LOCUS       NM_172943               6025 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus alkB homolog 5, RNA demethylase (Alkbh5), mRNA.
ACCESSION   NM_172943 XM_906478
VERSION     NM_172943.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6025)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6025)
  AUTHORS   Wang,W., Li,H., Qian,Y., Li,M., Deng,M., Bi,D. and Zou,J.
  TITLE     ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A
            Demethylation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (12), 34 (2024)
   PUBMED   39441582
  REMARK    GeneRIF: ALKBH5 Regulates Corneal Neovascularization by Mediating
            FOXM1 M6A Demethylation.
REFERENCE   3  (bases 1 to 6025)
  AUTHORS   Jiang,X., Yan,F., Geng,Y., Cheng,X., Zhang,S., Zhao,T., Guo,J.,
            Dai,Z., Gao,J., Yue,X., Zhao,M. and Zhu,L.
  TITLE     ALKBH5 deficiency attenuates oxygen-glucose deprivation-induced
            injury in mouse brain microvascular endothelial cells in an m6A
            dependent manner
  JOURNAL   Exp Neurol 380, 114910 (2024)
   PUBMED   39098715
  REMARK    GeneRIF: ALKBH5 deficiency attenuates oxygen-glucose
            deprivation-induced injury in mouse brain microvascular endothelial
            cells in an m6A dependent manner.
REFERENCE   4  (bases 1 to 6025)
  AUTHORS   Qiu,Y., Fan,Y., Huang,G. and Liu,J.
  TITLE     N6-methyladenosine demethylase ALKBH5 homologous protein protects
            against cerebral I/R injury though suppressing SNHG3-mediated
            neural PANoptosis: Involvement of m6A-related macromolecules in the
            diseases of nervous system
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133815 (2024)
   PUBMED   38996894
  REMARK    GeneRIF: N6-methyladenosine demethylase ALKBH5 homologous protein
            protects against cerebral I/R injury though suppressing
            SNHG3-mediated neural PANoptosis: Involvement of m6A-related
            macromolecules in the diseases of nervous system.
REFERENCE   5  (bases 1 to 6025)
  AUTHORS   Wang,K., Liu,F., Muchu,B., Deng,J., Peng,J., Xu,Y., Li,F. and
            Ouyang,M.
  TITLE     E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to
            promote colon inflammation and Th17/Treg imbalance in ulcerative
            colitis mice
  JOURNAL   Arch Pharm Res 47 (7), 645-658 (2024)
   PUBMED   39060657
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5
            axis to promote colon inflammation and Th17/Treg imbalance in
            ulcerative colitis mice.
REFERENCE   6  (bases 1 to 6025)
  AUTHORS   Zheng,G., Dahl,J.A., Niu,Y., Fedorcsak,P., Huang,C.M., Li,C.J.,
            Vagbo,C.B., Shi,Y., Wang,W.L., Song,S.H., Lu,Z., Bosmans,R.P.,
            Dai,Q., Hao,Y.J., Yang,X., Zhao,W.M., Tong,W.M., Wang,X.J.,
            Bogdan,F., Furu,K., Fu,Y., Jia,G., Zhao,X., Liu,J., Krokan,H.E.,
            Klungland,A., Yang,Y.G. and He,C.
  TITLE     ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism
            and mouse fertility
  JOURNAL   Mol Cell 49 (1), 18-29 (2013)
   PUBMED   23177736
REFERENCE   7  (bases 1 to 6025)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   8  (bases 1 to 6025)
  AUTHORS   Simon,G.M. and Cravatt,B.F.
  TITLE     Endocannabinoid biosynthesis proceeding through
            glycerophospho-N-acyl ethanolamine and a role for
            alpha/beta-hydrolase 4 in this pathway
  JOURNAL   J Biol Chem 281 (36), 26465-26472 (2006)
   PUBMED   16818490
REFERENCE   9  (bases 1 to 6025)
  AUTHORS   Lee,D.H., Jin,S.G., Cai,S., Chen,Y., Pfeifer,G.P. and O'Connor,T.R.
  TITLE     Repair of methylation damage in DNA and RNA by mammalian AlkB
            homologues
  JOURNAL   J Biol Chem 280 (47), 39448-39459 (2005)
   PUBMED   16174769
REFERENCE   10 (bases 1 to 6025)
  AUTHORS   Liang,Y., Wang,A., Belyantseva,I.A., Anderson,D.W., Probst,F.J.,
            Barber,T.D., Miller,W., Touchman,J.W., Jin,L., Sullivan,S.L.,
            Sellers,J.R., Camper,S.A., Lloyd,R.V., Kachar,B., Friedman,T.B. and
            Fridell,R.A.
