LOCUS       NM_145223              10005 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus ALMS1, centrosome and basal body associated (Alms1),
            mRNA.
ACCESSION   NM_145223 XM_355793 XM_358366
VERSION     NM_145223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10005)
  AUTHORS   Ganguly,S., Rosenthal,S.B., Ishizuka,K., Troutman,T.D., Rohm,T.V.,
            Khader,N., Aleman-Muench,G., Sano,Y., Archilei,S., Soroosh,P.,
            Olefsky,J.M., Feldstein,A.E., Kisseleva,T., Loomba,R., Glass,C.K.,
            Brenner,D.A. and Dhar,D.
  TITLE     Lipid-associated macrophages' promotion of fibrosis resolution
            during MASH regression requires TREM2
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2405746121 (2024)
   PUBMED   39172787
REFERENCE   2  (bases 1 to 10005)
  AUTHORS   McKay,E.J., Luijten,I., Broadway-Stringer,S., Thomson,A., Weng,X.,
            Gehmlich,K., Gray,G.A. and Semple,R.K.
  TITLE     Female Alms1-deficient mice develop echocardiographic features of
            adult but not infantile Alstrom syndrome cardiomyopathy
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38756069
REFERENCE   3  (bases 1 to 10005)
  AUTHORS   McKay,E.J., Luijten,I., Weng,X., Martinez de Morentin,P.B., De
            Frutos Gonzalez,E., Gao,Z., Kolonin,M.G., Heisler,L.K. and
            Semple,R.K.
  TITLE     Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic
            features of Alstrom syndrome
  JOURNAL   Mol Metab 84, 101933 (2024)
   PUBMED   38583571
  REMARK    GeneRIF: Mesenchymal-specific Alms1 knockout in mice recapitulates
            metabolic features of Alstrom syndrome.
REFERENCE   4  (bases 1 to 10005)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 10005)
  AUTHORS   Stephenson,E.J., Kinney,C.E., Stayton,A.S. and Han,J.C.
  TITLE     Energy expenditure deficits drive obesity in a mouse model of
            Alstrom syndrome
  JOURNAL   Obesity (Silver Spring) 31 (11), 2786-2798 (2023)
   PUBMED   37712194
REFERENCE   6  (bases 1 to 10005)
  AUTHORS   Arsov,T., Silva,D.G., O'Bryan,M.K., Sainsbury,A., Lee,N.J.,
            Kennedy,C., Manji,S.S., Nelms,K., Liu,C., Vinuesa,C.G., de
            Kretser,D.M., Goodnow,C.C. and Petrovsky,N.
  TITLE     Fat aussie--a new Alstrom syndrome mouse showing a critical role
            for ALMS1 in obesity, diabetes, and spermatogenesis
  JOURNAL   Mol Endocrinol 20 (7), 1610-1622 (2006)
   PUBMED   16513793
REFERENCE   7  (bases 1 to 10005)
  AUTHORS   Collin,G.B., Cyr,E., Bronson,R., Marshall,J.D., Gifford,E.J.,
            Hicks,W., Murray,S.A., Zheng,Q.Y., Smith,R.S., Nishina,P.M. and
            Naggert,J.K.
  TITLE     Alms1-disrupted mice recapitulate human Alstrom syndrome
  JOURNAL   Hum Mol Genet 14 (16), 2323-2333 (2005)
   PUBMED   16000322
  REMARK    GeneRIF: Disruption in ALMS1 manifests human Alstrom syndrome
REFERENCE   8  (bases 1 to 10005)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 10005)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 10005)
  AUTHORS   Collin,G.B., Marshall,J.D., Ikeda,A., So,W.V., Russell-Eggitt,I.,
            Maffei,P., Beck,S., Boerkoel,C.F., Sicolo,N., Martin,M.,
            Nishina,P.M. and Naggert,J.K.
  TITLE     Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory
            degeneration in Alstrom syndrome
  JOURNAL   Nat Genet 31 (1), 74-78 (2002)
   PUBMED   11941369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF425257.1, AC104743.28, DV650553.1 and BM942574.1.
