LOCUS       NM_011786               2538 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus arachidonate lipoxygenase 3 (Aloxe3), mRNA.
ACCESSION   NM_011786
VERSION     NM_011786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2538)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2538)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 2538)
  AUTHORS   Miyamoto,M., Itoh,N., Sawai,M., Sassa,T. and Kihara,A.
  TITLE     Severe Skin Permeability Barrier Dysfunction in Knockout Mice
            Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide
            Production
  JOURNAL   J Invest Dermatol 140 (2), 319-326 (2020)
   PUBMED   31356814
REFERENCE   4  (bases 1 to 2538)
  AUTHORS   Higgins,C.B., Zhang,Y., Mayer,A.L., Fujiwara,H., Stothard,A.I.,
            Graham,M.J., Swarts,B.M. and DeBosch,B.J.
  TITLE     Hepatocyte ALOXE3 is induced during adaptive fasting and enhances
            insulin sensitivity by activating hepatic PPARgamma
  JOURNAL   JCI Insight 3 (16), 120794 (2018)
   PUBMED   30135298
  REMARK    GeneRIF: Study demonstrated that the epidermal-type lipoxygenase,
            eLOX3 (encoded by its gene, Aloxe3) is a fasting-responsive
            hepatocyte effector that is sufficient to attenuate insulin
            resistance, weight gain, and hepatic fat deposition in dietary and
            genetically obese models, in part by activating hepatic PPARgamma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2538)
  AUTHORS   Pichery,M., Huchenq,A., Sandhoff,R., Severino-Freire,M.,
            Zaafouri,S., Opalka,L., Levade,T., Soldan,V., Bertrand-Michel,J.,
            Lhuillier,E., Serre,G., Maruani,A., Mazereeuw-Hautier,J. and
            Jonca,N.
  TITLE     PNPLA1 defects in patients with autosomal recessive congenital
            ichthyosis and KO mice sustain PNPLA1 irreplaceable function in
            epidermal omega-O-acylceramide synthesis and skin permeability
            barrier
  JOURNAL   Hum Mol Genet 26 (10), 1787-1800 (2017)
   PUBMED   28369476
REFERENCE   6  (bases 1 to 2538)
  AUTHORS   Epp,N., Furstenberger,G., Muller,K., de Juanes,S., Leitges,M.,
            Hausser,I., Thieme,F., Liebisch,G., Schmitz,G. and Krieg,P.
  TITLE     12R-lipoxygenase deficiency disrupts epidermal barrier function
  JOURNAL   J Cell Biol 177 (1), 173-182 (2007)
   PUBMED   17403930
  REMARK    GeneRIF: The 12R-LOX-eLOX-3 pathway plays a key role in the process
            of epidermal barrier acquisition by affecting lipid metabolism, as
            well as protein processing.
REFERENCE   7  (bases 1 to 2538)
  AUTHORS   Yu,Z., Schneider,C., Boeglin,W.E. and Brash,A.R.
  TITLE     Human and mouse eLOX3 have distinct substrate specificities:
            implications for their linkage with lipoxygenases in skin
  JOURNAL   Arch Biochem Biophys 455 (2), 188-196 (2006)
   PUBMED   17045234
  REMARK    GeneRIF: The substrate preference of mouse eLOX3 and the unique
            occurrence of an 8S-LOX enzyme in mouse skin point to a potential
            LOX pathway for the production of epoxyalcohol in murine epidermal
            differentiation.
REFERENCE   8  (bases 1 to 2538)
  AUTHORS   Madsen,L., Petersen,R.K., Sorensen,M.B., Jorgensen,C.,
            Hallenborg,P., Pridal,L., Fleckner,J., Amri,E.Z., Krieg,P.,
            Furstenberger,G., Berge,R.K. and Kristiansen,K.
  TITLE     Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on
            lipoxygenase activity during the initial stages of the
            differentiation process
  JOURNAL   Biochem J 375 (Pt 3), 539-549 (2003)
   PUBMED   18320708
  REMARK    GeneRIF: findings suggest that endogenous PPARgamma ligand(s)
            promoting adipocyte differentiation are generated via a
            baicalein-sensitive pathway involving the novel eLOX-3
REFERENCE   9  (bases 1 to 2538)
  AUTHORS   Bessho,Y., Miyoshi,G., Sakata,R. and Kageyama,R.