  TITLE     Characterization of the human and mouse unconventional myosin XV
            genes responsible for hereditary deafness DFNB3 and shaker 2
  JOURNAL   Genomics 61 (3), 243-258 (1999)
   PUBMED   10552926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596386.16.
            
            On Mar 1, 2008 this sequence version replaced NM_172943.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053695.1, BC052076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1513              AL596386.16        53752-55264
            1514-1594           AL596386.16        63757-63837
            1595-1750           AL596386.16        69783-69938
            1751-6025           AL596386.16        70307-74581
FEATURES             Location/Qualifiers
     source          1..6025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..6025
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /note="alkB homolog 5, RNA demethylase"
                     /db_xref="GeneID:268420"
                     /db_xref="MGI:MGI:2144489"
     exon            1..1513
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /inference="alignment:Splign:2.1.0"
     CDS             741..1928
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /EC_number="1.14.11.53"
                     /note="alkylated DNA repair protein alkB homolog 5;
                     probable alpha-ketoglutarate-dependent dioxygenase ABH5;
                     oxoglutarate and iron-dependent oxygenase domain
                     containing; alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 5; alkB, alkylation repair homolog 5"
                     /codon_start=1
                     /product="RNA demethylase ALKBH5"
                     /protein_id="NP_766531.2"
                     /db_xref="CCDS:CCDS24794.1"
                     /db_xref="GeneID:268420"
                     /db_xref="MGI:MGI:2144489"
                     /translation="MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAA
                     AAAAEPYPASGTTKRKYQEDSDPERSDYEEHQLQKEEEARKVKSGIRQIRLFSQDECS
                     KIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPG
                     DVDEIPDWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVS
                     VSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKE
                     RRAVIILRKTRLDAPRLETKSLSSSTLPPSYASDRLSGNTRDPALKPKRSHRKADPDA
                     AHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCPEAASSPTRKVKM
                     RRH"
     exon            1514..1594
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1750
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..6025
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /note="hexamer: AATAAA"
     polyA_site      3421
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /note="major polyA site"
     regulatory      6007..6012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /note="hexamer: AATACA"
     polyA_site      6025
                     /gene="Alkbh5"
                     /gene_synonym="Abh5; E130207K11; Ofoxd"
                     /note="major polyA site"
ORIGIN      
        1 gggttgtggc gattcccgag gatttgtgcg ctggaagctg aggcgtctgc gggcatccgc
       61 acgatgccgt gacgcggcag cgctgtccag tggacaccgc gagcacactc cggcgggtgg
      121 agtccctcgg ccccggaggc ggcttggcgt gcaggcaaat tgttgttttc gggagctgtt
      181 ctcgaagctt tccgcgggtg gggggagggg cggcggccga cgagcgggcc tcgtctgcgc
      241 atgcgccggc ctctccgccg actgggcggc acgcacgcgc atgctcaaag tacgtggagt
      301 ctcgtggccg ccggcagtgc gcacgcgcgt cgagaagccc gctaaggagc ggcgctgtcg
