LOCUS       NM_198027                945 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus alkB homolog 6 (Alkbh6), mRNA.
ACCESSION   NM_198027
VERSION     NM_198027.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Lee,D.H., Jin,S.G., Cai,S., Chen,Y., Pfeifer,G.P. and O'Connor,T.R.
  TITLE     Repair of methylation damage in DNA and RNA by mammalian AlkB
            homologues
  JOURNAL   J Biol Chem 280 (47), 39448-39459 (2005)
   PUBMED   16174769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149067.3.
            
            On Aug 21, 2018 this sequence version replaced NM_198027.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU512639.1, BC029805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC149067.3         117452-117533
            83-161              AC149067.3         118180-118258
            162-230             AC149067.3         118685-118753
            231-291             AC149067.3         120539-120599
            292-443             AC149067.3         120936-121087
            444-560             AC149067.3         121290-121406
            561-945             AC149067.3         122618-123002
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.38 cM"
     gene            1..945
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /note="alkB homolog 6"
                     /db_xref="GeneID:233065"
                     /db_xref="MGI:MGI:2142037"
     exon            1..82
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
     exon            83..161
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..824
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /EC_number="3.4.22.17"
                     /note="alkylated DNA repair protein alkB homolog 6;
                     probable alpha-ketoglutarate-dependent dioxygenase ABH6;
                     alkB, alkylation repair homolog 6"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 6"
                     /protein_id="NP_932144.2"
                     /db_xref="CCDS:CCDS21085.1"
                     /db_xref="GeneID:233065"
                     /db_xref="MGI:MGI:2142037"
                     /translation="MEEQDARVPALEPFRVEQAPPLIYYVPDFISKEEEEYLLRQVFN
                     APKPKWTQLSGRKLQNWGGLPHPRGMVPERLPPWLQRYVDKVSDLSLFGGLPANHVLV
                     NQYLPGEGIMPHEDGPLYYPTVSTISLGSHTVLDFYEPRQPDDDVPMEQPRPPQRPIT
                     SLLVEPRSLLVLRGTAYTRLLHGISATRVDELDATSLPPNATACKSALPGAHLVRGTR
                     VSLTIRRVPRVLRASLLLSK"
     exon            162..230
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
     exon            231..291
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
     exon            292..443
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
     exon            444..560
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
     exon            561..945
                     /gene="Alkbh6"
                     /gene_synonym="Abh6; C130099A02"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaatgctt ggcggaagtg gcaggggggg cgtgcgagga tgcgcgcgtt gagtctggat
       61 atccgagaag acgctgtaga cggacggcgc acaaggagtt ggtatccatg gaggagcagg
      121 acgccagggt cccagcactg gaacctttca gggtggaaca ggcgccacct ctaatctact
      181 atgtccctga cttcatctcc aaggaagaag aggaatattt gcttcgacag gttttcaatg
      241 ccccaaagcc aaagtggacc cagctgtctg ggaggaagct tcagaactgg ggtgggctcc
      301 cgcatcctcg ggggatggtc cctgagcgac tccctccatg gcttcaacgc tacgtggaca
      361 aagtgtctga cctcagcctt tttgggggtc tcccagctaa ccatgtcctt gtgaaccagt
      421 atctgcctgg ggagggcatc atgcctcatg aagatggacc actgtactac ccaactgtca
      481 gcaccatcag cctgggctcc catactgtcc tcgatttcta tgaacctcga cagccagacg
      541 atgatgtccc tatggagcag cccaggcctc ctcaacggcc catcacctcg ctgctggtgg
      601 aaccacggag cctgctggtg ctccggggca cagcttacac acgcctgctc cacggcatct
      661 cagctacccg tgtggatgag ctggacgcca cctcgctgcc acccaatgcc accgcttgca
      721 agtcagcgct gcccggagcc cacctggtgc gcggcacccg tgtctcactg accattcgcc
      781 gcgtgccccg tgtgctgcgc gccagcctcc tgctgagcaa gtgaccacca ggttctaaga
      841 ccttggaacc ctagggcaga ggtagctgtc cagggttatt tatttcccca gtaactatgg
      901 aaaccatgga gaagacacca ttccaaataa acagaaaata ccttt
//
