LOCUS       NM_001243161            4970 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ALG11 alpha-1,2-mannosyltransferase (Alg11),
            transcript variant 1, mRNA.
ACCESSION   NM_001243161 XR_107983
VERSION     NM_001243161.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4970)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4970)
  AUTHORS   Nishimura,Y., Shimono,N., Yoshimoto,T., Kamiguchi,H. and
            Nishikawa,Y.
  TITLE     Cloning and transcriptional expression of mouse mannosyltransferase
            IV/V cDNA, which is involved in the synthesis of lipid-linked
            oligosaccharides
  JOURNAL   Biosci Biotechnol Biochem 78 (3), 400-409 (2014)
   PUBMED   25036826
  REMARK    GeneRIF: Hence, we concluded that there is different
            transcriptional control mechanism between mALG11 and hALG11
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157746.1 and BC061469.1.
            
            On Jul 30, 2011 this sequence version replaced XR_107983.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157746.1, AB288237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1993              AK157746.1         1-1993
            1994-4970           BC061469.1         1977-4953
FEATURES             Location/Qualifiers
     source          1..4970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.92 cM"
     gene            1..4970
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /note="ALG11 alpha-1,2-mannosyltransferase"
                     /db_xref="GeneID:207958"
                     /db_xref="MGI:MGI:2142632"
     exon            1..50
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1485
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /EC_number="2.4.1.131"
                     /note="isoform 1 is encoded by transcript variant 1;
                     asparagine-linked glycosylation protein 11 homolog;
                     asparagine-linked glycosylation 11 homolog (yeast,
                     alpha-1,2-mannosyltransferase); mannosyltransferase IV(V);
                     defective mannosyltransferase IV(V); glycolipid
                     2-alpha-mannosyltransferase;
                     GDP-Man:Man(3)GlcNAc(2)-PP-Dol
                     alpha-1,2-mannosyltransferase; asparagine-linked
                     glycosylation 11 (alpha-1,2-mannosyltransferase)"
                     /codon_start=1
                     /product="GDP-Man:Man(3)GlcNAc(2)-PP-Dol
                     alpha-1,2-mannosyltransferase isoform 1"
                     /protein_id="NP_001230090.1"
                     /db_xref="CCDS:CCDS57613.1"
                     /db_xref="GeneID:207958"
                     /db_xref="MGI:MGI:2142632"
                     /translation="MAADTGSWCVYAVLRFFYSLFFPGLMICGVLCVYLVIGLWVIRW
                     HLQRKKKSVSTSKNGKEQTVVAFFHPYCNAGGGGERVLWCALRALQKKYPEAVYVVYT
                     GDINVSGQQILDGAFRRFNIKLAHPVQFVFLRKRYLVEDSRYPHFTLLGQSLGSILLG
                     WEALMQRVPDVYIDSMGYAFTLPLFKYVGGCRVGSYVHYPTISTDMLSVVKNQNPGFN
                     NAAFISRNALLSKAKLIYYYLFAFVYGLVGSCSDIVMVNSSWTLNHILSLWKVGHCTN
                     IVYPPCDVQTFLDIPLHEKKVTPGHLLVSIGQFRPEKNHALQIKAFAKLLNEKAAELG
                     HSLKLVLIGGCRNKDDEFRVNQLRSLSENLGVQENVEFKINISFDELKNYLSEATIGL
                     HTMWNEHFGIGVVECMAAGTVILAHNSGGPKLDIVIPHEGQITGFLAESEEGYADSMA
                     HILSLSAEERLQIRKNARASISRFSDQEFEVAFLCSMEKLLT"
