LOCUS       NM_145684               2324 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus arachidonate lipoxygenase, epidermal (Alox12e), mRNA.
ACCESSION   NM_145684
VERSION     NM_145684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Patil,S., Reedy,J.L., Scroggins,B.T., White,A.O., Kwon,S.,
            Shankavaram,U., Lopez-Coral,A., Chung,E.J. and Citrin,D.E.
  TITLE     Senescence-associated tumor growth is promoted by 12-Lipoxygenase
  JOURNAL   Aging (Albany NY) 14 (3), 1068-1086 (2022)
   PUBMED   35158337
  REMARK    GeneRIF: Senescence-associated tumor growth is promoted by
            12-Lipoxygenase.
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Leiria,L.O., Wang,C.H., Lynes,M.D., Yang,K., Shamsi,F., Sato,M.,
            Sugimoto,S., Chen,E.Y., Bussberg,V., Narain,N.R., Sansbury,B.E.,
            Darcy,J., Huang,T.L., Kodani,S.D., Sakaguchi,M., Rocha,A.L.,
            Schulz,T.J., Bartelt,A., Hotamisligil,G.S., Hirshman,M.F., van
            Leyen,K., Goodyear,L.J., Bluher,M., Cypess,A.M., Kiebish,M.A.,
            Spite,M. and Tseng,Y.H.
  TITLE     12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by
            Producing the Omega-3 Lipid 12-HEPE from Brown Fat
  JOURNAL   Cell Metab 30 (4), 768-783 (2019)
   PUBMED   31353262
  REMARK    GeneRIF: 12-Lipoxygenase Regulates Cold Adaptation and Glucose
            Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Krieg,P., Kinzig,A., Heidt,M., Marks,F. and Furstenberger,G.
  TITLE     cDNA cloning of a 8-lipoxygenase and a novel epidermis-type
            lipoxygenase from phorbol ester-treated mouse skin
  JOURNAL   Biochim Biophys Acta 1391 (1), 7-12 (1998)
   PUBMED   9518531
REFERENCE   7  (bases 1 to 2324)
  AUTHORS   Kinzig,A., Furstenberger,G., Burger,F., Vogel,S., Muller-Decker,K.,
            Mincheva,A., Lichter,P., Marks,F. and Krieg,P.
  TITLE     Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase
            isoform
  JOURNAL   FEBS Lett 402 (2-3), 162-166 (1997)
   PUBMED   9037187
REFERENCE   8  (bases 1 to 2324)
  AUTHORS   Funk,C.D., Keeney,D.S., Oliw,E.H., Boeglin,W.E. and Brash,A.R.
  TITLE     Functional expression and cellular localization of a mouse
            epidermal lipoxygenase
  JOURNAL   J Biol Chem 271 (38), 23338-23344 (1996)
   PUBMED   8798535
REFERENCE   9  (bases 1 to 2324)
  AUTHORS   van Dijk,K.W., Steketee,K., Havekes,L., Frants,R. and Hofker,M.
  TITLE     Genomic and cDNA cloning of a novel mouse lipoxygenase gene
  JOURNAL   Biochim Biophys Acta 1259 (1), 4-8 (1995)
   PUBMED   7492614
REFERENCE   10 (bases 1 to 2324)
  AUTHORS   Chen,X.S., Kurre,U., Jenkins,N.A., Copeland,N.G. and Funk,C.D.
  TITLE     cDNA cloning, expression, mutagenesis of C-terminal isoleucine,
            genomic structure, and chromosomal localizations of murine
            12-lipoxygenases
  JOURNAL   J Biol Chem 269 (19), 13979-13987 (1994)
   PUBMED   8188678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596096.7, AK138743.1 and BX630350.1.
            
            On Feb 13, 2018 this sequence version replaced NM_145684.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013751.1, U39200.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AL596096.7         5050-5108           c
            60-2306             AK138743.1         2-2248
            2307-2324           BX630350.1         2-19                c
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..2324
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /note="arachidonate lipoxygenase, epidermal"
                     /db_xref="GeneID:11685"
                     /db_xref="MGI:MGI:1274790"
     exon            1..209
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2063
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /EC_number="1.13.11.31"
                     /note="arachidonate 12-lipoxygenase, epidermal;
                     arachidonate 12-lipoxygenase, epidermal-type; e(12S)-LOX;
                     linoleate (13S)-lipoxygenase; arachidonate
                     (12S)-lipoxygenase, epidermal-type"
                     /codon_start=1
                     /product="polyunsaturated fatty acid
                     (12S)/(13S)-lipoxygenase, epidermal-type"
                     /protein_id="NP_663717.1"
                     /db_xref="CCDS:CCDS24943.1"
                     /db_xref="GeneID:11685"
                     /db_xref="MGI:MGI:1274790"
                     /translation="MVKYKILVATGDSVFAGSANLVHLWLVGEHGEADLGKQLRPLLG
                     RKTELEVDVPLHLGRLLAVKLRKQKGLLDSDWFCKSITVQGPGTQGEAFFPCYSWVQG
                     KETICLTEGTALKVTDDTQNLFRKYREQELENRRNVYRWGSWKEGLILPIAGSTERDL
                     PRNQRFMKDKDLDFSLSLVKELKNFAIKGTLDFVSRVQKLEDYQKVFPHTKTALPERV