  TITLE     Hes7: a bHLH-type repressor gene regulated by Notch and expressed
            in the presomitic mesoderm
  JOURNAL   Genes Cells 6 (2), 175-185 (2001)
   PUBMED   11260262
REFERENCE   10 (bases 1 to 2538)
  AUTHORS   Kinzig,A., Heidt,M., Furstenberger,G., Marks,F. and Krieg,P.
  TITLE     cDNA cloning, genomic structure, and chromosomal localization of a
            novel murine epidermis-type lipoxygenase
  JOURNAL   Genomics 58 (2), 158-164 (1999)
   PUBMED   10366447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141003.1, BC116259.1 and AL645527.20.
            
            On Apr 16, 2009 this sequence version replaced NM_011786.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14695.1, BC116259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               AK141003.1         164-869
            707-1046            BC116259.1         706-1045
            1047-1562           AK141003.1         3813-4328
            1563-1984           BC116259.1         1562-1983
            1985-2538           AL645527.20        65125-65678
FEATURES             Location/Qualifiers
     source          1..2538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.38 cM"
     gene            1..2538
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /note="arachidonate lipoxygenase 3"
                     /db_xref="GeneID:23801"
                     /db_xref="MGI:MGI:1345140"
     exon            1..173
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2162
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /EC_number="5.4.4.7"
                     /EC_number="4.2.1.152"
                     /note="epidermis-type lipoxygenase 3; epidermal LOX-3;
                     hydroperoxy icosatetraenoate dehydratase; hydroperoxy
                     dehydratase ALOXE3; hydroperoxy icosatetraenoate
                     isomerase"
                     /codon_start=1
                     /product="hydroperoxide isomerase ALOXE3"
                     /protein_id="NP_035916.2"
                     /db_xref="CCDS:CCDS24884.1"
                     /db_xref="GeneID:23801"
                     /db_xref="MGI:MGI:1345140"
                     /translation="MAVYRLCVTTGSYLKAGTLDNIYATLVGTCGESPKQKLDRVGRD
                     FASGSVQKYKVRCEAELGEILLLRLHKERFAFFCKDPWYCSRICVTAPDGSAVHFPCY
                     QWIDGYCTVELRPGTARTICQDSLPLLLDHRKRELQARQECYRWKIFAPGFPRMVDVS
                     SFQEMESDKKFALTKTVPCAEQDDNSGNRYLPGFPMKIDIPSLLHMEPNIRYSATKTA
                     SLIFNALPASFGMKIRGLLDRKGSWKRLDDIRNIFWCHKTFTSEYVTEHWCEDSFFGY
                     QYLNGVNPVMLHCLSSLPSKLPVTNDMVAPLLGPGTCLQTELERGHIFLADYWILAEA
                     PVHCINGLQQYVTAPLCLLWLNPQGVLLPLAIQLSQTPGPESPIFLPTDCELDWLLAK
                     TWVRNSEFLVHENNTHFLCTHLLCEAFSMATLRQLPLCHPVYKLLLPHTRYTLQVNTI
                     ARATLLNPDGLVDKVTSIGRQGLIYLMSTGLAHFTYTDFCLPDSIRARGVLTIPNYHY
                     RDDGLKIWAAIERFVSEIVSYYYPSDASVQQDCELQAWVGEIFAQAFLGRESSGFPSR
                     LCTPGELVKYLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGDTTMKS
                     YLDTLPEVNTTCRNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRQSIAAFQNCLAQI
                     SKDIRERNQSLALPYAYLDPPLIENSVSI"
     exon            174..378
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..460
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            461..580
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..706
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..810
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            811..983
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1127
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1331
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1418
