LOCUS       NM_001037294            7250 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus alpha-kinase 2 (Alpk2), mRNA.
ACCESSION   NM_001037294 XM_001002606 XM_001002615 XM_914598 XM_985897
VERSION     NM_001037294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7250)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7250)
  AUTHORS   Bogomolovas,J., Feng,W., Yu,M.D., Huang,S., Zhang,L., Trexler,C.,
            Gu,Y., Spinozzi,S. and Chen,J.
  TITLE     Atypical ALPK2 kinase is not essential for cardiac development and
            function
  JOURNAL   Am J Physiol Heart Circ Physiol 318 (6), H1509-H1515 (2020)
   PUBMED   32383995
  REMARK    GeneRIF: murine Alpk2-gKO models developed in this work display no
            overt cardiac phenotype. Our results suggest ALPK2, as a rapidly
            evolving gene, lost its essential cardiac functions in mammals.
REFERENCE   3  (bases 1 to 7250)
  AUTHORS   Budry,L., Balsalobre,A., Gauthier,Y., Khetchoumian,K., L'honore,A.,
            Vallette,S., Brue,T., Figarella-Branger,D., Meij,B. and Drouin,J.
  TITLE     The selector gene Pax7 dictates alternate pituitary cell fates
            through its pioneer action on chromatin remodeling
  JOURNAL   Genes Dev 26 (20), 2299-2310 (2012)
   PUBMED   23070814
REFERENCE   4  (bases 1 to 7250)
  AUTHORS   Ryazanov,A.G., Pavur,K.S. and Dorovkov,M.V.
  TITLE     Alpha-kinases: a new class of protein kinases with a novel
            catalytic domain
  JOURNAL   Curr Biol 9 (2), R43-R45 (1999)
   PUBMED   10021370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157910.4.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_914598.2, XM_985897.1, XM_001002615.1, XM_001002606.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.20089.1,
                                           SRR10223971.17514.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC157910.4         22419-22673
            256-382             AC157910.4         38165-38291
            383-500             AC157910.4         43469-43586
            501-2181            AC157910.4         65599-67279
            2182-5545           AC157910.4         108494-111857
            5546-5693           AC157910.4         116146-116293
            5694-5821           AC157910.4         121968-122095
            5822-5857           AC157910.4         122192-122227
            5858-6132           AC157910.4         124777-125051
            6133-6221           AC157910.4         126541-126629
            6222-6439           AC157910.4         135212-135429
            6440-6488           AC157910.4         139613-139661
            6489-7250           AC157910.4         150017-150778
FEATURES             Location/Qualifiers
     source          1..7250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 38.41 cM"
     gene            1..7250
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /note="alpha-kinase 2"
                     /db_xref="GeneID:225638"
                     /db_xref="MGI:MGI:2449492"
     exon            1..255
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            256..382
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..6708
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /EC_number="2.7.11.1"
                     /note="heart alpha-kinase; heart alpha-protein kinase"
                     /codon_start=1
