LOCUS       NM_001416017            2396 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ALG12 alpha-1,6-mannosyltransferase (Alg12),
            transcript variant 3, mRNA.
ACCESSION   NM_001416017 XM_006520842
VERSION     NM_001416017.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Oh-Hashi,K., Tejima,T., Hirata,Y. and Kiuchi,K.
  TITLE     Characterization of the 5'-flanking region of the mouse
            asparagine-linked glycosylation 12 homolog gene
  JOURNAL   Cell Mol Biol Lett 18 (3), 315-327 (2013)
   PUBMED   23818223
  REMARK    GeneRIF: Data indicate that each of the mutations in the GC-rich
            sequence and YY1-binding element reduced asparagine-linked
            glycosylation 12 homolog (ALG12 promoter activity, and the
            combination of these mutations additively decreased reporter
            activity.
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Oh-Hashi,K., Koga,H., Ikeda,S., Shimada,K., Hirata,Y. and Kiuchi,K.
  TITLE     Role of an ER stress response element in regulating the
            bidirectional promoter of the mouse CRELD2 - ALG12 gene pair
  JOURNAL   BMC Genomics 11, 664 (2010)
   PUBMED   21106106
  REMARK    GeneRIF: These results show that the mouse CRELD2 and ALG12 genes
            are arranged as a unique bidirectional gene pair.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Oriol,R., Martinez-Duncker,I., Chantret,I., Mollicone,R. and
            Codogno,P.
  TITLE     Common origin and evolution of glycosyltransferases using
            Dol-P-monosaccharides as donor substrate
  JOURNAL   Mol Biol Evol 19 (9), 1451-1463 (2002)
   PUBMED   12200473
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Chantret,I., Dupre,T., Delenda,C., Bucher,S., Dancourt,J.,
            Barnier,A., Charollais,A., Heron,D., Bader-Meunier,B., Danos,O.,
            Seta,N., Durand,G., Oriol,R., Codogno,P. and Moore,S.E.
  TITLE     Congenital disorders of glycosylation type Ig is defined by a
            deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl
            mannosyltransferase
  JOURNAL   J Biol Chem 277 (28), 25815-25822 (2002)
   PUBMED   11983712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117700.22.
            
            On Jan 10, 2023 this sequence version replaced XM_006520842.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.13378245.1,
                                           SRR17253014.2898270.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC117700.22        84567-84894
            329-516             AC117700.22        87608-87795
            517-649             AC117700.22        87872-88004
            650-823             AC117700.22        88395-88568
            824-1018            AC117700.22        89214-89408
            1019-1122           AC117700.22        91703-91806
            1123-1346           AC117700.22        92342-92565
            1347-1510           AC117700.22        97141-97304
            1511-1586           AC117700.22        97388-97463
            1587-2396           AC117700.22        97808-98617
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.3 cM"
     gene            1..2396
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /note="ALG12 alpha-1,6-mannosyltransferase"
                     /db_xref="GeneID:223774"
                     /db_xref="MGI:MGI:2385025"
     exon            1..328
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            329..516
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1812
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /EC_number="2.4.1.260"
                     /note="isoform 1 is encoded by transcript variant 3;
                     dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,
                     6-mannosyltransferase; mannosyltransferase ALG12 homolog;
                     asparagine-linked glycosylation protein 12 homolog;
                     dol-P-Man:Man(7)GlcNAc(2)-PP-Dol
                     alpha-1,6-mannosyltransferase; asparagine-linked
                     glycosylation 12 homolog (yeast,
                     alpha-1,6-mannosyltransferase); asparagine-linked
                     glycosylation 12 (alpha-1,6-mannosyltransferase)"
                     /codon_start=1
                     /product="dol-P-Man:Man(7)GlcNAc(2)-PP-Dol
                     alpha-1,6-mannosyltransferase isoform 1"
                     /protein_id="NP_001402946.1"
                     /db_xref="GeneID:223774"
                     /db_xref="MGI:MGI:2385025"