            
            On Jul 25, 2007 this sequence version replaced NM_145223.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF425257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AF425257.1         1-54
            55-188              AF425257.1         56-189
            189-195             AC104743.28        144044-144050
            196-8237            AF425257.1         197-8238
            8238-8975           DV650553.1         89-826
            8976-9875           AF425257.1         8977-9876
            9876-10005          BM942574.1         218-347
FEATURES             Location/Qualifiers
     source          1..10005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.48 cM"
     gene            1..10005
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /note="ALMS1, centrosome and basal body associated"
                     /db_xref="GeneID:236266"
                     /db_xref="MGI:MGI:1934606"
     exon            1..496
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..9871
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /note="alstrom syndrome protein 1 homolog; Alstrom
                     syndrome 1 homolog"
                     /codon_start=1
                     /product="centrosome-associated protein ALMS1"
                     /protein_id="NP_660258.2"
                     /db_xref="CCDS:CCDS20298.1"
                     /db_xref="GeneID:236266"
                     /db_xref="MGI:MGI:1934606"
                     /translation="MEPEDLPWPDELEEEEEEEEEEGEEEEGKKEVENASAAATEEAL
                     TSEESGRLEEFEEAGPDLDFNYESQRQESSDEEEDELAKAWLQAHPDRPGSAFSLPPP
                     TPPPPPPPLSPRLRYTPVEHLGKTEVVPLTCRVWQQSSYQDNSRAQFSNSSTMLLETG
                     VRWGSEEDQRTESWHCLPQERDSSQTLAMSQTEIGRVEGTEVPDLPSQEGGLPAQSQC
                     PGKKPKLNVLCSPLLVIQDNFAAPDLPLLTCLIQDQEEVEPDSLFQQSELEFAPLRGI
                     PDKSEDSEWLARPSEVSEALIQATSETSSDLANSCFSISQHPLTEGLQGKAESGVLTR
                     CGDAKYSSLYENLGAQSERIAVLQREVGCSNLGISQASPSSLPSFVPQEPTSEPEYHS
                     SNLRMLRVSPDTLLTTHTHSAGSADQKIGAAVVSSAYSQEIKPGSFHQEELPDRHLNE
                     EIRKVSPALRTAGQKPEMLPVQSSSYSKGMKSIFYQHPVSHGHQGKEPLSVSAVCGSA
                     GNKAFHQLSTLSDSLLTEETWPVSVIPGLGNQKTPLPSEFSLSYSHRGKNLPEDVVKV
                     STDSGSAHKKADILTASSRTYQHKMKPANIYHQELPDSRVPIGTRKVAFESGPAGQKS
                     GVSHPYGEMPSVFYQQGLPDRHSAKSPTKTFIPGPADQKTDLSPVPPTSSSHAEKPVS
                     PYQLTLPGSHLPEDVFKASSVCKSSDELSGITALTSASYSYKGRPNSSYQQKFPDSHL
                     NEEAQKILGTTGTVDQKTVTPTMSSSFLQKEKPSIFYQQTLPDGGLSEEDLQVSAVPW
                     PADQNIAIPTVTSAAFSQREKPRIFYQQTLSVDRLPGEPLNVLGTSGPPDQNTGAPTV
                     TPSSYFPGEESIIFYQAGFPGNTLSAMSFKVPRISGSTEQTNVTTGSSSSYSVGEKSI
                     IFYHQALPDGRLPQEASPAPADLNTGEPPMYLASCSVGVKPIIFYQQPMSDSQRTKGH
                     KESDVPGPTDQKTGIATVHSTSQSYIGRRTVSYQKEFPDLSEKALKVLGDVGSTEQKT