                     /product="alpha-protein kinase 2"
                     /protein_id="NP_001032371.1"
                     /db_xref="CCDS:CCDS50310.1"
                     /db_xref="GeneID:225638"
                     /db_xref="MGI:MGI:2449492"
                     /translation="MTDPGCPERRTLCFLSTLLSQKVPEKSDVVLRCMIAGQPKPEVT
                     WYKNGQAIDLGGTVSSYEFFENQYIHLLHLSCCTQSDAAVYQVSARNCVGMICCSASL
                     EVQCLQDPQVSPDPGGGRDAAGECKTEIREEDSINHTDEKWNPCKKGESTADSFLDKF
                     NHLSSPQIVARGDSGASNSENPQYIKETRQRMGQYNSNNMQENSFNSNNTAEKQDVSQ
                     LWTVNATVPGLVSDGLGYEESNESVSPSHQTPKVQKYISFSLPLPETTLGPYPEDSNS
                     INMQPGPQVSSEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRSL
                     QGTDRVFLLESDDEEMEFNECGLGGCEHFFTEMGCGPQVSGGMWSMNVATGFCSYHSQ
                     PQEVRVRSSGTSGHSPLPLHSEMTLTLGPHQDETAKMTEPGRAPLPTAPEAVENDCSG
                     IRGETRDNPEAGEEFSGDNLQTMDKVETEASVKPLSGGSDKTEVKQGLESLARERTDE
                     KYPGSKKAALRPTRARRPGMKANTKKQLLRDSAPKGTLDLLPKEPTRQPLPGSYGQEP
                     THTEAGAPGWDSHFHAEVCIPLPAEQDSKILRPPADPLSKEEDSSFEGGGALLNKLFE
                     ASQIPDRTDHLQMQIQETIGESSSLDQMLAFSVPAEESSTFAGATTHSVSNLSEINRE
                     NLSLAQYPGLESCPQSLQQEGRPNRDRDLPGALWAESACELSLLEDNEEEESQPPASV
                     ALPQGDGVPCREPEGLSDSFPQPTAPSLPLENVGSGSRVREAAGGVGCFEAGDQETCY
                     ATMDLLVGAPVDKYLPQEICPEDLELTEGQSEVCDLCSPDKILAVLQTQGSEPPRSTD
                     KRSQDGKSAEGLLFNSTFTWDTAKEASEDAVGETAADVENPPSTFSSTLPYSERGFGE
                     TQPLCSETISFVKDSEGSYRSSSLSIPAAIDTLASYSSDRECSKEQSAESTANVDCHQ
                     VTREMEGISTNAAEVHEIKCHSVSVPQDNDFDVGADQVSCEARDEDNSQSLPDDDSQS
                     GRSLSSSTGEATGETLVPAPSSAGDHGHFSMPEGQGLCSRALQMDNQPVCQSQAMEGA
                     HSRGLEEHFQEKGSGMKHGIRPQSTSHQVSLSANDFQEILPSIPTMQQETNVEPLEHS
                     LADSREEIECSSDPRTSDLVVAEKTVGEDSHLVVSVPALPDILLGEKDDVGLGSWAVG
                     GKVKIITLEAPVFEIWPPELVRHPGYKEAEAGLTMPGRSWALSDILRAGATRSEPGAL
                     GGAAWVPSPQADALMALGANRDTWLGAAPDRQANCNCLSSQCLSQPRFLESSVDPVED
                     KELEVTDSPSEVSKTGEMEMPETLNEEQEETQQILRHPAVVNQSVNFPRILESSVDPI
                     DDRGELEGVWPEKPEPSDSSVEGNEFIVGNTCQRVDIQPASLQLPHPQDSGEIIPYEH
                     TTNQNRVDGERAEAKTSLPDKAKAEAEAVVWQAQGPGEEGQGIPSVCSMSQTQDGGDR
                     SLGEAGQRGTDETEVISPLSPLSSCLTGVTHTCVKAETNNSTGHIYGGSEPRTRQSVI
                     PMKTEKGTIESKCGNHVRSSDDLTNTPCTSSPKGNVTRLSISHGLEELKSEKLQIAET
                     KPLNSSDSPTMTLALISGECESEKDPKSLLRRDPCPKGSTLDSGKKSRDQQQKPVAAQ
                     VSKAPGDQSAMAGSEEGKKKQEASGSGHLTAGIKKKILSRVAALRLRLEEKENSRKNS
                     IVKKTPKFERSLSRTDEKRDPKRAPCKAEGKAPVLLKRIQAEMAPEHSGNIKLSCQFS
                     EIHEDSTVCWTKDSKSIAQAKKSAGDNSSVSLAIVQAGQKDQGLYYCCLKNSYGKVTA
                     EFNLTAEVLKQLSSHTEYRGCEEIEFSQLIFKEDVFNDSYFGDHLRGQISTEELHFGE
                     GVHRKAFRSKVMQGLMPVFQPGHACVLKVHNAVAHGTRNNDELVQRNYKLAAQECYVQ
                     NTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIR
                     DGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLARGYK
                     GFKGNCSMTFIDQFRALHQCNKYCKMLGLKSLQNNSQKPKKPIVGKGRVPTNATQVKT
                     PESETPPAERKT"
     exon            383..500
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            501..2181
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..5545
