LOCUS       NM_054085               6369 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus alpha-kinase 3 (Alpk3), mRNA.
ACCESSION   NM_054085
VERSION     NM_054085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6369)
  AUTHORS   Zhao,S., Zhao,H., Zhao,L., Cheng,X., Zheng,Z., Wu,M., Wen,W.,
            Wang,S., Zhou,Z., Xie,H., Ruan,D., Li,Q., Liu,X., Ou,C., Li,G.,
            Zhao,Z., Chen,G., Niu,Y., Yin,X., Hu,Y., Zhang,X., Liu,P., Qiu,G.,
            Liu,W., Zhao,C., Wu,Z., Zhang,J. and Wu,N.
  CONSRTM   Deciphering disorders Involving Scoliosis and COmorbidities (DISCO)
            study
  TITLE     Unraveling the genetic architecture of congenital vertebral
            malformation with reference to the developing spine
  JOURNAL   Nat Commun 15 (1), 1125 (2024)
   PUBMED   38321032
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6369)
  AUTHORS   Agarwal,R., Wakimoto,H., Paulo,J.A., Zhang,Q., Reichart,D.,
            Toepfer,C., Sharma,A., Tai,A.C., Lun,M., Gorham,J., DePalma,S.R.,
            Gygi,S.P., Seidman,J.G. and Seidman,C.E.
  TITLE     Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an
            Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere
  JOURNAL   Circulation 146 (22), 1674-1693 (2022)
   PUBMED   36321451
REFERENCE   4  (bases 1 to 6369)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 6369)
  AUTHORS   Van Sligtenhorst,I., Ding,Z.M., Shi,Z.Z., Read,R.W., Hansen,G. and
            Vogel,P.
  TITLE     Cardiomyopathy in alpha-kinase 3 (ALPK3)-deficient mice
  JOURNAL   Vet Pathol 49 (1), 131-141 (2012)
   PUBMED   21441111
  REMARK    GeneRIF: ALPK3 plays a role in establishing normal structure and
            function of the myocardium.
            GeneRIF: Cardiomyopathy developed in mice deficient for
            alpha-kinase 3 (ALPK3)
REFERENCE   6  (bases 1 to 6369)
  AUTHORS   Hosoda,T., Monzen,K., Hiroi,Y., Oka,T., Takimoto,E., Yazaki,Y.,
            Nagai,R. and Komuro,I.
  TITLE     A novel myocyte-specific gene Midori promotes the differentiation
            of P19CL6 cells into cardiomyocytes
  JOURNAL   J Biol Chem 276 (38), 35978-35989 (2001)
   PUBMED   11418590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109220.16.
            
            On Nov 13, 2006 this sequence version replaced NM_054085.1.
            
            Sequence Note: This RefSeq record was created using sequence from
            the reference genome strain C57BL/6J because transcripts from the
            reference strain were not available for the full length of the
            gene.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF338872.1, SRR10223969.7462.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC109220.16        157406-157578       c
            174-212             AC109220.16        151191-151229       c
            213-334             AC109220.16        147178-147299       c
            335-452             AC109220.16        138188-138305       c
            453-1740            AC109220.16        136345-137632       c
            1741-3778           AC109220.16        120994-123031       c
            3779-3926           AC109220.16        120124-120271       c
            3927-4054           AC109220.16        119649-119776       c