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1588
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1710
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1811
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1982
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2538
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /note="hexamer: AATAAA"
     polyA_site      2538
                     /gene="Aloxe3"
                     /gene_synonym="e-LOX-3; eLOX-3"
                     /note="major polyA site"
ORIGIN      
        1 ctggtttggg gttattgggt ccagtcatgg cagtatatcg gctgtgtgtg accactggtt
       61 cctacctgaa ggctggcaca ttggataaca tctatgctac attggtaggc acctgtggtg
      121 aaagccctaa gcagaagctg gatcgcgtag gcagggactt cgcctctgga tcggttcaga
      181 agtataaggt gcgctgtgaa gcagagctgg gtgagatctt gctgttgcgc ttacacaagg
      241 agcgctttgc tttcttctgc aaggaccctt ggtactgcag tcgaatctgt gtcactgccc
      301 ccgatggctc tgctgtccac tttccctgct accagtggat cgatggctac tgtactgtgg
      361 agctgcggcc aggaacagca agaaccatct gtcaggattc tcttcccctc cttctggacc
      421 acaggaaacg ggaactccaa gcccgccaag aatgttatcg ctggaagatc ttcgcccctg
      481 gcttccctcg gatggtggat gtcagcagct ttcaggagat ggagtcagat aagaaatttg
      541 ccttgaccaa gacagtacct tgtgcagaac aggatgacaa ctctgggaac cggtacctgc
      601 ctggctttcc tatgaagatt gacatcccat ctctgctgca catggaaccc aacattcgat
      661 actcagccac caagacggcc tcactgatct tcaacgccct tcctgcatcc tttggcatga
      721 agattcgagg tctcctggac cgcaagggct cctggaagag gctggacgac atccggaaca
      781 tcttctggtg ccataagacc ttcacttcag agtacgtcac cgagcattgg tgtgaggaca
      841 gcttctttgg gtaccagtac ctgaatggtg tcaaccctgt catgcttcat tgcctctcca
      901 gcttgcccag caagctgcct gtcaccaatg acatggtggc acctttgctg ggaccaggca
      961 cctgcctaca aacagagcta gagagggggc acatcttcct ggcggactac tggatcctgg
     1021 cggaggcccc agtccattgc ataaacggtc tccaacagta cgtaacagcg cccctctgcc
     1081 tgttgtggct caacccacag ggggtgctgc tgccattggc aatccagctc agccagacac
     1141 cagggccaga gagccccatc tttctgccca ctgattgcga gttggactgg ctgctggcca
     1201 agacgtgggt gcgcaactct gagtttttgg tgcacgagaa caacacgcat tttctgtgca
     1261 cgcatttgct atgcgaggcc ttctccatgg ctacactgcg tcagctgccg ctctgtcatc
     1321 cagtctacaa gctcctgctt cctcatactc gctacacgct gcaagtgaac accatcgcaa
     1381 gagccacgct gctcaaccca gacggcctcg tggacaaggt cacgtccatc ggtaggcagg
     1441 gcctcatcta cctcatgagc accgggctgg cccacttcac ctacacggat ttctgcctac
     1501 cggatagcat acgggctcgt ggcgtcctga ccattcccaa ctaccactac cgagacgacg
     1561 gcctgaagat ctgggcggct attgagaggt ttgtctcaga gattgtgagt tactattatc
     1621 ccagcgatgc gtctgtgcag caggactgtg aactgcaggc ctgggtgggt gagatttttg
     1681 ctcaggcgtt cctcggacgg gaaagttcag gcttcccaag ccggctgtgc accccaggag
     1741 agctcgtgaa gtatctcacc gcaatcatct ttaattgctc cgcccagcac gctgcggtca
     1801 atagtgggca gcatgacttt ggggcctgga tgcccaacgc cccatcatcc atgaggcagc
     1861 ctccgcctca gaccaagggc gacacgacaa tgaagagtta cctagacacc ctcccagagg
     1921 tgaacaccac ctgtagaaac cttctcctct tctggctggt cagccaagag ccaaaggacc
     1981 agagacctct gggcacctac ccagatgaac acttcacaga ggaggcccca cggcagagca
     2041 tcgcagcctt ccagaactgc ctggcccaga tctcaaagga catcagggag cgcaaccaga
     2101 gcctggcact gccctatgcc tacttggatc ctccactcat tgagaacagt gtttccattt
     2161 gagtcccact tggagccatc ccagaggaaa ggaagttaca actaagggga aggctaactc
     2221 cctagggcct tctaggcctc tttaatctca gtttggacct tctcctctgc ccatgggacc
     2281 acgatggcct tgacattata tcaatgtgcc ctgagctgtg agggaccagt acagcagtgt
     2341 tcagggtgaa agccgctaac taaagtcaaa tgcacaatag aacccatgcc cttctaacgt
     2401 gtggaatcct ctcccacatc aggttgctca gcttgagttt ctgagctctc tttccacatc
     2461 ccagttaaac ccactcccat cctattgtct gtctttgagc ccagtgactt caataaaagc
     2521 taacgtattt ggctctca
//