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            5546..5693
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            5694..5821
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            5822..5857
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            5858..6132
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            6133..6221
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            6222..6439
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            6440..6488
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     exon            6489..7250
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7227..7232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /note="hexamer: ATTAAA"
     polyA_site      7250
                     /gene="Alpk2"
                     /gene_synonym="Gm549; Hak"
                     /note="major polyA site"
ORIGIN      
        1 attcaagggc aggcaaaaca agctcttctt ccagagcttg cttgggcacg gacttttccc
       61 tcttaggaag acatgagttt tttctgaaac agacccaact gcgctttgat ctgtttgtgg
      121 acaagacctt gaatttgagt ccctgtcagg ggacaaggac agaaggacat ccaatcaatg
      181 cttcacatac agccagggga ccccaacaac gagccagccc ttcaataacg tctctcggat
      241 aaacagtatt gaaaaatcac gtggcatgaa aggatgacag atccaggctg ccccgagagg
      301 cgcacgctat gtttcttatc aacgttactt tcccagaagg ttccggagaa gtctgacgtc
      361 gtgcttcgat gcatgatagc tggtcagccc aagccagagg tgacttggta taagaatggt
      421 caagccatag acttgggagg cactgtttcc agttatgagt tctttgagaa ccagtatatt
      481 catttgttgc atctctcgtg ctgtacccag agcgacgccg ctgtttacca ggtctcggca
      541 agaaactgcg tggggatgat ctgctgttca gcatccctcg aggtccagtg tctgcaggac
      601 ccacaggtct ctcctgatcc tggaggcggc agggacgcgg ctggcgagtg taaaacagag
      661 atacgtgaag aagacagcat aaaccacacg gatgagaaat ggaatccttg taagaaagga
      721 gaaagtacag ctgattcctt cctcgacaaa ttcaaccatt tgagttcacc ccagatagtg
      781 gctaggggtg actctggtgc ttccaattct gagaatcccc aatatattaa agagacgaga
      841 caaaggatgg ggcagtacaa ttcaaataac atgcaagaaa attcttttaa ttcaaataac
      901 actgctgaaa aacaagatgt atcccagctc tggacagtga atgccactgt gccagggtta
      961 gttagtgatg gcctaggata cgaagaatct aatgagagtg tcagccctag tcatcaaacc
     1021 cccaaagtac agaaatacat cagtttcagt cttccattgc cggagacaac cctgggtcct
     1081 tacccagaag acagcaactc catcaacatg cagccgggac cccaggtttc cagcgaagac
     1141 tctgacagtg actatgaact ttgcccagag ataaccctaa cctacacgga ggagttttcg
     1201 gatgatgacc tggagtatct ggaatgttcc gatgttatga cggattactc taatgcggtc
     1261 tggcaaagga gcctgcaagg gactgaccga gtttttttat tagaaagcga tgacgaagag
     1321 atggaattca atgagtgtgg tctgggtggg tgtgagcatt tcttcactga aatgggttgt
     1381 gggcctcagg tgtcgggtgg catgtggtct atgaatgttg ccactggctt ctgtagttat
     1441 cactcacaac ctcaggaagt gagggttagg agcagcggaa cctcagggca tagcccgtta
     1501 cccctgcatt cagaaatgac tcttaccctg ggacctcacc aggatgaaac agctaagatg
     1561 acagaaccgg ggagggctcc actccctact gctcccgagg ctgttgaaaa tgattgttca
     1621 ggaattcggg gagaaaccag agacaaccct gaagcaggag aggaattctc cggtgacaat
     1681 ctacagacta tggataaggt agagacagag gcatcagtga agcccttgtc tgggggctca
     1741 gataagacag aggtgaagca gggtttggaa agcctggctc gggaacgcac agacgaaaag
     1801 tacccaggca gcaagaaggc agccctgaga cccaccaggg cgaggcggcc cggaatgaag
     1861 gcaaacacca agaagcagct gttgagagac agtgccccca aaggcactct agatctcctc