     exon            51..281
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /inference="alignment:Splign:2.1.0"
     exon            282..1213
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..4960
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4942..4947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /note="hexamer: AATAAA"
     polyA_site      4960
                     /gene="Alg11"
                     /gene_synonym="B230397C21; Mmat-4(5)"
                     /note="major polyA site"
ORIGIN      
        1 gataagatgg cggcggacac tgggagctgg tgcgtgtacg ccgtgctgcg gtttttctat
       61 tcactcttct ttcctggact gatgatatgc ggagttttgt gtgtatattt ggtcattggc
      121 ctttgggtta tcaggtggca tctacagaga aagaagaagt ctgtgtcgac cagcaaaaat
      181 ggaaaagaac aaacggtggt tgcatttttc catccatact gtaatgcagg tggcggagga
      241 gagagagttc tgtggtgtgc tttgagagcc ctgcagaaaa agtatcctga agcagtttat
      301 gttgtatata ctggtgacat taatgtcagt ggtcaacaga tactagatgg tgctttcaga
      361 aggtttaaca tcaagttggc tcacccagtg cagtttgttt tcttaaggaa acgctacctt
      421 gtggaagatt cccggtatcc tcacttcaca ttgctaggcc aaagtcttgg atccattctt
      481 ctcggctggg aagctctgat gcagcgcgtt cctgatgttt acatcgactc aatgggatac
      541 gccttcacac tccctctctt taagtatgtg ggaggttgcc gagtcggaag ctatgttcac
      601 tatcccacga tcagcactga catgctgtct gtggtgaaga atcagaatcc tggatttaat
      661 aatgctgctt tcattagcag aaatgctctt ctcagcaaag caaagctcat ctattactat
      721 ttatttgctt ttgtttatgg ccttgttgga tcttgcagtg acatagtcat ggttaattct
      781 tcttggacat taaaccatat cctctcactg tggaaggttg ggcattgcac taacattgtc
      841 tatccacctt gtgatgtgca gacatttctg gacatccctt tacatgagaa gaaggtgacc
      901 ccagggcatt tgctggtttc cattggccag ttcagacctg aaaagaatca tgctttgcag
      961 atcaaagcct ttgctaaatt gttaaatgag aaagcagctg agttaggcca ttctcttaaa
     1021 cttgtcctta ttggagggtg tcgcaacaaa gatgatgagt ttagagtaaa ccaactgaga
     1081 agtctatctg agaatttggg agttcaagaa aatgtggaat ttaaaataaa catttcattc
     1141 gatgaattga agaattactt gtctgaagcg accatcggtc tgcatactat gtggaatgag
     1201 cattttggga ttggagttgt cgagtgtatg gcagctggca cagttatcct tgcacacaac
     1261 tcaggaggcc cgaagctgga cattgtcatt cctcatgaag gacagataac tggctttctg
     1321 gctgagagtg aagaaggcta tgctgactct atggctcaca ttctttctct gtctgcagaa
     1381 gagagactcc aaatcaggaa gaatgctaga gcgtctataa gcagattctc cgaccaggag
     1441 tttgaagtag cattcctgtg ttccatggag aagttactta cttagtgtcc agtctgcaca
     1501 gtctgggtat tttatacagc atggagctgg agctataggt catgggagaa cccgtgcttc
     1561 gtgtgtggga gtcccgagct ccatctccag caccaaaagt aaaaggaaac accttcacct
     1621 gtaaatattt cctaaattta ttctttatca taatcaaagc agcctgagca acattctcag
     1681 caatatgtat ataggcaagg cagtagttaa caaaaaggca gaattaatct atatggaaaa
     1741 agtaatctca cgtagctttt tttttttttt cttttttttt tttttttttc tttttgagac
     1801 agggtttctc tgtgtagccc tggctgttct agaactcact ctgtagacca ggctggcctt
     1861 gaactcatag agatccgccc gcctctgtct cccaagtgct gggactaaag gcgtgccacc
     1921 acacccagct tcatgtagct caatgtacag attttactaa ctgtttgctc tcaaaatctg
     1981 agcagtacag atctcaaaga aaaaaaatta ccagtcaaat ttccatatac tcatacatct
     2041 tttaatcttt tcctttcctt gtcttaatcc ctgagtgttc ctgcctccac ctcccagaat
     2101 acaccagtgt gtgcagtgct ggtgatggga cccagggcct cctgcagtct agacaagcac
     2161 tagcactctg ccaactgagc tacatcctaa gccccaaacc ctgctttcca aatcacttct
     2221 gcttgcgaga acatgaagta atatttcctg gtttttaatc tgttctatga cgctggagta