                     QIPVVSSALLHKEGPSAYQEDLPDLTEEPLQILGVSEEVSSSSYQRKLPDHIEVFLKS
                     VGSGSADRKTGAQIVSSSREKSSGFHQQELPNTGGDAVDAFHPEPVVQEVRKVQTPGA
                     PAGPSSSHFHKEKLSDYQKASPHRDLTESSLKASTVPGLSDQKKKPAVSSGFCLHKEK
                     HEISASALLNCQTAELLTVTQRSCLHREDPAISTVIKPDDQKIPLPTTFHGSSDQKVK
                     PVIFVQKQLRDRDQSEDIPKISTVSEPTVVNTVLPVLLPGSYSHREKSDSFYPQELPD
                     GHLTEVDLKVSSGLGQADQISGLPTGIPGTYSHSEKHQLISEHVQELMDNLNSSESSC
                     LSVDSMPLNSQIDDGVIICKPESLGFANAGCEEMQNIDRGSKTLKEIQTLLMEAENMA
                     LKRCNFSVPLVPFRDVNDVSFIRSKKVVCFKESSTTDVCTQRESFVEEVPHIEYVQKD
                     IGTQTNLKYQRGVGNWEFISSATFRSPLQEAEGTARMAYDETFRQYKAARSVMRSEPE
                     GCSTGIGNKMIIPMMTIIKSDSSSDVSDGCCSWDNNLPESLESVSDVFLNFFPYTSPK
                     TSITDSREEEWLSESEDGYGSTDSLAAHVKYLLQCETSLNQAKQILKNAEEEEYRVRT
                     QAWNLKFNLGRDRGYSISELNEDDRRKVEEIKAKLFGHGRATHMSEGLRSPQGIGCLP
                     EAVCSRIIIESHEKGCFRTLTAEQPRPDSCHCAFRSVEPSDLIRGHRSPSSWRGRHIN
                     LSRSIEQSNPCFKVGSSFQLQSHPPFQKLLPDDIKISKGVGMPVHAYMDPQPSELVEP
                     TCVPAKEMDFPSSSQILPPEPKKQFTTAITFSSHEHSECISDSSGCKVGVTADSQCSG
                     PSLGVFKPHIPEEQISPRDLKQKTSFQSSLERHGSTPVTILADGSRQRQKLPVDFEHS
                     HQKEKLLQRLGFKVSHSEPNVSTNVSNFKGVQFSGKDTIVSQDKLTSTVEVKEKNVTV
                     TPDLPSCIFLEQPELFEESHTPHTDLQMRKYPSPSCPEIASRIFLEQPKLSEQSKAPH
                     VDREIREDHSFFPKCQDYIVADPSPDFPDQQQCKPPDVVGHTRKQNSLLSEGQDYELE
                     EVQHIPQSYFSNMVNVEAKVSDAISQSAPDHCTAASTPPSNRKALSCVRITLCPKTSS
                     KLDSGTLGERFHSLDPASKTRINSEFNSDLRIISSRSLEPTSKLLTCKPVAQDQESLV
                     FLGPKSPLDLQVAQSSLPDSKTIFQDLKTKPPQNSQIVTSRQTQVNISHLEGYSKPEG
                     TPVSADGSQEQSKVSFTTSFGKLSSDAITQITTESPEKTTFSSEIFIHADDRGQGILD
                     PMAQKPSRFASSSSVQQIPASHGKDAQPVLLPYKPSGSSKMYYVPLLKRVPSYLDSKS
                     DTTVESSHSGSNDAIAPDFPPQMLGTRDDDLSNTVNIKHKEGIYSKRAATKGKNPSQK
                     GDAAAPVQMPITWDENVLDENQEEVISRGVVIKMAGPEEMSSLEKDLAGPSDITVQDR
                     KTENLPDTKSIKQKEGSLEIESECHSAFENTAHSVFRSAKFYFHHPVHLPHEQDFCHE
                     SLGRSVFMQHSWKDFFHHHSGHSCLPPPGPSSDKLDKTKMDYTRIKSLSINLNLGEHE
                     KIHTIKNQARDPKGKRQANEQKKDQKVTPELTTECPVSLNELWNRYQERQKQQNPSGA
                     CDTKELSLVERLDRLAKLLQNPITHSLRASESAQDDSRGGHRAREWTGRRQQKQKGKQ
                     HRKWSKSLERGQSTGDFRKSKVFSPHQGGKSSQFKIEQIKLDKYILRKEPGFNNVSNT
                     SLDSRPSEESVSLTDSPNIFSSTDSPVDSDVLTPTDRDMPLNERSSSISTIDTVRLIQ
                     AFGQDRLSLSPRRIKLYSTVTSQRRRYLEQPCKHNRKALNTACPQMTSEHSRRRHIQV
                     ANHMTSSDSVSSPGSLLSLDSALSNEETVRMVSKGVQAGNLEIVAGVKKYTQDVGVTF
                     PTPSSSEARLEEDSDVTSSSEEKAKEKKFLSNYLQTKNLRKNKPNPCAGVSWFVPVES
                     GQSGSKKENLPKIYRPVISWFEPVTKTKPWREPLREQNWQAQCMNSRGSLGGPGRDSG