      361 gaggtcgggc gggctggcgg tgacgtcgtg aggagagctt taaagtgcgg gccgggccgg
      421 gcgtctgagg gtccgaccgg gagtctggcg gagtcttggc cgaagccctc cgcggcatga
      481 ggcgctgccg gcgccttttt ccctcaggac gcggagaagg tggaggagga ggaagccccg
      541 ctgtagctgg tgctgcatga ccgaccgcgg ctgaggttcg accccttccc ggcccctcta
      601 cgcctacccc tttggtccct tgagccacgc atgggggcct ggcactgagg accctcgctt
      661 ccctttcggg tccctttcgg gtcccctgag agccatgccg gaccgccgcg gaggacccta
      721 gagttgagtt ggcgggggcc atggcggccg ccagcggcta caccgacctg cgggagaagc
      781 tcaagtccat gacgtcccgg gacaactaca aggcgggcag tcgggaggcc gccgccgctg
      841 cggccgccgc cgtggctgcc gctgccgctg ccgcggccgc cgctgagcct tacccggcgt
      901 ccgggaccac caagcggaaa taccaggagg actcggaccc cgagcgcagc gactacgagg
      961 agcatcagtt gcagaaggag gaagaggcgc gcaaggtgaa gagcggcatc cggcagatcc
     1021 ggctcttcag tcaggatgag tgctccaaga tcgaggcccg catcgatgag gtggtgtccc
     1081 gcgccgagaa gggcctgtac aacgagcaca cggtggaccg ggcccccctg cgcaacaagt
     1141 acttcttcgg cgagggctac acgtacgggg cccagctgca gaagcgcggg ccgggccagg
     1201 agcgcctcta cccgccgggc gacgtcgacg agatcccgga ctgggtgcat cagctggtga
     1261 tccagaagct ggtggagcac cgcgtcatcc ccgagggctt cgtcaacagc gcggtcatca
     1321 acgactacca gcccggcggc tgcatcgtgt cccacgttga ccccatccac atcttcgagc
     1381 gccccatcgt gtccgtgtct ttcttcagcg actcggcact ttgcttcggc tgcaagttcc
     1441 agttcaagcc catccgggtg tcggaacctg tgctttctct gccggtgcgc agggggagcg
     1501 tgactgtgct cagtgggtat gctgctgatg aaatcactca ctgcatacgg cctcaggaca
     1561 ttaaggaacg ccgggcggtc atcattctca ggaagacaag attagatgca ccgcgattgg
     1621 aaacaaaatc cctgagcagc tccacattgc cacccagcta tgcttcagat cgcctgtcag
     1681 gaaacaccag agaccctgcg ctgaaaccca aaaggtccca ccgcaaggca gaccctgatg
     1741 ctgcccacag gccccggatc ctggaaatgg acaaagaaga aaaccggcgg tctgtgctcc
     1801 tgcccacaca ccggcggagg gggagtttta gctctgagaa ctattggcgc aaatcctatg
     1861 agtcctcgga agattgccca gaggcagcca gcagccccac ccgcaaggtg aagatgagga
     1921 gacactgagg ctctgtgccc tcttgggact ctggctaatc ctgatgtagc taccccatct
     1981 tctgttccgt ttgagtgttt tttttctttg ttattttggt cctatatacg ttttccttgc
     2041 tttgttgacc attaaggcta aagagcgaat tggtaaaaga cctgggttct tttgttcttg
     2101 gctttcctcc ttgatggaaa aagctgttgg cttctgtaga gaattgttca caccagagta
     2161 gccagtagag acaatgggga cagctgtctt caagtggaag tttattgaaa cacacaaaat
     2221 gttttggtta tgaaattcta gtttgggctt taaaatgtaa atctttgtag tgttttaaac
     2281 aaaaactatt cttttgccag ccttttcttc cactgatgct catgcttgga tgaggtctct
     2341 tggagccata caggtcctgc attgggtctg ctgtgcccat acatctcacc tgctgtccag
     2401 gctctggaat ctcatgcaaa taccctgttc cccactgttc aagtttgctg cgtatggggc
     2461 ttaaacagtg ccatcccccc gccatcccat ttctgagtcc ccaggttttc tgcatgccct
     2521 ctggcttgct ctgcccacca atcctggatg gtcaaggaac tagcacaatg gttctgacct
     2581 cttttgctaa gagcatgcct gtttgctggg ttgctcctgt taggcatatg tgtgtgattg
     2641 tatggaactg ttagacttgc tgcagtgggt catttgtagg aattgtttct agctagagga
     2701 actgattggc ttccaatcta gcatttgggt tatgggaact tggggtgtgt ggtagggctt
     2761 catttctttt gttctgaggt gtttctcctc cctttagtct ctttctcctc atttgaccat
     2821 cttgggcctc ttttcccata tcatctccct aagaagatgt gcctgctctg tccacatata
     2881 gcatatatcc aaggccagaa gtcagacctg catattggat taatactttc tcagtcttgg
     2941 ggccgggcct gggggctggg aaaggaactt ctaaaaataa tagaaaaaaa aatacaaagg
     3001 taaagtcttt gagagtttct gcctatttag atcctggaag gtggggttca ttaggattga
     3061 ctttggcagc caggccagga ctgagcctgc tgaaaacaga ggccttctaa gcagccatgc
     3121 caccaccact ctaagtacac aaaggtctgg ctctcgggcc tcagtggctg cagaggtgtg
