LOCUS       NM_001159743            1509 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus ALK and LTK ligand 2 (Alkal2), transcript variant 1,
            mRNA.
ACCESSION   NM_001159743
VERSION     NM_001159743.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Christova,T., Ho,S.K., Liu,Y., Gill,M. and Attisano,L.
  TITLE     LTK and ALK promote neuronal polarity and cortical migration by
            inhibiting IGF1R activity
  JOURNAL   EMBO Rep 24 (7), e56937 (2023)
   PUBMED   37291945
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Defaye,M., Iftinca,M.C., Gadotti,V.M., Basso,L., Abdullah,N.S.,
            Cumenal,M., Agosti,F., Hassan,A., Flynn,R., Martin,J., Soubeyre,V.,
            Poulen,G., Lonjon,N., Vachiery-Lahaye,F., Bauchet,L., Mery,P.F.,
            Bourinet,E., Zamponi,G.W. and Altier,C.
  TITLE     The neuronal tyrosine kinase receptor ligand ALKAL2 mediates
            persistent pain
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35608912
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Ahmed,M., Kaur,N., Cheng,Q., Shanabrough,M., Tretiakov,E.O.,
            Harkany,T., Horvath,T.L. and Schlessinger,J.
  TITLE     A hypothalamic pathway for Augmentor alpha-controlled body weight
            regulation
  JOURNAL   Proc Natl Acad Sci U S A 119 (16), e2200476119 (2022)
   PUBMED   35412887
  REMARK    GeneRIF: A hypothalamic pathway for Augmentor alpha-controlled body
            weight regulation.
            Erratum:[Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2209128119.
            doi: 10.1073/pnas.2209128119.. PMID: 35787061]
REFERENCE   4  (bases 1 to 1509)
  AUTHORS   Zhang,H., Pao,L.I., Zhou,A., Brace,A.D., Halenbeck,R., Hsu,A.W.,
            Bray,T.L., Hestir,K., Bosch,E., Lee,E., Wang,G., Liu,H., Wong,B.R.,
            Kavanaugh,W.M. and Williams,L.T.
  TITLE     Deorphanization of the human leukocyte tyrosine kinase (LTK)
            receptor by a signaling screen of the extracellular proteome
  JOURNAL   Proc Natl Acad Sci U S A 111 (44), 15741-15745 (2014)
   PUBMED   25331893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160932.3.
            
            On Dec 12, 2019 this sequence version replaced NM_001159743.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134499.1, BC046522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-716               AC160932.3         83202-83917         c
            717-770             AC160932.3         81142-81195         c
            771-851             AC160932.3         80981-81061         c
            852-917             AC160932.3         78143-78208         c
            918-1509            AC160932.3         74385-74976         c
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     gene            1..1509
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /note="ALK and LTK ligand 2"
                     /db_xref="GeneID:100294583"
                     /db_xref="MGI:MGI:3697448"
     exon            1..716
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..916
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Protein FAM150B; family with sequence
                     similarity 150, member B; Augmentor alpha"
                     /codon_start=1
                     /product="ALK and LTK ligand 2 isoform 1 precursor"
                     /protein_id="NP_001153215.1"
                     /db_xref="CCDS:CCDS49044.1"
                     /db_xref="GeneID:100294583"
                     /db_xref="MGI:MGI:3697448"
                     /translation="MRVSGRPMLLALLLLLSTVGDRGRAQSRGPADRQTLLRLLVELV
                     QELKKFHIGDSKRLQLLGESDFALGRREATDYGADQEEQRVEIVPRDLRMKDKFLKHL
                     TGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMER"
     exon            717..770
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /inference="alignment:Splign:2.1.0"
     exon            771..851
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /inference="alignment:Splign:2.1.0"
     exon            852..917
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1509
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1487..1492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /note="hexamer: AATGAA"
     polyA_site      1509
                     /gene="Alkal2"
                     /gene_synonym="6230419C23Rik; Augalpha; Fam150b"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagcag ggtgagcgct gtccccgtag gagctgcgcg tcctgtgtcc ctgcgctgga
       61 caagtggggc tggagctcat caagtagtgt cgggactggg ggaccgagga gcgcggcaga
      121 cgcgggacct ctggtgatca ggtgcccgag gacgacgcgg gatccacggc gtgggcgcag
      181 gtgcccgagg gcagtgcggg gcccaccgct ggcaggtgcc cggacctctc aagtccaggg
      241 ctgcccatct gctccgcggc tccggacctc ggcagccccc ggggcgtcac ctgtggcctc
      301 gcatctcaaa gaggtgtcca aagaccccgc gcgccgtccc cgctgtgaaa gaaagttgtg
      361 cggcgggctc aggctgcgcc tggactccgc gtgcgggaaa cttgggcgcc ggctgctggg
      421 gcggcgggtc ccaagacccg cgacacaggc caccagggcc atgcgcgtgt ccgggcgccc
      481 gatgctcctt gcgctgctgc tactgctgag cacggtgggg gaccggggac gagcgcagtc
      541 cagggggcct gcagaccggc aaacgctgct gaggttgcta gttgagctgg tccaggagct
      601 gaagaaattc cacataggag actccaagag gttgcagctc cttggcgagt ccgactttgc
      661 cctgggccgc agagaggcca cggattatgg ggcagaccaa gaggagcaga gagtggagat
      721 tgttcctcga gatctaagga tgaaggacaa gtttctgaaa catctcacag gtcctcttta
      781 tttcagtccg aagtgcagca agcactttca cagactttac cacaacacga gagactgcac
      841 catccccgca tactataaaa gatgtgccag gttacttact cggctggcgg tcagtcccat
      901 gtgcatggag agataagctg caaaggagcg acacaccagg aaccttgaaa agtgccttgg
      961 aaaccaacag aacagaacca tcttcatgcc cacttcctgt ggacagagat ttatttttgc
     1021 actcttccat aattcctttg cattttctat gttgctgaca gtttacaaat atgcattcag
     1081 tgaatcagtg tatctgtcag tgagatttgc cactcttatg attgtaaaaa cagacaacat
     1141 tccacatttg atgtattgtt ctgtaaaatg aggtattttc tttttaagat taggtggaac
     1201 cacaaggaat atttctttag aaacataggc agaacattaa actgtatttt catagagcat
     1261 atagtatgat ttgacatttt gtattctaca attaaaatcc caaagtatag tttggaactg
     1321 catgaaaaat tttaatgaaa accaaaaaaa cctcagttgt gttgaaaaca gtggcatatg
     1381 tatctgtggc tatgccaagg ccagtcccac ttgtcctctg taaatgtaaa agtacattcc
     1441 aggtattgta caatatgtaa atactgtgaa taaatacaag gaaataaatg aagtgtttgg
     1501 aataatgaa
//
