LOCUS       NM_001081082            2337 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus alkaline phosphatase, intestinal (Alpi), mRNA.
ACCESSION   NM_001081082 XM_129951
VERSION     NM_001081082.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Song,H.J., Kim,J.E., Roh,Y.J., Seol,A., Kim,T.R., Park,K.H.,
            Park,E.S., Hong,J.T., Choi,S.I. and Hwang,D.Y.
  TITLE     Novel Role of the ALPI Gene Associated with Constipation Caused by
            Complement Component 3 Deficiency
  JOURNAL   Int J Mol Sci 25 (17), 9530 (2024)
   PUBMED   39273477
  REMARK    GeneRIF: Novel Role of the ALPI Gene Associated with Constipation
            Caused by Complement Component 3 Deficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Ingle,H., Makimaa,H., Aggarwal,S., Deng,H., Foster,L., Li,Y.,
            Kennedy,E.A., Peterson,S.T., Wilen,C.B., Lee,S., Suthar,M.S. and
            Baldridge,M.T.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Chattaraj,P.,
            Kidwai,F., Faucz,F.R., Iben,J., Mitra,A., Campbell,K., Fridell,G.,
            Esnault,C., Cotney,J.L., Dale,R.K. and D'Souza,R.N.
  TITLE     Multimodal spatiotemporal transcriptomic resolution of embryonic
            palate osteogenesis
  JOURNAL   Nat Commun 14 (1), 5687 (2023)
   PUBMED   37709732
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Saisa-Borreill,S., Davidson,G., Kleiber,T., Thevenot,A., Martin,E.,
            Mondot,S., Blottiere,H., Helleux,A., Mengus,G., Plateroti,M.,
            Duluc,I., Davidson,I. and Freund,J.N.
  TITLE     General transcription factor TAF4 antagonizes epigenetic silencing
            by Polycomb to maintain intestine stem cell functions
  JOURNAL   Cell Death Differ 30 (3), 839-853 (2023)
   PUBMED   36639541
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Chen,L., Toke,N.H., Luo,S., Vasoya,R.P., Aita,R., Parthasarathy,A.,
            Tsai,Y.H., Spence,J.R. and Verzi,M.P.
  TITLE     HNF4 factors control chromatin accessibility and are redundantly
            required for maturation of the fetal intestine
  JOURNAL   Development 146 (19) (2019)
   PUBMED   31345929
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Hu,R., Liu,W., Li,H., Yang,L., Chen,C., Xia,Z.Y., Guo,L.J., Xie,H.,
            Zhou,H.D., Wu,X.P. and Luo,X.H.
  TITLE     A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse
            osteoblast differentiation
  JOURNAL   J Biol Chem 286 (14), 12328-12339 (2011)
   PUBMED   21324897
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Nakano,T., Inoue,I., Alpers,D.H., Akiba,Y., Katayama,S.,
            Shinozaki,R., Kaunitz,J.D., Ohshima,S., Akita,M., Takahashi,S.,
            Koyama,I., Matsushita,M. and Komoda,T.
  TITLE     Role of lysophosphatidylcholine in brush-border intestinal alkaline
            phosphatase release and restoration
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 297 (1), G207-G214 (2009)
   PUBMED   19407215
  REMARK    GeneRIF: Suggest role for lysophosphatidylcholine in brush-border
            intestinal alkaline phosphatase release and restoration.
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Narisawa,S., Hoylaerts,M.F., Doctor,K.S., Fukuda,M.N., Alpers,D.H.
            and Millan,J.L.
  TITLE     A novel phosphatase upregulated in Akp3 knockout mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 293 (5), G1068-G1077 (2007)
   PUBMED   17901166
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Shibata,K., Gross,C.J. and Henderson,L.M.
  TITLE     Hydrolysis and absorption of pantothenate and its coenzymes in the
            rat small intestine
  JOURNAL   J Nutr 113 (10), 2107-2115 (1983)
   PUBMED   6619987
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Eaton,R.H. and Moss,D.W.
  TITLE     Organic pyrophosphates as substrates for human alkaline
            phosphatases
  JOURNAL   Biochem J 105 (3), 1307-1312 (1967)
   PUBMED   16742561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102611.10 and AC138595.10.