                     QVSLRPFVRATLQESLQLHRPDFISHSGERIKRLKLLVQERKLQSLFQSEREALFHSA
                     RPLPRRVLLAVQKNKPIGKKEMIQRTRRIYEQLPEVKKKREEEKRKSEYKSYWLRAQH
                     YKMKVTNHLLGRKVPWD"
     exon            497..622
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            623..815
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            816..936
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1076
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1195
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1355
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..5123
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..5257
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..7053
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            7054..7283
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            7284..7409
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            7410..7565
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            7566..7700
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            7701..7790
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            7791..8944
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            8945..9062
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            9063..9266
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            9267..9508
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            9509..9662
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            9663..9726
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            9727..9826
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
     exon            9827..9984
                     /gene="Alms1"
                     /gene_synonym="bbb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagggcag gtgcgcctgc gcgcagccgc aaccgccagt caactcgctt cccctccctt
       61 cctcgcccct ccccctctcc tcctcttcca aaggcgcctg gagcgcgagg ccaacatgga
      121 gcctgaggac ctgccgtggc ctgacgagct ggaggaggag gaggaagaag aggaggagga
      181 gggcgaggaa gaggagggga agaaagaggt ggagaacgcc tcggcggcgg cgaccgagga
      241 ggccctgacc tctgaggaga gtgggagact ggaagagttc gaagaggcgg ggcccgactt
      301 ggattttaac tacgagtccc agcggcagga gagctcggac gaagaggagg acgagctggc
      361 taaagcctgg ctgcaggctc accccgaccg tcctggcagt gctttctctc tgccccctcc
      421 cacgcctccg cctccgcctc cgcctctgtc cccgcggctc cggtacaccc cagtggagca
      481 tctgggcaag actgaggttg tcccactgac ttgccgtgta tggcagcagt catcatatca
      541 agataattct agagcccagt tttccaactc cagtacaatg ttattggaaa caggggtccg
      601 gtggggctct gaggaggatc agagaacaga gtcttggcat tgtcttcctc aagaaaggga
      661 ttcttcccaa accttggcta tgtcccagac tgagatcggc agagtagaag gaacagaagt
      721 accagaccta ccctctcagg agggaggttt accagctcag tcacagtgtc caggaaagaa
      781 gccaaagctg aatgtcttgt gttctccatt gctagtgata caggataact ttgctgctcc
