LOCUS       NM_027808               4795 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus alpha-kinase 1 (Alpk1), mRNA.
ACCESSION   NM_027808 XM_001479503 XM_001481048 XM_894534 XM_924200
VERSION     NM_027808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4795)
  AUTHORS   Zhao,J., Feng,Y., Liu,X., Li,H., Guo,H., Ke,J. and Long,X.
  TITLE     The relationship of ALPK1, hyaluronic acid and M1 macrophage
            polarization in the temporomandibular joint synovitis
  JOURNAL   J Cell Mol Med 28 (7), e18172 (2024)
   PUBMED   38494837
  REMARK    GeneRIF: The relationship of ALPK1, hyaluronic acid and M1
            macrophage polarization in the temporomandibular joint synovitis.
REFERENCE   2  (bases 1 to 4795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4795)
  AUTHORS   He,J., Nascakova,Z., Leary,P., Papa,G., Valenta,T., Basler,K. and
            Muller,A.
  TITLE     Inactivation of the tumor suppressor gene Apc synergizes with H.
            pylori to induce DNA damage in murine gastric stem and progenitor
            cells
  JOURNAL   Sci Adv 9 (46), eadh0322 (2023)
   PUBMED   37967175
REFERENCE   4  (bases 1 to 4795)
  AUTHORS   Liu,X., Li,Y., Zhao,J., Hu,Z., Fang,W., Ke,J., Li,W. and Long,X.
  TITLE     Pyroptosis of chondrocytes activated by synovial inflammation
            accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3
            signaling
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110781 (2023)
   PUBMED   37625369
REFERENCE   5  (bases 1 to 4795)
  AUTHORS   Cui,X., Li,Y., Yuan,S., Huang,Y., Chen,X., Han,Y., Liu,Z., Li,Z.,
            Xiao,Y., Wang,Y., Sun,L., Liu,H. and Zhu,X.
  TITLE     Alpha-kinase1 promotes tubular injury and interstitial inflammation
            in diabetic nephropathy by canonical pyroptosis pathway
  JOURNAL   Biol Res 56 (1), 5 (2023)
   PUBMED   36732854
  REMARK    GeneRIF: Alpha-kinase1 promotes tubular injury and interstitial
            inflammation in diabetic nephropathy by canonical pyroptosis
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4795)
  AUTHORS   Zhou,P., She,Y., Dong,N., Li,P., He,H., Borio,A., Wu,Q., Lu,S.,
            Ding,X., Cao,Y., Xu,Y., Gao,W., Dong,M., Ding,J., Wang,D.C.,
            Zamyatina,A. and Shao,F.
  TITLE     Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial
            ADP-heptose
  JOURNAL   Nature 561 (7721), 122-126 (2018)
   PUBMED   30111836
  REMARK    GeneRIF: findings identify ALPK1 and ADP-beta-D-manno-heptose as a
            pattern recognition receptor and an effective immunomodulator,
            respectively
REFERENCE   7  (bases 1 to 4795)
  AUTHORS   Kuo,T.M., Yeh,K.T., Hsu,H.T., Chiang,S.L., Chang,J.G., Huang,C.M.,
            Tu,H.P., Liu,C.S. and Ko,Y.C.
  TITLE     ALPK1 affects testosterone mediated regulation of proinflammatory
            cytokines production
  JOURNAL   J Steroid Biochem Mol Biol 154, 150-158 (2015)
   PUBMED   26275947
  REMARK    GeneRIF: data suggests that the balance between ALPK1 and
            testosterone plays a critical role in the testosterone-mediated
            inhibition of proinflammatory cytokines
REFERENCE   8  (bases 1 to 4795)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   9  (bases 1 to 4795)
  AUTHORS   Chen,M. and Xu,R.
  TITLE     Motor coordination deficits in Alpk1 mutant mice with the inserted
            piggyBac transposon
  JOURNAL   BMC Neurosci 12, 1 (2011)
   PUBMED   21208416
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4795)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163391.4 and AC158308.4.