            
            On Feb 25, 2011 this sequence version replaced NM_001081082.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119800.1, SRR5189685.152622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC102611.10        59733-59873         c
            142-258             AC102611.10        59531-59647         c
            259-289             AC102611.10        59383-59413         c
            290-374             AC138595.10        172406-172490       c
            375-549             AC138595.10        172064-172238       c
            550-722             AC138595.10        171824-171996       c
            723-857             AC138595.10        171446-171580       c
            858-930             AC138595.10        171280-171352       c
            931-1065            AC138595.10        171024-171158       c
            1066-1257           AC138595.10        170745-170936       c
            1258-1374           AC138595.10        170427-170543       c
            1375-2337           AC138595.10        169377-170339       c
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.05 cM"
     gene            1..2337
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /note="alkaline phosphatase, intestinal"
                     /db_xref="GeneID:76768"
                     /db_xref="MGI:MGI:1924018"
     exon            1..141
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1736
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /EC_number="3.1.3.1"
                     /note="alkaline phosphatase 6"
                     /codon_start=1
                     /product="intestinal alkaline phosphatase precursor"
                     /protein_id="NP_001074551.1"
                     /db_xref="CCDS:CCDS35650.1"
                     /db_xref="GeneID:76768"
                     /db_xref="MGI:MGI:1924018"
                     /translation="MQGDWVLLLFLGLRIHLSFGIIPAEEENPAFWNKKAAEALDAAK
                     KLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPLAMDLFPYMALSKT
                     YNVDRQVPDSAGTATAYLCGVKANYKTIGLSAAARLDQCNTTFGNEVFSVMYRAKKAG
                     KSVGVVTTTRVQHASPAGTYAHTVNRNWYSDAEMPASALQDGCKDIATQLISNMDIDV
                     ILGGGRKFMFPKGTPDPEYPSDSNQSGTRLDDQNLVQTWLSKHQGARYVWNRSELIQA
                     SQDPAVTHLMGLFEPTEMKYDANRNPSVDPSLAEMTEVAVRMLSRNPQGFYLFVEGGR
                     IDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLILITADHSHVFAFGGYTLRGT
                     SIFGLAPLKALDDKSYTSILYGNGPGYELKSGNRPNVTEAQSVDPNYKQQAAVPLSSE
                     THGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPAGQSPVITP
                     GQATTTNNAAGQATTTNNAAGQATVLLSLQLLVSMLLLVGTAMVVS"
     exon            142..258
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            259..374
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            375..549
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            550..722
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            723..857
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            858..930
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1065
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1257
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1374
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2337
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2315..2320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /note="hexamer: AATAAA"
     polyA_site      2337
                     /gene="Alpi"
                     /gene_synonym="2010001C14Rik; Akp6; gIAP"
                     /note="major polyA site"
ORIGIN      
        1 gagcccaggc agactaagca ggagctggtg ccttggttcc ctagccgggc agcccatcag
       61 taaccccaac catgcaggga gactgggtgc tgctgttgtt tttgggtctc aggatccatc
      121 tgtcctttgg tatcatccca gctgaagagg agaacccggc cttctggaac aagaaggcag
      181 ctgaagccct ggatgctgcc aagaagctgc agcccattca gacatcagct aagaacctca
      241 tcatcttcct gggagacggg atgggggtac ccacagtgac agccaccagg atcctaaagg
      301 ggcagttgga aggccatcta ggaccggaga cacccctagc catggacctc ttcccataca
      361 tggctctgtc caagacatac aacgtggaca gacaggtccc agacagcgca ggcacagcaa
      421 ccgcctatct ctgtggggtc aaggccaact acaagaccat cggcctgagt gcagctgctc
      481 gattagacca gtgcaacacc acatttggca atgaggtctt ctcagtgatg taccgtgcca
      541 agaaagcagg gaagtctgtg ggagtggtga ccacgaccag ggtgcagcat gcctctccag
      601 ccggcaccta cgcacacacg gtgaaccgta attggtactc agatgcagag atgcctgcct
      661 ctgcactgca ggacggctgc aaggacatcg ccactcaact catctccaac atggacattg
      721 atgtgatcct cggtggaggc cgaaagttca tgtttcccaa ggggactcca gaccctgagt
      781 acccaagtga cagtaaccag tctggaacca ggctggatga tcagaacctg gtgcaaacgt
      841 ggctgtcaaa gcatcaggga gcccggtatg tttggaaccg atcagagctc attcaggcat
      901 cccaggaccc agcagtaact cacctcatgg gcctctttga gccaacagaa atgaaatatg
      961 atgccaaccg aaacccctca gtagaccctt ccctggcgga gatgacagag gtggctgtgc
     1021 gcatgctcag caggaatcca caaggcttct acctctttgt agaagggggt cgtattgacc
     1081 aaggccacca tgcgggcaca gcttacctgg cactgactga ggctgtcatg ttcgactctg
     1141 ccatcgaaaa ggccagccag cttaccaatg agaaggacac gctaatactc atcactgctg
     1201 accactccca tgtcttcgca tttggtggct acacacttag ggggacctcc atctttggtc
     1261 tggccccact caaagcccta gatgacaaat cctacacctc cattctctat ggcaatggtc
     1321 caggttatga gctgaaatca ggcaaccggc ccaatgtcac cgaagctcag agtgttgatc
     1381 ccaactacaa gcagcaggcg gctgtacccc tgtcgtcaga gacccacggc ggggaggacg
     1441 tggccatatt tgcgcgcggc cctcaggcac acctggtgca cggagttcag gagcagaact
     1501 acatcgcgca cgtcatggca ttcgcaggct gcttagagcc ctacaccgac tgcggcctgg
     1561 cgccccctgc cggccagagc cccgtcatca ccccgggcca ggccaccacc acaaacaacg
     1621 cggccggcca ggccaccacc acaaacaacg ccgccggcca ggccactgtc ctgctgtcct
     1681 tgcaactgct ggtcagcatg ctgctgctag tagggacagc catggtggtg tcctgatggt
     1741 caggtcctcc gctgggcccc ccgctaggct cctccccagg gtcccaccgc tggttacttt
     1801 cacacccctc ttgccataga tttcctgagc ccaatcagtt ccgggttcac cgttttctac
     1861 acaagggtct caatgctagt ttttgcaccc caacttggta gttttcttat ccagatgttg
     1921 agacatcatc tcagcccaca gctctaaggg ccacctctga gaaaacactc tgggatttat
     1981 aatttgcttt ataactctag gcttctgctt ttcaactgac ttcctctgga gtggggaggt
     2041 accaactgat ttccagaagg ctaaagcacg gcgctgcccc agactcccct tcaaaccacc
     2101 acccttcaca gggacccaag taactcatat tttcaggtct tggctttttc ccatgcaaaa
     2161 gaaatctcaa aagtccggga ggctgtgggg tctcaagcaa gcagcccaga gcagcctttg
     2221 gcccccaccc ctggtccatc tcaggctgca tatagaaact gaacaaagaa tattattagg
     2281 ttcttgtccc cagtcctaga agagacataa caataataaa attaactgtt tatataa
//
