LOCUS       NM_026247               1640 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus asparagine-linked glycosylation 13 (Alg13), transcript
            variant 1, mRNA.
ACCESSION   NM_026247
VERSION     NM_026247.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Guo,B., Xia,Y., Wang,C., Wang,F., Zhang,C., Xiao,L., Zhang,X.,
            Meng,Y., Wang,Y., Ding,J., Wang,L., Zhu,C., Jiang,S., Huo,X.,
            Sun,Y., Gao,P., Wu,J., Yu,B., Huo,J. and Sun,T.
  TITLE     Decreased cognitive function of ALG13KO female mice may be related
            to the decreased plasticity of hippocampal neurons
  JOURNAL   Neuropeptides 96, 102290 (2022)
   PUBMED   36152356
  REMARK    GeneRIF: Decreased cognitive function of ALG13KO female mice may be
            related to the decreased plasticity of hippocampal neurons.
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Gao,P., Wang,F., Huo,J., Wan,D., Zhang,J., Niu,J., Wu,J., Yu,B. and
            Sun,T.
  TITLE     ALG13 Deficiency Associated with Increased Seizure Susceptibility
            and Severity
  JOURNAL   Neuroscience 409, 204-221 (2019)
   PUBMED   30872163
  REMARK    GeneRIF: Expression of ALG13 in the central nervous system (CNS)
            had histologically and cellular specificity, mainly in the neurons
            in the cortex and hippocampus. KA-induced seizures significantly
            affected the expression levels of ALG13 mRNA and protein in the
            forebrain of wild-type (WT) mice. KA-induced epileptic progressions
            were dramatically increased in Alg13 knockout (KO) mice.
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137692.1 and AK086546.1.
            
            On Jan 7, 2010 this sequence version replaced NM_026247.2.
            
            Transcript Variant: This variant (1) is the protein-coding variant.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086546.1, AK089102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1254              BC137692.1         1-1254
            1255-1640           AK086546.1         1148-1533
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 65.42 cM"
     gene            1..1640
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /note="asparagine-linked glycosylation 13"
                     /db_xref="GeneID:67574"
                     /db_xref="MGI:MGI:1914824"
     exon            1..156
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..573
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /EC_number="2.4.1.141"
                     /note="glycosyltransferase 28 domain containing 1;
                     UDP-N-acetylglucosamine transferase subunit ALG13 homolog;
                     glycosyltransferase 28 domain-containing protein 1;
                     asparagine-linked glycosylation 13 homolog; putative
                     bifunctional UDP-N-acetylglucosamine transferase and
                     deubiquitinase ALG13"
                     /codon_start=1
                     /product="UDP-N-acetylglucosamine transferase subunit
                     ALG13"
                     /protein_id="NP_080523.2"
                     /db_xref="CCDS:CCDS30456.1"
                     /db_xref="GeneID:67574"
                     /db_xref="MGI:MGI:1914824"
                     /translation="MKRAFVTVGTTSFDELVARVVANDCVQILESLGYNHLVLQVGRG
                     TVVPKPFRTESFTLDVYRYKDSLKEDLQQADLVISHAGAGSCLESLEKGKPLVVVVNE
                     KLMNNHQFELAKQLHKEGHLFYCTCSTLPGLLQSMDLSTLKCYPPGQPEKFSAFLDKV
                     VGLQK"
     exon            157..319
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /inference="alignment:Splign:2.1.0"
     exon            320..458
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1640
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /inference="alignment:Splign:2.1.0"
     regulatory      569..574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /note="hexamer: AATAAA"
     polyA_site      593
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /note="major polyA site"
     regulatory      1617..1622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /note="hexamer: AATAAA"
     polyA_site      1635
                     /gene="Alg13"
                     /gene_synonym="2810046O15Rik; 4833435D08Rik; Glt28d1;
                     MDS031"
                     /note="major polyA site"
ORIGIN      
        1 gtttcccctc tggcattggt gcgagccgcc tgacgtcaca tccgctcccg caattccgaa
       61 tctggaaccc gcgcgatgaa gagagcgttt gtgactgtcg ggaccaccag tttcgacgag
      121 ctcgtcgcac gggtggtcgc taacgactgc gttcagatcc tcgagagtct gggttacaac
      181 catcttgtcc tccaagttgg tagaggcact gtggtgccca aaccattccg tactgagtca
      241 ttcactctgg atgtttacag gtataaggat tctttgaaag aagaccttca gcaagctgat
      301 cttgtcatta gccacgcagg tgcaggaagc tgtttggaga gtctggagaa aggcaaacca
      361 cttgtggtag ttgtaaatga aaagttaatg aacaatcatc aatttgaatt ggcaaagcag
      421 ttgcacaaag aaggccatct cttttattgt acctgcagca cgcttcctgg gctgttacag
      481 tcaatggatt tatcaacact gaaatgttat cctcctggcc agccagaaaa attttctgca
      541 tttttggata aagttgttgg attacaaaaa taaactctca acactttaaa atacccctaa
      601 gtccagttca tgggatatga taaaatcaaa ataaattcat gacatgtttt tgtagaacag
      661 tataaaccca tatatttaaa caatattata aggattttgt ggcataaaca ttacagttgt
      721 gtctagatcc taattttagt aaatgtttga ggtttcccta actttgaata tgtagtgagc
      781 cctaactttg aaaactatag ccttcacagt tttgtactaa aatttcaaaa aagcaaaaac
      841 tgggcagtgg tggtgaatgc ctttaattct aacctttggg agccagaagc aggtgtatct
      901 tgagttcagg gccatccttt tctacccaga gaaactctgt ctttaaaatc caaaacaaaa
      961 ctccaaaaca agaaattgta aaaaaatgtt aagactcaag tattagatgt ttttgaataa
     1021 taaatgctaa caatgtaaca ttttggtgag aaaaatcagc atttttagga tcataatctc
     1081 aagagacagc atttttgtat taagcagaaa aaaatgggtt tactttgtag aagctaattt
     1141 gaaaaagatc aaagtaattg atagagtaac catgcttatc ctgaagaata aaatagatat
     1201 gttcatcttt tgaacttgtg atccttcaag tcctgggatt acaggcacat gccaccattc
     1261 ctggtaatat ttgttcctgt aaaatagaca agggctgggg aaattgttta gtgagtaaag
     1321 tacttgtata agtgtgagag cctgagtttg catcttcagc ataaacttta ggcatggcag
     1381 tgtgtattta aatccttgtg cctatgatga tattggaaga tgtagataga attccctgga
     1441 agacattgga ctaagcagcc tagtattcac aacagtgaat ggtaaaaata cctgttacca
     1501 agcaaggtaa aaagtaagga tatagctcac tataggatcc atggctatat tcacatgagt
     1561 acatggagat atataggtag aatgtgataa tcttaacaat gtcttaaatg atagcgaata
     1621 aatctaaaaa tataatagtg
//
