LOCUS       NM_007440               3018 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus arachidonate 12-lipoxygenase (Alox12), transcript
            variant 1, mRNA.
ACCESSION   NM_007440
VERSION     NM_007440.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3018)
  AUTHORS   Pernet,E., Sun,S., Sarden,N., Gona,S., Nguyen,A., Khan,N.,
            Mawhinney,M., Tran,K.A., Chronopoulos,J., Amberkar,D., Sadeghi,M.,
            Grant,A., Wali,S., Prevel,R., Ding,J., Martin,J.G.,
            Thanabalasuriar,A., Yipp,B.G., Barreiro,L.B. and Divangahi,M.
  TITLE     Neonatal imprinting of alveolar macrophages via neutrophil-derived
            12-HETE
  JOURNAL   Nature 614 (7948), 530-538 (2023)
   PUBMED   36599368
  REMARK    GeneRIF: Neonatal imprinting of alveolar macrophages via
            neutrophil-derived 12-HETE.
REFERENCE   2  (bases 1 to 3018)
  AUTHORS   Chandrasekaran,P., Negretti,N.M., Sivakumar,A., Liberti,D.C.,
            Wen,H., Peers de Nieuwburgh,M., Wang,J.Y., Michki,N.S.,
            Chaudhry,F.N., Kaur,S., Lu,M., Jin,A., Zepp,J.A., Young,L.R.,
            Sucre,J.M.S. and Frank,D.B.
  TITLE     CXCL12 defines lung endothelial heterogeneity and promotes distal
            vascular growth
  JOURNAL   Development 149 (21) (2022)
   PUBMED   36239312
REFERENCE   3  (bases 1 to 3018)
  AUTHORS   Chen,S. and Zou,H.
  TITLE     Key Role of 12-Lipoxygenase and Its Metabolite
            12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy
  JOURNAL   Curr Eye Res 47 (3), 329-335 (2022)
   PUBMED   35129022
  REMARK    GeneRIF: Key Role of 12-Lipoxygenase and Its Metabolite
            12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.
            Review article
REFERENCE   4  (bases 1 to 3018)
  AUTHORS   Zhang,X.J., Ji,Y.X., Cheng,X., Cheng,Y., Yang,H., Wang,J.,
            Zhao,L.P., Huang,Y.P., Sun,D., Xiang,H., Shen,L.J., Li,P.L.,
            Ma,J.P., Tian,R.F., Yang,J., Yao,X., Xu,H., Liao,R., Xiao,L.,
            Zhang,P., Zhang,X., Zhao,G.N., Wang,X., Hu,M.L., Tian,S., Wan,J.,
            Cai,J., Ma,X., Xu,Q., Wang,Y., Touyz,R.M., Liu,P.P., Loomba,R.,
            She,Z.G. and Li,H.
  TITLE     A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic
            steatohepatitis in mice and macaques
  JOURNAL   Sci Transl Med 13 (624), eabg8116 (2021)
   PUBMED   34910548
REFERENCE   5  (bases 1 to 3018)
  AUTHORS   Zhang,X.J., She,Z.G., Wang,J., Sun,D., Shen,L.J., Xiang,H.,
            Cheng,X., Ji,Y.X., Huang,Y.P., Li,P.L., Yang,X., Cheng,Y., Ma,J.P.,
            Wang,H.P., Hu,Y., Hu,F., Tian,S., Tian,H., Zhang,P., Zhao,G.N.,
            Wang,L., Hu,M.L., Yang,Q., Zhu,L.H., Cai,J., Yang,J., Zhang,X.,
            Ma,X., Xu,Q., Touyz,R.M., Liu,P.P., Loomba,R., Wang,Y. and Li,H.
  TITLE     Multiple omics study identifies an interspecies conserved driver
            for nonalcoholic steatohepatitis
  JOURNAL   Sci Transl Med 13 (624), eabg8117 (2021)
   PUBMED   34910546
REFERENCE   6  (bases 1 to 3018)
  AUTHORS   Funk,C.D.
  TITLE     The molecular biology of mammalian lipoxygenases and the quest for
            eicosanoid functions using lipoxygenase-deficient mice
  JOURNAL   Biochim Biophys Acta 1304 (1), 65-84 (1996)
   PUBMED   8944751
  REMARK    Review article
REFERENCE   7  (bases 1 to 3018)
  AUTHORS   Krieg,P., Kinzig,A., Ress-Loschke,M., Vogel,S., Vanlandingham,B.,
            Stephan,M., Lehmann,W.D., Marks,F. and Furstenberger,G.
  TITLE     12-Lipoxygenase isoenzymes in mouse skin tumor development
  JOURNAL   Mol Carcinog 14 (2), 118-129 (1995)
   PUBMED   7576099
REFERENCE   8  (bases 1 to 3018)
  AUTHORS   Nakamura,M., Ueda,N., Kishimoto,K., Yoshimoto,T., Yamamoto,S. and
            Ishimura,K.