     3181 ggagcaccca gtcatcagga agtctctttg gggtcagatc ctttgccagt gtggagccct
     3241 caagttgaga ctgcataact aaagcagtca cagatcttct gtggtttggg gtttttgttt
     3301 tgttttgttt tcttgttttt tactgctctt ttccaaaaaa tgatttgtag ttgtgtgtgc
     3361 agcactttgc cctaatatgt gtgtgctcta caataaaaac caaatctaat atattttgaa
     3421 acagttgtct gatgctgtgg tgagagaaag cctgactttg gtttttccct taatttattt
     3481 tcttgacctt ccaactggat ttggagaaag ctaatttatt gcccaccagt cctctgaaga
     3541 ttggtcactg acaccccttg attgatggct aaaggtggac ttgtgtttgc ccactgccct
     3601 ctccccttca aggagggtgg ccagggatac acctcatgga attctagaag atacagtctc
     3661 tccctggctt ggtagagaag ctgcaggcca gtacaaacac aggtggagct ggagcaggga
     3721 cagaggagct caggtagagg acgtggccat tcttgtactc agcagctagg ctcttggcct
     3781 ccctgggtgt agaacattgg tagataaagc aggtaggata ggatgagatt gggactcagt
     3841 gggctcctcc agtccactgg ggtccctaat gtggatccca gggtattgcc aactgtcagc
     3901 agctctccag ctctgctcca gtgatctgag ccaatttgct caaattgcca ctgtgaatct
     3961 tggtcaagcc atttcattgc ccatagaatg actggccaac agtttgaaaa gcagtggtag
     4021 gtctagaagg gtcagggcct ctgtatgaac tgtgcagtgg actgggatga cactagaact
     4081 gagaggaagc accaaatgtc atcccagctg tgatgttgca gaagggcaga tcccaatcca
     4141 tgcttgggtg gctcttccta gggacaaggg atggaagaga ttttgatacc agtgatctag
     4201 gcttcagtct gtcctgggat agtgccccca gtccttatga agtaatagcc ttaagcaagt
     4261 ctctcagagt cccacacctg actctgaatc tttcttgttc tagccatggc actgggccta
     4321 gagctttgtt tggcccctga ctcagtcttc atgtttataa agtagttttc taacagcaac
     4381 tggatgtacc agccctaccc acctaagatc tcattccatt cctttaacct tgttgtgtga
     4441 agagtgttct gtaggccagg ctcaggatgg gaaacagacc tgtatatgac atgcttacat
     4501 gcatgtaaag gtgttctata atgtatagga aggcagtaga gcccattaac tgtaagtgta
     4561 aataacatgt acagtgtgct tgtaaatctc tgtagttagt tgttgcccac agaacatttt
     4621 aattggcttt ctgtttaagt gtggaattca ttatctacct gtggttataa ttcacacacc
     4681 atgtgaggga gatgcatttt accagtttct cttagttttc tatggctgcc aaaacattac
     4741 cacaaacttg agagcttaaa gcaaaagaaa tttgctaggt atggtggtgc gtgcctctaa
     4801 ttccagcaca ggctgaggca gaaggatcaa aagtttaagg cctgcctggg ccttgtctca
     4861 aaaagcaaag cagccaggca tggtgcttgt ctgtaatgcc agcaggagtg tcgcaggttt
     4921 gaggccagtt tagtctacat agggagcttg aggacagcct aggctacatt gtgagaccct
     4981 gtctcaacaa caaagatata gactgttttg tgctctcctt aagactttgg taggaagcct
     5041 attcctgcct cttgcggctt ggtatggctc taaccactct agttgcaagt actctagatt
     5101 catagtcaca tggcctcttt ttgtatgcta catttcagtg cctctctgca ccccaccgtg
     5161 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtataga
     5221 aaggatagaa agggtctcac tctagctcag gccatccttg aaatagcaat cttgccactg
     5281 catccagcct tttctgtctg tcttagttgg gcatttgtct ttggatatag ggactcccat
     5341 atactccaca gctgcatagc tccacttcct tttttttttt tttttttttt tttttttttt
     5401 tttttttttt gacagtgcta gggatggaac ccagcgcctc tccagtgtta agcaaggact
     5461 ctaccactga tccacaccct aactcccacc tactccttat aaaaataaag tatatgcctt
     5521 ccagaaacta gaacctgaga accttggggg ccgacatgca gcttacgatg ctgctctttc
     5581 ttcagaaatt gttactaaat ctgtggccta ttgattcctc aaagaaattg tattaatttc
     5641 gattgaaatt tcttagcctc agcactattt taaaatttaa tctggatgat gataattact
     5701 ccattgcttg cttgtatttt tttctgtagt gctggggatt aggtgagggc cttgtgcatt
     5761 ctaggccttg taaatgttac ctatgcccca gcagctcatt gctttcttaa gtttaaacct
     5821 atgctgtcca atctggaacc actggactcc ggcttttgag cacttgaaat atggctagtt
     5881 tcaattgaga tatgctttat acaccagaat ttgaagttag tattaaaaag aatgtaaaat
     5941 atataattga taactttata ttgattacat gttgaaatac tattttggac atactgagtt
     6001 aaataaaata cattatttaa attaa
//