            4055-4090           AC109220.16        119485-119520       c
            4091-4365           AC109220.16        116157-116431       c
            4366-4454           AC109220.16        114919-115007       c
            4455-4678           AC109220.16        114047-114270       c
            4679-4727           AC109220.16        111785-111833       c
            4728-6369           AC109220.16        109566-111207       c
FEATURES             Location/Qualifiers
     source          1..6369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..6369
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /note="alpha-kinase 3"
                     /db_xref="GeneID:116904"
                     /db_xref="MGI:MGI:2151224"
     exon            1..173
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..5073
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /EC_number="2.7.11.1"
                     /note="myocytic induction/differentiation originator;
                     myocyte induction differentiation originator"
                     /codon_start=1
                     /product="alpha-protein kinase 3"
                     /protein_id="NP_473426.2"
                     /db_xref="CCDS:CCDS40004.1"
                     /db_xref="GeneID:116904"
                     /db_xref="MGI:MGI:2151224"
                     /translation="MGSRRAAGRGWGLGGRAGAGGDSEDDGPVWTPGPASRSYLLSVR
                     PEASLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRAVSEDSDVRFTCIVTG
                     YPEPEVTWYKDDIELDRYCGLPKYEITHQGNRHTLQLYRCQEEDAAIYQASARNTKGI
                     VSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKMREIEQSWKHGKEASGEADTLLRKIS
                     PDRFQRKRRLSGVEEAVLSTPVREMEEGSSAAWQEGETESAQHPGLGLINSFAPGEAP
                     TNGEPAPENGEDEERGLLTYICEVMELGPQNSPPKESGAKKKRKDEESKPGEQKLELE
                     KAEGSQCSSENVVPSTDKPNSSRREKSTDTQPAQTQPRGRVARGPGIESTRKTASVLG
                     IQDKVQDVPAPAPAPVPAPALAPAPVPVPAPTPVPSRSSEQVYFSLKDMFMETTRAGR
                     SQEEEKPPPPSTRVAGESPPGKTPVKSRLEKVPMVSSQPTSSMVPPPIKPLNRKRFAP
                     PKSKVESTTTSLSSQTSESMAQSLGKALPSASTQVPTPPARRRHGTRDSPLQGQTSHK
                     TPGEALESPATVAPTKSANSSSDTVSVDHDSSGNQGATEPMDTETQEDGRTLVDGRTG
                     SRKKTHTDGKLQVDGRTQGDGAQDRAHASPRTQAGEKAPTDVVTQGSERPQSDRSSWK
                     NLVTQRRVDMQVGQMQAGERWQQDPGDARIQEEEKETQSAAGSIPVAFETQSEQLSMA
                     SLSSLPGALKGSPSGCPRESQAIECFEKSTEAPCVQERSDLMLRSEEAAFRSHEDGLL
                     GPPSGNRTYPTQLPPEGHSEHLGGQTHQRSEQEDSLSQCPKKEQPQEPLHVGLSGGHS
                     TGLSQEVPAMPSLPGTGLTSSLQEELPGTAASLHTNTDVPLPSRDQDFPSSAPTLQLG
                     PGSPTQSHPPEAMATSSEGACAKEPNVDGRSSGTRSCDPGLIDSLKNYLLLLLKLSSP
                     ETSEARAESQEVADTGGLTSSSTLVPTMEVAGLSPRTSRRILERVENNHLVQSAQTLL
                     LSPCTSRRLTGLLDREVQAGQQALAAAQCSRGPCPTPLTIPAIVVGEEGSAGEDSEER
                     TSQESDKKGLLGEVEGHTVESRTQEPCQEEAMPGEALTGLPAATPEELALGARRKRFL
                     PKVRAGSDGEANKAEERESPTVSPRGPRKGLTPGSPGTPGRERRSPTQARKASMLEVP
                     GAEEEPATGDLVSRSKDSGLDSEPAVDEGKQEALAKQRKAKDLLKAPQVIRKIRVEQF
                     PDSSGSLKLWCQFFNIVSDSVLTWAKDQHPVGEVNRSAGDEGPAALAIVQASPTDCGV