      841 tgatttgcct ttgctgacat gtttgataca agaccaagaa gaggttgagc ctgattcctt
      901 gtttcaacaa agtgaactag aatttgcacc tttgagagga attcctgata agtctgaaga
      961 ttctgaatgg cttgctcgac catcagaagt tagtgaagct ttaatccaag ccacctcaga
     1021 aacatcttca gacttagcta acagttgctt tagtatatct cagcatccac ttacagaggg
     1081 cctgcagggg aaggctgaat ctggtgtcct tactaggtgt ggtgatgcta agtactccag
     1141 cctttatgaa aaccttggtg cacagagtga aagaattgct gtattgcaga gagaggtagg
     1201 ttgttctaat ctgggcatta gccaggcttc tccatcttca ttgccttcat ttgttcctca
     1261 agaaccaacc agtgagccgg aataccattc ctccaatctc agaatgttga gggtatctcc
     1321 cgacactctg ctaacaacgc atacacattc agcaggatct gctgaccaga agattggagc
     1381 agcagtagtc tcttctgctt actcacagga aataaagcct gggagttttc accaagaaga
     1441 gttgccagat aggcatctta atgaagagat tcggaaagtg tcacctgctc ttaggacagc
     1501 tggccagaag ccagagatgc taccagtaca atctagttct tactctaaag gaatgaaatc
     1561 tattttctat caacatcctg tgtcacatgg ccatcaaggc aaagagcctc taagtgtttc
     1621 agctgtttgt ggatcagctg gtaataaagc tttccaccag ctttccacat tatcagacag
     1681 tctactaact gaagaaacat ggccagtttc tgttattcct ggcctaggta accagaagac
     1741 tcctttacca tcagaattct ctctttcata ttctcataga ggaaagaacc tgcccgaaga
     1801 tgttgtgaaa gtttccactg attctggatc tgctcacaag aaggctgaca ttctaacagc
     1861 gtcctctaga acctaccagc acaaaatgaa acctgctaat atttaccacc aagagttgcc
     1921 agacagtcgt gtacctatag ggactagaaa ggttgcattt gaatctggac cagctggcca
     1981 gaagtctggg gtttctcacc catatggtga gatgcccagt gttttctatc agcaggggtt
     2041 gccagatagg cattcagcaa aaagccctac aaaaaccttt atcccaggac cagctgacca
     2101 gaagactgat ctatcaccag taccccctac ttcctcttcg catgcagaga agcctgtttc
     2161 cccctaccag ttaaccttgc caggtagtca tctacctgaa gatgttttca aagcttcttc
     2221 tgtttgtaag tcatctgatg agctatctgg aataacagct ctaacctctg cttcctactc
     2281 atataaaggg agacccaata gttcttatca gcagaagttt ccagacagcc acctaaatga
     2341 agaggcccag aaaatcttgg gtacaactgg aacagtagac cagaagacag tgacaccaac
     2401 aatgtcttct tcctttttac aaaaagaaaa gcctagtatt ttctaccaac aaaccctgcc
     2461 agatggtggt ctgtctgaag aggatctgca ggtttcagct gttccttggc cagctgacca
     2521 gaacattgct ataccaacag taacttctgc tgctttctca caaagagaaa agcctcggat
     2581 tttctaccaa cagactctgt cagttgatcg tttgcctgga gagcctctga atgttttagg
     2641 gacttctgga ccacctgacc agaacactgg ggcaccaaca gtaactccta gttcctactt
     2701 ccctggagaa gagtccatta ttttttacca agctggcttt ccaggtaaca ctctgtctgc
     2761 aatgtctttt aaagttccaa ggatttctgg atcaactgaa cagactaacg taacaacagg
     2821 atcatcaagt tcctactcag ttggagagaa gtccattatt ttctaccatc aggccttgcc
     2881 agatggtcgt cttcctcaag aagcttctcc tgcaccagct gacctaaaca ctggggagcc
     2941 accaatgtat ttggcttcct gttctgttgg agtaaagccc attattttct accagcagcc
     3001 tatgtcagat agtcagcgaa ctaaaggtca caaagaatca gatgttcctg gaccaactga
     3061 ccagaagact ggcatagcaa cagtgcattc tacttcccaa tcatatatag ggaggcgcac