     1921 cccaaagaac cgactaggca acccttaccc gggagctatg gacaagagcc cacacacacg
     1981 gaagcaggag ctcctggctg ggattcccac ttccacgcag aagtgtgtat tccacttcct
     2041 gcagagcaag actccaaaat ccttcgacca ccagcagacc cactttccaa ggaagaggac
     2101 agcagcttcg agggaggtgg ggcactgctt aataaattat ttgaagcaag ccagattcca
     2161 gaccggactg accatcttca gatgcaaatt caggaaacca ttggggagag cagttctctc
     2221 gaccagatgt tggccttttc agtgcctgct gaggagtcat ctacatttgc tggggccaca
     2281 acacattctg tctccaactt gagtgagatc aacagggaaa atctgtcatt ggcccaatac
     2341 ccaggactgg aaagctgtcc tcaaagcctc cagcaggaag gcagaccaaa cagagacaga
     2401 gacttgcctg gtgctctctg ggcagaatca gcctgtgaac tgagtctcct agaagacaat
     2461 gaggaagaag agtcgcagcc tccagcctca gtggctctcc ctcagggtga tggtgtcccc
     2521 tgcagggagc cagagggtct ctctgattct ttcccccagc ccactgctcc ctccctcccc
     2581 ctggaaaatg tgggcagtgg gtcaagggtc agagaagctg caggtggggt ggggtgtttt
     2641 gaagccggtg accaagaaac atgttatgct accatggatc tccttgttgg agcaccagtt
     2701 gataaatatt tgcctcaaga aatttgcccc gaggacttgg agctgacaga aggtcaaagc
     2761 gaagtgtgtg atttatgttc tcctgacaag atactggctg ttctacagac acaaggttct
     2821 gagcctccac ggtccacaga caagcgcagc caggatggca agtcagccga gggccttctt
     2881 tttaacagta ccttcacctg ggacacggca aaggaggcca gtgaagatgc tgtgggagag
     2941 acagcagctg atgtggagaa tcctccctcc accttctctt ctacgctacc ctacagtgaa
     3001 agagggtttg gggagacaca acccctttgt tctgagacta tctcctttgt aaaggatagt
     3061 gaagggagct acagaagttc cagtctcagc atcccagctg ccatagacac acttgccagc
     3121 tacagttctg acagggagtg ctcaaaagag cagtcagccg aatcaactgc taatgtcgac
     3181 tgtcatcagg tgaccaggga gatggagggc atatcaacta atgccgctga ggtccacgaa
     3241 atcaaatgcc actccgtttc tgtcccccag gacaatgact ttgatgttgg tgctgaccag
     3301 gtctcgtgtg aggcacgaga tgaagataat tcccaatctc ttccagacga cgactcacag
     3361 tcaggtcgtt cattaagtag ctccacaggt gaagcaaccg gggagactct ggtgccagca
     3421 cccagcagtg caggagatca tggccacttc tccatgcccg agggacaggg tttgtgtagc
     3481 agggctcttc agatggataa ccagcctgtg tgtcagagcc aggctatgga gggagcccac
     3541 agcagaggcc ttgaggagca cttccaagaa aagggaagtg gaatgaagca tggcatccgg
     3601 ccacagagca catcccacca ggtttctctt tctgcaaatg acttccaaga aattttgccc
     3661 tccataccca ccatgcaaca ggagaccaat gtggaaccct tggagcactc cctagcagat
     3721 tccagggaag aaattgagtg tagctcagac ccgaggacca gtgacttggt ggtggctgag
     3781 aagactgtgg gagaagacag tcatttggta gtcagtgtcc cagctctccc tgacatcctc
     3841 cttggagaga aagatgacgt tgggctagga agttgggctg tgggcggcaa agtgaagatc
     3901 ataactctag aagctcccgt ctttgaaatc tggccaccag aactagtgag gcaccctggg
     3961 tacaaggagg cagaagctgg tctcaccatg cctggtagga gctgggctct gtctgacatc
     4021 ctcagagcag gtgccaccag atctgagcca ggtgccttgg gaggagcagc atgggttccc
     4081 agcccccagg ctgatgctct catggccctt ggagcgaaca gggacacctg gctaggtgct
     4141 gcaccagaca gacaagcaaa ctgcaattgt ctgtcttccc agtgtctgag tcaaccccga
     4201 ttcctggagt catctgtaga ccctgttgag gacaaggagt tagaggtcac ggactctcca
     4261 tcagaggttt ccaaaactgg agagatggaa atgcctgaga ctctgaatga ggaacaggag
     4321 gaaacccagc agatactgcg tcaccccgcc gttgttaacc agtcggtgaa cttccctagg
     4381 atcctggaat cctctgtgga ccccattgac gacaggggtg agctggaggg tgtctggccc
     4441 gagaagccag agccctctga ctccagcgta gaaggaaacg aattcattgt tggaaacacg
     4501 tgtcagaggg tagacatcca acctgctagc ctacagctcc cacatcccca ggacagcggg
