LOCUS       NM_001303423            2681 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus aldolase C, fructose-bisphosphate (Aldoc), transcript
            variant 2, mRNA.
ACCESSION   NM_001303423
VERSION     NM_001303423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2681)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2681)
  AUTHORS   Votava,J.A., John,S.V., Li,Z., Chen,S., Fan,J. and Parks,B.W.
  TITLE     Mining cholesterol genes from thousands of mouse livers identifies
            aldolase C as a regulator of cholesterol biosynthesis
  JOURNAL   J Lipid Res 65 (3), 100525 (2024)
   PUBMED   38417553
REFERENCE   4  (bases 1 to 2681)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2681)
  AUTHORS   Wang,T., Numata,N., Ji,Q., Mizuno,Y., Viet,N.M., Luo,Y., Chao,Y.,
            Panezai,S.K. and Sugihara,I.
  TITLE     Single axonal characterization of trigeminocerebellar projection
            patterns in the mouse
  JOURNAL   J Comp Neurol 532 (1), e25581 (2024)
   PUBMED   38289187
REFERENCE   6  (bases 1 to 2681)
  AUTHORS   Howell,B.W., Hawkes,R., Soriano,P. and Cooper,J.A.
  TITLE     Neuronal position in the developing brain is regulated by mouse
            disabled-1
  JOURNAL   Nature 389 (6652), 733-737 (1997)
   PUBMED   9338785
REFERENCE   7  (bases 1 to 2681)
  AUTHORS   Segre,J.A., Nemhauser,J.L., Taylor,B.A., Nadeau,J.H. and
            Lander,E.S.
  TITLE     Positional cloning of the nude locus: genetic, physical, and
            transcription maps of the region and mutations in the mouse and rat
  JOURNAL   Genomics 28 (3), 549-559 (1995)
   PUBMED   7490093
REFERENCE   8  (bases 1 to 2681)
  AUTHORS   Ahn,A.H., Dziennis,S., Hawkes,R. and Herrup,K.
  TITLE     The cloning of zebrin II reveals its identity with aldolase C
  JOURNAL   Development 120 (8), 2081-2090 (1994)
   PUBMED   7925012
REFERENCE   9  (bases 1 to 2681)
  AUTHORS   Paolella,G., Buono,P., Mancini,F.P., Izzo,P. and Salvatore,F.
  TITLE     Structure and expression of mouse aldolase genes. Brain-specific
            aldolase C amino acid sequence is closely related to aldolase A
  JOURNAL   Eur J Biochem 156 (2), 229-235 (1986)
   PUBMED   3009179
REFERENCE   10 (bases 1 to 2681)
  AUTHORS   Sato,S., Shimizu,K., Sugimura,T., Takaoka,T. and Katsuta,H.
  TITLE     Aldolase C in cultured mouse glioblastoma cells
  JOURNAL   Cancer Res 32 (6), 1290-1292 (1972)
   PUBMED   4337889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591070.19.
            
            Summary: This gene encodes a member of the aldolase family of
            enzymes that is mainly expressed in neuronal tissues. The encoded
            protein is an enzyme of the glycolysis pathway, and catalyzes the
            conversion of fructose-1,6-bisphosphate to
            glyceraldehyde-3-phosphate and dihydroxyacetone phosphate.
            Alternate splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008184.1, SRR6116558.190644.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AL591070.19        26792-26917         c
            127-150             AL591070.19        26768-26791         c
            151-274             AL591070.19        25477-25600         c
            275-486             AL591070.19        25175-25386         c
            487-541             AL591070.19        25027-25081         c
            542-702             AL591070.19        24781-24941         c
            703-786             AL591070.19        24578-24661         c
            787-961             AL591070.19        24174-24348         c
            962-1161            AL591070.19        23856-24055         c
            1162-1658           AL591070.19        23232-23728         c
            1659-2681           AL591070.19        22209-23231         c
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..2681
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /note="aldolase C, fructose-bisphosphate"
                     /db_xref="GeneID:11676"
                     /db_xref="MGI:MGI:101863"
     exon            1..150
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            151..274
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1254
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /EC_number="4.1.2.13"
                     /note="scrapie-responsive protein 2; brain-type aldolase;
                     zebrin II; scrapie responsive gene 2"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase C"
                     /protein_id="NP_001290352.1"
                     /db_xref="CCDS:CCDS25099.1"
                     /db_xref="GeneID:11676"
                     /db_xref="MGI:MGI:101863"
                     /translation="MPHSYPALSAEQKKELSDIALRIVTPGKGILAADESVGSMAKRL