     2281 ccatgtagag cctcagactg tgaggaagag cagggatgtg tacactgcca ccacaaagta
     2341 tactgagctg atctcaaaga ctgccttcca aagggaaggg aggtgctgaa agaaacagca
     2401 ggctatcagc tggcactctc aaaatgcatt cctaaatttt tggattaaat tctgtttgag
     2461 gggtgggttt agagggttta gaggttgaac ctagagccat gctcatggta cacgagtgtt
     2521 ctaacccctg agctacttta cctcaactcc aggagtgccg aaataacagc gtgggtgacc
     2581 cttttaagta cacctattaa ttttcttaaa aggaagaaga aacttcaaac aggcatctct
     2641 aatcctacac ctaaagtatc agtcaggaga tggggtggac tcatttcttc atgggtgtgt
     2701 acagatatgt taaagtcaaa acaggcagcc atctttccca taactaggtt tgtatggaaa
     2761 ttggggtttg tatgggtttc tcatctctta acagccccat ttaaggctaa agtcagcctc
     2821 agttcattca agagaatatc aagctaagtt gcttttctga aactgaccat gtatttataa
     2881 tgtatataca tatatatttc tgtgtataaa tatatataca taattttaat gaacttttct
     2941 ctttcttctg gactgacata tgagccaaag accgcctaac agaaaaccca accccagaca
     3001 caagattcct ttttttattg cccagggttg tccaggagac tccccaaagc atagagccta
     3061 ttgcttttgc ccttggttac ccctagcagt ggaagataag tcccgaatgc tgaagacaca
     3121 atgtacttta gaaagaggcc aaagacccct gagctggaac tgacctgaaa gtgcacacag
     3181 agagagagag agctgttgct gccccaggac tagctttcat ggtatgaagg tgccaggcga
     3241 gcttccaaag gggaagggca accaatagtc cgacccagct atcccaccta taaaccacat
     3301 ggaaaaccag catggcacgc acacttgaca gtaaccaaca gctcttaaat tggacacacg
     3361 acctgctcaa ctaggagaac ctagctaact attccgcact agagaacagc cactgtttac
     3421 taaaccagca taattcctaa caacaatcta taaacatttg tctagactct taaactatac
     3481 agttcttcag gtatagccta caaactaatg tcaacttaca cattttctct ctttaaatga
     3541 atatgcattt cactgaggac tctttcctag acccctggag atctcactgt gagtgaggca
     3601 gatacagtct taactcgtga tatagaggtc tgttggctgt ttaccaagta acttagcact
     3661 ataaaaacaa tttttaaaac ttttttttta caatagtaac cactaatagt aaaggttttc
     3721 tgcactccca ttattacaga tagatgtgat tacaagtctg tagtttctta gtagctgaaa
     3781 atcagtataa atttcacctg gtcttattct gcgtaactgg caggtgtgtg ggagctgagg
     3841 ctgtgactct aagaagctgt aacgtgagca gatgggactc taaaggcatt caccattctg
     3901 tacatacata gttccttcta gttaaatgaa ttacccacac tgtttgacat tggtgttaga
     3961 gcatacaaaa gaggcacact gtctcttcca gctggttggt tggtttgatt gttggttgtt
     4021 tttgctttgt ttggatctcc ctagcttcat tatctattcc caattacatt gttaattcac
     4081 tacagtggaa actcagcaaa ccatcagctg gggttagaga taattcagtc tacaaagatt
     4141 tcagagactg gaggtggacg ggaccttcca cgttctctat tttgttttca actttacaga
     4201 ccaaaacaat ttaaagaact gagttgactt cttcattgtc acaaaactgg ttaatgacag
     4261 aatcaggatt ctggccttgt attctgactc ttggcccact ctgttaaggc cagtctgcgg
     4321 taaaatttgt ctgtagccca cacagcctac acaaagtaat aggactttaa agtaattcta
     4381 gaaattggaa tgaacataga ttgggagtgt ggtaaaagaa acgattctca atttcttaaa
     4441 aaagcacttt ttcattaact ttccaacgtt attttaatgg gttagaagca tatgactgat
     4501 ttacagcatt cctgatcatg ttttacagat gtttactttt tactagattt caggtaggta
     4561 ctgtgtgaaa tggtgagact cgtttttatc tgtttctgtg agacttctca gtggttgtta
     4621 agtccactac aactgtgatt ttccccctcg gtggtccaag cattcagttt tgagtccaca
     4681 acagcagagg ttcaaattcc tgtttacatt gataacacaa ctgtgaagta tccgttacct
     4741 agtctttgta taatatattt atatctcatt gtgatgtaga actgttgata caaaatcgta
     4801 tctaaatgtg tcaggtggtt tcgttcattc aattaaaatg tttttacatc atctttccct
     4861 ttcttcctta ccttcccatc tttctacctc tcgagttcat ggtttctttt ccttgaatga
     4921 ttattgctac atatgtatgc aaataaatgt atgaatgcaa aaaaaaaaaa
//
