LOCUS       NM_009662               2827 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus arachidonate 5-lipoxygenase (Alox5), mRNA.
ACCESSION   NM_009662 XM_132832
VERSION     NM_009662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Castro-Lopez,N., Campuzano,A., Mdalel,E., Vanegas,D.,
            Chaturvedi,A., Nguyen,P., Pulse,M., Cardona,A.E. and Wormley,F.L.
            Jr.
  TITLE     Inhibition of host 5-lipoxygenase reduces overexuberant
            inflammatory responses and mortality associated with Cryptococcus
            meningoencephalitis
  JOURNAL   mBio 15 (9), e0148324 (2024)
   PUBMED   39082787
  REMARK    GeneRIF: Inhibition of host 5-lipoxygenase reduces overexuberant
            inflammatory responses and mortality associated with Cryptococcus
            meningoencephalitis.
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Huang,J., Xie,Y., Chen,B., Xia,Y., Jiang,Y., Sun,Z. and Liu,Y.
  TITLE     GPR146 regulates pulmonary vascular remodeling by promoting
            pulmonary artery smooth muscle cell proliferation through
            5-lipoxygenase
  JOURNAL   Eur J Pharmacol 961, 176123 (2023)
   PUBMED   37926274
  REMARK    GeneRIF: GPR146 regulates pulmonary vascular remodeling by
            promoting pulmonary artery smooth muscle cell proliferation through
            5-lipoxygenase.
REFERENCE   5  (bases 1 to 2827)
  AUTHORS   Wang,M., Zeng,G., Xiong,B., Zhu,X., Guo,J., Chen,D., Zhang,S.,
            Luo,M., Guo,L. and Cai,L.
  TITLE     ALOX5 promotes autophagy-dependent ferroptosis by activating the
            AMPK/mTOR pathway in melanoma
  JOURNAL   Biochem Pharmacol 212, 115554 (2023)
   PUBMED   37080437
  REMARK    GeneRIF: ALOX5 promotes autophagy-dependent ferroptosis by
            activating the AMPK/mTOR pathway in melanoma.
REFERENCE   6  (bases 1 to 2827)
  AUTHORS   Chen,X.S., Naumann,T.A., Kurre,U., Jenkins,N.A., Copeland,N.G. and
            Funk,C.D.
  TITLE     cDNA cloning, expression, mutagenesis, intracellular localization,
            and gene chromosomal assignment of mouse 5-lipoxygenase
  JOURNAL   J Biol Chem 270 (30), 17993-17999 (1995)
   PUBMED   7629107
REFERENCE   7  (bases 1 to 2827)
  AUTHORS   Funk,C.D., Chen,X.S., Kurre,U. and Griffis,G.
  TITLE     Leukotriene-deficient mice generated by targeted disruption of the
            5-lipoxygenase gene
  JOURNAL   Adv Prostaglandin Thromboxane Leukot Res 23, 145-150 (1995)
   PUBMED   7732821
REFERENCE   8  (bases 1 to 2827)
  AUTHORS   Goulet,J.L., Snouwaert,J.N., Latour,A.M., Coffman,T.M. and
            Koller,B.H.
  TITLE     Altered inflammatory responses in leukotriene-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12852-12856 (1994)
   PUBMED   7809134
REFERENCE   9  (bases 1 to 2827)
  AUTHORS   Chen,X.S., Sheller,J.R., Johnson,E.N. and Funk,C.D.
  TITLE     Role of leukotrienes revealed by targeted disruption of the
            5-lipoxygenase gene
  JOURNAL   Nature 372 (6502), 179-182 (1994)
   PUBMED   7969451
REFERENCE   10 (bases 1 to 2827)
  AUTHORS   Funk,C.D., Kurre,U. and Griffis,G.
  TITLE     Targeted gene disruption by homologous recombination. Toward an
            understanding of specific blood cell functions
  JOURNAL   Ann N Y Acad Sci 714, 253-258 (1994)
   PUBMED   8017775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205433.1, AK171413.1 and BY555055.1.