            
            On or before Jul 23, 2009 this sequence version replaced
            XM_001479503.1, XM_924200.2, XM_894534.2, XM_001481048.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AC163391.4         119742-120108
            368-598             AC163391.4         170768-170998
            599-753             AC158308.4         175760-175914       c
            754-952             AC158308.4         146939-147137       c
            953-1012            AC158308.4         138967-139026       c
            1013-1099           AC158308.4         137642-137728       c
            1100-1176           AC158308.4         136623-136699       c
            1177-1272           AC158308.4         135727-135822       c
            1273-1377           AC158308.4         134893-134997       c
            1378-3469           AC158308.4         130746-132837       c
            3470-3623           AC158308.4         129071-129224       c
            3624-3786           AC158308.4         124705-124867       c
            3787-3973           AC158308.4         123745-123931       c
            3974-4795           AC158308.4         121695-122516       c
FEATURES             Location/Qualifiers
     source          1..4795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 56.54 cM"
     gene            1..4795
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /note="alpha-kinase 1"
                     /db_xref="GeneID:71481"
                     /db_xref="MGI:MGI:1918731"
     exon            1..367
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            368..598
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..4173
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /EC_number="2.7.11.1"
                     /note="lymphocyte alpha-kinase; lymphocyte alpha-protein
                     kinase"
                     /codon_start=1
                     /product="alpha-protein kinase 1"
                     /protein_id="NP_082084.1"
                     /db_xref="CCDS:CCDS51067.1"
                     /db_xref="GeneID:71481"
                     /db_xref="MGI:MGI:1918731"
                     /translation="MNNQDAVASILHECKQVLDRLLLETPDVSTEDKSEDQRCRASLP
                     SELRTLIQEAEEMKWPFVPEKWQYKQAMSPEDKTNLQDVIGAGLQQLLAALRASILVQ
                     DCAAASAIVFLMDRFLYGLDVSGKLLQVAKGLHKLKPATPIAPQVVIRQARVSVNSGK
                     LLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIW
                     ASVIGYLTLPQPDKKGISTSLGILADIFVSMSKTDYEKFKKSPKVNLALLKEFDHHLL
                     SASEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSCSADCPPGMKSVHLCEAKEAFEI
                     GLLTKKDGELVSGKQELHSFIKAAFGLTTVHSRLHGETDAVRAARQLCSEAVGKLYTF
                     STSPTSQDREGLSQEIMSLISQVKGHLRVQSFPNLDACSYVPESFKCGLDRLILHGHV
                     DFQQILETYSQHHTSVCEVFESTCGNSKRNQRDTKSEVCITTLKTETNTADTMVATLE
                     RVSSQDSRSTASSKMSKKDQGKLQRERGRSWTHSKAFRVSLDLDMETETEPPNHSNGG
                     TDVFNKSLRDNSSSCSWGRLSGLSSSTSWEEVNCAVQDVVRKGSGQEEHPVEAQSSEA
                     ASEEPKRNRSSRAVYLSSKLRGVSLQTTGDDNLESSPSQLHNHTSILPFNAKDTCLAS
                     GAGLVETAEGSSNTSLQSSHSCGSDSWSLSSSDRFTDVTTNPSVQEEEPSGIMGDVPE
                     SKYDCKDWHGEKNGGTLAEICTGPELTSAPSSVDPEGETAESTDDGLSPSQVALGCLE
                     GSHSMSTRRTFFPDGSVQNADSAKTGCSVRDQTVDPDASTVDEEGQMLDSTEICSIGQ
                     DGAHRPRALRSGQSAEGPKSFVNGSSPSPIFDEDFSTTEEGEELGSMLKSSQNSSSYS
                     PWWLKSPAFSRSSSDGESSWSLLNSSRSSFASLAGQTSQEILEARTLQPDDLEKLLAG
                     VRHDWLLQRLENTGVLKSNQLQQAHSALLLKYSKKSELWTAQETVVYLGDYLKVKKKG
