LOCUS       NM_199035               2002 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ALG8 alpha-1,3-glucosyltransferase (Alg8), mRNA.
ACCESSION   NM_199035 XM_355921
VERSION     NM_199035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Besse,W., Dong,K., Choi,J., Punia,S., Fedeles,S.V., Choi,M.,
            Gallagher,A.R., Huang,E.B., Gulati,A., Knight,J., Mane,S.,
            Tahvanainen,E., Tahvanainen,P., Sanna-Cherchi,S., Lifton,R.P.,
            Watnick,T., Pei,Y.P., Torres,V.E. and Somlo,S.
  TITLE     Isolated polycystic liver disease genes define effectors of
            polycystin-1 function
  JOURNAL   J Clin Invest 127 (5), 1772-1785 (2017)
   PUBMED   28375157
  REMARK    Erratum:[J Clin Invest. 2017 Sep 1;127(9):3558. doi:
            10.1172/JCI96729.. PMID: 28862642]
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK166897.1, AK166755.1 and BE852155.1.
            
            On May 17, 2008 this sequence version replaced NM_199035.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166755.1, BC061244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK166897.1         2-7
            7-1996              AK166755.1         2-1991
            1997-2002           BE852155.1         2-7                 c
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.48 cM"
     gene            1..2002
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /note="ALG8 alpha-1,3-glucosyltransferase"
                     /db_xref="GeneID:381903"
                     /db_xref="MGI:MGI:2141959"
     exon            1..116
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1602
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /EC_number="2.4.1.265"
                     /note="probable dolichyl pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase;
                     dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl
                     glucosyltransferase; asparagine-linked glycosylation 8
                     (alpha-1,3-glucosyltransferase); asparagine-linked
                     glycosylation protein 8 homolog;
                     dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl
                     alpha-1,3-glucosyltransferase; asparagine-linked
                     glycosylation 8 homolog (yeast,
                     alpha-1,3-glucosyltransferase)"
                     /codon_start=1
                     /product="dolichyl pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase"
                     /protein_id="NP_950200.2"
                     /db_xref="CCDS:CCDS52313.1"
                     /db_xref="GeneID:381903"
                     /db_xref="MGI:MGI:2141959"
                     /translation="MAASGSATAGGHWFSALALGVTLLKCLLIPTYHSTDFEVHRNWL
                     AITHSLPISQWYYEATSEWTLDYPPFFAWFEYALSHIAKYFDQEMLNIHNLNYYSSRT
                     LLFQRFSVILTDALFVYAVHECCKCIDGKRTGKDLTEKPKFILSVLLLWNFGLLIVDH
                     IHFQYNGFLSGLLLLSIARLFQKRHIEGALLFAVLLHLKHIYLYVAPAYGVYLLRSYC
                     FTASKPDGSVRWSSFSVVRVTSLGLIVFLVSALSLGPFLALNQLPQVFSRLFPFKRGL
                     CHAYWAPNFWALYNALDKVLSVIGLKLKLLDPSQIPRASMTSGLVQQFQHTVLPSVSP
                     LATLICTLIAILPSVFCLWFKPQGPRGFLRCLVLCALSSFMFGWHVHEKAILLAILPM
                     SLLSVEKAGDATVFLILATTGHYSLFPLLFTAPELPIKILLMLLFTVYSISSLKTLFR
                     KEKPLFNWMETVYLLGLGPLEVCCEFLLPFTSWKLKYPFIPLLLTSVYCAVGITYAWT
                     RLYASVLTGSLVSKTKKH"
     exon            117..195
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            196..389
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            390..499
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            500..567
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            568..694
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            695..798
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            799..919
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1059
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1199
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1297
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1370
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2002
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /note="hexamer: AATAAA"
     polyA_site      1629
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /note="major polyA site"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /note="hexamer: TATAAA"
     polyA_site      2002
                     /gene="Alg8"
                     /gene_synonym="Gm1089"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgacg ggactccagg aatggcggcg tccgggtctg caaccgctgg tggccattgg
       61 ttctctgctt tggctcttgg ggtgactctc cttaagtgcc ttctcatccc cacctaccat
      121 tccacggatt ttgaagtaca ccgaaattgg cttgcaatca ctcacagcct cccaatatct
      181 cagtggtatt atgaggcaac ttcagagtgg accttggatt accccccctt ttttgcatgg
      241 tttgagtacg ccttatcaca tattgccaaa tactttgatc aagagatgct caatattcat
      301 aacctgaact attacagttc aaggacattg cttttccaga ggttttctgt catcttgaca
      361 gatgcactct ttgtgtatgc tgtccatgag tgctgtaaat gcattgatgg aaaaagaaca
      421 ggcaaagacc tcacagagaa accaaagttt attctgtccg tgctcctgct gtggaacttt
      481 gggttgttaa ttgtagacca tattcatttt cagtacaatg gctttctgtc tggattactg
      541 ctgttgtcca ttgcacgtct atttcagaaa aggcacattg aaggggcgtt gctctttgct
      601 gtcctcctcc atctcaagca catctaccta tatgtggcac cagcctatgg tgtctatctg
      661 ctgcggtcct actgcttcac tgcaagtaaa ccagatggca gtgtccgttg gagcagcttc
      721 agcgttgtcc gcgttacttc cctggggctg atcgtgttcc tagtttctgc tctttcgttg
      781 ggccctttcc tagccttgaa ccagctgcca caagtctttt cccgactctt tcctttcaag
      841 aggggccttt gccatgccta ctgggctcca aacttctggg ctttgtacaa tgctttggac
      901 aaagtactgt ctgtaattgg tttgaaattg aagcttcttg accccagcca gatccccagg
      961 gcctcaatga caagtggttt ggttcagcag ttccagcaca cagtccttcc ctcagtttcc
     1021 cctttggcaa ccctcatctg cacactgata gccatattgc cctctgtttt ctgtctttgg
     1081 tttaaacccc aagggcccag aggctttctc cgatgcctgg ttctttgtgc cttgagttcc
     1141 ttcatgtttg ggtggcatgt ccatgagaaa gccatactcc ttgcgattct cccaatgagc
     1201 ctgttgtctg tggaaaaagc aggagatgcg acagtttttc tgattctggc gacaacagga
     1261 cactattccc tcttccccct gctcttcact gcaccagaac ttcccattaa aatcttactc
     1321 atgttactgt tcacggttta tagtatttcc tcactgaaga cactattcag aaaagaaaaa
     1381 cctcttttta attggatgga aactgtgtac ctccttggcc tggggcctct ggaagtctgc
     1441 tgtgaattcc tactcccgtt tacctcctgg aagctgaagt accccttcat ccctttgctg
     1501 ctgacctcgg tgtactgtgc agtgggcatc acatacgcct ggaccaggct gtatgcttca
     1561 gtgttgactg gctcccttgt cagcaagaca aagaaacatt gaataaagaa gtgtttgggt
     1621 gaaggccaag caattacttc atgggtatta atcagaactt gaagaaagtt gccagtggca
     1681 ggatctattt atttagtaga tccgttgaag gaccattctt ccacacttgg ccttgccctg
     1741 cctagcaacc tgattgtttc catggtgagg agccacttgc cctctataag caacaaaaca
     1801 cttttgagaa aactctcacc ttcctctgta aaaatagtct gcaattgttg aaactgctgt
     1861 gtccactgag ggtgaaccgg ggtgggtggg tgaaaagtgg cataattttc tgtggctggt
     1921 actgaccatt gttaggatat agtgcataat tagattctgt acctaaggaa atataaatgt
     1981 cattttatat ttatgcatca aa
//