                     /translation="MAGKKSSGKRSWPLLGLLVTVATIHLVICPYTKVEESFNLQATH
                     DLLYHQLDIDKYDHHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRG
                     VLGLGVISGLWTLQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLP
                     ALTAWLQRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAG
                     LLCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCS
                     LLFIPLGAVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYILN
                     KKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGVAMQQLHELVPPQTDVLLHI
                     DVAAAQTGVSRFLQVNDDWRYDKSEDVGAAAMLNYTHILMEAVPGHPALYRDTHRVLA
                     SIEGTTGISLNLMKLPPFDVNLQTKLVLLERLLRPA"
     exon            517..649
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            650..823
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1018
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1122
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1346
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1510
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1586
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..2396
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /note="hexamer: AATAAA"
     polyA_site      2396
                     /gene="Alg12"
                     /gene_synonym="ECM39"
                     /note="major polyA site"
ORIGIN      
        1 agtctgctca gttccgcggg gtcctgcgga gaggagaggt tagcgcgcgt cgccgggatt
       61 ggtgtactcg ggcgggaggt ggcgaagctg gggttctccc gagcgcgcgt gacggccttt
      121 gagttcctca acccggggat ggacctgtca cttagaggct gagcgtgtcc ctgggggcgg
      181 gacatctcgc ccgaggcctg gaccgttcat ccatcctcct cacctggcgc ccggagctgt
      241 catccgtaaa cagagctcta catctgggtc ctgctcagtg tggttgaggg ggccccagtg
      301 gtcgacattt cctcaggggc ctcaggcagc gcatgaagtt caaagctcta catggctggc
      361 aagaagtcat cgggcaagcg gtcatggccg cttctggggc tgctggtcac tgtagccacc
      421 atccacctgg ttatatgtcc ctacaccaag gtagaagaga gcttcaacct tcaggccaca
      481 catgacctcc tgtaccacca gctggacata gacaagtacg accaccacga gtttcctgga
      541 gttgttccta ggacgttcct cgggccgctg gtgatcgcag cgttctccag ccccgtggtt
      601 tatgtgctct cgcttttaga agtatccaaa ttttattctc agctgatagt cagaggagtc
      661 cttgggcttg gtgtgatttc tggactctgg acattacaaa aggaagtgag acagcagttc
      721 ggagccacgg tggctgtcat gttctgctgg atatcagcca cacagtttca tctcatgttc
      781 tactgtacga ggacactccc caacgtgttg gccctggctg tggtcttacc agccctcaca
      841 gcctggctgc agcggaggtg ggccctgttt gtctggctct cagccttcgt catcattggc
      901 ttcagggctg agctggccat gctgctgggc attgcgctgc tgctgacctt gtaccaaaga
      961 agactgacgg tggccagagt gctccgacac gccatcccag cagggcttct ctgtctaggg
     1021 ctgacggttg ctgtggactc ctatttctgg cgataccttg tatggccgga aggagtggtg
     1081 ctttggtaca acactgtcct gaacaaaagt tccaactggg gcacttcccc actcctgtgg
     1141 tatttctact cagccctgcc ccgaggcctg ggctgcagcc ttctcttcat acccctgggt
     1201 gcagtggaca ggaggaccta tgcactggcc ctgccaagct tgggattcgt ggctctatac
     1261 tcactcctcc cacacaagga gctgcggttc atcatctata ccttccctgt cctcaacatc
     1321 atggctgcca gaggctgcac ctatatcctg aataaaaagt cttggccata caaggtgaga
     1381 gctatgctgg tgacagggca tatcttggtg aatgtggcat atacagccac gtccctctat
     1441 gtgtctcatt tcaactaccc tggtggggtt gcgatgcagc agctacatga gctggtacca
     1501 cctcagacag atgtccttct tcacattgat gtggctgctg cccagacagg agtgtcacgg
     1561 tttctacagg tcaatgatga ctggaggtat gacaagagtg aagatgtggg agcagcggcc
     1621 atgctgaact acacccacat cctcatggag gcagtgcctg ggcacccggc cctctacagg
     1681 gacacacatc gagtcctggc cagtattgag ggcactacag gtataagcct gaatttgatg
     1741 aaactgccac cctttgatgt caacctgcag acaaagctgg tacttctaga gcggctgctt
     1801 aggccagcct gagaggacag gagatctcca ggaacatcga gtgtggtcac cttctaatgc
     1861 agtgaagaca attcaagaaa acagcaaaga ccagggactt ccagcatgtc tacagcatgc
     1921 ctggtgttag cctacatcag tctgggccag gccctacaat agccacacct aaggcacagg
     1981 gctgagaatg tggagaacag accaccaagt gtgatagtgg cctgctcaaa ctgtctgcta
     2041 tggttaggtg gcccacagga tcatttacat tcatactggg aaccattcat aactaagaac
     2101 agtgagtcag gctagaacac cctggcaccc tagctctgcg gtgaccctca gtgtatattt
     2161 cttgcccctg aaaaccacac ttgttgccca tggcctcagg agaccacgat ataaaccagg
     2221 tctttatggg acagacagac acacacacac accaccacca ccaccaccac caccacctcc
     2281 tccaccacca atcatggcag ctgttatagc ccgaggcatg ttatctccat ttcagattaa
     2341 ctctgaggac ctacacatgt tcataaaaga atggaaataa aaattatgtt ttctta
//