                     YRCTIQNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDK
                     LFGRLVSEELRGGGHGLQKASRAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLL
                     GRNYDVTIQGCKIQNMSREYCKIFAAEARAASGFGEVPEIIPLYLIYRPANNIPYATL
                     EEDLGKPLQTYCSRQWGCAGAPAAASSSEALQKCQTFQHWLYQWTNGSFLVTDLTGAD
                     WKMTDVQIATKLRGYQGLKESCFPALLDQFASSHQCNTYCDMLGLKPLKGPEAAHPQA
                     KAKGSKSPSAGRKGSQLSPQPQKKGLPSPQGSRKSAPSSRATLQASQAATVQLLGQPP
                     VQDGSSKAQSMR"
     exon            174..212
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            213..334
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            335..452
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            453..1740
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..3778
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3926
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4054
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4090
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4365
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4454
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4678
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4727
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..6369
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6331..6336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /note="hexamer: AATAAA"
     polyA_site      6369
                     /gene="Alpk3"
                     /gene_synonym="D330016D04; MAK; Midori; mKIAA1330"
                     /note="major polyA site"
ORIGIN      
        1 gccggggctg gaggcagggg ctgcggtgcc atggggtcgc ggagggccgc gggccggggc
       61 tggggcctgg gtggtcgagc aggagctggt ggagatagcg aggacgacgg gccggtgtgg
      121 acgcccggcc cagccagtcg cagctacttg cttagcgtgc ggccagaggc tagcttatca
      181 agcaaccggt tgtctcaccc cagctctgga aggagcacct tctgctccat cattgctcag
      241 ctcacagagg agacccagcc actgttcgag accacactca agtcccgtgc cgtgtccgaa
      301 gacagtgacg tcaggttcac ctgcattgtc acaggatacc cagagccaga ggtgacctgg
      361 tacaaggatg acatagaact ggaccgttac tgtggcttgc caaaatacga gatcactcat
      421 caaggcaacc gtcacaccct gcagctgtac aggtgtcagg aagaagatgc tgccatctac
      481 caagcctctg cccggaacac caagggcatc gtgtcctgct caggggtcct agaggtgggc
      541 actatgacgg agtacaagat tcaccagcgc tggttcgcca agttgaagcg caaggctgca
      601 gccaagatga gggagattga gcagagctgg aagcatggaa aagaggcttc aggggaggct
      661 gacacgcttc ttcgcaagat cagccccgac cgcttccaaa gaaagcgccg actgagtgga
      721 gtcgaagagg ctgtcctctc cacgccagtc agggaaatgg aggaaggctc ctcagcggct
      781 tggcaggaag gagagactga gtctgctcag cacccggggt tgggtttgat caacagtttt
      841 gctcctggag aggcgcccac caatggggag cctgctccag agaacgggga agacgaagag
      901 cgtggcttgc tgacatacat ctgcgaggtc atggaactgg ggcctcagaa cagccctcca
      961 aaggagtctg gggctaagaa gaaaaggaag gatgaggaat ctaaaccagg agagcagaag
     1021 ctggagttag aaaaggcaga agggagccag tgctcttcag aaaacgtcgt ccccagtaca
     1081 gacaaaccca actccagtag aagggagaag tccacggata cacagccagc tcagacccag
     1141 cccagaggcc gggtagcacg ggggcctggg atagaaagca ccaggaagac agcctctgtc
     1201 ctgggcattc aagacaaggt ccaggatgtc cccgcccccg cccctgcccc ggtccccgcc
