LOCUS       NM_001195732             858 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ALK and LTK ligand 1 (Alkal1), mRNA.
ACCESSION   NM_001195732 XM_973835 XM_975315
VERSION     NM_001195732.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Wu,N., Li,J., Li,L., Yang,L., Dong,L., Shen,C., Sha,S., Fu,Y.,
            Dong,E., Zheng,F., Tan,Z. and Tao,J.
  TITLE     MerTK+ macrophages promote melanoma progression and immunotherapy
            resistance through AhR-ALKAL1 activation
  JOURNAL   Sci Adv 10 (40), eado8366 (2024)
   PUBMED   39365866
  REMARK    GeneRIF: MerTK[+] macrophages promote melanoma progression and
            immunotherapy resistance through AhR-ALKAL1 activation.
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Ahmed,M., Kaur,N., Cheng,Q., Shanabrough,M., Tretiakov,E.O.,
            Harkany,T., Horvath,T.L. and Schlessinger,J.
  TITLE     A hypothalamic pathway for Augmentor alpha-controlled body weight
            regulation
  JOURNAL   Proc Natl Acad Sci U S A 119 (16), e2200476119 (2022)
   PUBMED   35412887
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2209128119.
            doi: 10.1073/pnas.2209128119.. PMID: 35787061]
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Zhang,H., Pao,L.I., Zhou,A., Brace,A.D., Halenbeck,R., Hsu,A.W.,
            Bray,T.L., Hestir,K., Bosch,E., Lee,E., Wang,G., Liu,H., Wong,B.R.,
            Kavanaugh,W.M. and Williams,L.T.
  TITLE     Deorphanization of the human leukocyte tyrosine kinase (LTK)
            receptor by a signaling screen of the extracellular proteome
  JOURNAL   Proc Natl Acad Sci U S A 111 (44), 15741-15745 (2014)
   PUBMED   25331893
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC139064.13
            and AK087278.1.
            
            On or before Sep 26, 2010 this sequence version replaced
            XM_975315.1, XM_973835.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087278.1, BB664463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC139064.13        90597-90721         c
            126-858             AK087278.1         2-734
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.89 cM"
     gene            1..858
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /note="ALK and LTK ligand 1"
                     /db_xref="GeneID:620393"
                     /db_xref="MGI:MGI:3645495"
     CDS             1..384
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /note="augmentor beta; protein FAM150A; family with
                     sequence similarity 150, member A; AUG-beta"
                     /codon_start=1
                     /product="ALK and LTK ligand 1 precursor"
                     /protein_id="NP_001182661.1"
                     /db_xref="CCDS:CCDS56620.1"
                     /db_xref="GeneID:620393"
                     /db_xref="MGI:MGI:3645495"
                     /translation="MWLTKPSTPVSALLLLALALSPPGTQGRPQRSLAARVAELRPEL
                     FLPVTGTRLPPRASRSTEIFPRDLTLKDKFIKHFTGPVTFSAECSKHFHRLYHNTRDC
                     STPAYYKRCARLLTRLAVSPLCSQT"
     exon            1..184
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /inference="alignment:Splign:2.1.0"
     exon            185..238
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /inference="alignment:Splign:2.1.0"
     exon            239..319
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /inference="alignment:Splign:2.1.0"
     exon            320..396
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /inference="alignment:Splign:2.1.0"
     exon            397..858
                     /gene="Alkal1"
                     /gene_synonym="Augbeta; EG620393; Fam150a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggctca ctaagcccag caccccggtg tccgcactgc tgctgctggc gctggctttg
       61 tccccgcctg ggactcaggg gcggccccag agaagcttgg cagcgcgtgt cgctgagctc
      121 aggccagagc tcttcctccc tgtgacaggg actcgcctgc ctcccagagc ctcccggagc
      181 acagaaatat tcccaagaga cttgacattg aaagacaaat tcataaagca tttcacaggg
      241 cctgtcacat tttcagctga atgtagcaaa cacttccatc gactttatca caatacccgg
      301 gattgctcga cgccagctta ttataaaaga tgtgctagat tgctgacaag attagctgtg
      361 agtccactat gctcccagac ctaggaaact tgtgctacat ttcataagaa gcaaatataa
      421 tttgaagaaa aagtgcctgg aatcatattt aatataaaaa atggacatgt ttagttttgt
      481 atgaacttgc atgaagtaac ttctcaggag aaacctatga gtggctacag gaagaggacg
      541 cttccctggc ttacgttatg gacacaaaaa gttagagtat tttttaagat cacatattgt
      601 aaatagaata tttaaaactg tgccttattt ttgctaggaa tattattttt atatggttaa
      661 tattgtatgg taaatattta attatgttaa ttgtatctca gtagtagtga aaaaataact
      721 attgcatata attttagtga tgtgtttgtc agatattgtg ttcagttttt taattcttat
      781 ttaatattta aaagctttta ttaataattt tctgtcctta tttgcattaa tttgaactgt
      841 gaattttatt aaaacagg
//
