LOCUS       NM_145939               1437 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ALG3 alpha-1,3- mannosyltransferase (Alg3), transcript
            variant 1, mRNA.
ACCESSION   NM_145939
VERSION     NM_145939.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1437)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1437)
  AUTHORS   Liu,P., Lin,C., Liu,Z., Zhu,C., Lin,Z., Xu,D., Chen,J., Huang,Q.,
            Li,C.Y., Hou,L., Pan,J.A. and Liu,X.
  TITLE     Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis
            to potentiate immunotherapy
  JOURNAL   Cell Mol Life Sci 79 (7), 352 (2022)
   PUBMED   35676564
  REMARK    GeneRIF: Inhibition of ALG3 stimulates cancer cell immunogenic
            ferroptosis to potentiate immunotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1437)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   4  (bases 1 to 1437)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 1437)
  AUTHORS   Pappano,W.N., Scott,I.C., Clark,T.G., Eddy,R.L., Shows,T.B. and
            Greenspan,D.S.
  TITLE     Coding sequence and expression patterns of mouse chordin and
            mapping of the cognate mouse chrd and human CHRD genes
  JOURNAL   Genomics 52 (2), 236-239 (1998)
   PUBMED   9782094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087898.19.
            
            On Oct 27, 2017 this sequence version replaced NM_145939.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KP189274.1, KP189259.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC087898.19        94353-94571
            220-319             AC087898.19        96028-96127
            320-467             AC087898.19        96225-96372
            468-628             AC087898.19        96468-96628
            629-749             AC087898.19        97230-97350
            750-955             AC087898.19        98149-98354
            956-1032            AC087898.19        98512-98588
            1033-1177           AC087898.19        99108-99252
            1178-1437           AC087898.19        99397-99656
FEATURES             Location/Qualifiers
     source          1..1437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.48 cM"
     gene            1..1437
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /note="ALG3 alpha-1,3- mannosyltransferase"
                     /db_xref="GeneID:208624"
                     /db_xref="MGI:MGI:1098592"
     exon            1..219
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1340
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /EC_number="2.4.1.258"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-1,3-mannosyltransferase ALG3;
                     dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl
                     mannosyltransferase; not56-like protein; asparagine-linked
                     glycosylation 3 (alpha-1,3-mannosyltransferase);
                     asparagine-linked glycosylation 3 homolog (yeast,
                     alpha-1,3-mannosyltransferase); asparagine-linked
                     glycosylation protein 3 homolog; dol-P-Man-dependent
                     alpha(1-3)-mannosyltransferase;
                     dolichyl-phosphate-mannose--glycolipid
                     alpha-mannosyltransferase;
                     dol-P-Man:Man(5)GlcNAc(2)-PP-Dol
                     alpha-1,3-mannosyltransferase"
                     /codon_start=1
                     /product="dol-P-Man:Man(5)GlcNAc(2)-PP-Dol
                     alpha-1,3-mannosyltransferase isoform 1"
                     /protein_id="NP_666051.2"
                     /db_xref="CCDS:CCDS37289.1"
                     /db_xref="GeneID:208624"
                     /db_xref="MGI:MGI:1098592"
                     /translation="MAAGLRKRGQPASVGQPAGIWKQWLQRAWQERYLLLREPRYTLL
                     VASCLCIAEVGITFWVIHRVAYTEIDWKAYMAQVEGFINGTYDYTQLQGDTGPLVYPA
                     GFLYIFTGLFYATDRGTDIPMAQNIFAVLYLVTLVLVFLIYHQTSKVPPFVFFFMCCA
                     SYRVHSIFVLRLFNDPVAMALLFLSINLFLAQCWSWGCCCFSLAVSVKMNVLLFAPGL
                     LFLLLTQFGFRGALPKLAICAALQVVLGLPFLLENPIGYLSRSFDLGRQFLFQWTVNW
                     RFLPETIFLHRAFHLALLAAHLSLLLLFALCRWHRTGESILALLKDPSKRKVPPQALT
                     PNQIVSILFTSNFIGICFSRSLHYQFYVWYFHTLPYLLWAMPARWLTHLLRLLVLGLI
                     ELSWNTYPSTSFSSAALHLCHAVVLLQLWLSPESFPKSIQPSRKTH"
     exon            220..319
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            320..467
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            468..628
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            629..749
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            750..955
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1032
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1177
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1437
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /note="hexamer: AATAAA"
     polyA_site      1423
                     /gene="Alg3"
                     /gene_synonym="D16Ertd36e; not"
                     /note="major polyA site"
ORIGIN      
        1 caaaagagtg gtgcactgtc aagatggctg ctgggctgcg gaaacgcggc cagccggctt
       61 ctgtcggcca gccggcagga atctggaaac aatggctaca gcgtgcctgg caagaacgct
      121 acctactgct gcgggaaccg cgctacacat tgctggtggc ctcctgcctc tgcatagcag
      181 aggtgggcat caccttctgg gtcattcaca gggtggcata cacagagatt gactggaagg
      241 cctacatggc ccaggtggag ggtttcatca atggcacata tgactacaca cagctgcagg
      301 gtgacaccgg acctcttgtc tacccagctg ggtttttgta catctttacg gggctattct
      361 atgctactga ccggggcact gatatcccta tggcccagaa catctttgct gtactctacc
      421 ttgtcacctt ggtgcttgtt ttcttgatat accaccagac ctccaaggta cctcccttcg
      481 tctttttctt catgtgttgt gcctcttacc gtgtccattc catctttgta ctgcggctct
      541 tcaatgaccc agtagctatg gccttgctct tcctgagcat caaccttttc ctggcacagt
      601 gctggagctg gggctgctgc tgtttcagcc tggctgtctc ggtgaagatg aatgtgctgc
      661 tcttcgcccc gggattgcta ttccttcttc ttactcagtt tggcttccgt ggtgccctcc
      721 ccaagctggc catctgtgct gctcttcagg tggtgctggg attgcccttc ctgctggaga
      781 accccattgg ctacctatcc cgctcctttg accttggtcg tcagtttctt ttccaatgga
      841 cagtaaactg gcgcttcctg cctgaaacca tcttcctgca tcgtgccttc catctagccc
      901 tgttggctgc ccaccttagc ctcctcttgc tgtttgccct ctgtaggtgg cacagaacag
      961 gggaaagtat tctggcactg ctgaaggatc cttccaaaag gaaagttcca ccccaagccc
     1021 tcacacctaa ccagattgtt tccatcctct tcacctccaa cttcattggc atctgcttta
     1081 gccgctcgct ccactaccag ttttatgtct ggtatttcca cacactgccc tacctcctgt
     1141 gggccatgcc tgcacgctgg ctcacacacc tgctcaggtt gctggtgctg ggactcattg
     1201 agctctcctg gaatacgtac ccatccacgt ccttcagctc tgccgccctc cacctgtgcc
     1261 acgctgtcgt cctgctgcag ctctggctgt cccccgagtc cttccctaag agcattcagc
     1321 caagcaggaa aactcactga aacccacccc ttccttctag gacgtgctca gcatcatggg
     1381 tggaacggac tctgtgttct tagaataaac cttgccaagt ccacctttgt gcagcat
//