     3121 tgtttcttac cagaaagagt ttccagatct tagtgaaaag gctttgaaag ttctaggtga
     3181 tgttggatcc actgaacaga aaactcaaat accagtagtg tcttctgctc tcttacacaa
     3241 agaggggcct agtgcttacc aggaggattt gccagatctt actgaagaac ctttgcaaat
     3301 tttaggtgtt tctgaagaag tttcttctag ctcttatcag aggaagttac cagatcatat
     3361 tgaagtattt ttgaaatcag taggctctgg ctctgctgat cggaagactg gggcacaaat
     3421 agtctcctca agtagagaga agtccagtgg ttttcatcag caggagttgc caaatactgg
     3481 tggggatgca gtagatgctt ttcatcccga accagttgtc caggaggtca ggaaggtaca
     3541 gacgcctggg gcaccagcag gaccttctag ttcccacttc cataaagaaa aactcagtga
     3601 ttatcaaaag gcctcgccac atcgtgatct aactgaaagt tctttgaagg cttcaactgt
     3661 tccaggacta tctgatcaga aaaagaaacc tgcagtctca tctggtttct gcttacacaa
     3721 agagaaacac gagatttcag cttcagcttt gctgaattgc cagacagccg agttgctaac
     3781 agttactcag aggtcctgtt tacatagaga ggatcctgca atttcaactg tgatcaaacc
     3841 agatgaccaa aagattccat taccaacaac ttttcatggc tccagtgatc aaaaagtaaa
     3901 acctgttatt tttgttcaaa aacagttacg agatagagat caaagtgaag atattccgaa
     3961 gatttcaact gtctctgagc caactgttgt aaatacagtt ctaccagtac ttctgcctgg
     4021 ttcttactca cacagagaga agtcagattc attttaccca caggaactgc cagatggaca
     4081 tctaactgaa gttgatctga aggtttcaag cggtcttggt caagctgacc agatttctgg
     4141 gttacctaca ggtattcctg gtacttattc acacagtgaa aagcaccagc ttatctcaga
     4201 acatgtccaa gagctgatgg ataacttgaa ttcttccgag tcgtcttgtc tcagtgtgga
     4261 tagtatgcct ctaaattcac aaatcgatga tggagttatc atatgtaagc cagaatcttt
     4321 aggttttgcc aatgctggct gtgaggaaat gcagaatata gatcgtggtt cgaaaactct
     4381 taaggaaatt cagactctct tgatggaagc agaaaatatg gcactgaaac gatgcaattt
     4441 ctctgttccc ttagtccctt tcagagatgt taacgatgtt tcatttatac gatcaaagaa
     4501 ggtggtttgc ttcaaagaat cctccacaac tgatgtttgt acccagaggg aatcatttgt
     4561 agaagaagtt ccacacattg aatatgtaca gaaggacatt ggcacacaga cgaaccttaa
     4621 gtaccagagg ggtgttggaa attgggaatt tatcagttca gctaccttta gaagtcctct
     4681 acaggaagca gaaggcacag ctagaatggc atatgatgaa acttttaggc aatataaagc
     4741 tgccaggtct gtaatgaggt ctgaacctga aggctgcagt acaggcattg ggaataaaat
     4801 gattatccct atgatgacaa tcataaagag tgactcgagt agtgatgtaa gtgatggttg
     4861 ctgctcatgg gacaacaatt taccagagtc tttggaatct gtttctgatg tttttctaaa
     4921 cttctttcca tatacttcac ccaagacaag tataacagat agccgagaag aggagtggtt
     4981 gtcagagagc gaggatggct atggtagtac agattcattg gctgcacatg tgaagtacct
     5041 tctgcagtgt gaaacttcac tgaatcaagc caaacagata cttaaaaatg cagaggaaga
     5101 ggaatatcgg gtccgaaccc aagcctggaa tctaaagttt aatttaggac gtgaccgtgg
     5161 atactccatt tcagaattaa atgaagatga cagaaggaaa gtagaagaga taaaagcaaa
     5221 gttgtttggt catggaagag caactcacat gtctgagggc ttacgaagtc cacaaggcat
     5281 aggatgtttg ccagaagctg tatgtagtcg aattattatt gagagccatg agaaaggatg
     5341 tttcaggact cttactgctg aacaaccacg gccagacagc tgccattgtg cttttcgatc
