LOCUS       NM_001081264            3114 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ALG6 alpha-1,3-glucosyltransferase (Alg6), mRNA.
ACCESSION   NM_001081264 NM_178784 XM_620085
VERSION     NM_001081264.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3114)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3114)
  AUTHORS   Pandey,P., Qin,S., Ho,J., Zhou,J. and Kreidberg,J.A.
  TITLE     Systems biology approach to identify transcriptome reprogramming
            and candidate microRNA targets during the progression of polycystic
            kidney disease
  JOURNAL   BMC Syst Biol 5, 56 (2011)
   PUBMED   21518438
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005053.5.
            
            On or before Feb 15, 2011 this sequence version replaced
            NM_178784.2, XM_620085.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050854.1, AK157903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BX005053.5         94575-94651         c
            78-280              BX005053.5         91048-91250         c
            281-365             BX005053.5         83334-83418         c
            366-455             BX005053.5         72068-72157         c
            456-544             BX005053.5         70979-71067         c
            545-627             BX005053.5         68665-68747         c
            628-692             BX005053.5         67862-67926         c
            693-878             BX005053.5         66341-66526         c
            879-1014            BX005053.5         65656-65791         c
            1015-1100           BX005053.5         63870-63955         c
            1101-1185           BX005053.5         61511-61595         c
            1186-1256           BX005053.5         59482-59552         c
            1257-1325           BX005053.5         57396-57464         c
            1326-1524           BX005053.5         57090-57288         c
            1525-3114           BX005053.5         46821-48410         c
FEATURES             Location/Qualifiers
     source          1..3114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.71 cM"
     gene            1..3114
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /note="ALG6 alpha-1,3-glucosyltransferase"
                     /db_xref="GeneID:320438"
                     /db_xref="MGI:MGI:2444031"
     exon            1..77
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            78..280
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1722
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /EC_number="2.4.1.267"
                     /note="dolichyl pyrophosphate Man9GlcNAc2
                     alpha-1,3-glucosyltransferase;
                     dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl
                     glucosyltransferase; asparagine-linked glycosylation
                     protein 6 homolog; dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,3-glucosyltransferase; asparagine-linked
                     glycosylation 6 homolog (yeast,
                     alpha-1,3,-glucosyltransferase); asparagine-linked
                     glycosylation 6 (alpha-1,3,-glucosyltransferase)"
                     /codon_start=1
                     /product="dolichyl pyrophosphate Man9GlcNAc2
                     alpha-1,3-glucosyltransferase precursor"
                     /protein_id="NP_001074733.1"
                     /db_xref="CCDS:CCDS38818.1"
                     /db_xref="GeneID:320438"
                     /db_xref="MGI:MGI:2444031"
                     /translation="MESWPWMAVVVLLGLTVRWTVSLSSYSGAGKPPMFGDYEAQRHW
                     QEITLNLPVKQWYFNSSDNNLLYWGLDYPPLTAYHSLLCAYVAKFINPDWVALHTSRG
                     YESQAHKLFMRATVLAADLLIYVPAVLLYCYSLKEISPKRKIASALCILLYPGLILID
                     YGHFQYNSVSLGFALWGVLGVSWDWDLLGSLAFCLALNYKQMELYHSLPFFCFLLGKC
                     FKKGLKGKGLALFIRIACTVLASFLLCWLPFLTEREHALQVVRRLFPVDRGLFEDKVA
                     NIWCSVNVFLKIKDTLPRHIQIAISFCFTLLSLLPACIKLTVRPSCKGFRFTLVSCAL
                     SFFLFSFQVHEKSILLVSLPVCLVLTEIPFMSTWFLLVSTFSMLPLLLKDELLLPSVV
                     TVMAFVIACGTFFPMLENTSEEQLQLKSFAVSVRRHLPGFTFLPRIMQCLFLSSVITM
                     VLLTILSVTLDPPQKLPDLFPVLICFVSCVNFVFFLVYFNIVIMWDSKNGRNRKKIE"
     exon            281..365
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..455
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..544
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            545..627
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..692