                     KQRNAFWVHYLHQEETLGRYVGKEYKERKGLRHHFTDVERQMTAQHYVTEFNKRLYEQ
                     KIPTQIFYIPSTILLILEDRTIKGCISVEPYILGEFVKLSNNTKAVKNEYKATEYGLA
                     YGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKDVTTNFGKRGIFYFF
                     NNQHASCNEICHRLSLTRPSLEQTSKV"
     exon            599..753
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            754..952
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1012
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1099
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1176
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1272
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1377
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..3469
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3623
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3786
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3973
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4795
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4707
                     /gene="Alpk1"
                     /gene_synonym="8430410J10Rik; LAK"
ORIGIN      
        1 gacaagctct ccttgtcccc ttttgggggt cgatctcgga attggagcgc agaggagaag
       61 taggcgtcgc agaggcacgt gtatcaacac gtttatttgc acttgaggcc aagctggggt
      121 tttcctggtg gacggtgcca gagtcagtaa cacgactccc agaagacctt tcccgcaaca
      181 gtccctaacg gggcgtgtct tggcgtggcg ttagacaagc acggtctgag caaggaagga
      241 cttttctttt cagattcccg tttcctgaaa cagaagctgt tgaggagaaa cgctgtgttt
      301 ccgggaggtt gtaccggaat aaagactctc ccgggtcaga ctgctgctct gaagtgttat
      361 tttctgagta cctcagcctt caagggcctt ctttattgag aatcaatgcc tctcctaggt
      421 aattgatcac catagaccca gggagactca attcatcctg gagggtgggt aatcgtcatg
      481 aataatcaag atgccgtggc ttcgatactg catgagtgca agcaagtgct ggatcgtctc
      541 ttgttggaaa cgccagatgt gtctacagag gacaagagtg aggaccagcg gtgcagagct
      601 tcactcccca gcgagttaag gaccctgatc caggaggcag aggaaatgaa gtggcccttc
      661 gtgcctgaaa agtggcaata caaacaagcc atgagcccag aggacaaaac aaacctgcaa
      721 gatgtgattg gcgccgggct gcagcagtta ctggcggcct tgcgagcctc catccttgtc
      781 caggactgcg ctgccgcctc cgctattgtc ttcttgatgg accggttcct gtatggactc
      841 gacgtctccg gaaaactcct gcaggtcgcc aaaggcttgc acaagctgaa gcctgcaacg
      901 cccatcgccc cgcaggtggt catccgacaa gcccgagtct ccgtcaactc agggaaactg
      961 ttgaaggcag aatacatcct gagcagcctg ataagcaaca acggagcaac cgggacctgg
     1021 ctgtatagga atgagagtga caaagtcctg gtacagtcgg tctgcataca gatcagaggg
     1081 cagattctgc agaagctagg catgtggtat gaagcggcag aattgatatg ggcctctgtc
     1141 ataggatatc tgacactccc tcagccagat aagaagggca tttccacatc actgggcata
     1201 ctggcagaca tctttgtttc catgagcaaa accgattatg aaaagtttaa gaagagccca
     1261 aaggttaact tggccctgct caaggagttt gaccaccatt tgttgtcagc ctcggaagcc
     1321 tgcaagctgg cagctgcctt cagtgcctac acacccctct ttgtgctcac ggctgtgaat
     1381 atccgtggca catgtttgtt gtcatatagc tgttctgctg actgccctcc gggaatgaaa
     1441 agtgtgcatc tgtgtgaagc caaagaagct tttgagattg gcctcctgac caagaaagat
     1501 ggcgagctgg ttagtggcaa gcaggagctg cacagtttca tcaaagctgc tttcggcctc
     1561 accacggtgc actccagact ccatggggag acagatgcag ttcgcgcagc aaggcagcta
     1621 tgcagtgaag ctgtgggcaa gctctacacc ttcagcactt cccccacaag ccaggacaga
     1681 gaaggcctgt ctcaggaaat catgtctctc atcagccagg tgaagggaca tctacgagtt
     1741 caaagcttcc caaatttaga tgcttgctct tatgtcccag agagtttcaa gtgtggttta
     1801 gatcgactca tcttgcatgg acacgtggat ttccaacaaa ttcttgaaac ctattcccag
     1861 caccatactt cagtgtgtga ggtatttgaa agcacttgtg ggaacagcaa acgcaaccag
     1921 agagacacaa aatcggaggt ctgtattacc actctgaaga cagaaacaaa caccgcagat