     5401 tgttgaacct tcagacttga ttagaggaca tcggagccca tcatcatgga gaggcaggca
     5461 catcaacctt tccagatcaa tagaacagag caatccctgt ttcaaagtag ggagttcctt
     5521 tcagttacag agtcatcccc catttcaaaa acttttacct gatgacatca aaattagcaa
     5581 gggtgttgga atgccagtcc atgcatacat ggatccccag ccatcagaat tagtagaacc
     5641 tacttgtgtg ccagctaaag aaatggattt tccttcctca tctcaaatac tgccccctga
     5701 gcccaagaag cagttcacta ctgccatcac tttttcttct cacgaacact ctgagtgcat
     5761 ttctgattcc tctggttgta aggttggtgt tactgcagat agccagtgta gtggaccatc
     5821 tttaggggta tttaagcctc atatccccga agagcagatt tctcctagag atcttaaaca
     5881 gaaaacctct ttccagtcat cacttgaaag gcatggttct acaccggtga ctattttagc
     5941 tgatggtagt aggcaaaggc aaaaattacc tgttgatttt gagcattctc atcaaaaaga
     6001 aaaactctta caaagattag gttttaaagt cagccattct gaacccaatg tcagtacaaa
     6061 tgttagcaat ttcaagggag ttcaattttc tggtaaggat accattgtta gccaggacaa
     6121 actaacttct acagtagagg taaaagagaa gaatgtaact gtaactcctg atcttccttc
     6181 ttgcattttt cttgaacaac cagagctctt tgaggaaagc cacaccccac atacagatct
     6241 tcagatgaga aaataccctt ctccctcttg tccagaaatt gcttctcgca tttttcttga
     6301 gcagccaaaa ctctctgaac aaagcaaagc cccacatgta gatcgtgaaa taagagaaga
     6361 tcactctttc tttcctaagt gccaggatta tatagttgca gacccttctc ccgattttcc
     6421 tgatcagcaa caatgcaaac ctccagacgt agttggccac acgagaaaac agaactctct
     6481 tctttctgaa ggtcaggatt atgagttaga agaggttcag catatacctc agtcatactt
     6541 ttctaatatg gtaaatgttg aagccaaggt cagtgatgcg atctcccagt cagcccctga
     6601 ccactgtaca gctgcatcta ctccaccttc aaatagaaaa gcactttcat gtgttcgtat
     6661 aactctttgt cccaagactt cttccaagtt ggatagtgga accttaggtg aaaggtttca
     6721 ttcattggat cctgcttcta aaacaaggat taatagtgag tttaactctg atctgcgaat
     6781 tatatcttca aggtcattgg aaccaacctc caaattactg acctgtaaac cagtagcaca
     6841 ggatcaagaa tctttagttt ttctaggacc taaatctcca ctggacttgc aagtcgcaca
     6901 gtcttctctt ccagatagta agactatttt tcaggacttg aaaaccaaac ctcctcagaa
     6961 tagccagata gtaacctcaa ggcaaacaca agtgaacatt tcacatttgg aaggatattc
     7021 caaaccagag gggactccag tatctgcgga tggttcacaa gaacagagta aggtttcctt
     7081 tactacgtcc tttggaaagt tatcatctga tgccatcact cagataacaa cagaaagtcc
     7141 agaaaagacc acattttcat ctgaaatttt tattcatgcg gatgatcgtg gacagggcat
     7201 tctagacccc atggcccaaa agccatccag gtttgcctca tcatcctcag tgcagcaaat
     7261 cccagcttct catggcaaag acgcccagcc tgtgctgtta ccatataagc catctggtag
     7321 ttcgaagatg tattatgttc cactgttaaa aagagttcct tcatatctgg attccaaatc
     7381 tgataccact gttgagagct cacattcagg ctcaaatgat gctattgccc cagactttcc
     7441 acctcaaatg ctaggcacaa gagacgatga cctctccaac actgtaaaca ttaagcacaa
     7501 agaagggatt tatagcaaga gggctgcaac aaaggggaaa aacccctctc agaaaggtga
     7561 tgcagcggcc ccagttcaaa tgcctataac ttgggatgag aatgtcttgg acgaaaacca
     7621 agaagaggtc atcagtagag gagttgtgat caagatggca ggacctgaag aaatgtcatc
     7681 cctggagaag gaccttgcag gtcccagtga tatcactgta caagacagaa aaactgaaaa
