LOCUS       NP_778181                239 aa            linear   ROD 14-JUN-2024
DEFINITION  DNA oxidative demethylase ALKBH2 isoform 1 [Mus musculus].
ACCESSION   NP_778181
VERSION     NP_778181.2
DBSOURCE    REFSEQ: accession NM_175016.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 239)
  AUTHORS   Jordan,J.J., Chhim,S., Margulies,C.M., Allocca,M., Bronson,R.T.,
            Klungland,A., Samson,L.D. and Fu,D.
  TITLE     ALKBH7 drives a tissue and sex-specific necrotic cell death
            response following alkylation-induced damage
  JOURNAL   Cell Death Dis 8 (7), e2947 (2017)
   PUBMED   28726787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 239)
  AUTHORS   You,C., Wang,P., Nay,S.L., Wang,J., Dai,X., O'Connor,T.R. and
            Wang,Y.
  TITLE     Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated
            and Ethylated Thymidine Lesions
  JOURNAL   ACS Chem Biol 11 (5), 1332-1338 (2016)
   PUBMED   26930515
  REMARK    GeneRIF: These results revealed that N3-ethylthymidine , but not
            other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in
            mammalian cells.
REFERENCE   3  (residues 1 to 239)
  AUTHORS   Calvo,J.A., Meira,L.B., Lee,C.Y., Moroski-Erkul,C.A.,
            Abolhassani,N., Taghizadeh,K., Eichinger,L.W., Muthupalani,S.,
            Nordstrand,L.M., Klungland,A. and Samson,L.D.
  TITLE     DNA repair is indispensable for survival after acute inflammation
  JOURNAL   J Clin Invest 122 (7), 2680-2689 (2012)
   PUBMED   22684101
  REMARK    GeneRIF: ALKBH2 and ALKBH3 provide cancer protection similar to
            that of the DNA glycosylase AAG and display apparent epistasis with
            Aag
REFERENCE   4  (residues 1 to 239)
  AUTHORS   Nay,S.L., Lee,D.H., Bates,S.E. and O'Connor,T.R.
  TITLE     Alkbh2 protects against lethality and mutation in primary mouse
            embryonic fibroblasts
  JOURNAL   DNA Repair (Amst) 11 (5), 502-510 (2012)
   PUBMED   22429847
  REMARK    GeneRIF: Although both Alkbh2 and Alkbh3 can protect against methyl
            methanesulfonate-induced cell death, only Alkbh2 shows
            statistically significant protection against mutations following
            treatment with this exogenous methylating agent.
REFERENCE   5  (residues 1 to 239)
  AUTHORS   Ringvoll,J., Moen,M.N., Nordstrand,L.M., Meira,L.B., Pang,B.,
            Bekkelund,A., Dedon,P.C., Bjelland,S., Samson,L.D., Falnes,P.O. and
            Klungland,A.
  TITLE     AlkB homologue 2-mediated repair of ethenoadenine lesions in
            mammalian DNA
  JOURNAL   Cancer Res 68 (11), 4142-4149 (2008)
   PUBMED   18519673
REFERENCE   6  (residues 1 to 239)
  AUTHORS   Ringvoll,J., Nordstrand,L.M., Vagbo,C.B., Talstad,V., Reite,K.,
            Aas,P.A., Lauritzen,K.H., Liabakk,N.B., Bjork,A., Doughty,R.W.,
            Falnes,P.O., Krokan,H.E. and Klungland,A.
  TITLE     Repair deficient mice reveal mABH2 as the primary oxidative
            demethylase for repairing 1meA and 3meC lesions in DNA
  JOURNAL   EMBO J 25 (10), 2189-2198 (2006)
   PUBMED   16642038
REFERENCE   7  (residues 1 to 239)
  AUTHORS   Lee,D.H., Jin,S.G., Cai,S., Chen,Y., Pfeifer,G.P. and O'Connor,T.R.
  TITLE     Repair of methylation damage in DNA and RNA by mammalian AlkB
            homologues
  JOURNAL   J Biol Chem 280 (47), 39448-39459 (2005)
   PUBMED   16174769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129080.6.
            
            On Mar 13, 2005 this sequence version replaced NP_778181.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062188.1, CA984476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.97 cM"
     Protein         1..239
                     /product="DNA oxidative demethylase ALKBH2 isoform 1"
                     /EC_number="1.14.11.33"
                     /note="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 2; alkylated DNA repair protein alkB homolog 2;
                     alkB, alkylation repair homolog 2; DNA oxidative
                     demethylase ALKBH2"
                     /calculated_mol_wt=26998
     Region          3..7
                     /region_name="PCNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q6NS38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P6J4.1)"
     Region          11..32
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P6J4.1)"
     Region          29..236
                     /region_name="AlkB"
                     /note="Alkylated DNA repair dioxygenase AlkB [Replication,
                     recombination and repair]; COG3145"
                     /db_xref="CDD:442379"
     CDS             1..239
                     /gene="Alkbh2"
                     /gene_synonym="9530023G02; Abh2; mABH2"
                     /coded_by="NM_175016.4:370..1089"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19559.1"
                     /db_xref="GeneID:231642"
                     /db_xref="MGI:MGI:2141032"
ORIGIN      
        1 mdkflvrpdl rdlqgggeep aptggasgdl kspdwrhlra eglscdytvl fgkaeadkif
       61 releqeveyf tgalakvqvf gkwhsvprkq atygdaglty tfsgltltpk pwvpvlervr
      121 drvcevtgqt fnfvlvnryk dgcdhigehr dderelapgs piasvsfgac rdfifrhkds
      181 rgkrprrtve vvrlqlahgs llmmnpptnt hwyhslpirk rvlaprvnlt frkilptkk
//