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            693..878
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1014
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1100
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1185
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1256
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1325
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1524
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..3114
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3112
                     /gene="Alg6"
                     /gene_synonym="E230028F23Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgctcct cgggctgtga gtgcgcaggc gcattcgctg gttctctgcg ggcgccaatt
       61 ctggagagca gaggctggct acaaagacat aatcaagttt tcactgtttt gaagcacagc
      121 atcgtttaca atcctctcaa gctcctaatg gtgacatcgc tttgaagaag gagacccgtg
      181 actgactttg gagcaagcat ggagagctgg ccgtggatgg cagtcgtggt cttactagga
      241 cttacggtgc ggtggacggt ctctctcagt tcctactcag gtgctggaaa accacctatg
      301 tttggtgatt atgaagctca gaggcactgg caggaaatta cccttaattt accagtcaaa
      361 cagtggtatt ttaacagtag tgataacaat ttactgtact ggggattgga ttacccacct
      421 cttacggcct atcatagcct cttatgtgca tatgtggcaa agtttataaa cccagactgg
      481 gttgctctcc acacatcacg aggctatgag agtcaggcac acaagctctt catgcgtgcc
      541 acagttcttg ctgctgattt gctcatttac gtacccgcgg tgcttttgta ctgttactcc
      601 ttaaaagaaa tctcacctaa gagaaagatt gctagtgcgt tatgcatatt gctgtatcca
      661 ggtcttattc ttatcgacta tggacatttt caatataatt ctgtgagtct tggctttgcg
      721 ttgtggggtg ttcttggagt atcttgggac tgggacctgc tagggtcact ggcattttgc
      781 ttagctctaa attataagca gatggaactt taccactccc tgccattttt ttgcttttta
      841 cttggcaagt gttttaaaaa aggcctcaaa ggaaaggggc ttgcattgtt cattaggata
      901 gcctgtactg tcctggcttc tttccttctg tgttggctgc cgttcttgac agaaagggag
      961 catgccctgc aggttgttag aagactcttc cctgttgacc gtggactgtt tgaggataaa
     1021 gtcgctaata tttggtgcag cgttaatgtc tttctgaaga ttaaggacac tttgcctcgc
     1081 cacatccaga tagcgatcag cttttgcttt acacttttga gcttgcttcc tgcatgtata
     1141 aaactgacag ttcgaccctc ttgtaaagga ttcagattta ctctggttag ctgtgcgcta
     1201 tcattctttc tgttttcttt ccaagtacat gaaaagtcca ttctcttggt atcattacca
     1261 gtttgcttag ttttaactga aattcctttc atgtcaacct ggtttttact agtttcaaca
     1321 tttagcatgc tgcctcttct attaaaggat gaactcctgc tgccctcggt tgtgacagtg
     1381 atggcatttg taatagcttg tggcactttc tttccaatgt tggagaacac ttccgaagaa
     1441 caactgcagt tgaagtcctt tgctgtctct gtaaggaggc accttccggg cttcacattt
     1501 ttgcccagaa ttatgcagtg tttgtttctt tcttcagtca tcaccatggt cctcctgacg
     1561 attttgagtg taacactgga ccctcctcag aaattaccag acttgtttcc tgtacttata
     1621 tgttttgttt cctgtgtaaa ttttgtattc ttcttggtat actttaatat tgtaatcatg
     1681 tgggattcca aaaatggaag aaatcggaag aaaattgagt agctacattc ccaagcagat
     1741 gcaatctttt tgttatgtat aagtgaacat aatcatcttt agaatcatgg aattacagga
     1801 aaagaaatgg tgaaagggca ttgttattta cacaaagtgt atacaaggac caaagcattt
     1861 gtcttcttag gttttttgtt tgtttgtttg tttgtttgtt tgttttgcta agcatactat
     1921 aattttggta atattcacag atatttaatg gtaaaacaag aaaaaaaatt gtcccagctg
     1981 gtcgtagtag ctcatctttg caatgtcagt accaggaggt agaggcaggc tacctagaga
     2041 tcaaggccat ccttggttat aaatagcaag tttgaggcta gcctaggcta tgtgagaccc
     2101 tgtctcaaca aaagggttcc caatgccaat atttaataat ggaatgcatc ctataaattg
     2161 taacttttaa aaactatgta ttttatatat agttttaaaa tgtaagacca gtcagaatgc
     2221 acacagagcc aggcctgctg gtacacattg ggcatctcag cacttggtag ggacaggcag
     2281 gaggagcatg aatttgaggc tagcctgagc tacataaaat cctgttttaa aaaacaaaac
     2341 aaagtcagac aaagtgtgct tcaataaatt taaactgagt ttattggaag aattaagcac
     2401 ctgacttgtt tagcgacaag tgatgagcat ctcattcaga agttgtatct ctgggctgaa
     2461 gagatggttt agcagttaag agccgtggct gctcttcaga ggacctgaat tcaattccag
     2521 caaccacatg gtggctcaca accatctgta atgggatctg ataccctttt ctggtgtgca
     2581 tgaagatatc atacttgtat gcataaaata tatgtatata tgtatttgta tacataaatc
     2641 tttagaagta tctcagggaa ttaacatttt tcttaattac tgagaaggta cattatgcta
     2701 tttgaaattt gaatatccat tattgcatat gcaaaattgg atacttatag attaagtagt
     2761 attcttgttt ccaagaatgt agaatctctt gatgctattt tttttaaaaa gaacttttat
     2821 tgaatataaa tctaagaagt ttgaagtctt tttagttact catggtattt agttctaaat
     2881 ttctagagtc attctaaatt gactaccata tcaacgactc catctccctt tctgttacct
     2941 tgttaacacc gaaataactg catattcaaa tcatggctaa caccggctct gtcccattgg
     3001 tagggttatc ccttcaccca tatcaattcc taaaaatcat gtagtgtgtt ttactttcac
     3061 aggaaagctg tttctttagt ctctgatgaa aattaaagcc actttacgac tagc
//