     1261 ccagccctgg ccccggcccc tgtcccagtc cctgcaccca cccctgttcc aagccgcagc
     1321 tcagagcagg tgtatttctc cctgaaggac atgttcatgg agaccacccg ggcaggcagg
     1381 tcccaggaag aggaaaaacc tccacctcca agtaccaggg tagctggaga aagtccccca
     1441 ggaaagacac cagtcaagtc tagactggag aaggtaccga tggtctccag ccagcccaca
     1501 tcttccatgg ttcccccgcc cattaagcct ttgaacagga agagatttgc ccctcctaaa
     1561 tccaaagtgg agtcaactac tacctctctc tcaagtcaga cttcagaatc tatggcccag
     1621 agcttaggga aggctctacc ttcagcctct acccaggtcc caacaccccc tgctcgacgg
     1681 agacacggca cccgagatag ccccttgcaa ggacaaacga gccacaagac tccaggagag
     1741 gctctggagt ccccagcaac cgtggctccc accaagtctg ccaacagcag ctccgatacc
     1801 gtctctgttg atcacgacag ctctggaaat caaggggcca cggagcccat ggatacagaa
     1861 actcaggaag atggaaggac acttgtggat gggagaactg gaagcaggaa gaaaacacac
     1921 acagatggaa agctgcaagt ggatgggagg actcagggag acggagcaca agacagagca
     1981 cacgcttcgc caaggacaca ggcaggtgag aaggcaccga cggacgttgt gacacaagga
     2041 agtgagaggc cacagtcaga caggagttca tggaagaatt tggtgacaca gagaagagtg
     2101 gatatgcagg taggacagat gcaggcaggt gagaggtggc agcaagaccc tggagacgca
     2161 aggatacagg aggaagaaaa agagacacag tcagcagcag gcagcattcc tgtagctttc
     2221 gaaacccaat cagagcagtt gtccatggcc agcctcagct cacttcctgg agctctcaaa
     2281 ggctcaccat caggatgccc tagagagtcc caggctatag aatgttttga gaagagcaca
     2341 gaggcaccct gtgtccaaga aagatctgac ttgatgctgc ggtctgaaga ggcagccttc
     2401 agaagccatg aggatgggct gctaggcccc ccatcaggga accgtaccta cccaacacag
     2461 ttgcctcccg aggggcactc agagcatttg ggaggacaaa cacatcaaag gtcagagcaa
     2521 gaggacagcc tgtctcagtg ccccaagaag gagcagcccc aggaaccgct tcatgtgggt
     2581 ctctctggtg ggcattcaac tggcttgagt caggaggtgc ctgccatgcc ttctcttcct
     2641 gggacgggcc taaccagtag tctgcaggag gagctaccag gcaccgcagc ttctctgcac
     2701 acaaacacag atgtccccct cccctccagg gaccaggact ttccgagttc tgctcccact
     2761 ctgcaattgg ggccagggtc ccccactcag agtcacccac cagaagccat ggctactagc
     2821 agtgagggag cctgtgccaa ggagccaaat gtggacggga ggtcctcagg tacccggagc
     2881 tgtgaccctg gccttataga ttccctgaag aactacttgc ttctgctgct gaagctatcc
     2941 agtccagaga caagtgaagc cagggccgag tcccaggaag tggcagacac cgggggctta
     3001 acctcctcct ctactctggt ccccaccatg gaggtggctg ggctgagtcc caggacgtcg
     3061 aggcgaatcc tggaacgcgt ggagaacaat cacttagtgc agagtgcaca gaccctgttg
     3121 ctgagcccct gcacctcccg ccgccttact ggccttctgg accgtgaggt acaggctggc
     3181 cagcaggctc tggctgctgc ccagtgctct cggggcccgt gccccacccc cctcaccatc
     3241 cctgccattg tggtgggtga ggaaggatct gcgggagagg attccgagga gaggacttcg
     3301 caggaaagtg acaagaaggg actgctaggg gaagtggagg ggcacacagt ggaaagcaga
     3361 acccaggagc cctgccaaga agaagcaatg ccaggggagg ctttgacggg tctccctgca
     3421 gctacacccg aggaactggc tctgggggcc cggaggaaga ggttcctccc taaggtcaga
     3481 gcagggtcag atggagaggc aaacaaggct gaagaaaggg agagccccac ggtttccccc
     3541 cggggaccca ggaagggcct gacacctggg tcaccaggga ctccagggcg ggagagacgg
     3601 tcccctaccc aggcccgaaa agccagcatg ttagaggtgc ctggcgcaga agaagagcct
     3661 gcaactggag acttggtctc cagatccaaa gacagtggcc tggactcaga gcctgcggtg
     3721 gatgaaggca agcaggaagc tctggccaag caaaggaaag ctaaggacct gctaaaagcc
     3781 ccacaggtga tccggaaaat tcgggtggaa cagtttccag attcttctgg tagtctgaag