     1981 actatggttg ctactctaga gagggtgagt tcccaagaca gcaggagtac agcttcttcc
     2041 aaaatgtcta agaaagatca agggaagctc caaagagaaa gggggagaag ctggacccat
     2101 tccaaggcat tccgagtctc cctggatcta gatatggaga ctgagactga gccaccaaat
     2161 cacagcaatg gagggacaga tgttttcaac aagtctctga gagacaactc tagctcctgt
     2221 tcttggggca gactgtcagg gctcagctct tccacaagct gggaggaagt gaactgcgct
     2281 gttcaggatg tagtaaggaa agggtctggc caagaagagc atcctgtgga ggcgcaaagc
     2341 tctgaggcag cgtctgagga gcccaagagg aacagaagca gcagagctgt gtatttgtct
     2401 tcaaagctcc gtggtgtctc tcttcagaca actggagatg acaacttaga gtcttcacca
     2461 agtcagttac acaatcacac atccatcctt cctttcaatg caaaagatac ttgtttggcc
     2521 tcgggtgcag gactggtaga aaccgctgaa ggatctagca atacttctct tcagtccagt
     2581 cattcgtgtg gttctgattc ctggtccttg tctagttcag acaggttcac ggatgtgacc
     2641 acgaatcctt cagttcagga agaagaaccc tctggaataa tgggtgatgt cccagaatcc
     2701 aagtatgact gtaaagactg gcacggagaa aagaatgggg gaacactcgc tgaaatatgc
     2761 acagggcctg aattaacatc tgccccctct tcggtcgacc cagaaggaga aacagcagaa
     2821 agcacagacg atggactatc accctctcag gtagccctgg gatgtttaga aggcagccat
     2881 tcaatgtcta cgcgtaggac tttctttccg gatgggtcgg ttcaaaacgc tgactcagca
     2941 aagactggct gctcagtcag agaccagact gtcgaccctg atgcctcaac ggtggatgag
     3001 gagggccaaa tgcttgacag cacagagatc tgctccattg gccaagatgg cgctcacaga
     3061 ccacgtgctt tgaggtccgg tcagagtgcg gaggggccaa agtcctttgt aaatggctcc
     3121 agtccttccc ctatcttcga tgaggacttc agcaccacag aggaaggaga ggagcttggg
     3181 agcatgctga agagcagcca aaactccagc tcatactcac catggtggct aaaatcacca
     3241 gccttttccc gcagttcgtc agatggggaa agctcctggt ctctgctgaa ctcaagcaga
     3301 agttccttcg cctcgctggc aggacagacc agtcaagaga tccttgaggc tcgaacccta
     3361 cagcctgatg accttgaaaa acttctggcg ggcgtgaggc atgattggct gcttcagaga
     3421 ctggagaata ctggcgtttt gaagtccaat caactccaac aagcccacag tgcccttctg
     3481 ctaaaatatt ccaaaaagtc tgagttgtgg acagcgcagg aaactgtggt gtatctggga
     3541 gactacctga aagtgaagaa gaagggcaag cagagaaatg cattttgggt ccactatctc
     3601 catcaagagg aaaccctggg gagatacgtt gggaaagaat acaaagagag gaaggggctc
     3661 cggcaccact tcactgatgt ggagcggcag atgacagcac agcactacgt gacagagttt
     3721 aacaagagac tctacgagca aaagattccg actcagatat tctacatccc ctctacaata
     3781 ttactgattt tggaagacag gactataaag ggatgcatca gtgtagagcc ttacatcctg
     3841 ggggaattcg tcaagttatc caataacacc aaagcagtca aaaatgagta caaagctaca
     3901 gaatatggct tggcctatgg ccatttttct tatgagtttt ctaaccatag agatgtggtg
     3961 gttgatttac aaggttgggt gactggtaat ggaaaaggcc tgatctatct cacggatcct
     4021 cagattcact ctgtagacca gaaagatgtc actacaaact ttggaaagcg gggaatattt
     4081 tacttcttta ataaccaaca tgcaagctgt aatgaaatat gccatcgtct ttctctgact
     4141 agaccttcac tagagcaaac aagtaaggta tagcctgtgg gttgggagtt gacaagactt
     4201 caagagccta gcatcagatc tgtctccttc caggcatgca gagcatattg acatattgat
     4261 tgattgggcc aacggatgat tctggtcact gacttatgag gggaatcaca agtgtcgatt
     4321 tcaggcctac ccttgcttgc caggaaaaga tcctacagac cttattccct ctgacacagg
     4381 gacatgtctg gtggctgtcc tagtctctac agttgtatat gatgttcgag atcctgagtt
     4441 gtatgaagac aacatggaaa agggccccaa ccaacccaca atggatgcag acctcagctg
     4501 aaaacaaact gctgtcatta agccattgtg gtttcggttt gttttgttgt tgtgtagtag
     4561 gttggttatg gcttggtttg tttggttttt gcttgtttgt ctgtttggag agttttggtc
     4621 attacctgta aaagctgata ctgttgctgc tttcatgtta acttgagagc tctttgtgaa
     4681 tttaaaacct ccagattcct gaaaagattt caaactttgt ttctcttttt acatttgcca
     4741 ttttgtaaaa ctgttatccg ttcagacttt ttttttaaac tgagctgttg ttacc
//
