LOCUS       NM_001102565            1968 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus alkB homolog 1, histone H2A dioxygenase (Alkbh1),
            mRNA.
ACCESSION   NM_001102565
VERSION     NM_001102565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Wang,X., Wong,C.C., Chen,H., Fu,K., Shi,L., Su,H., Guo,S., Gou,H.,
            Hu,X., Zhang,L., Ji,J. and Yu,J.
  TITLE     The N6-methyladenine DNA demethylase ALKBH1 promotes gastric
            carcinogenesis by disrupting NRF1 binding capacity
  JOURNAL   Cell Rep 42 (3), 112279 (2023)
   PUBMED   36989111
  REMARK    GeneRIF: The N[6]-methyladenine DNA demethylase ALKBH1 promotes
            gastric carcinogenesis by disrupting NRF1 binding capacity.
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Cai,G.P., Liu,Y.L., Luo,L.P., Xiao,Y., Jiang,T.J., Yuan,J. and
            Wang,M.
  TITLE     Alkbh1-mediated DNA N6-methyladenine modification regulates bone
            marrow mesenchymal stem cell fate during skeletal aging
  JOURNAL   Cell Prolif 55 (2), e13178 (2022)
   PUBMED   35018683
  REMARK    GeneRIF: Alkbh1-mediated DNA N6-methyladenine modification
            regulates bone marrow mesenchymal stem cell fate during skeletal
            aging.
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Luo,L., Liu,Y., Nizigiyimana,P., Ye,M., Xiao,Y., Guo,Q., Su,T.,
            Luo,X., Huang,Y. and Zhou,H.
  TITLE     DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and
            Suppresses Diet-Induced Hepatic Steatosis
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (6), 1213-1233 (2022)
   PUBMED   36058506
  REMARK    GeneRIF: DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid
            Metabolism and Suppresses Diet-Induced Hepatic Steatosis.
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Ouyang,L., Su,X., Li,W., Tang,L., Zhang,M., Zhu,Y., Xie,C.,
            Zhang,P., Chen,J. and Huang,H.
  TITLE     ALKBH1-demethylated DNA N6-methyladenine modification triggers
            vascular calcification via osteogenic reprogramming in chronic
            kidney disease
  JOURNAL   J Clin Invest 131 (14) (2021)
   PUBMED   34003800
  REMARK    GeneRIF: ALKBH1-demethylated DNA N6-methyladenine modification
            triggers vascular calcification via osteogenic reprogramming in
            chronic kidney disease.
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Ougland,R., Lando,D., Jonson,I., Dahl,J.A., Moen,M.N.,
            Nordstrand,L.M., Rognes,T., Lee,J.T., Klungland,A., Kouzarides,T.
            and Larsen,E.
  TITLE     ALKBH1 is a histone H2A dioxygenase involved in neural
            differentiation
  JOURNAL   Stem Cells 30 (12), 2672-2682 (2012)
   PUBMED   22961808
  REMARK    GeneRIF: Results suggest that ALKBH1 is involved in neural
            development by modifying the methylation status of histone H2A.
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Nordstrand,L.M., Svard,J., Larsen,E., Nilsen,A., Ougland,R.,
            Furu,K., Lien,G.F., Rognes,T., Namekawa,S.H., Lee,J.T. and
            Klungland,A.
  TITLE     Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye
            defects
  JOURNAL   PLoS One 5 (11), e13827 (2010)
   PUBMED   21072209
  REMARK    GeneRIF: Data suggest that Alkbh1 mediates gene regulation in
            spermatogenesis, and that Alkbh1 is essential for normal sex-ratio
            distribution and embryonic development.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Pan,Z., Sikandar,S., Witherspoon,M., Dizon,D., Nguyen,T.,
            Benirschke,K., Wiley,C., Vrana,P. and Lipkin,S.M.
  TITLE     Impaired placental trophoblast lineage differentiation in
            Alkbh1(-/-) mice
  JOURNAL   Dev Dyn 237 (2), 316-327 (2008)
   PUBMED   18163532
  REMARK    GeneRIF: Alkbh1 performs important functions in placental
            trophoblast lineage differentiation and participates in mechanisms
            of transcriptional regulation.
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Gorba,T., Bradoo,P., Antonic,A., Marvin,K., Liu,D.X., Lobie,P.E.,
            Reymann,K.G., Gluckman,P.D. and Sieg,F.
