LOCUS       NM_009663               1031 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus arachidonate 5-lipoxygenase activating protein
            (Alox5ap), transcript variant 1, mRNA.
ACCESSION   NM_009663
VERSION     NM_009663.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Montford,J.R., Bauer,C., Dobrinskikh,E., Hopp,K., Levi,M.,
            Weiser-Evans,M., Nemenoff,R. and Furgeson,S.B.
  TITLE     Inhibition of 5-lipoxygenase decreases renal fibrosis and
            progression of chronic kidney disease
  JOURNAL   Am J Physiol Renal Physiol 316 (4), F732-F742 (2019)
   PUBMED   30649890
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Ibarra-Soria,X., Jawaid,W., Pijuan-Sala,B., Ladopoulos,V.,
            Scialdone,A., Jorg,D.J., Tyser,R.C.V., Calero-Nieto,F.J., Mulas,C.,
            Nichols,J., Vallier,L., Srinivas,S., Simons,B.D., Gottgens,B. and
            Marioni,J.C.
  TITLE     Defining murine organogenesis at single-cell resolution reveals a
            role for the leukotriene pathway in regulating blood progenitor
            formation
  JOURNAL   Nat Cell Biol 20 (2), 127-134 (2018)
   PUBMED   29311656
  REMARK    GeneRIF: Within the endothelial population, cells that transition
            from haemogenic endothelial to erythro-myeloid progenitors
            specifically express Alox5 and its co-factor Alox5ap, which control
            leukotriene production. Functional assays using mouse embryonic
            stem cells demonstrate that leukotrienes promote haematopoietic
            progenitor cell generation.
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Rauch,F., Geng,Y., Lamplugh,L., Hekmatnejad,B., Gaumond,M.H.,
            Penney,J., Yamanaka,Y. and Moffatt,P.
  TITLE     Crispr-Cas9 engineered osteogenesis imperfecta type V leads to
            severe skeletal deformities and perinatal lethality in mice
  JOURNAL   Bone 107, 131-142 (2018)
   PUBMED   29174564
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Elias,I., Ferre,T., Vila,L., Munoz,S., Casellas,A., Garcia,M.,
            Molas,M., Agudo,J., Roca,C., Ruberte,J., Bosch,F. and
            Franckhauser,S.
  TITLE     ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production
            and Protection Against Diet-Induced Obesity and Insulin Resistance
  JOURNAL   Diabetes 65 (8), 2139-2150 (2016)
   PUBMED   27207555
  REMARK    GeneRIF: ALOX5AP Overexpression in Adipose Tissue Leads to LXA4
            Production and Protection Against Diet-Induced Obesity and Insulin
            Resistance
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Griffiths,R.J., Smith,M.A., Roach,M.L., Stock,J.L., Stam,E.J.,
            Milici,A.J., Scampoli,D.N., Eskra,J.D., Byrum,R.S., Koller,B.H. and
            McNeish,J.D.
  TITLE     Collagen-induced arthritis is reduced in 5-lipoxygenase-activating
            protein-deficient mice
  JOURNAL   J Exp Med 185 (6), 1123-1129 (1997)
   PUBMED   9091585
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Byrum,R.S., Goulet,J.L., Griffiths,R.J. and Koller,B.H.
  TITLE     Role of the 5-lipoxygenase-activating protein (FLAP) in murine
            acute inflammatory responses
  JOURNAL   J Exp Med 185 (6), 1065-1075 (1997)
   PUBMED   9091580
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Lam,B.K., Penrose,J.F., Rokach,J., Xu,K., Baldasaro,M.H. and
            Austen,K.F.
  TITLE     Molecular cloning, expression and characterization of mouse
            leukotriene C4 synthase
  JOURNAL   Eur J Biochem 238 (3), 606-612 (1996)
   PUBMED   8706658
REFERENCE   9  (bases 1 to 1031)
  AUTHORS   Roach,M.L., Stock,J.L., Byrum,R., Koller,B.H. and McNeish,J.D.
  TITLE     A new embryonic stem cell line from DBA/1lacJ mice allows genetic
            modification in a murine model of human inflammation
  JOURNAL   Exp Cell Res 221 (2), 520-525 (1995)
   PUBMED   7493652
REFERENCE   10 (bases 1 to 1031)
  AUTHORS   Vickers,P.J., O'Neill,G.P., Mancini,J.A., Charleson,S. and
            Abramovitz,M.
  TITLE     Cross-species comparison of 5-lipoxygenase-activating protein
  JOURNAL   Mol Pharmacol 42 (6), 1014-1019 (1992)
   PUBMED   1480129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG085800.2, BC026209.1, AK004002.1 and BE944409.1.
            
            On May 7, 2015 this sequence version replaced NM_009663.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075967.1, DV047732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BG085800.2         1-54
            55-471              BC026209.1         1-417
            472-652             AK004002.1         431-611
            653-908             BC026209.1         599-854
            909-1031            BE944409.1         1-123               c
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.18 cM"
     gene            1..1031
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /note="arachidonate 5-lipoxygenase activating protein"
                     /db_xref="GeneID:11690"
                     /db_xref="MGI:MGI:107505"
     exon            1..179
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /inference="alignment:Splign:2.1.0"
     exon            180..279
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /inference="alignment:Splign:2.1.0"
     exon            280..350
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /inference="alignment:Splign:2.1.0"
     exon            351..432
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /inference="alignment:Splign:2.1.0"
     exon            433..1014
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /note="hexamer: AATAAA"
     polyA_site      908
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
     regulatory      978..983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /note="hexamer: ATTAAA"
     polyA_site      1004
                     /gene="Alox5ap"
                     /gene_synonym="Flap"
                     /note="major polyA site"
ORIGIN      
        1 tggaaactga tggtaaaagg cagagcacag cctggcactt cccctttctg cgcaggaagg
       61 ctgaggtgct agcaccagcc tggttgtctc tggcgggcct gaagcaagca tggatcaaga
      121 ggctgtgggc aacgttgtgc tcctggccct tgtcaccctc atcagcgtgg tccagaatgc
      181 gttctttgcc cacaaggtgg agcatgaaag caaggcgcat aatgggagaa gcttccagag
      241 gaccgggact cttgcctttg agcgggtcta cactgccaac cagaactgcg tagatgcgta
      301 ccccactttc cttgtggtac tctggactgc aggactactt tgcagccaag tccctgccgc
      361 cttcgccgga ctgatgtacc tgtttgtgag gcaaaaatac tttgtcggct atctgggaga
      421 gagaactcag agcacccctg gctacatctt cggcaagcgg atcatcctgt tcctgttcct
      481 catgtccttc gccgggatac tcaaccatta cctcatcttc ttcttcggaa gcgactttga
      541 gaactacatc agaacggtaa gcacgacgat ctccccgctg cttctcatcc cctgattgct
      601 ggagacagag aaggacgctc accagatcaa tagagacgca tcataacgca acgccgcgaa
      661 ggcttctgct cctcttcaag ctgtagatgc tgtcaatctt gctgccctcg gggctctgtg
      721 gcatccgtta actttgcttt tccgggaaga aaaatgtctt gtgctagctc cacccctcga
      781 atgcggcggt ggcccaggat ttattgtcta catccagcct atacttctcc tggcttatcc
      841 tgctttctga agatgtcttg taatcagaca cgtgttttcc taaaataaag ggtatagaca
      901 aaatttaagc ccatggctca gattggggtg atatttctgt attagctatt agtgtttctt
      961 caacctacat gatgataatt aaaatcacaa tttccatata tggacgctaa cgtcaaaaaa
     1021 aaaaaaaaaa a
//