  TITLE     Immunocytochemical localization of platelet-type arachidonate
            12-lipoxygenase in mouse blood cells
  JOURNAL   J Histochem Cytochem 43 (3), 237-244 (1995)
   PUBMED   7868854
REFERENCE   9  (bases 1 to 3018)
  AUTHORS   Hagmann,W., Gao,X., Zacharek,A., Wojciechowski,L.A. and Honn,K.V.
  TITLE     12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity,
            intracellular distribution of activity and protein, and
            Ca(2+)-dependent translocation from cytosol to membranes
  JOURNAL   Prostaglandins 49 (1), 49-62 (1995)
   PUBMED   7792391
REFERENCE   10 (bases 1 to 3018)
  AUTHORS   Chen,X.S., Kurre,U., Jenkins,N.A., Copeland,N.G. and Funk,C.D.
  TITLE     cDNA cloning, expression, mutagenesis of C-terminal isoleucine,
            genomic structure, and chromosomal localizations of murine
            12-lipoxygenases
  JOURNAL   J Biol Chem 269 (19), 13979-13987 (1994)
   PUBMED   8188678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669869.10 and AK087724.1.
            
            On Sep 8, 2016 this sequence version replaced NM_007440.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087724.1, AK036898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL669869.10        120784-120812       c
            30-2393             AK087724.1         2-2365
            2394-3018           AK087724.1         2367-2991
FEATURES             Location/Qualifiers
     source          1..3018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..3018
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /note="arachidonate 12-lipoxygenase"
                     /db_xref="GeneID:11684"
                     /db_xref="MGI:MGI:87998"
     exon            1..233
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2090
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /EC_number="1.13.11.31"
                     /EC_number="1.13.11.33"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arachidonate 12-lipoxygenase, 12S-type; 12S-LOX;
                     12S-lipoxygenase; platelet-type lipoxygenase 12; lipoxin
                     synthase 12-LO; linoleate 13S-lipoxygenase; arachidonate
                     15-lipoxygenase,15S-type; arachidonate (12S)-lipoxygenase;
                     arachidonate (15S)-lipoxygenase; polyunsaturated fatty
                     acid lipoxygenase ALOX12"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX12
                     isoform 1"
                     /protein_id="NP_031466.2"
                     /db_xref="CCDS:CCDS24942.1"
                     /db_xref="GeneID:11684"
                     /db_xref="MGI:MGI:87998"
                     /translation="MGRYRVRVVTGAWLFSGSLNLVRLWLVGEHREAKLELQLRPARG
                     KEEEFDFDVPEDLGPLQFVKLHKQHTVVDDAWFCNLITVQGPGTSAEAVFPCYRWVQG
                     EGILSLPEGTARLAGDNALDVFQKYREKELKERQQTYCWATWKEGLPQTIAADCKDDL
                     PPNMRFHEEKRLDFEWTLKAGVLEMGLKRVYTLLRSWNHLEDFDQIFWGQKSALAEKV
                     HQCWQEDELFGYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELKNGSLFEA
                     DFILLDGIPANVIRGEPQYLAAPLVMLRMDPGGKLLPMAIQIQPPNPSSPAPTLFLPS
                     DPPLAWLLAKIWVRNSDFQLQELQFHLLNTHLVAEVIAVATMRCLPGLHPIFKLLVPH
                     IRYTMEINTRSRTQLISDGGIFDQVVSTGGGGHVQLLTRAVAQLTYHSLCPPDDLANR
                     GLLRIPSALYARDALQLWEVTARYVKGMVHLFYQSDDIVRGDPELQAWCREITEVGLC
                     HAQDRGFPVSFQSRAQLCHFLTMCVFTCTAQHAAINQGQLDWYGWVPNAPCTMRMPPP
                     TSKDDVTMETVMGSLPDVQKACLQMTITWHLGRLQPDMVPLGHHTEKYFSDPRTKAVL
                     SQFQADLDNLEKEITARNEQLDLPYEYLKPSRIENSITI"
     exon            234..435
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            436..517
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            518..640
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            641..744
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            745..905
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1049
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1259
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1346
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1516
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1638
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1739
