ertd816e; EAP"
                     /note="major polyA site"
ORIGIN      
        1 gtctctgccc ctggagtggc agattaaagg tgtgcccagt tatttggttg ctgttggaac
       61 taaatcttcg cctatttaag aggaacacat caggacctca gctagtgttg tggtattgca
      121 gcttctccat ccgccatcct cacagaccag caccctgcca cagcaatgtg gggagcctgc
      181 ttgctgctgc tgggcctcag cctacaggtg tgcccgagcg tcatcccagt ggaggaggag
      241 aatccagcct tctggaaccg aaaggcagcc gaggccctgg atgctgccaa gaagctgaag
      301 cccattcaga catcagctaa gaacctcgtt atcctcatgg gagatgggat gggggtgtct
      361 acagtaaccg ctacccggat cctaaagggg cagcagcaag gccatctggg acctgagaca
      421 cagctagcta tggatcgctt tccacacatg gctctgtcca agacatacaa cacagacaag
      481 cagatcccgg acagcgcagg cacaggtaca gcctttctct gcggggtcaa aaccaacatg
      541 aaggtcattg gcttgagtgc agctgcacgc ttcaaccagt gcaacacgac atggggtaac
      601 gaggtcgtct cggtgatgca ccgtgctaag aaagcaggaa agtctgtggg agtggtgacc
      661 accacgtcgg tgcagcatgc ttctccggcc ggcacctacg cgcacactgt gaaccgtggt
      721 tggtactcgg atgcacaaat gcctgcctca gcgctacagg atggctgcaa agacatctct
      781 actcagctca tctccaacat ggacattgat gtgatcctcg gtggtggccg caagttcatg
      841 tttcccaagg ggacaccaga ccaggaatat ccaactgaca ccaagcaggc tggaaccagg
      901 ctggatggac gcaacctagt tcaagagtgg ctggcaaagc accagggagc ccggtatgtt
      961 tggaaccgct cagagctcat tcaggcatcc ctgaaccgat ctgtgacaca cctcatgggc
     1021 ctctttgagc ctaacgacat gaaatatgaa atccaccgag accctgctca ggacccttcc
     1081 ctggccgaga tgacggaggt ggctgtgcgc atgctcagca ggaaccccaa aggcttctat
     1141 ctctttgtgg aagggggtcg catcgaccat ggccaccatg aaactgtagc ctatcgtgcc
     1201 ctgactgagg ctgtcatgtt cgactcagct gttgacaagg cagacaagct caccagtgag
     1261 caggacacga tgatccttgt cactgccgac cactctcacg tcttctcttt tggtggttac
     1321 acacagagag gggcttccat ctttggactg gctcccttca aggctgagga tggcaaatcc
     1381 tttacctcga tactatacgg caacggtcct ggttacaagc tccataatgg cgcccgggct
     1441 gatgtcactg aggaagagag cagcaacccc acgtaccagc agcaggctgc tgtacccctg
     1501 tcgtcagaga cccacagcgg ggaggacgtg gcaatattcg cgcgtggccc acaggcgcac
     1561 ctggtgcacg gagttcagga gcagaactac atcgcgcacg tcatggcctt cgcagcctgc
     1621 ctggagccct acactgactg cggcctggca tcccctgctg gccagagcag tgcagtgagc
     1681 ccgggctaca tgtccacctt gctgtgcctg ttggcaggga aaatgttgat gctgatggcg
     1741 gcggctgaac cctgactacc taagctcact acctaagact ccacttgttg gcttgttcag
     1801 tgcctttctg ccagtactgt tttctgggct ccagctggaa acccacttcc taagctcaga
     1861 actaacttgg tttgtcagct ataccttagt atgaggcctc cttcatctgg tacttttttt
     1921 ccctgcagtt ttttgagaca gggtctggcc tagtcaagat ttcagtccac catcttaacc
     1981 tcagcttccc cgaatctggg actgtaggtg cctcctcctg tgtctggctg ccataaaaat
     2041 gaagagtgtt tatcttcttg gacccttctt tttttttttt gtggggacaa taaaaccaac
     2101 tgttacacac aaa
//
