LOCUS       NM_175016               1132 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus alkB homolog 2, alpha-ketoglutarate-dependent
            dioxygenase (Alkbh2), transcript variant 1, mRNA.
ACCESSION   NM_175016
VERSION     NM_175016.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland
            A, Samson LD and Fu D.
  TITLE     ALKBH7 drives a tissue and sex-specific necrotic cell death
            response following alkylation-induced damage
  JOURNAL   Cell Death Dis 8 (7), e2947 (2017)
   PUBMED   28726787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   You C, Wang P, Nay SL, Wang J, Dai X, O'Connor TR and Wang Y.
  TITLE     Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated
            and Ethylated Thymidine Lesions
  JOURNAL   ACS Chem Biol 11 (5), 1332-1338 (2016)
   PUBMED   26930515
  REMARK    GeneRIF: These results revealed that N3-ethylthymidine , but not
            other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in
            mammalian cells.
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N,
            Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland
            A and Samson LD.
  TITLE     DNA repair is indispensable for survival after acute inflammation
  JOURNAL   J Clin Invest 122 (7), 2680-2689 (2012)
   PUBMED   22684101
  REMARK    GeneRIF: ALKBH2 and ALKBH3 provide cancer protection similar to
            that of the DNA glycosylase AAG and display apparent epistasis with
            Aag
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Nay SL, Lee DH, Bates SE and O'Connor TR.
  TITLE     Alkbh2 protects against lethality and mutation in primary mouse
            embryonic fibroblasts
  JOURNAL   DNA Repair (Amst) 11 (5), 502-510 (2012)
   PUBMED   22429847
  REMARK    GeneRIF: Although both Alkbh2 and Alkbh3 can protect against methyl
            methanesulfonate-induced cell death, only Alkbh2 shows
            statistically significant protection against mutations following
            treatment with this exogenous methylating agent.
REFERENCE   5  (bases 1 to 1132)
  AUTHORS   Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A,
            Dedon PC, Bjelland S, Samson LD, Falnes PO and Klungland A.
  TITLE     AlkB homologue 2-mediated repair of ethenoadenine lesions in
            mammalian DNA
  JOURNAL   Cancer Res 68 (11), 4142-4149 (2008)
   PUBMED   18519673
REFERENCE   6  (bases 1 to 1132)
  AUTHORS   Ringvoll J, Nordstrand LM, Vagbo CB, Talstad V, Reite K, Aas PA,
            Lauritzen KH, Liabakk NB, Bjork A, Doughty RW, Falnes PO, Krokan HE
            and Klungland A.
  TITLE     Repair deficient mice reveal mABH2 as the primary oxidative
            demethylase for repairing 1meA and 3meC lesions in DNA
  JOURNAL   EMBO J 25 (10), 2189-2198 (2006)
   PUBMED   16642038
REFERENCE   7  (bases 1 to 1132)
  AUTHORS   Lee DH, Jin SG, Cai S, Chen Y, Pfeifer GP and O'Connor TR.
  TITLE     Repair of methylation damage in DNA and RNA by mammalian AlkB
            homologues
  JOURNAL   J Biol Chem 280 (47), 39448-39459 (2005)
   PUBMED   16174769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079195.1, BC062188.1 and BG083657.1.
            
            [WARNING] On Oct 2, 2023 this sequence was replaced by NM_175016.4.
            
            On Jan 19, 2018 this sequence version replaced NM_175016.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062188.1, CA984476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK079195.1         3-44
            43-1107             BC062188.1         1-1065
            1108-1132           BG083657.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.97 cM"
     gene            1..1132
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /note="alkB homolog 2, alpha-ketoglutarate-dependent
                     dioxygenase"
                     /db_xref="GeneID:231642"
                     /db_xref="MGI:MGI:2141032"
     exon            1..343
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..587
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1093
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /EC_number="1.14.11.33"
                     /note="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 2; alkylated DNA repair protein alkB homolog 2;
                     alkB, alkylation repair homolog 2"
                     /codon_start=1
                     /product="DNA oxidative demethylase ALKBH2"
                     /protein_id="NP_778181.2"
                     /db_xref="CCDS:CCDS19559.1"
                     /db_xref="GeneID:231642"
                     /db_xref="MGI:MGI:2141032"
                     /translation="MDKFLVRPDLRDLQGGGEEPAPTGGASGDLKSPDWRHLRAEGLS
                     CDYTVLFGKAEADKIFRELEQEVEYFTGALAKVQVFGKWHSVPRKQATYGDAGLTYTF
                     SGLTLTPKPWVPVLERVRDRVCEVTGQTFNFVLVNRYKDGCDHIGEHRDDERELAPGS
                     PIASVSFGACRDFIFRHKDSRGKRPRRTVEVVRLQLAHGSLLMMNPPTNTHWYHSLPI
                     RKRVLAPRVNLTFRKILPTKK"
     exon            588..786
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1115
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggttcct ggggctgcgt gtgtctgtgc agagacctga cccaccgctc cgggctctcc
       61 ggtggagccc ggttgctcgc ccgtgccagc ccctaccccg cggggccgca gggcagaggc
      121 aaccctgctt ttctgggtaa ctgggcgagc ctcatgcctc tctgcgcttg cgtcttccca
      181 tgtgtagcct tttgggtttg ggcagccgtt tgcagccaaa gctctcgaat tccgaagagg
      241 acggacgggt ctttaaaagt actccattcc agggcgggcc tggggatgcg tgcccgggat
      301 tcctaccgat gggcgcctgg ggcgtgagga cagcgtggtt cgggacgcgt ctgagctgtg
      361 agtgggcggc gggatggaca agttcctggt gaggccagac ctccgcgacc tccaaggggg
      421 aggggaggag cccgccccga cgggaggagc ctcgggcgac ctgaagagcc cggactggcg
      481 acaccttcgc gcggaaggtc tgagctgtga ttacaccgtc ctattcggca aagccgaggc
      541 agacaagatt ttccgagagt tggagcaaga agtggagtat tttactggtg cactggccaa
      601 ggtccaggtg ttcggaaagt ggcacagtgt tcccaggaag caggcgacct atggcgatgc
      661 tggcctcacg tacacgtttt ctggtcttac cctgacacca aagccctggg ttcctgttct
      721 agagcgtgtt cgagatcgag tctgcgaggt gacaggacag accttcaact ttgtactcgt
      781 gaacaggtac aaagatggtt gcgaccacat cggcgagcac agagatgacg agcgagaact
      841 ggctccgggg agccccatcg cgtctgtctc ctttggcgct tgcagagact tcattttccg
      901 gcacaaagac tctcgaggga agaggccccg gaggacagtg gaggtggtca ggctgcagct
      961 ggcacacgga agcctgctga tgatgaaccc cccaaccaac acccactggt accacagtct
     1021 ccccatccgc aagagggtcc tggctccgcg ggtcaacttg acttttcgga aaattttacc
     1081 tactaagaaa taaaatgtct ttatttatta ttgtaaaaaa aaaaaaaaaa aa
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