                     RGSWKEDALFGYQFLNGANPMLLRRSMRLPARLVLPPGMEDVQTQLEKELKAGSLFEV
                     DFSLLDGVKPNIIIFKQQYVTAPLVMLKLQPDGRLLPMVIQLQPPRHGCPPPLLFLPS
                     DPPMAWLLAKIWVRSSDFQLHQLQSHLLRGHLMAEVISVATMRSLPSLHPIYKLLAPH
                     FRYTMEINTLARNNLVSEWGIFDLVVSTGSGGHVDILQRATSCLTYRSFCPPDDLADR
                     GLVGVKSSLYAQDALRLWEIISRYVERMVELFYRSDTDVKEDPELQVWCREVTEVGLL
                     GAQDRGFPLSLESRAELCRFVAMCIFTCTGQHASTHLGQLDWYAWIPNGPCTMRKPPP
                     ISKDVTERDIVDSLPCLQQARMQITVTKFLGRRQPVMVALGQHKEEYFSGPRPRDVLK
                     QFQEELAIMDKEIEVRNASLDLPYEYLRPSLVENSVTI"
     exon            210..411
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..493
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..616
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..720
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..881
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1025
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1235
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1322
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1492
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1615
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1715
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1883
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2324
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /note="hexamer: AATAAA"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /note="hexamer: AACAAA"
     polyA_site      2320
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /note="major polyA site"
     polyA_site      2324
                     /gene="Alox12e"
                     /gene_synonym="12-LOX; 12-LOX-e; 8-LOX; Alox12-ps1;
                     Alox12-ps2; Aloxe; e-LOX1"
                     /note="major polyA site"
ORIGIN      
        1 gactctctgg aggcagcctc tcagatcctc ttaagagcag tttcccccca ggtccctcta
       61 gaggatcagc cgagatggtc aagtacaaga tcctcgtagc cactggagac tcggtttttg
      121 cgggctccgc caacctggtg catctgtggc tggtgggcga gcatggagag gcggaccttg
      181 ggaagcagct gcggccactg ctgggaagga agacagagct ggaggtcgac gtccccttgc
      241 atctagggcg cctcctggcg gtgaagctgc gcaaacagaa aggcctattg gattctgact
      301 ggttctgcaa gagcatcact gtgcagggcc ctgggaccca aggagaagcc tttttcccct
      361 gctacagttg ggtgcagggc aaggagacta tctgcctaac cgagggcact gccctgaagg
      421 taactgatga cactcagaac ctgtttagga agtatcgaga gcaggagctg gagaacagaa
      481 ggaatgtgta tcggtggggc tcctggaagg agggattaat cctgcctata gcagggagta
      541 ctgaacggga cctcccccgg aaccagagat tcatgaagga taaggattta gatttttccc
      601 tctctctggt caaagagttg aagaactttg ctattaaggg gactctagat tttgtaagtc
      661 gtgtacaaaa gctggaagat taccagaaag tattcccaca tacaaagact gctctgcctg
      721 agcgggtccg tggttcctgg aaggaagatg ctctctttgg gtaccagttc ctcaacggtg
      781 caaaccccat gctcctgagg cggtccatgc gccttccagc ccggctggtc ctgcctccag
      841 ggatggaaga cgtacagacc cagctggaga aggagctcaa ggctggatct ctgttcgaag
      901 ttgatttctc cctgctggat ggagtcaaac ctaacatcat catttttaag cagcaatatg
      961 tgacagcccc tttggtcatg ctgaaactac agcccgatgg gaggctctta cccatggtca
     1021 tccagctcca gccaccacga cacggatgtc ccccgcctct gctcttcttg ccctcagatc
     1081 cccccatggc ctggctcttg gccaagatct gggtccgaag ctctgacttc caactgcacc
     1141 agttacagtc acatctgctg aggggacacc tcatggccga ggttatttct gtggccacaa
     1201 tgaggagttt acccagcctg caccccatat acaagctcct tgccccccac tttcgataca
     1261 ccatggagat caacaccctg gcacggaata atcttgtctc cgaatgggga atttttgacc
     1321 tggtggtgag cacggggagc ggaggccatg tggacattct ccagagagcc acgtcgtgtt
     1381 tgacctaccg ctccttttgc cctccggatg acttggctga ccgtggactc gtgggggtga
     1441 aatcttctct gtatgcccag gatgccctca ggctgtggga gatcatcagt cggtatgtgg
     1501 aaaggatggt tgagcttttc tacaggagtg acaccgatgt gaaggaggac ccggagctgc
     1561 aggtctggtg ccgcgaggtc actgaggttg gactgcttgg agcccaggac cgagggttcc
     1621 ccctgtcctt agagtcccgg gctgagctgt gccgctttgt cgctatgtgc atcttcacgt
     1681 gcactggtca gcacgcatct acacatctgg gtcagctgga ctggtatgcc tggatcccaa
     1741 atggcccatg caccatgcgg aagcccccac ccatctccaa ggatgtgaca gagagggaca
     1801 ttgtggactc gttgccttgc cttcagcagg cacggatgca gataacagtc accaagttcc
     1861 ttggcagacg ccagcctgtc atggtggccc tggggcagca taaagaggag tatttctcag
     1921 gccccaggcc ccgggatgtg ctgaagcaat tccaggagga gctggctatc atggacaagg
     1981 agattgaggt ccggaatgca agcctggacc tgccctatga gtacctccga cccagcctgg
     2041 tggaaaacag tgtgaccatc tgagaggcct tgcccatctc agccccagag gaggctgctg
     2101 tctctgtgtg tgtgcacagt cttgtcctcc ttggccacac cctctggtga atagacagct
     2161 tcgcaccaca cagccctggg gaatgcacag cgattatccc tgttgtgttt tagctgcccc
     2221 aactctatga tatgtgcttg tttagtcttg aatccctagt acccacttct cttccccaaa
     2281 agatatggtt tatacattaa taaaacaaaa atctctccct taaa
//
