LOCUS       NM_025538                939 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus alkB homolog 7 (Alkbh7), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_025538
VERSION     NM_025538.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Kulkarni,C.A., Nadtochiy,S.M., Kennedy,L., Zhang,J., Chhim,S.,
            Alwaseem,H., Murphy,E., Fu,D. and Brookes,P.S.
  TITLE     ALKBH7 mediates necrosis via rewiring of glyoxal metabolism
  JOURNAL   Elife 9, e58573 (2020)
   PUBMED   32795389
  REMARK    GeneRIF: ALKBH7 mediates necrosis via rewiring of glyoxal
            metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Jordan,J.J., Chhim,S., Margulies,C.M., Allocca,M., Bronson,R.T.,
            Klungland,A., Samson,L.D. and Fu,D.
  TITLE     ALKBH7 drives a tissue and sex-specific necrotic cell death
            response following alkylation-induced damage
  JOURNAL   Cell Death Dis 8 (7), e2947 (2017)
   PUBMED   28726787
  REMARK    GeneRIF: results uncover an in vivo role for ALKBH7 in mediating a
            sexually dimorphic tissue response to alkylation damage that could
            influence individual responses to chemotherapies based upon
            alkylating agents.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Solberg,A., Robertson,A.B., Aronsen,J.M., Rognmo,O., Sjaastad,I.,
            Wisloff,U. and Klungland,A.
  TITLE     Deletion of mouse Alkbh7 leads to obesity
  JOURNAL   J Mol Cell Biol 5 (3), 194-203 (2013)
   PUBMED   23572141
  REMARK    GeneRIF: the first direct demonstration that murine Alkbh7 is a
            mitochondrial resident protein involved in fatty acid metabolism
            and the development of obesity.
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Lee,D.H., Jin,S.G., Cai,S., Chen,Y., Pfeifer,G.P. and O'Connor,T.R.
  TITLE     Repair of methylation damage in DNA and RNA by mammalian AlkB
            homologues
  JOURNAL   J Biol Chem 280 (47), 39448-39459 (2005)
   PUBMED   16174769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010930.1, AK009812.1 and AC073683.3.
            
            On Nov 20, 2010 this sequence version replaced NM_025538.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009812.1, SRR7345562.2073284.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK010930.1         2-15
            15-921              AK009812.1         2-908
            922-939             AC073683.3         8492-8509           c
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.61 cM"
     gene            1..939
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /note="alkB homolog 7"
                     /db_xref="GeneID:66400"
                     /db_xref="MGI:MGI:1913650"
     exon            1..229
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..691
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; spermatogenesis associated 11; alkylated DNA
                     repair protein alkB homolog 7; probable
                     alpha-ketoglutarate-dependent dioxygenase ABH7;
                     alpha-ketoglutarate-dependent dioxygenase alkB homolog 7,
                     mitochondrial; alkB, alkylation repair homolog 7"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 7, mitochondrial isoform 1 precursor"
                     /protein_id="NP_079814.1"
                     /db_xref="CCDS:CCDS28921.1"
                     /db_xref="GeneID:66400"
                     /db_xref="MGI:MGI:1913650"
                     /translation="MAGSRRLAMRLLSGCAWVRGSDSAVLGRLRDEAVVHPGFLSQEE
                     EDTLTRELEPQLRRRRYEYDHWDAAIHGFRETEKSCWSDASQVILQRVRAAAFGPDQS
                     LLSPVHVLDLEPRGYIKPHVDSVKFCGSTIAGLSLLSPSVMKLVHTQEPEQWLELLLE
                     PGSLYILRGSARYDFSHEILRDEESFFGEHRVPRGRRISVICRSLPEGMGPGRPEEPP
                     PAC"
     exon            230..403
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /inference="alignment:Splign:2.1.0"
     exon            404..528
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /inference="alignment:Splign:2.1.0"
     exon            529..939
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      718..723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /note="hexamer: AATAAA"
     polyA_site      736
                     /gene="Alkbh7"
                     /gene_synonym="2310045B01Rik; 2510008E23Rik; Abh7;
                     Spata11"
                     /note="major polyA site"
ORIGIN      
        1 agcctgctgt ggtcaatccc tgaagatggc gggcagcagg aggctagcga tgcggttgct
       61 ttctgggtgc gcctgggtgc gcggctcaga ctctgccgtg ctgggccgcc tgcgtgatga
      121 ggccgtggtg catccaggct tcctgagcca ggaggaggag gacacgctaa cacgcgaact
      181 ggagccccag ctgcggcgcc ggcgctacga gtacgaccac tgggacgcgg ccatccatgg
      241 cttcagggag acagagaaat cctgctggtc tgatgcaagc caggtcatcc tgcagcgggt
      301 tcgggcggct gcatttggtc ctgaccagag cctgctatcc ccagtacatg tgttggacct
      361 ggaacctcgg ggctacatca agcctcatgt tgacagtgtc aagttctgtg gatctaccat
      421 tgctggcctt tccctgttgt ctccaagtgt tatgaagctg gtgcatacac aggaacctga
      481 gcagtggctg gaactgttgc tggagccagg gtctctctat atcttaaggg gttcagcccg
      541 atatgacttc tcccatgaga tccttagaga tgaagaatca ttttttgggg agcaccgggt
      601 tccccggggc cgacgcatct cagtgatttg ccgctccctc cctgagggga tggggccagg
      661 aaggccagaa gagccacctc cagcctgctg acctcccaca tatcctccat atttgtgaat
      721 aaagtaggga aaatgctgtc atgggatctt caaatgaccg tctgccaggg ctggggctct
      781 taagagacga tcagggtctc aggattcaca tagcatggtg gctgccaggg tgcacctgat
      841 cacacacact cttaaggcca cgagaatatc atttattgca tccactgctg attaaaaaaa
      901 aaaaaaaact aacaagcaag caaagaaaga aacaaaaaa
//