     4561 gaaatcattc catatgaaca cacaaccaac caaaatcgcg tagatggaga gagagcagaa
     4621 gccaaaacca gtctgccgga taaagccaaa gcggaagcag aagctgttgt ttggcaggcc
     4681 caggggcctg gtgaagaggg acaaggaatt ccaagtgtat gcagcatgag ccaaacacaa
     4741 gatggtggtg acagaagcct aggagaagct gggcaaaggg gaacggatga gaccgaggtc
     4801 atttcccccc tgtctcctct ttctagctgt ctcacaggag tgacacatac atgtgtcaag
     4861 gctgaaacca acaactccac aggccacatt tatggcggat ctgagcccag aacccgtcaa
     4921 agtgtaattc ctatgaagac agaaaaggga actatcgaga gcaagtgtgg gaaccatgtg
     4981 cgctcttcag atgatctcac aaacacacct tgtacttcat ctcccaaagg aaatgtcaca
     5041 cgcttgtcaa taagccatgg cctggaggaa ctgaaatcag agaagctgca gattgcggaa
     5101 accaaacccc taaactcatc tgactcccca acaatgacct tagctctcat ttcaggagaa
     5161 tgtgagtcag agaaagaccc caaaagcttg ttacgtaggg acccatgtcc aaagggctcc
     5221 accctggata gcgggaagaa gtccagagac caacagcaga agcctgtggc agcccaggtc
     5281 agcaaggcac ctggggacca atcagcaatg gctgggtcag aggagggcaa gaagaagcaa
     5341 gaggcttcgg ggagtggaca cttgactgca gggataaaga agaaaattct atccagggtc
     5401 gcagccctga gactgaggct ggaggaaaag gaaaattcga ggaagaactc catcgtgaag
     5461 aagacaccta agtttgaaag gtccttatcc cgcactgatg agaaaagaga ccccaaaagg
     5521 gccccttgca aagctgaagg gaaagctcca gtattgctga agaggatcca ggccgagatg
     5581 gctcccgagc actccggaaa tataaagttg agctgccagt tttcagaaat ccatgaagac
     5641 tctaccgtct gctggacaaa agattccaag tcgatagccc aggccaagaa aagcgcaggg
     5701 gacaactcca gtgtttcctt ggccatcgtc caagctggtc agaaggacca gggcctgtat
     5761 tactgctgcc tcaagaacag ttatggaaaa gtcactgctg agtttaacct cacagctgaa
     5821 gttctcaaac agctttcaag tcacacagaa tatagaggat gtgaagagat tgaattcagc
     5881 cagctcatct tcaaagaaga tgttttcaat gacagctact tcggggacca cctacgtggc
     5941 cagatctcca cggaggagct tcactttggc gaaggggtgc accgcaaagc tttccggagc
     6001 aaggtgatgc agggcctcat gccggtcttc cagcccggcc acgcatgcgt actcaaggtg
     6061 cacaatgccg tcgcccatgg gaccagaaac aatgacgaac ttgtgcagag gaactacaaa
     6121 ctggctgccc aggaatgcta cgtccagaat actgccagat actacgccaa gatctacgcc
     6181 gctgaagcac agcctctgga aggcttcgga gaggtgccgg agatcattcc tattttcctt
     6241 atccatcggc ccgagaacaa catcccatat gccacagtgg aagaagagct gattggagaa
     6301 ttcgtgaagt attccatccg ggacgggaag gaaatcaact tcctcagacg agattcagag
     6361 gctggccaga aatgttgcac cttccagcac tgggtatacc agaaaacaag tggctgtctc
     6421 ctggtcacgg acatgcaggg tgtgggaatg aagttaactg acgttggcat agcaacacta
     6481 gctagagggt acaaaggatt taagggcaac tgttccatga ccttcattga tcagttcaga
     6541 gcgctgcatc agtgtaacaa gtactgtaaa atgctggggc tgaaatccct tcaaaacaac
     6601 agccagaaac ccaagaagcc catcgtcggg aaaggcaggg ttccgacaaa cgccacgcag
     6661 gtgaagacgc ctgagtctga gacgccgccc gcagaaagaa aaacctagcc tccctcctcc
     6721 cttcatcacc agtgaccacc aagccagcat cgcgcaggct tgcacgtgga catctgcaag
     6781 cacacaaggg acacgagcct gcagcctgca gccgagtgcc agtcctctca gctcctatca
     6841 ctggctgtct gctgaaatga caatggcatg gctcttccag actagccttg tagagagact
     6901 tagcagttct gttgatgctc tcaaaggcag cccactgttt gtgtacacag ctagcctttc
     6961 tacacacacc ctcccctccc accgcatcgt ctatctatct gtgtgtcgcg cgtggtttgt
     7021 tgacaagagt tcccccgctg ccttggcgac tggccactgt caaaatcctt cccacctcga
     7081 ccccctcacc tcaggatgtt cctgcagtca tgaatgtcaa gttgttgtta tcagtgtcac
     7141 cgacgctatt gttgctggag gcggcttccc agatgcgagc ccatttcccg ccactaccca
     7201 cgcagcctgg cacagtgttc tgtttcatta aattcatatt taagcaaaaa
//