  TITLE     Neural regeneration protein is a novel chemoattractive and neuronal
            survival-promoting factor
  JOURNAL   Exp Cell Res 312 (16), 3060-3074 (2006)
   PUBMED   16860792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144828.1 and BC094381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144828.1, SRR1660815.220444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AK144828.1         2-533
            533-1283            AK144828.1         535-1285
            1284-1968           BC094381.1         1218-1902
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.65 cM"
     gene            1..1968
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /note="alkB homolog 1, histone H2A dioxygenase"
                     /db_xref="GeneID:211064"
                     /db_xref="MGI:MGI:2384034"
     exon            1..198
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1185
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /EC_number="4.2.99.18"
                     /EC_number="1.14.11.33"
                     /EC_number="1.14.11.51"
                     /note="Alkylated DNA repair protein alkB homolog 1; DNA
                     lyase ABH1; alpha-ketoglutarate-dependent dioxygenase
                     ABH1; DNA oxidative demethylase ALKBH1; alkB, alkylation
                     repair homolog 1; DNA 6mA demethylase; DNA demethylase
                     ALKBH1; tRNA N1-methyl adenine demethylase; mRNA
                     N(3)-methylcytidine demethylase; DNA N6-methyl adenine
                     demethylase ALKBH1"
                     /codon_start=1
                     /product="nucleic acid dioxygenase ALKBH1"
                     /protein_id="NP_001096035.1"
                     /db_xref="CCDS:CCDS49120.1"
                     /db_xref="GeneID:211064"
                     /db_xref="MGI:MGI:2384034"
                     /translation="MGKMAAAVASLATLAAEPREDAFRKLFRFYRQSRPGTADLGAVI
                     DFSEAHLARSPKPGVPQVVRFPLNVSSVTERDAERVGLEPVSKWRAYGLEGYPGFIFI
                     PNPFLPGCQRHWVKQCLKLYSQKPNVCNLDKHMTKEETQGLWEQSKEVLRSKEVTKRR
                     PRSLLERLRWVTLGYHYNWDSKKYSADHYTPFPSDLAFLSEQVATACGFQGFQAEAGI
                     LNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLKRDEAPTAMFMHSGDIM
                     VMSGFSRLLNHAVPRVLPHPDGECLPHCLETPLPAVLPSNSLVEPCSVEDWQVCATYL
                     RTARVNMTVRQVLATGQDFPLEPVEETKRDIAADGLCHLHDPNSPVKRKRLNPNS"
     exon            199..307
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /inference="alignment:Splign:2.1.0"
     exon            308..470
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /inference="alignment:Splign:2.1.0"
     exon            471..561
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /inference="alignment:Splign:2.1.0"
     exon            562..755
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1949
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /note="hexamer: AATAAA"
     polyA_site      1949
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /note="major polyA site"
ORIGIN      
        1 gttggcagcc tcgagatggg gaagatggcg gctgctgtgg cttcattagc cacgctggct
       61 gcagagccca gagaggatgc tttccggaag cttttccgct tctaccggca gagccggccg
      121 gggacagcgg acctgggagc cgtcatcgac ttctcagagg cgcacttggc tcggagcccg
      181 aagcccggcg tgccccaggt ggtcaggttt cctctgaatg tgtcctctgt cactgagcgt
      241 gatgccgaga gggtgggact tgaacctgtg agcaagtgga gggcctatgg actcgaaggc
      301 tatcctggat ttattttcat tccaaacccc ttcctcccgg gatgccagag gcactgggta
      361 aaacagtgcc ttaagttgta ctcccagaaa cctaatgtgt gtaacctgga caagcacatg
      421 actaaagaag agacccaagg actgtgggaa cagagcaaag aggtcctaag gtctaaagaa
      481 gtgactaagc gaagaccccg aagtttacta gagagactgc gttgggtcac cctgggctac
      541 cattataact gggacagtaa gaaatactca gcagatcatt atacaccttt cccttctgac
      601 ctggctttcc tctcagagca agtcgccact gcctgtggat ttcagggttt ccaagcagaa
      661 gcagggatcc tgaattacta tcgcctagac tccacactgg gaatccacgt ggacagatct
      721 gagctagatc actccaaacc cttgctgtcc ttcagctttg gacagtctgc catctttctc
      781 ctgggtggcc tcaagagaga tgaagccccc accgccatgt ttatgcacag tggtgacatc
      841 atggtaatgt cgggtttcag ccgcctgtta aatcatgcgg tccctcgagt ccttccacat
      901 cctgatgggg agtgcctgcc tcactgcctg gagacacctc tcccagctgt cctccctagc
      961 aactcattgg ttgagccctg ttctgtggag gactggcagg tgtgtgccac ctacctgaga
     1021 actgctcgag ttaatatgac tgtgcgtcag gtactggcca caggccagga ctttccttta
     1081 gaacccgtgg aagagacaaa aagagacatt gctgcagatg gtttgtgcca tctgcatgac
     1141 ccgaatagcc cagtaaaacg aaaaaggtta aatcctaaca gctaaaactt aggggctaga
     1201 ttctcttact cagtcaggct tttgttgcca cacacaggga caggaagaag taagtcatct
     1261 atgatgttgc tgccttgggc ccatcttaga gcgaaaactg attagagttt gtccagagaa
     1321 gtgtcctact ccatccagtt ttaagctctt atgaggagtg tgtgtttctc ataccatatt
     1381 ggtatcatga tccacacaga cataagcatc caagagaagg aggaagtgag agagggagag
     1441 agagagtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     1501 tacatacaca tctgtgctga gtcagcacct cagtttgtta ggatatggtg tttttcccag
     1561 cactatgtga cttatgatct agccaccaga attcctacct cctcctagtc gtcaaattaa
     1621 ttcttcggct cttcactctt ctctgctctc acagaggaat cttaagcaga tgaagacaat
     1681 ggaattaaag tgtccctagg agccacagtt gtcacttggc tggtagagca catgcttggc
     1741 atgcacggag ccctgggttc agtatccagc acctcgtaag ccaggtgtag ctcgtgcact
     1801 ccaagggtag aagatcagac gggcaaggtg atcttgcatc tatagactct tcctagtagg
     1861 tttttaattt gttttaaatg actaaaagtc tctagggtgt ttcattagct gttttctcca
     1921 tgaataaagt tactctattt taaattaaaa aaaaaaaaaa aaaaaaaa
//