     7741 tctgccagac actaaatcca ttaaacagaa ggaaggatcc ttagagatag aatctgaatg
     7801 tcattctgca tttgaaaaca ctgctcactc tgtcttcaga tcagccaagt tttatttcca
     7861 tcatccagtg cacctgcccc atgagcaaga cttctgccat gaatctttgg gaaggagtgt
     7921 tttcatgcaa cattcttgga aggatttctt tcaccatcat tcaggacaca gctgccttcc
     7981 tccccctggc ccaagttcgg acaagttgga caagaccaag atggattaca ccagaattaa
     8041 gagcctcagc atcaacttga atttgggaga gcatgagaaa atacatacta tcaagaatca
     8101 ggccagagac ccaaaaggca aaagacaagc aaatgagcaa aagaaggatc agaaggtcac
     8161 cccagagcta acaactgagt gccccgtgag tttgaatgaa ctctggaaca gataccagga
     8221 gcgacagaag cagcagaatc catctggtgc ttgtgatacg aaagagctct ccttggtgga
     8281 acgacttgat cgcttggcta aactgcttca gaatcccatc acacattcac tccgggcctc
     8341 agaaagtgca caggatgata gcagaggggg acatagagcc agggagtgga ctgggaggag
     8401 gcaacaaaaa cagaaaggca agcaacacag gaagtggagt aagagcctag agaggggcca
     8461 gagtacaggg gactttagga aaagcaaagt gttttctcct catcaaggtg ggaaatccag
     8521 tcagttcaag attgagcaga ttaaactaga taagtacatc ctgaggaaag agccaggttt
     8581 taataatgtc agcaatacct ccttggattc tagaccctca gaggaaagcg tgtctctcac
     8641 agatagtccc aacatttttt ctagcacgga ttctcctgtg gactcagatg tattgacccc
     8701 aactgatagg gacatgcctt taaatgagag gagcagctcc atatccacca ttgacacagt
     8761 ccggttgatc caggcttttg gccaagatag actgtctttg tcgcccaggc gaattaaatt
     8821 atacagtact gtcactagtc aacggaggag atatctggag cagccatgca agcacaacag
     8881 gaaggcattg aacacagcct gtccccaaat gacttctgag cacagcagaa ggaggcacat
     8941 ccaggtggca aaccatatga cttcttctga ctctgtttca tctcctggga gcttgttgag
     9001 cttggactct gctctttcca atgaggaaac tgtacgcatg gtgagcaagg gtgtacaagc
     9061 tggtaacttg gagattgtgg ctggtgtcaa aaaatacact caggatgttg gggtgacttt
     9121 cccaactccc agttctagtg aggccagatt ggaagaggac agtgatgtga cttcttcgtc
     9181 agaagaaaaa gccaaagaga aaaagtttct ttccaattat ctgcagacca aaaacttaag
     9241 gaagaacaag ccaaatccct gtgcaggagt ctcatggttt gttcctgtgg aaagtggaca
     9301 atcaggatct aagaaggaaa acctgcccaa gatttacaga cctgttatct cctggtttga
     9361 accagtaacc aaaaccaaac cctggaggga gccactgagg gaacaaaact ggcaggccca
     9421 atgcatgaac agtcgtgggt ccctgggagg cccaggcagg gatagtggcc aggtttctct
     9481 tcggccattt gtgagagcaa ctctgcagga atcacttcag cttcacagac ctgatttcat
     9541 ctcccactct ggggagcgca taaagcgtct gaagttactt gtccaggaga ggaagctcca
     9601 gagcctgttc cagagtgagc gggaggctct gttccactca gcgaggcccc tgcccaggag
     9661 agtcctcctg gctgtccaga agaacaagcc tattggaaag aaggaaatga ttcagaggac
     9721 cagacgaatt tatgagcagc ttccagaagt gaagaagaag agagaagagg agaagagaaa
     9781 atcagaatat aaatcctact ggctacgtgc tcaacactat aaaatgaaag tgaccaatca
     9841 tctcctgggg agaaaagtgc cttgggactg acataagact actttcttca gagcctagga
     9901 atcctttttt tttttttttt tatgatccca aagagactaa tttatatttg tgtgaatatg
     9961 atttaataaa gcattgtctt tgtcaaaaaa aaaaaaaaaa aaaaa
//