                     SQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKG
                     ILVGIKVDKGVVPLAGTDGETTTQGLDGLLERCAQYKKDGADFAKWRCVLKISDRTPS
                     ALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALS
                     DHHVYLEGTLLKPNMVTPGHACPIKYSPEEIAMATVTALRRTVPPAVPGVTFLSGGQS
                     EEEASLNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEM
                     NGLAAQGRYEGSGDGGAAAQSLYIANHAY"
     exon            275..486
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..541
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..702
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..786
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..961
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1161
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..2681
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /note="hexamer: AATAAA"
     polyA_site      1658
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /note="major polyA site"
     regulatory      2644..2649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
                     /note="hexamer: AATAAA"
     polyA_site      2681
                     /gene="Aldoc"
                     /gene_synonym="Aldo3; Scrg2"
ORIGIN      
        1 gaggtatctg tcacgccccc agggagtcac gtagctctgc ggcaagtgct gccaccttat
       61 ttactccagc ttggaccgag ctaatcagag gaaaagtgag ctgtgctgtg gctcccgcgg
      121 ctgactggct gagtgactgg ctgagtatag acaactgtca tcatgcccca ctcataccca
      181 gctctttctg ctgagcagaa gaaggagttg tcggatattg ctctacggat cgtgaccccc
      241 ggcaagggca ttctggctgc agatgagtcc gtaggcagca tggccaaaag gctgagccaa
      301 attggggtgg agaacactga ggagaatcgc cggctgtacc gccaggtcct attcagtgct
      361 gatgaccgtg tgaaaaagtg cattgggggg gtcatcttct tccatgagac actctaccag
      421 aaagatgaca atggtgtccc cttcgtccgc accatccagg ataagggcat tctcgtaggc
      481 atcaaggttg acaagggtgt agtgcctcta gctgggaccg acggggaaac caccactcaa
      541 gggctggatg ggctcttgga acgctgtgct cagtataaga aggacggtgc tgattttgcc
      601 aaatggcgct gtgtactaaa aatcagtgat cgcacgccgt cggcactggc catattggag
      661 aatgccaacg tgctggcccg ctatgccagc atctgccagc agaatgggat cgtgcctatt
      721 gtggagcctg agattctgcc tgacggagac catgacctca aacgttgcca gtatgttaca
      781 gagaaggtcc tggctgctgt atacaaggcc ctgagtgacc atcatgtata cctcgaaggg
      841 actctgctca agcccaatat ggtgacccct ggccatgcct gtcccatcaa gtatagccca
      901 gaagagatcg ccatggcaac tgtcactgcc ctgcgtcgta ctgtgccccc agctgtccca
      961 ggggtgactt tcctgtctgg gggtcagagt gaagaggagg cttctctcaa cctcaatgcc
     1021 atcaaccgct gcccacttcc ccggccctgg gccctcacct tctcctatgg gcgtgccctg
     1081 caggcatctg cactcaatgc ctggagagga caaagggata atgctggggc tgctactgag
     1141 gagtttatca agcgggcaga gatgaacggg cttgcagccc agggcagata tgaaggcagt
     1201 ggagatggcg gagcggcagc acagtccctc tacatcgcca accatgccta ctgaggcacg
     1261 ctgactctac ccacagccct tggcctagca atgcacatcc cattttgcct atagtcacag
     1321 ccagggccaa atagctatgc agaacagaga tatctttatc cagcgccaag tcatctcaca
     1381 tctcacatgc cttacattgc tgtacccgag accacaggat gggagggtag agatgccctc
     1441 ccatgtttga agatgggggg actttctaga agtcagaaca gaacatgtgg acctttttcc
     1501 tgtctccacc agcccttaca gttacccttg atggtatagt ttgtccttgg gctctgcttg
     1561 ctaattttct ctcttgggat cagggggacg tgaactccag ccctgactcg tgctccttat
     1621 gctctgagta catagcaaat aaatgagagc aaaacacagc acaccgctct gtctgtctgt
     1681 ctgttgcaca taccaaagtc tacctccatg tgtgcgacct cttgctgatc ctatctcaga
     1741 gcccctctga ttgtggtggt ggtggtgagg tgagatctga gttttcctga gcttcaagtt
     1801 ttgtggagga agggttcacc tggctcacca tccctagctc aggctcctac ctgctgattt
     1861 ccaaagctgg agttgttgtt agagggcctg ggggtggaga ggagggtaca ggtcttccag
     1921 ggactgacac attaaaggat ccagcaggat gagaaactcc attttgtgca aggctcaaag
     1981 gggacaagca gggatcagag tgggccagtt ctcctccatc tctgaagaat gtgcacttag
     2041 gtcttttcca ataaggaaac cttccaagcc tcggggctac agagctgagt gtctagaagc
     2101 ttgccaaggg ctatgaccca cttccatgta gagaagggat tcatcggagg gttctggact
     2161 tgttagaact gatagggctt tgtggtgaat gattacccct gggctagagt gtgaggtagg
     2221 gtgacactag acagatgtgc actggaaaag tcattgatgt tctgctctgt gtggcctgac
     2281 cttataatca aagcagctaa ctcagcaatt tccatatgct tctgccaggc actgttcttc
     2341 taaccattat tatatgcatt aacacagctc tgtaaagtag gtaccattgt acttttcata
     2401 ggaggaaaca ggcttcaaag agaggctgag aggctattta ggattcgaac agcaggcatt
     2461 actatataga ggctgtgctc aggaattttt caatgaagca tcctcaatcg ctcgaattgg
     2521 aatcgatttt taaatcctag tctatagtct cggctagttg ggaggctgag gtatcagaca
     2581 ttagggacag gatcacttta accctctgga tcgtataggg agatctgtct caacattaac
     2641 taaaataaaa ttaatcacat agtagccaac catgctaaaa a
//