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1910
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..3018
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /note="major polyA site"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
                     /note="hexamer: AATAAA"
     polyA_site      2440
                     /gene="Alox12"
                     /gene_synonym="9930022G08Rik; Alox12p; P-12LO"
ORIGIN      
        1 ttttaaagtt ttggacctgg ccccgaggcg acggtggccc tgggcggtct tcgaattgaa
       61 cttaacttgg atcgcctcct gagaggccag agggagccat gggccgctac cgcgtccgtg
      121 tggtcactgg ggcctggctc ttctccggat ccctcaacct agtgcgtttg tggctggttg
      181 gggagcaccg ggaggcgaaa ctggagctgc aactgcggcc agcgcggggc aaggaggagg
      241 agtttgactt cgacgttccc gaggacttgg ggccactgca gtttgtgaaa ctgcacaaac
      301 agcacacagt tgtggatgac gcctggttct gcaacctcat cacagttcag gggccgggga
      361 caagtgcaga ggccgtgttt ccctgctacc gctgggtgca gggagaggga atcctgagcc
      421 tcccggaggg gacagcccgc ctggcaggag acaatgcctt agatgtcttc cagaagtatc
      481 gagaaaagga actgaaggaa agacaacaga cctactgctg ggccacctgg aaagaaggct
      541 tacctcagac aatagcagcg gactgtaagg atgaccttcc tccaaatatg agattccatg
      601 aggagaagag actggacttt gaatggacgt tgaaggcggg ggttctggaa atgggcctca
      661 aacgtgttta taccctcctg agaagctgga accatctgga agactttgat cagatcttct
      721 ggggccagaa gagtgccttg gccgagaagg ttcaccagtg ttggcaggaa gatgaactct
      781 ttggctacca gttcctcaat ggcgccaacc ccatgctttt gagacgctcc acctctctgc
      841 cctccagact ggtactgccc tctgggatgg aggagcttca agctcagttg gagaaagaac
      901 tcaagaatgg atccctgttt gaagctgact ttatcctgct ggatggaatt ccagctaatg
      961 tgatccgagg agaaccacag tacctggctg cccctcttgt catgctgagg atggaccccg
     1021 gtgggaagct gctacccatg gctatccaga ttcagccccc taaccccagc tccccagctc
     1081 caacactgtt cctgccctcg gatcctccac ttgcctggct cttggctaag atctgggtcc
     1141 gaaattcaga tttccaactg caggagctcc aattccattt gctgaacacc catctggtgg
     1201 ctgaggtcat cgctgttgcc accatgagat gcctcccagg actgcaccct atcttcaagc
     1261 tcctcgttcc acacatccgt tacactatgg aaattaacac gcgaagccgg acccagctca
     1321 tctcagatgg aggaatattt gatcaggtag tgagcacagg tggaggcggc catgttcagt
     1381 tgcttactcg ggcagtggct cagctgactt accactccct ctgtcctcct gatgatctgg
     1441 ctaaccgagg cctgctgaga atcccaagtg ctctctatgc tcgggatgct ttacagctct
     1501 gggaagtcac tgccaggtat gtgaagggga tggtccatct cttctaccag agtgatgata
     1561 ttgtgagggg agacccagag ctgcaggcct ggtgtcggga gatcactgaa gtggggctgt
     1621 gccatgccca ggacagagga ttccctgtct ccttccagtc ccgggctcag ctctgccatt
     1681 tcctcaccat gtgtgttttc acatgcactg cccagcatgc tgccatcaac cagggccagc
     1741 tggactggta tggttgggta cctaatgctc catgcacaat gaggatgcct ccgcccacca
     1801 gcaaggacga cgtgacgatg gagaccgtga tggggtcgct acctgatgtg cagaaggcct
     1861 gtcttcagat gactatcaca tggcacctgg gtcgcctgca gccagacatg gtacctctag
     1921 gacaccacac agaaaaatat ttctcagacc caaggaccaa agctgtgctc agccaatttc
     1981 aagcagattt ggacaatttg gagaaagaga ttacagcccg gaatgagcaa cttgacctgc
     2041 cttatgaata cctcaagccc agccgcatag agaacagtat caccatctga ggcagagctg
     2101 ctgggaccca gaaggcttcg tcagccctag gactgccact acccacttga ttctgtgcct
     2161 tcttatgtct gctgctgaga ctctaattcc tctcctgact aaacactcca cattagtatt
     2221 ctaactacag ggcactaaat gtcttgctgt tatgaggaac aatttagtct ttggagggcc
     2281 acccactttc taccacaatt acttagcttt ctcactatac cactagtgtg tgactatgtt
     2341 ccaataaaac tttaggtatg gacactgaga tatgaacttc acatgtcaca gggtcttttt
     2401 ttggcttgtt taggcattta aaaataaaaa caaagccagg tgtggtggtg cactccttta
     2461 atctcagcac ctttaatctc tggaggcaga tgcagcagat ctctgagttc aaggccagcc
     2521 tggcctacag agtgagctcc acgacagtca gggatgaagc cctgtctcaa caaaacaaaa
     2581 gtgcaaaacc aggcgtgggg acacacgcct ttagttccag cactctggag gcagagacag
     2641 gcagatttct cagttcaagg ccagcctggt ctacaaaatg agttccagga cagccagggc
     2701 tacacagaga aaccctgact cgaaaaacaa aacaaaaaca aacaaaaagt gctttgcatg
     2761 atttcaggtt agatttggtc taacctcata cagacctcag gctccaaacc tcattttcaa
     2821 aatatccaag agccatggtg gaggagagga aaattgtatt tctggataaa atcaactact
     2881 tcagctagtt ctcctttgcc aggaaccaga cttcatgctt gacggccaac gtgtaaattt
     2941 cagactctct tcccctccac gtttccattt tgaacacata ccctgaatag ttctaaataa
     3001 aggtgttact ggccccaa
//