            
            On Oct 26, 2006 this sequence version replaced NM_009662.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171413.1, AK170879.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY205433.1         38-81
            45-2817             AK171413.1         2-2774
            2818-2827           BY555055.1         398-407
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.79 cM"
     gene            1..2827
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /note="arachidonate 5-lipoxygenase"
                     /db_xref="GeneID:11689"
                     /db_xref="MGI:MGI:87999"
     exon            1..304
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2179
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /EC_number="1.13.11.34"
                     /note="5-lipoxygenase"
                     /codon_start=1
                     /product="polyunsaturated fatty acid 5-lipoxygenase"
                     /protein_id="NP_033792.1"
                     /db_xref="CCDS:CCDS20452.1"
                     /db_xref="GeneID:11689"
                     /db_xref="MGI:MGI:87999"
                     /translation="MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYN
                     DFERGAVDSYDVTVDEELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYR
                     WITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKC
                     HKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNT
                     ISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQE
                     VQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGE
                     SNPIFLPTDSKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHP
                     LFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLC
                     FPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVVSIYYENDQVVEEDQELQD
                     FVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIP
                     NAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEE
                     HFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI"
     exon            305..503
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            504..585
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            586..708
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            709..815
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            816..988
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1135
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1339
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1426
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1605
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1727
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1828
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1999
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2827
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /note="hexamer: AATAAA"
     polyA_site      2624
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /note="major polyA site"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
                     /note="hexamer: AATAAA"
     polyA_site      2719
                     /gene="Alox5"
                     /gene_synonym="5-LO; 5-LOX; 5LO; 5LX; F730011J02"
ORIGIN      
        1 agggtggagc cagacccaag cgcaaggctg gcccgctgct ggccactgtg gcagggagct
       61 gccgcgagtg acagggtcaa gaagttggtg ggctgccacg ccgagcttcg cgggctcctg
      121 ctcccacacc agcagcactc acttgcccgg agtcatgccc tcctacacgg tcaccgtggc
      181 caccggcagc cagtggttcg cgggcaccga cgactacatc tacctcagcc tcattggctc
      241 tgcgggctgt agcgagaagc atctgctgga caaggcattc tacaatgact tcgaacgggg
      301 cgcggtggac tcctacgatg tcaccgtgga tgaggagctg ggcgagatct acctagtcaa
      361 aattgagaag cgcaaatact ggctccatga tgactggtac ctgaagtaca tcacactgaa
      421 gacaccccac ggggactaca tcgagttccc atgttaccgc tggatcacag gcgagggcga
      481 gattgtcctg agggatggac gtgcaaaatt ggcccgagat gaccaaattc acatcctcaa
      541 gcagcacaga cgtaaagaac tggaggcacg gcaaaaacag tatcgatgga tggagtggaa
      601 ccccggcttc cctttgagta ttgatgccaa atgccacaag gatctgcccc gagatatcca
      661 gtttgatagt gaaaaaggag tggactttgt tctgaactac tcaaaagcga tggagaacct
      721 gttcatcaac cgcttcatgc acatgttcca gtcttcctgg cacgactttg ctgactttga
      781 gaaaatcttc gtcaaaatca gcaacactat atctgagcga gtcaagaacc actggcagga
      841 agacctcatg tttggctacc agttcctgaa tggctgcaac ccagtactca tcaagcgctg
      901 cacagcgttg cccccgaagc tcccagtgac cacagagatg gtggagtgca gcctagagcg
      961 gcagctcagt ttagaacagg aagtacagga agggaacatt ttcatcgttg attacgagct
     1021 actggatggc atcgatgcta acaaaactga cccctgtaca caccagttcc tggctgcccc
     1081 catctgcctg ctatataaga acctagccaa caagattgtt cccattgcca tccagctcaa
     1141 ccaaacccct ggagagagta acccaatctt cctccctacg gattcaaagt acgactggct
     1201 tttggccaaa atctgggtgc gttccagtga cttccacgtc catcaaacga tcacccacct
     1261 tctgcgcacg catctggtgt ctgaggtgtt tggtatcgcc atgtaccgcc agctgcctgc
     1321 tgtgcatccc cttttcaagc tgctggtagc ccatgtgagg ttcaccattg ctatcaacac
     1381 taaggcccgg gaacagctta tctgcgagta tggccttttt gacaaggcca atgccaccgg
     1441 gggtggaggg cacgtgcaga tggtgcagag ggctgtccag gatctgacct attcctccct
     1501 gtgtttcccg gaggccatca aggcccgggg catggacagc acggaagaca tccccttcta
     1561 cttctatcgt gatgatggac tgctcgtgtg ggaggctatc cagtcgttca caatggaggt
     1621 ggtgagcatc tactatgaga acgaccaggt ggtggaggag gaccaggaac tgcaggactt
     1681 cgtgaaggat gtttacgtgt acggcatgcg gggcaaaaag gcctcaggtt tccccaagtc
     1741 catcaagagc agggagaagc tgtccgagta cctgacggtg gtgatcttca cggcctctgc
     1801 ccagcatgca gctgtaaact tcggccagta tgactggtgc tcctggatcc ccaacgctcc
     1861 tccaactatg cgggccccac cacccacggc caagggtgtg gtcaccatcg agcagatcgt
     1921 ggatactcta ccagaccgtg gccgatcatg ttggcatcta ggtgcagtgt gggccttgag
     1981 ccagtttcaa gaaaatgagc tgtttctagg catgtaccca gaggagcatt tcattgagaa
     2041 gccagtgaag gaagccatga tccgattccg caagaacctg gaggccatcg tcagcgtgat
     2101 cgccgagcgc aataagaaca aaaagctccc ctactactac ctgtcaccag acaggattcc
     2161 caacagcgta gccatctaag gccttgcctc cctacccagc agctctctgg gaaggccagt
     2221 ggctttatta gccagatccc agcttgcctg gcaggctctg ggtcgatctt cctgcagctg
     2281 gtgcctcttc caagctcgaa gtgctgctct tgggcctagg tggtctggtt gaaactgaag
     2341 gctgttgtag gatggggaga catcacagag cctcagcatg tgctacttct tcagtggaca
     2401 cagttgagga acctcccagg cagggcagag atgtgcagct gtgtccccca gcccagctca
     2461 gtgcctcgtc actcggtagc atcagaataa gtgacaactg ttctggctgg gtcaggggta
     2521 ctttattcta tttatgcttc ctccaattgc ttgcatagag taggtgctta gagaaagttc
     2581 ttggattaag agtttgttat aaaataaact tcatttaaaa caggtgtcat accacatgct
     2641 gaggtccagt cacccccact cccaccccca ccaaaatcac tgttctcttt cgatcaacaa
     2701 taaaaaagct ggtctactac ctcctccaac tgacaaggtc tttgcccccc actccatacc
     2761 agtggccctt tctgcttttg tagacaatac aggtattcta aattaaacac acaaatctaa
     2821 agatctg
//