     3841 ctttggtgcc agtttttcaa cattgttagt gactcagtct tgacatgggc gaaggatcag
     3901 cacccagtgg gcgaagtgaa caggagtgca ggggacgagg ggccagcggc tttggccatc
     3961 gtgcaggcgt ctcccacgga ctgtggtgtg tatcgctgta ccatccaaaa cgagcatggc
     4021 tcagcgtcca ctgacttctg cctcagcccc gaggtattgt ccggcttcat ctccagagag
     4081 gaaggtgaag ttggagaaga gattgagatg acccccatgg tgtttgctaa gggtctggct
     4141 gactctggct gctgggggga caagctcttt gggcgattgg tgagcgagga acttcgaggg
     4201 ggtggacatg gccttcagaa ggcgtcccgg gccaaggtca tctatgggct ggaacccatc
     4261 ttcgaatctg gccgcacgtg catcatcaaa gtatccagcc tgcttgtgtt cggacccagc
     4321 agtgagacct ctcttctggg cagaaactat gacgtcacta tccagggatg caagatccag
     4381 aacatgagtc gagagtactg caaaatcttt gcagctgaag cccgggcggc ctctggcttc
     4441 ggagaggtgc ccgagatcat cccactctac ttgatctacc ggcctgcaaa caatatacca
     4501 tatgcaaccc tggaggaaga tctgggcaag cccctgcaga cttactgttc caggcagtgg
     4561 ggctgtgctg gggcccccgc agcagccagc agctccgagg ccttgcagaa atgccaaacc
     4621 ttccagcact ggctgtatca gtggacaaac ggcagctttc ttgtcacaga tctgacagga
     4681 gctgactgga agatgactga tgtacagatt gctaccaaac ttcgaggata ccaaggcctc
     4741 aaggagagct gttttcctgc cctgctggac cagtttgcct cttcccacca gtgtaacacc
     4801 tactgtgaca tgctggggct gaagcccctc aaaggccctg aggctgccca ccctcaagcc
     4861 aaggccaaag gctccaaaag tccatctgct ggcagaaaag gctcacagct gagtcctcaa
     4921 ccccagaaga aaggccttcc cagtccccag ggctccagga agagcgctcc aagctccagg
     4981 gctacacttc aggcctccca ggcagccact gttcagttac tgggacagcc tcctgtccaa
     5041 gatgggagct ctaaggccca gagcatgcgg tagccccacc aggaagcggg gggcctctac
     5101 ccgagagcag accaaccagg aagcagcttg aaccagatgg agacattttc gattcaggac
     5161 taaccagaga aggtgcccag aggaggcatg cctttgggac ctctctgagt agtttcacct
     5221 cattggaagg ctttgggcac atgacctatt ggcctcttca actttcatta tcacccaggg
     5281 ctcccaggcc ccaagtgggg cccacctcca agtacctggt ggcctagacc ctcatctaag
     5341 tttacacttg ccactgctgg gggctcctga gtcctctgca tgagttctgc actctgaccc
     5401 cttgccccaa tcaccacaca agtaagtgtt gcactctggg gccagcaggc cagcatttac
     5461 ctttttgccc ctgcttatcc tggctctctc cctgtcctca gggcactaga cttcttgtgt
     5521 ggggtctagc cttgtgcctc tcagggtttc atctcctttc agcttctttg cctcattcat
     5581 cacagtttat cctgccacta acctgtcctg agtccccccc tgggccccag agccctctgg
     5641 agcctatcac ttctttgtgc agtgtttttt gttttttttt ttttttgttt tttttttgat
     5701 gaaccatgtt cttgtcactc tgcacttact tgtttcccat gctgccttgc acacacgccc
     5761 gtcccccatc ccaggctttg aacccaattc agtctgctgc ctgcccttcc ctggcttttg
     5821 cttatccctt tgtctaaggg ctccttctat cctgaccctg catcctaccc accagcgtat
     5881 gggcaaggaa cagcctgtct gacttcactc taccctagtg ccctctcccc tggctctccc
     5941 aggttctctg ctcaggagga gggaggtggc acgggaacct gtgaacagct actggggcca
     6001 gggattaact ctaagtgcct tatactctgt tctgaaagga gtgaggttgc agtaaatgtc
     6061 acatctctat cctcaaggac tagagactag gactcacttg ggggaagagg aggcacaggg
     6121 tgttcctgga gggtttcgat ccattcacac gcttgtgtag agaaggatat ctttctgcct
     6181 acctccaacc atttgctctt gatcctgctc aggtgtgggt ccccagggaa tttctgtgca
     6241 ggggtccagc accctgggcc ctttctagat acccctcctg agacctggaa tggagtaggg
     6301 tctggagcta gcctgctccc cttgctatgc aataaaggca gtgactgtgt gtcctgtttg
     6361 ttgctctca
//
